最新的两项研究结果显示,两种疫苗有助于妇女对性传播疾病(STDs)和宫颈癌的预防。研究人员在随机的双盲对照试验中发现,人乳头状瘤病毒(HPV)-16疫苗对此前未曾暴露过的妇女的预防效果可高达100％。 Laura A.Koutsky及其同事进行的研究表...最新的两项研究结果显示,两种疫苗有助于妇女对性传播疾病(STDs)和宫颈癌的预防。研究人员在随机的双盲对照试验中发现,人乳头状瘤病毒(HPV)-16疫苗对此前未曾暴露过的妇女的预防效果可高达100％。 Laura A.Koutsky及其同事进行的研究表明,经HPV-16疫苗处理后。展开更多
Herpes simplex virus type 1 （HSV-1）, a neurotropic member of the alphaherpes virus family, is among the most prevalent and successful human pathogens. HSV-1 can cause serious diseases at every stage of life includin...Herpes simplex virus type 1 （HSV-1）, a neurotropic member of the alphaherpes virus family, is among the most prevalent and successful human pathogens. HSV-1 can cause serious diseases at every stage of life including fatal disseminated disease in newborns, cold sores, eye disease, and fatal encephalitis in adults. HSV-1 infection can trigger rapid immune responses, and efficient inhibition and clearance of HSV-1 infection rely on both the innate and adaptive immune responses of the host. Multiple strategies have been used to restrict host innate immune responses by HSV-1 to facilitate its infection in host cells. The adaptive immunity of the host plays an important role in inhibiting HSV-1 infections. The activation and regulation of T cells are the important aspects of the adaptive immunity. They play a crucial role in host-mediated immunity and are important for clearing HSV-1. In this review, we examine the findings on T cell immune responses during HSV-1 infection, which hold promise in the design of new vaccine can- didates for HSV-I.展开更多
基金supported by the Wuhan Institute of Virology (WIV) “One-Three-Five” Strategic Programs,China
文摘Herpes simplex virus type 1 （HSV-1）, a neurotropic member of the alphaherpes virus family, is among the most prevalent and successful human pathogens. HSV-1 can cause serious diseases at every stage of life including fatal disseminated disease in newborns, cold sores, eye disease, and fatal encephalitis in adults. HSV-1 infection can trigger rapid immune responses, and efficient inhibition and clearance of HSV-1 infection rely on both the innate and adaptive immune responses of the host. Multiple strategies have been used to restrict host innate immune responses by HSV-1 to facilitate its infection in host cells. The adaptive immunity of the host plays an important role in inhibiting HSV-1 infections. The activation and regulation of T cells are the important aspects of the adaptive immunity. They play a crucial role in host-mediated immunity and are important for clearing HSV-1. In this review, we examine the findings on T cell immune responses during HSV-1 infection, which hold promise in the design of new vaccine can- didates for HSV-I.
