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山东临沭 手机下单老汉乐
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《致富天地》 2019年第6期80-80,共1页
'前几天叫儿子回来打农药,儿子说打工挣钱多,为这几亩麦子回来不值得。过一会儿他又回电话叫俺别管了,他叫人来干,刚开始俺还不相信呢。'近日,在山东省临沭县青云镇季岭村的地头,69岁的季英沛看着开进地里的新农机,一脸惊讶。
关键词 公社 金丰 单老 临沭
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绿化老人单昭祥
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作者 常振祥 《国土绿化》 2006年第2期34-35,共2页
关键词 单老 宣化 黄羊滩 中信公司 北京人民广播电台 基金会 多伦 老人
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Cardiac toxicity of trastuzumab in elderly patients with breast cancer 被引量:10
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作者 Andrea Denegri Tiziano Moccetti +3 位作者 Marco Moccetti Paolo Spallarossa Claudio Brunelli Pietro Ameri 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2016年第4期355-363,共9页
Breast cancer (BC) is diagnosed in 〉 65 year old women in about half of cases. Experts currently recommend that systemic therapy is offered to elderly patients with BC, if, based on their overall conditions and lif... Breast cancer (BC) is diagnosed in 〉 65 year old women in about half of cases. Experts currently recommend that systemic therapy is offered to elderly patients with BC, if, based on their overall conditions and life expectancy, it can be reasonably anticipated that the benefits will outweigh the risks of treatment. Like for young subjects, the monoclonal antibody against human epidermal growth factor receptor-2 (HER-2), trastuzumab, represents a valid therapeutic option when BC over-expresses this receptor. Unforttmately, administration of trastu- zumab is associated with the occurrence of left ventricular dysfunction and chronic heart failure (CHF), possibly because of interference with the homeostatic functions of HER-2 in the heart. Registry-based, retrospective analyses have reported an incidence of CHF around 25% in elderly women receiving trastuzumab compared with 10%-15% in those not given any therapy for BC, and the risk of CHF has been estimated to be two-fold higher in 〉 60455 year old trastuzumab users vs. non-users. Extremely advanced age and preexisting cardiac disease have been shown to predispose to trastuzumab cardiotoxicity. Therefore, selection of older patients for treatment with trastuzumab should be primarily based on their general status and the presence of comorbidities; previous chemotherapy, especially with anthracyclines, should be also taken into account. Once therapy has started, efforts should be made to ensure regular cardiac surveillance. The role of selected biomarkers, such as cardiac troponin, or new imaging techniques (three-dimension, tissue Doppler echocardiography, magnetic resonance imaging) is promising, but must be further investigated especially in the elderly. Moreover, additional studies are needed in order to better understand the mechanisms by which trastuzumab affects the old heart. 展开更多
关键词 CARDIOTOXICITY ELDERLY Heart failure HER-2 TRASTUZUMAB
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Discourse Intonation and Teacher Cognition
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作者 Mahmoud Jeidani 《Sino-US English Teaching》 2014年第10期746-754,共9页
This study examines the relationship between discourse intonation (henceforth DI) and teacher cognition. Drawing on the rich literature on the teacher cognition in grammar, this study borrows some relevant insights ... This study examines the relationship between discourse intonation (henceforth DI) and teacher cognition. Drawing on the rich literature on the teacher cognition in grammar, this study borrows some relevant insights for a better understanding of the relationship between teacher cognition and DI. Following a qualitative treatment, the study concludes that instruction on D1 is a dynamic debate fed by both teacher training and teachers' experience of teaching and learning in general, which leads into suggesting the need for any teacher training on DI to take into account both DI knowledge as well as teacher core and peripheral belief. The contribution of the study lies in its tapping of a relatively poorly investigated area and offering advances on the many negative or simplistic teacher attitudes regarding intonation instruction as expressed in the literature, as well as in bringing to the surfaces something which teachers sometimes are not explicitly aware of. 展开更多
关键词 discourse intonation PROMINENCE TONES TEACHABILITY LEARNABILITY Lingua Franca Core (LFC)
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Research on the impact of pension income and expenditure patterns on the pension replacement rate of public institutions
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作者 LUO Shiyan 《International English Education Research》 2016年第4期64-65,共2页
Currently in China, to study the replacement rate of pension reform in public institutions and to find out the key problems, which is of practical significance for the reform of the pension insurance system. In this p... Currently in China, to study the replacement rate of pension reform in public institutions and to find out the key problems, which is of practical significance for the reform of the pension insurance system. In this paper, the impact of pension income and expenditure patterns on the substitution rate is analyzed, and the factors that affect the level of substitution rate are analyzed, and the corresponding policy recommendations are put forward. 展开更多
关键词 Government-affiliated institutions Substitution rate Pension reform
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Non-platinum doublets versus single agents in non-small cell lung cancer (NSCLC) patients with elderly age and/or poor performance status: a meta-analysis
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作者 Huijuan Qju Fang Wang +3 位作者 Guifang Guo Feifei Zhou Wenzhuo He Liangping Xia 《The Chinese-German Journal of Clinical Oncology》 CAS 2011年第3期134-139,共6页
Objective: The aim of the study was to compare the efficacies and toxicities of non-platinum doublets (doublets group) with a non-platinum single agent (single-agent group) in previously untreated advanced non-sm... Objective: The aim of the study was to compare the efficacies and toxicities of non-platinum doublets (doublets group) with a non-platinum single agent (single-agent group) in previously untreated advanced non-small cell lung cancer (NSCLC) patients with elderly age and/or poor performance status (PS). Methods: The PubMed database was screened. Subsequently, the hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS), relative risks (RRs) for overall response rate (ORR) and one-year survival, and odds ratios (ORs) for the different types of toxicities were pooled using the Review Manager 5.0 package. Results: This study comprised of 1427 patients enrolled in four randomized controlled trials. The pooled HR showed that the doublet group could increase ORR (P = 0.002) with no heterogeneity (P = 0.64), and might improve OS (P = 0.01 / P = 0.06) with heterogeneity (P 0.001). There was no significant difference in PFS (P = 0.16) and one-year survival (P = 0.25) between two treatment groups. The doublet group led to more grade 3/4 neutropenia and thrombocytopenia than the single-agent group (P = 0.02 and P = 0.000, respectively). The incidences of grade 3/4 anemia, vomiting, mucositis, constipation, diarrhea, neurotoxicity, allergy, and fatigue between the two treatment groups were insignificant. Conclusion: Except for neutropenia and thrombocytopenia, the non-platinum doublets could increase ORR, and might improve OS for NSCLC patients with elderly age and/or poor PS without addition of more side effects; however, the doublets showed an increased rate of neutropenia and thrombocytopenia. The addition of doublets may not improve PFS and one-year survival. 展开更多
关键词 fielderly non-small cell lung cancer (NSCLC) META-ANALYSIS doublets single non-platinum
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The Translation of a Few Words With Old-Fashioned Meanings in Pride and Prejudice
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作者 LI Xiu-li 《Sino-US English Teaching》 2013年第6期478-484,共7页
Word meanings change with time. This paper analyzes the meanings of three language units from Jane Austen's Pride and Prejudice and their Chinese renderings by seven translators. These three units are recollect, hand... Word meanings change with time. This paper analyzes the meanings of three language units from Jane Austen's Pride and Prejudice and their Chinese renderings by seven translators. These three units are recollect, handsome, and come upon the town. By studying the linguistic, situational, or cultural contexts of each language unit, the analysis shows that of the renderings of these three language units, the accuracy rate is three out of seven, one out of seven, and two out of seven respectively. The paper points out that one of the most important causes of the low accuracy rates is that these language units denote old-fashioned meanings. Another cause of the low accuracy rates is that some of the translators are not careful enough in their identification of the meanings of these language units. The paper suggests that in the translation of a classic novel like Pride and Prejudice, translators need to analyze carefully the linguistic, situational, or cultural contexts of a tricky language unit in the novel for very likely it denotes an old-fashioned meaning. Translators could also consult and compare what a tricky language unit means in other places of the novel, use an encyclopedic dictionary instead of a dictionary of contemporary English, and study the notes on tricky words in the novel made by established scholars. 展开更多
关键词 old-fashioned meaning Pride and Prejudice CONTEXTS TRANSLATION
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Study of China's pension merger issues
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作者 Huang Jue 《International English Education Research》 2015年第9期20-22,共3页
The merger of the pension not only in relation to the social justice, but also the relationship between the construction of social security system, pensions merger is beyond doubt. Pension dual track the biggest drawb... The merger of the pension not only in relation to the social justice, but also the relationship between the construction of social security system, pensions merger is beyond doubt. Pension dual track the biggest drawback is that a significant loss of fairness, the gap between different groups of pension is too wide, causing social conflicts. The merger of the pension has be imperative. Therefore, it is necessary to establish and perfect the system of the civil service pension insurance legal mandatory occupational pension system, strengthen the basic social pension, broaden the channels for pension investment, reform organs and institutions pension system and pension system Retbrm and civil service pay rise, in order to promote the reform of the civil service pension system. The merger of the pension reform is scientific and reasonable, healthy and orderly and can achieve a smooth transition. 展开更多
关键词 endowment insurance Double track MERGER REFORM
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Effect of bone marrow-derived monocytes transfected with RNA of mouse colon carcinoma on specific antitumor immunity 被引量:2
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作者 Xiao-YuanChu Long-BangChen JingZang Jing-HuaWang QunZhang Huai-ChengGeng 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第5期760-763,共4页
AIM: To investigate the effect of bone marrow-derived monocytes transfected with RNA of CT-26 (a cell line of mouse colon carcinoma) on antitumor immunity. METHODS: Mouse bone marrow-derived monocytes were incubated w... AIM: To investigate the effect of bone marrow-derived monocytes transfected with RNA of CT-26 (a cell line of mouse colon carcinoma) on antitumor immunity. METHODS: Mouse bone marrow-derived monocytes were incubated with mouse granulocyte macrophage colony stimulating factor (mGM-CSF) in vitro, and the purity of monocytes was detected by flow cytometry. Total RNA of CT-26 was obtained by TRIzol's process, and monocytes were transfected by TransMessenger in vitro. The activity of cytotoxic T lymphocytes (CTL) in vivo was estimated by the modified lactate dehydrogenase (LDH) release assay. Changes of tumor size in mice and animal's survival time were observed in different groups. RESULTS: Monocytes from mouse bone marrow were successfully incubated, and the positive rate of CDllb was over 95%. Vaccination of the monocytes transfected with total RNA induced a high level of specific CTL activity in vivo, and made mice resistant to the subsequent challenge of parental tumor cells. In vivo effects induced by monocytes transfected with total RNA were stronger than those induced by monocytes pulsed with tumor cell lysates. CONCLUSION: Antigen presenting cells transfected with total RNA of CT-26 can present endogenous? tumor antigens, activate CTL, and effectively induce specific antitumor immunity. 展开更多
关键词 Colon carcinoma RNA Bone marrow-derived monocytes Cytotoxic T lymphocytes
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