A single-mode laser noise model driven by quadratic colored pump noise and amplitude modulation signal is proposed. The real and imaginary parts of the pump noise are assumed to be cross-correlation. The effect of cro...A single-mode laser noise model driven by quadratic colored pump noise and amplitude modulation signal is proposed. The real and imaginary parts of the pump noise are assumed to be cross-correlation. The effect of cross- correlation of noise and amplitude modulation of signal on laser statistical properties is studied by using the linearized approximation. The analytic expression of signal-to-noise ratio （SNR） is calculated. It is found that the phenomena of stochastic resonance （SR） respectively exist in the curves of the SNR versus the noise cross-correlation coefficient λ and the SNR versus the pump parameter a, as well as the SNR versus the signal frequency ω in our model. It is shown that there are three different typies of SR in the model： the conventional form of SR, the SR in the broad sense, and the bona fide SR.展开更多
The effect on intensity correlation time T by input signal is studied for gain-noise model of a single-mode laser driven by colored pump noise and colored quantum noise with colored cross-correlation with a bias signa...The effect on intensity correlation time T by input signal is studied for gain-noise model of a single-mode laser driven by colored pump noise and colored quantum noise with colored cross-correlation with a bias signal modulation in this paper. By using the linear approximation method, we detect that there exists maximum （i.e., resonance） in the curve of the intensity correlation time T upon bias current io when the noise correlation coefficient λ is positive; and there exists minimum （i.e., suppression） in the T-io curve when λ is negative. And whenλ is zero, T increases monotonously with increasing io. Furthermore, the curve of T upon the signal frequency Ω is also studied. Our study shows that no matter what the value of λ is, there exists minimum （i.e., suppression） in the T-Ω curve.展开更多
During infections,bacteria stimulate host cells to produce and release histamine,which is a key mediator of vital cellular processes in animals.However,the mechanisms underlying the bacterial cell’s ability to sense ...During infections,bacteria stimulate host cells to produce and release histamine,which is a key mediator of vital cellular processes in animals.However,the mechanisms underlying the bacterial cell’s ability to sense and respond to histamine are poorly understood.Herein,we show that HinK,a Lys R-type transcriptional regulator,is required to evoke responses to histamine in Pseudomonas aeruginosa,an important human pathogen.HinK directly binds to and activates the promoter of genes involved in histamine uptake and metabolism,iron acquisition,and Pseudomonas quinolone signal(PQS)biosynthesis.The transcriptional regulatory activity of HinK is induced when histamine is present,and it occurs when HinK binds with imidazole-4-acetic acid(Im AA),a histamine metabolite whose production in P.aeruginosa depends on the HinK-activated histamine uptake and utilization operon hin DAC-pa0222.Importantly,the inactivation of HinK inhibits diverse pathogenic phenotypes of P.aeruginosa.These results suggest that histamine acts as an interkingdom signal and provide insights into the mechanism used by pathogenic bacteria to exploit host regulatory signals to promote virulence.展开更多
基金The project supported by National Natural Science Foundation of China under Grant No.10275025
文摘A single-mode laser noise model driven by quadratic colored pump noise and amplitude modulation signal is proposed. The real and imaginary parts of the pump noise are assumed to be cross-correlation. The effect of cross- correlation of noise and amplitude modulation of signal on laser statistical properties is studied by using the linearized approximation. The analytic expression of signal-to-noise ratio （SNR） is calculated. It is found that the phenomena of stochastic resonance （SR） respectively exist in the curves of the SNR versus the noise cross-correlation coefficient λ and the SNR versus the pump parameter a, as well as the SNR versus the signal frequency ω in our model. It is shown that there are three different typies of SR in the model： the conventional form of SR, the SR in the broad sense, and the bona fide SR.
文摘The effect on intensity correlation time T by input signal is studied for gain-noise model of a single-mode laser driven by colored pump noise and colored quantum noise with colored cross-correlation with a bias signal modulation in this paper. By using the linear approximation method, we detect that there exists maximum （i.e., resonance） in the curve of the intensity correlation time T upon bias current io when the noise correlation coefficient λ is positive; and there exists minimum （i.e., suppression） in the T-io curve when λ is negative. And whenλ is zero, T increases monotonously with increasing io. Furthermore, the curve of T upon the signal frequency Ω is also studied. Our study shows that no matter what the value of λ is, there exists minimum （i.e., suppression） in the T-Ω curve.
基金supported by the Ministry of Science and Technology(MOST)of China(2016YFA0501503 and 2019ZX09721001-004-003)the National Natural Science Foundation of China(31670136,31870127,and 81861138047)+1 种基金the Science and Technology Commission of Shanghai Municipality(19JC1416400)the State Key Laboratory of Drug Research(SIMM2003ZZ-03)。
文摘During infections,bacteria stimulate host cells to produce and release histamine,which is a key mediator of vital cellular processes in animals.However,the mechanisms underlying the bacterial cell’s ability to sense and respond to histamine are poorly understood.Herein,we show that HinK,a Lys R-type transcriptional regulator,is required to evoke responses to histamine in Pseudomonas aeruginosa,an important human pathogen.HinK directly binds to and activates the promoter of genes involved in histamine uptake and metabolism,iron acquisition,and Pseudomonas quinolone signal(PQS)biosynthesis.The transcriptional regulatory activity of HinK is induced when histamine is present,and it occurs when HinK binds with imidazole-4-acetic acid(Im AA),a histamine metabolite whose production in P.aeruginosa depends on the HinK-activated histamine uptake and utilization operon hin DAC-pa0222.Importantly,the inactivation of HinK inhibits diverse pathogenic phenotypes of P.aeruginosa.These results suggest that histamine acts as an interkingdom signal and provide insights into the mechanism used by pathogenic bacteria to exploit host regulatory signals to promote virulence.
