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单路信号激励的非接触超声马达的试验研究 被引量:3
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作者 刘景全 杨志刚 +2 位作者 吴博达 程光明 蔡炳初 《压电与声光》 CAS CSCD 北大核心 2001年第2期152-155,共4页
目前研究的非接触超声马达都是建立在行波理论基础上的 ,这类马达需将定子弹性体激励出行波 ,因而它至少需要两路相位差成π/ 2的信号源 ,其驱动电路复杂。文章提出了一种新型的圆筒型非接触超声马达 ,它只需单路信号激励。定子采用在... 目前研究的非接触超声马达都是建立在行波理论基础上的 ,这类马达需将定子弹性体激励出行波 ,因而它至少需要两路相位差成π/ 2的信号源 ,其驱动电路复杂。文章提出了一种新型的圆筒型非接触超声马达 ,它只需单路信号激励。定子采用在圆筒弹性体外表面粘贴矩形板压电陶瓷构成。根据有限元分析设计制造了定子 ,并进行了可行性试验。文章给出了转子结构尺寸对马达转速的影响试验 ,当采用四叶片转子时马达无负载的最高转速为 2 0 2 6 r/ m in。 展开更多
关键词 超声马达 单路信号激励 非接触 试验
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一种不用先验知识的单路混合信号的盲源分离新方法 被引量:7
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作者 成谢锋 马勇 +2 位作者 张学军 刘琚 张少白 《电子学报》 EI CAS CSCD 北大核心 2011年第10期2317-2321,2330,共6页
基于单路混合信号的分层技术,提出了一种单路混合信号的盲源分离新方法,它的特点是不需要利用先验知识.如何做单路原始信号的分层工作?它应该被分几层?通过对分层技术的深入讨论和加入一个参考信号,上述问题找到了很好的答案.并且文中... 基于单路混合信号的分层技术,提出了一种单路混合信号的盲源分离新方法,它的特点是不需要利用先验知识.如何做单路原始信号的分层工作?它应该被分几层?通过对分层技术的深入讨论和加入一个参考信号,上述问题找到了很好的答案.并且文中给出了一种改进型圆周卷积数据等长度分层的方法和获取独立子波函数的技术;然后通过结合独立子波函数进入原始信号,使原始信号由一维向量转化成为多维向量,从而实现其盲分离;最后的分离实验,验证了本方法的有效性和可行性. 展开更多
关键词 盲分离 独立子波函数 单路信号 分层技术 改进型圆周卷积
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基于WPT分层和独立子波函数的单路心音混合信号BSS新方法 被引量:2
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作者 成谢锋 陶冶薇 张少白 《南京邮电大学学报(自然科学版)》 2009年第4期50-54,63,共6页
提出了一种基于小波变换分层和独立子波函数的单路混合信号的盲源分离新方法。首先讨论了单路混合信号分离模型,以及如何利用WPT进行窄带分层和获取独立子波函数的技术;然后通过结合独立子波函数进入单路混合信号,使单路混合信号由一维... 提出了一种基于小波变换分层和独立子波函数的单路混合信号的盲源分离新方法。首先讨论了单路混合信号分离模型,以及如何利用WPT进行窄带分层和获取独立子波函数的技术;然后通过结合独立子波函数进入单路混合信号,使单路混合信号由一维向量转化成为多维向量,以实现其盲分离;最后通过心音信号的分离实验,验证了本方法的有效性和可行性。 展开更多
关键词 盲分离 独立子波函数 单路信号 心声信号
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一种单路混沌信号盲源分离方法 被引量:2
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作者 徐亮 成谢锋 《安徽师范大学学报(自然科学版)》 CAS 北大核心 2010年第1期28-33,共6页
提出一种基于经验模态分解(EMD)对单路混沌信号进行盲源分离的方法.首先讨论了混沌信号的特征,利用EMD对信号进行分层并且得到独立子波函数,然后把独立子波函数加入到单路混合信号中,从而实现混沌信号的盲分离;最后通过混沌信号的分离实... 提出一种基于经验模态分解(EMD)对单路混沌信号进行盲源分离的方法.首先讨论了混沌信号的特征,利用EMD对信号进行分层并且得到独立子波函数,然后把独立子波函数加入到单路混合信号中,从而实现混沌信号的盲分离;最后通过混沌信号的分离实验,证明了本方法的有效性和可靠性. 展开更多
关键词 经验模态分解(EMD) 混沌信号 盲源分离 单路信号
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独立子波函数和小波分析在单路含噪信号盲分离中的应用研究:模型与关键技术 被引量:19
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作者 成谢锋 陶冶薇 +2 位作者 张少白 张学军 刘琚 《电子学报》 EI CAS CSCD 北大核心 2009年第7期1522-1528,共7页
本文提出了一种基于独立子波函数和小波分析的单路含噪混合信号的盲源分离新方法.首先分析了独立子波函数的组成原理,以及获得独立子波函数的方法;然后通过结合独立子波函数进入单路混合信号,使单路混合信号由一维向量转化成为多维向量... 本文提出了一种基于独立子波函数和小波分析的单路含噪混合信号的盲源分离新方法.首先分析了独立子波函数的组成原理,以及获得独立子波函数的方法;然后通过结合独立子波函数进入单路混合信号,使单路混合信号由一维向量转化成为多维向量;其次讨论了利用小波进行二次去噪和解决数据段顺序不确定性的问题,并且文中还给出了独立子波函数个数判定方法和相似相图;最后通过消除瞬态诱发耳声发射中伪迹的实验,验证了本方法的有效性和可行性. 展开更多
关键词 盲源信号分离 独立子波函数 单路含噪信号 小波 独立分量分析 瞬态诱发耳声发射
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一种心音信号盲源分离方法 被引量:10
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作者 孙科学 成谢锋 《电子测量与仪器学报》 CSCD 2012年第6期498-502,共5页
为了有效实现单路心音混合信号的盲分离,本文提出了一种基于EMD分解和独立成分函数的单路含噪心音信号盲源分离的方法。首先讨论了单路混合信号的分离模型,含噪信号预处理的方法,以及如何利用EMD变换进行窄带分层和获取独立成分函数的技... 为了有效实现单路心音混合信号的盲分离,本文提出了一种基于EMD分解和独立成分函数的单路含噪心音信号盲源分离的方法。首先讨论了单路混合信号的分离模型,含噪信号预处理的方法,以及如何利用EMD变换进行窄带分层和获取独立成分函数的技术;然后通过独立成分函数作为基函数对单路含噪心音信号进行分解,使单路心音信号由一维向量转变为多维向量,从而实现心音信号的盲源分离;最后通过实际的心音分离实验,验证了本方法的实用性,其分离结果的相似度达到0.9792。 展开更多
关键词 盲源分离 经验模值分解 独立基函数 单路含噪信号
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单路口交通灯的控制与显示电路仿真设计
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作者 赵慧勇 罗永革 刘珂路 《湖北汽车工业学院学报》 2010年第1期5-7,29,共4页
在Proteus环境下进行了单路交通信号显示与控制电路的模块化设计,使用译码电路完成了单片机选择与控制电路的设计。在MPlab环境下进行了PIC16F877单片机的编程,并通过2种软件的联合仿真分析,完成了单路口交通灯的控制与显示电路。
关键词 单路交通信号显示 单片机选择控制 仿真
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一种新型的圆筒非接触超声马达 被引量:5
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作者 刘景全 吴博达 +2 位作者 杨志刚 程光明 鲁勇 《声学学报》 EI CSCD 北大核心 2001年第2期113-116,共4页
提出了一种新型的圆筒非接触超声马达.该马达主要工作在驻波状态下,且仅需单路信号激励。文中给出了马达定子的振动解析,并依此设计定子。当马达稳定转动时,采用激光测振仪测得了马达定子的振动模态。实验表明,单路信号激励下同样... 提出了一种新型的圆筒非接触超声马达.该马达主要工作在驻波状态下,且仅需单路信号激励。文中给出了马达定子的振动解析,并依此设计定子。当马达稳定转动时,采用激光测振仪测得了马达定子的振动模态。实验表明,单路信号激励下同样可以实现非接触驱动。此外还采用高速摄像机拍摄了马达的起动特性。 展开更多
关键词 非接触超声马达 圆筒 定子 振动 结构 单路信号激励 超动特性
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极点配置法确定超混沌系统同步与控制的条件
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作者 程丽 彭建华 黄秋楠 《广西师范大学学报(自然科学版)》 CAS 2002年第1期79-82,共4页
利用控制理论中的极点配置方法 ,解析分析了离散超混沌系统同步与控制的条件 .其同步与控制方案均采用单路组合信号反馈的形式 .研究对象是离散超混沌系统 .通过数值计算方法验证解析分析的结果 。
关键词 极点配置法 超混沌系统 混沌同步 混沌控制 控制理论 单路组合信号反馈
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非等同广义离散超混沌系统的多同步研究 被引量:2
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作者 欧阳超常 陈菊芳 彭建华 《深圳大学学报(理工版)》 EI CAS 北大核心 2012年第3期242-246,共5页
提出用广义依农映像和广义立方映像两个离散超混沌系统,在单向驱动控制信号的作用下,构建了非等同超混沌同步的驱动-响应系统,根据离散系统局域稳定性理论,确定这一系统在不同维数下出现完全同步和完全反同步、广义同步和广义反同步的... 提出用广义依农映像和广义立方映像两个离散超混沌系统,在单向驱动控制信号的作用下,构建了非等同超混沌同步的驱动-响应系统,根据离散系统局域稳定性理论,确定这一系统在不同维数下出现完全同步和完全反同步、广义同步和广义反同步的解析条件,设计和构建非等同超混沌系统的实验电路,依据理论分析得到的参数范围,通过数值计算和测量实验电路,所得到的结果均与理论分析的结果相符合.研究结果表明,恰当选择单路驱动控制信号,也可实现非等同超混沌离散系统多种类型的同步. 展开更多
关键词 高维混沌 广义离散超混沌系统 单路驱动信号 非等同系统 多同步态 电路实验
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Structural basis of immunosuppression by the therapeutic antibody daclizumab 被引量:5
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作者 Hui Yang Jianchuan Wang +5 位作者 Jiamu Du Chen Zhong Dapeng Zhang Huaizu Guo Yajun Guo Jianping Ding 《Cell Research》 SCIE CAS CSCD 2010年第12期1361-1371,共11页
Interleukin-2 (IL)-2 signaling plays a pivotal role in the activation of immune responses, and drugs that block this pathway have been shown to be effective for the immunosuppression in patients with organ transplan... Interleukin-2 (IL)-2 signaling plays a pivotal role in the activation of immune responses, and drugs that block this pathway have been shown to be effective for the immunosuppression in patients with organ transplantation to alleviate/eliminate allograft rejection. The first humanized monoclonal antibody (mAb) daclizumab falls into this category and shows high specificity and affinity against a key component of the IL-2 receptor complex, namely IL-2Ra. To reveal the molecular mechanism of the inhibition of the IL-2 signaling pathway by dacllzumab, we determined the crystal structures of the daclizumab Fab in free form and in complex with the IL-2Ra ectodomain at 2.6 and 2.8 A resolution, respectively. The daclizumab Fab adopts a similar conformation in the presence or absence of the IL- 2Ra ectodomain. The antigen-binding site of daclizumab is mainly composed of live complementarity determining regions (CDRs) that form a large positively charged surface depression and two flanking patches that are generally hydrophobic. The conformational epitope consists of several discontinuous segments of the IL-2Ru ectodomain, a large portion of which overlaps with the regions that interact with IL-2, suggesting that the binding of daclizumab to IL-2Ra would prevent the IL-2 binding to IL-2Ra and the subsequent formation of the IL-2fIL-2Ra[~/c complex, and therefore block the IL-2 signaling pathway. These results also have implications for the design and development of improved mAb drugs targeting IL-2Ra. 展开更多
关键词 IL-2Ra IL-2 signaling DACLIZUMAB therapeutic antibody crystal structure
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Dendroaspis natriuretic peptide relaxes gastric antral circular smooth muscle of guinea-pig through thecGMP/cGMP-dependent protein kinase pathway 被引量:1
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作者 Chun-Yu Cai Zheng-Xu Cai +5 位作者 Xin-Yi Gu Lu-Juan Shan Yong-Xiao Wang Xue-Zhe Yin Qing-Hui Qi Hui-Shu Guo 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第35期5461-5466,共6页
AIM: To systematically investigate if cGMP/cGMP- dependent protein kinase G (PKG) signaling pathway may participate in dendroaspis natriuretic peptide (DNP)-induced relaxation of gastric circular smooth muscle. METHOD... AIM: To systematically investigate if cGMP/cGMP- dependent protein kinase G (PKG) signaling pathway may participate in dendroaspis natriuretic peptide (DNP)-induced relaxation of gastric circular smooth muscle. METHODS: The content of cGMP in guinea pig gastric antral smooth muscle tissue and perfusion solution were measured using radioimmunoassay; spontaneous contraction of gastric antral circular muscles recorded using a 4-channel physiograph; and Ca2+-activated K+ currents (IK(Ca)) and spontaneous transient outward currents (STOCs) in isolated gastric antral myocytes were recorded using the whole-cell patch clamp technique. RESULTS: DNP markedly enhanced cGMP levels in gastric antral smooth muscle tissue and in the perfusion medium. DNP induced relaxation in gastricantral circular smooth muscle, which was inhibited by KT5823, a cGMP-dependent PKG inhibitor. DNP increased IK(Ca). This effect was almost completely blocked by KT5823, and partially blocked by LY83583, an inhibitor of guanylate cyclase to change the production of cGMP. DNP also increased STOCs. The effect of DNP on STOCs was abolished in the presence of KT5823, but not affected by KT-5720, a PKA-specific inhibitor. CONCLUSION: DNP activates IK(Ca) and relaxes guinea-pig gastric antral circular smooth muscle via the cGMP/PKG-dependent singling axis instead of cAMP/ PKA pathway. 展开更多
关键词 Dendroaspis natriuretic peptide Cyclic guanosine monophosphate Protein kinase G Proteinkinase A Gastric motility
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T Cell Receptor Signaling Pathways:New Targets for Herpes Simplex Virus
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作者 You-jia CAO Ya-peng LI +1 位作者 Ying-chi ZHANG Cui-zhu ZHANG 《Virologica Sinica》 SCIE CAS CSCD 2008年第6期429-437,共9页
Herpes simplex viruses (HSV-1 and HSV-2) cause global morbidity and synergistically correlate with HIV infection. HSV exists life-long in a latent form in sensory neurons with intermittent reactivation, in despite o... Herpes simplex viruses (HSV-1 and HSV-2) cause global morbidity and synergistically correlate with HIV infection. HSV exists life-long in a latent form in sensory neurons with intermittent reactivation, in despite of host immune surveillatlce. While abundant evidence for HSV interfering with innate immune responses so as to favor the replication and propagation of the virus, several lines of evidence declare that HSV attenuates adaptive immunity by various mechanisms, including but not limited to the ablation of antigen presentation, induction of apoptosis, and interruption of cellular signaling. In this review, we will focus on the perturbative role of HSV in T cells signaling. 展开更多
关键词 Herpes simplex virus T cell receptor Signaling
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A Synonymous Polymorphism of APCDD1 Affects Translation Efficacy and is Associated with Androgenic Alopecia
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作者 Nikoletta Nagy Katalin Farkas +9 位作者 Agnes Kinyo Barbara Fazekas Kornelia Szabo Edit Kollar Balazs Sztano Angela Meszes Dora Beke Lajos Kemeny Laszlo Royo Marta Szell 《Journal of Life Sciences》 2014年第2期106-114,共9页
The APCDDI (adenomatosis polyposis coli down-regulated 1) gene is an inhibitor of the Wnt signaling pathway, and a rare mutation of this gene has been associated with hereditary hypotrichosis simplex. In this study,... The APCDDI (adenomatosis polyposis coli down-regulated 1) gene is an inhibitor of the Wnt signaling pathway, and a rare mutation of this gene has been associated with hereditary hypotrichosis simplex. In this study, the authors aimed to investigate whether common APCDD1 gene polymorphisms contribute to the development of androgenic alopecia. Patients (n = 210) with androgenic alopecia and 98 controls were investigated. SNPs (Single nucleotide polymorphisms) in the coding region of the gene were sequenced. A significant difference in genotype distribution was found for the c. 1781C/T, p.L476L SNP (rs3185480) of the APCDD1 gene. This SNP is located in exon 5 and is associated with a 3.5- and a 2.8-fold increase in risk for the development of androgenic alopecia for homozygote (CI 0.933-13.125; nominal regression P = 0.063) and heterozygote (CI 1.086-7.217; nominal regression P = 0.033) carriers, respectively. These data suggest that the rs3185480 polymorphism contributes to the development of androgenic alopecia. Protein expression experiments revealed that the polymorphism is associated with reduced APCDDI protein abundance. This reduction is likely due to altered codon usage for leucine from a preferred codon (CTC) to a rare codon (CTT), which might influence translation efficiency and, thus, APCDDI protein level. 展开更多
关键词 Adenomatosis polyposis coli down-regulated 1 gene hereditary hypotrichosis simplex androgenic alopecia polymorphism synonymous translation efficacy preferable codon.
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Effect of penehyclidine hydrochloride on patients with acute lung injury and its mechanisms 被引量:12
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作者 李百强 孙海晨 +3 位作者 聂时南 邵旦兵 刘红梅 钱晓明 《Chinese Journal of Traumatology》 CAS 2010年第6期329-335,共7页
Objective: To assess the effects of penehyclidine hydrochloride on patients with acute lung injury (ALI), to observe the expression of Toll-like receptor 4 (TLR4) on the peripheral monocytes of ALI patients and c... Objective: To assess the effects of penehyclidine hydrochloride on patients with acute lung injury (ALI), to observe the expression of Toll-like receptor 4 (TLR4) on the peripheral monocytes of ALI patients and changes of inflammatory & anti-inflammatory cytokines and to investigate the mechanism of TLR4 in ALI.Methods: Forty-five patients with ALI were randomly divided into penehyclidine hydrochloride treatment group (P group, n=21) and conventional treatment group (control group, C group, n=24). Patients in both groups received conventional treatment, including active treatment of the primary disease, respiratory support, nutritional support and fluid management therapy, while those in P group were given penehyclidine hydrochloride (1 mg, im, q. 12 h) in addition.The TLR4 expression of 20 healthy volunteers were detected.The clinical effect, average length of stay in ICU and hospital,values of PaO2 and PaO2/FiO2, expression of TLR4 on the surface of peripheral blood mononuclear cells and some serum cytokines were evaluated for 48 h.Results: The general conditions of the two groups were improved gradually and PaO2 increased progressively.Compared with 0 h, PaO2 and PaO2/FiO2 at 6, 12, 24 and 48 h after treatment were significantly increased (P<0.05). The improvement in P group was obviously greater than that in C group (P<0.05). The average length of hospitalization showed no difference between the two groups, but penehyclidine hydrochloride significantly decreased the average length of stay in ICU (t=3.485, P<0.01). The expression of TLR4 in two groups were both obviously higher than that of healthy volunteers (P<0.01). It decreased significantly at 24 h (t=2.032, P<0.05) and 48 h (t=3.620, P<0.01)and was lower in P group than in C group. The patients who showed a higher level of TLR4 expression in early stage had a worse prognosis and most of them developed acute respiratory distress syndrome (ARDS). The incidence of ARDS was 23.8% in P group and 29.17% in C group at 24 h.Until148 h, there were other two patients developing ARDS in control group. Serum IL-l, IL-8 and TNF-α expressions reduced after 24 h in both groups. The reduction in P group was more obvious than that in C group (P<0.05). IL-13 increased gradually from 0 h to 24 h, and decreased slightly at 48 h, which showed no difference between two groups (t=1.028, P>0.05).Conclusions: Penehyclidine hydrochloride improves the arterial oxygen pressure, down-regulates the expression of TLR4 and restrains the inflammatory cytokines in the downstream of TLR4 signaling pathway. It prevents the development of ALI and can be considered as an important drug in ALI treatment. 展开更多
关键词 PENEHYCLIDINE Acute lunginjury Wounds and injuries Toll-like receptor 4
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