Prader-Willi Syndrome （PWS） is a genetic disorder that is difficult to detect, particularly at an early age. PWS is caused by disruption of normal, epigenetically controlled gene function in the chromosome 15q11-q13...Prader-Willi Syndrome （PWS） is a genetic disorder that is difficult to detect, particularly at an early age. PWS is caused by disruption of normal, epigenetically controlled gene function in the chromosome 15q11-q13 region. Clinical symptoms are difficult to diagnose in infants and only become clearer at later ages as the patients develop hyperphagia and morbid obesity. Molecular genetic tests are able to definitively diagnose PWS and allow early diagnosis of the syndrome. High resolution cytogenetic testing, methylation-specific PCR （MS-PCR）, and linkage analysis are routinely used to diagnose PWS. To establish a linkage analysis method for Chinese patients, this study identified a useful set of STR markers in the typical PWS deletion and adjacent area, for linkage analysis in two Chinese families with PWS offspring. Using this method, the authors confn＇rned that one patient had a paternal deletion in chromosome 15q 11-q 13 and the other patient had maternal uniparental heterodisomy of chromosome 15. MS -PCR and high resolution chromosome G-banding also confirmed this diagnosis. This linkage analysis method can detect both deletion and uniparental disomy, thus providing valuable information for genetic counseling and the opportunity to analyze the relationship between the genotype and phenotype of PWS.展开更多
In multiloci-based genetic association studies of complex diseases, a powerful and high efficient tool for analyses oflinkage disequilibrium (LD) between markers, haplotype distributions and many chi-square/p values w...In multiloci-based genetic association studies of complex diseases, a powerful and high efficient tool for analyses oflinkage disequilibrium (LD) between markers, haplotype distributions and many chi-square/p values with a large numberof samples has been sought for long. In order to achieve the goal of obtaining meaningful results directly from raw data,we developed a robust and user-friendly software platform with a series of tools for analysis in association study withhigh efficiency. The platform has been well evaluated by several sets of real data.展开更多
With a particular focus on the connection between liquid flow distribution and gas-liquid mass transfer in monolithic beds in the Taylor flow regime, hydrodynamic and gas-liquid mass transfer experiments were carriedo...With a particular focus on the connection between liquid flow distribution and gas-liquid mass transfer in monolithic beds in the Taylor flow regime, hydrodynamic and gas-liquid mass transfer experiments were carriedout in a column with a monolithic bed of cell density of 50 cpsi with trio different distributors （nozzle and packed bed distributors）. Liquid saturation in individual channels was measured by using self-made micro-conductivity probes. A mal-distribution factor was used to evaluate uniform degree of phase distribution in monoliths. Overall bed pressure drop and mass transfer coefficients were measured. For liquid flow distribution and gas-liquid masstransfer, it is found that the superficial liquid velocity is a crucial factor and the packed bed distributor is better than the nozzle distributor. A semi-theoretical analysis using single channel models shows that the packed bed distributor always yields shorter and uniformly distributed liquid slugs compared to the nozzle distributor, which in turn ensures a better mass transfer performance. A bed scale mass transfer model is proposed by employing the single channel models in individual channels and incorporating effects of non-uniform liquid distribution along the bedcross-section. The model predicts the overall gas-liquid mass transfer coefficient wig a relative error within ＋30%.展开更多
A design of diode-pumped Nd.YAG laser with a single crystal that generates simultaneous laser action at the wavelengths of 1064 nm and 1319 nm was presented and continuous-wave （CW） of 588.9 nm was obtained for the ...A design of diode-pumped Nd.YAG laser with a single crystal that generates simultaneous laser action at the wavelengths of 1064 nm and 1319 nm was presented and continuous-wave （CW） of 588.9 nm was obtained for the first time by use of type-I critical phase-matching LBO crystal intracavity sumfrequency mixing. The maximum output power of 62 mW is achieved with an incident pump power of 1.8 W. The optical-to-optical conversion efficiency is up to 3.4% ,and the power instability in 24 h is better than ± 2.7 %.展开更多
A graph is symmetric or 1-regular if its automorphism group is transitive or regular on the arc set of the graph, respectively. We classify the connected pentavalent symmetric graphs of order 2p^3 for each prime p. Al...A graph is symmetric or 1-regular if its automorphism group is transitive or regular on the arc set of the graph, respectively. We classify the connected pentavalent symmetric graphs of order 2p^3 for each prime p. All those symmetric graphs appear as normal Cayley graphs on some groups of order 2p^3 and their automorphism groups are determined. For p = 3, no connected pentavalent symmetric graphs of order 2p^3 exist. However, for p = 2 or 5, such symmetric graph exists uniquely in each case. For p 7, the connected pentavalent symmetric graphs of order 2p^3 are all regular covers of the dipole Dip5 with covering transposition groups of order p^3, and they consist of seven infinite families; six of them are 1-regular and exist if and only if 5 |(p- 1), while the other one is 1-transitive but not 1-regular and exists if and only if 5 |(p ± 1). In the seven infinite families, each graph is unique for a given order.展开更多
A multiresolution hexahedron element is presented with a new multiresolution analysis(MRA)framework.The MRA framework is formulated out of a mutually nesting displacement subspace sequence,whose basis functions are co...A multiresolution hexahedron element is presented with a new multiresolution analysis(MRA)framework.The MRA framework is formulated out of a mutually nesting displacement subspace sequence,whose basis functions are constructed of scaling and shifting on element domain of a basic node shape function.The basic node shape function is constructed from shifting to other seven quadrants around a specific node of a basic isoparametric element in one quadrant and joining the corresponding node shape functions of eight elements at the specific node.The MRA endows the proposed element with the resolution level(RL)to adjust structural analysis accuracy.As a result,the traditional 8-node hexahedron element is a monoresolution one and also a special case of the proposed element.The meshing for the monoresolution finite element model is based on the empiricism while the RL adjusting for the multiresolution is laid on the solid mathematical basis.The simplicity and clarity of shape function construction with the Kronecker delta property and the rational MRA enable the proposed element method to be more rational,easier and efficient in its implementation than the conventional mono-resolution solid element method or other MRA methods.The multiresolution hexahedron element method is more adapted to dealing with the accurate computation of structural problems.展开更多
文摘Prader-Willi Syndrome （PWS） is a genetic disorder that is difficult to detect, particularly at an early age. PWS is caused by disruption of normal, epigenetically controlled gene function in the chromosome 15q11-q13 region. Clinical symptoms are difficult to diagnose in infants and only become clearer at later ages as the patients develop hyperphagia and morbid obesity. Molecular genetic tests are able to definitively diagnose PWS and allow early diagnosis of the syndrome. High resolution cytogenetic testing, methylation-specific PCR （MS-PCR）, and linkage analysis are routinely used to diagnose PWS. To establish a linkage analysis method for Chinese patients, this study identified a useful set of STR markers in the typical PWS deletion and adjacent area, for linkage analysis in two Chinese families with PWS offspring. Using this method, the authors confn＇rned that one patient had a paternal deletion in chromosome 15q 11-q 13 and the other patient had maternal uniparental heterodisomy of chromosome 15. MS -PCR and high resolution chromosome G-banding also confirmed this diagnosis. This linkage analysis method can detect both deletion and uniparental disomy, thus providing valuable information for genetic counseling and the opportunity to analyze the relationship between the genotype and phenotype of PWS.
基金This work was supported by the Major State Basic Research Development program of Chinathe National High Technology Research and Development Program of China.
文摘In multiloci-based genetic association studies of complex diseases, a powerful and high efficient tool for analyses oflinkage disequilibrium (LD) between markers, haplotype distributions and many chi-square/p values with a large numberof samples has been sought for long. In order to achieve the goal of obtaining meaningful results directly from raw data,we developed a robust and user-friendly software platform with a series of tools for analysis in association study withhigh efficiency. The platform has been well evaluated by several sets of real data.
基金Supported by the State Key Development Program for Basic Research of China (2006CB202503)
文摘With a particular focus on the connection between liquid flow distribution and gas-liquid mass transfer in monolithic beds in the Taylor flow regime, hydrodynamic and gas-liquid mass transfer experiments were carriedout in a column with a monolithic bed of cell density of 50 cpsi with trio different distributors （nozzle and packed bed distributors）. Liquid saturation in individual channels was measured by using self-made micro-conductivity probes. A mal-distribution factor was used to evaluate uniform degree of phase distribution in monoliths. Overall bed pressure drop and mass transfer coefficients were measured. For liquid flow distribution and gas-liquid masstransfer, it is found that the superficial liquid velocity is a crucial factor and the packed bed distributor is better than the nozzle distributor. A semi-theoretical analysis using single channel models shows that the packed bed distributor always yields shorter and uniformly distributed liquid slugs compared to the nozzle distributor, which in turn ensures a better mass transfer performance. A bed scale mass transfer model is proposed by employing the single channel models in individual channels and incorporating effects of non-uniform liquid distribution along the bedcross-section. The model predicts the overall gas-liquid mass transfer coefficient wig a relative error within ＋30%.
文摘A design of diode-pumped Nd.YAG laser with a single crystal that generates simultaneous laser action at the wavelengths of 1064 nm and 1319 nm was presented and continuous-wave （CW） of 588.9 nm was obtained for the first time by use of type-I critical phase-matching LBO crystal intracavity sumfrequency mixing. The maximum output power of 62 mW is achieved with an incident pump power of 1.8 W. The optical-to-optical conversion efficiency is up to 3.4% ,and the power instability in 24 h is better than ± 2.7 %.
基金supported by National Natural Science Foundation of China (Grant Nos. 11571035 and 11231008)
文摘A graph is symmetric or 1-regular if its automorphism group is transitive or regular on the arc set of the graph, respectively. We classify the connected pentavalent symmetric graphs of order 2p^3 for each prime p. All those symmetric graphs appear as normal Cayley graphs on some groups of order 2p^3 and their automorphism groups are determined. For p = 3, no connected pentavalent symmetric graphs of order 2p^3 exist. However, for p = 2 or 5, such symmetric graph exists uniquely in each case. For p 7, the connected pentavalent symmetric graphs of order 2p^3 are all regular covers of the dipole Dip5 with covering transposition groups of order p^3, and they consist of seven infinite families; six of them are 1-regular and exist if and only if 5 |(p- 1), while the other one is 1-transitive but not 1-regular and exists if and only if 5 |(p ± 1). In the seven infinite families, each graph is unique for a given order.
基金supported by the Foundation of Municipal Key Laboratory of Geomechanics and Geological Environment Protection at Chongqing Institute of Logistics Engineering of PLA(Grant No.GKLGGP 2013-02)the National Natural Science Foundation of China(Grant No.51178222)
文摘A multiresolution hexahedron element is presented with a new multiresolution analysis(MRA)framework.The MRA framework is formulated out of a mutually nesting displacement subspace sequence,whose basis functions are constructed of scaling and shifting on element domain of a basic node shape function.The basic node shape function is constructed from shifting to other seven quadrants around a specific node of a basic isoparametric element in one quadrant and joining the corresponding node shape functions of eight elements at the specific node.The MRA endows the proposed element with the resolution level(RL)to adjust structural analysis accuracy.As a result,the traditional 8-node hexahedron element is a monoresolution one and also a special case of the proposed element.The meshing for the monoresolution finite element model is based on the empiricism while the RL adjusting for the multiresolution is laid on the solid mathematical basis.The simplicity and clarity of shape function construction with the Kronecker delta property and the rational MRA enable the proposed element method to be more rational,easier and efficient in its implementation than the conventional mono-resolution solid element method or other MRA methods.The multiresolution hexahedron element method is more adapted to dealing with the accurate computation of structural problems.
