Using optimal interpolation data assimilation of observed wave spectrum around Northeast coast of Taiwan Island, the typhoon driven wave nowcasting model in Southeast China Sea is setup. The SWAN (simulating waves nea...Using optimal interpolation data assimilation of observed wave spectrum around Northeast coast of Taiwan Island, the typhoon driven wave nowcasting model in Southeast China Sea is setup. The SWAN (simulating waves nearshore) model is used to calculate wave field and the input wind field is the QSCAT/NCEP (Quick Scatterometer/National Centers for Environmental Prediction) data. The two-dimensional wavelet transform is applied to analyze the X-band radar image of nearshore wave field and it reveals that the observed wave spectrum has shoaling characteristics in frequency domain. The reverse calculation approach of wave spectrum in deep water is proposed and validated with experimental tests. The two-dimensional digital low-pass filter is used to obtain the initialization wave field. Wave data during Typhoon Sinlaku is used to calibrate the data assimilation parameters and test the reverse calculation approach. Data assimilation corrects the significant wave height and the low frequency spectra energy evidently at Beishuang Station along Fujian Province coast, where the entire assimilation indexes are positive in verification moments. The nowcasting wave field shows that the present model can obtain more accurate wave predictions for coastal and ocean engineering in Southeast China Sea.展开更多
In recent years, great progress has been made regarding the treatment of inflammatory bowel disease (IBD), particularly in the field of biological therapies. Nevertheless, the ultimate treatment is not in sight. With ...In recent years, great progress has been made regarding the treatment of inflammatory bowel disease (IBD), particularly in the field of biological therapies. Nevertheless, the ultimate treatment is not in sight. With the development of new medication, it has become clear that we need a new understanding of IBD. Therapy needs to fit the different subtypes of IBD; e.g. mild disease in comparison to severe chronic active disease or Crohn's disease with or without fistulation or stenosis. The following article gives a practical overview of actual treatments for IBD. The intention of this article is not to provide a complete review of all new scientific developments, but to give a practical guideline for therapy of IBD.展开更多
Focusing on sustainability of water resources and ecology in the complex karst critical zone, we illustrated functions of the hydro-geochemical analysis on hydrology from the aspects of connection and interaction amon...Focusing on sustainability of water resources and ecology in the complex karst critical zone, we illustrated functions of the hydro-geochemical analysis on hydrology from the aspects of connection and interaction among hydrology–vegetation–soils/rock fractures along the karst subsurface profile. We reviewed isotopic and geochemical interpretations on tracing water sources for plant uptake, quantifying watershed outlet flow composition and residence times, and evaluating long-term evolution among climate–landscape–hydrology in the karst critical zone. In this paper, the application of the hydro-geochemical analysis on the above aspects in the karst areas of southwest China was summarized.展开更多
Hospital Gunshots On the morning of April 17,2016,in front of the People’s Hospital of Linying County of Henan Province,a number of relatives of a dead child cried incessantly,hung banners and posted the child’s pho...Hospital Gunshots On the morning of April 17,2016,in front of the People’s Hospital of Linying County of Henan Province,a number of relatives of a dead child cried incessantly,hung banners and posted the child’s photos in front of the hospital.展开更多
Objective:To standardize the distress management of gastric cancer patients receiving chemotherapy,the adapted Cancer-related Distress Management Guidelines were implemented in nursing practice among gastric cancer pa...Objective:To standardize the distress management of gastric cancer patients receiving chemotherapy,the adapted Cancer-related Distress Management Guidelines were implemented in nursing practice among gastric cancer patients receiving chemotherapy based on A Guideline Adaptation and Implementation Planning Resource(CAN-IMPLEMENT).Methods:Based on the theoretical framework of CAN-IMPLEMENT,A multidisciplinary team was established,barriers and facilitators obstacles of guidelines implementation in medical oncology units were assessed,corresponding solutions were formulated,the guidelines implementation process was monitored,and implementation results were evaluated.Results:The multidisciplinary team developed review criteria,standardized work paths,assessment tools,training manuals for healthcare professionals,education manuals for patients and their caregivers.After guidelines implementation,the completion rate of the distress management record came up to 97.9%(189/193).From September 2017 to December 2018,the compliance of medical staff on most items in the audit checklist was improved,ranging from 57.1%(100/175)to 100.0%(193/193).The positive distress rate of gastric cancer patients receiving chemotherapy was decreased from 22.7%(32/141)to 9.3%(18/193)(P<0.05),and the Median(range)of the distress score declined from 2(0e9)to 0(0e7)(P<0.001).Conclusions:The implementation of guidelines based on CAN-IMPLEMENT promotes the establishment of a distress management system in the medical oncology units.The review standards,standardized work paths,and evaluation tools for distress in cancer patients formulated by the multidisciplinary team had clinical applicability and effectiveness.Quality control in the practice of distress management was effective.The compliance of healthcare professionals with distress management was improved.The distress of gastric cancer patients receiving chemotherapy was alleviated effectively.展开更多
AIM: To examine the epidemiologic and clinical characteristics of hepatitis B virus (HBV) related liver failure in patients in China. METHODS: This study was conducted with a retro- spective design to examine 1066...AIM: To examine the epidemiologic and clinical characteristics of hepatitis B virus (HBV) related liver failure in patients in China. METHODS: This study was conducted with a retro- spective design to examine 1066 patients with HBV- related liver failure in the southwest of China. RESULTS: There were more male than female patients. Young and middle-aged people comprised most of the patients. Farmers and laborers comprised the larg- est proportion (63.09%). Han Chinese accounted for 98.12%, while minority ethnic groups only accounted for 0.88% of patients. A total of 43.47% patients had a family history of HBV-related liver failure and 56.66% patients had a history of drinking alcohol. A total of 42.59% patients with HBV-related liver failure had defi- nite causes. With regard to the clinical manifestation of HBV-related liver failure, the symptoms were: hypodynamia, anorexia and abdominal distension. Total bilirubin (TBIL) and alanine aminotransferase (ALT) levels were altered in 46.23% of patients with evident damage of the liver. Univariate logistic regression analysis showed that the patients' prognoses were correlated with ALT, aspartate aminotransferase, albumin, TBIL, prothrombin activity (PTA), and alpha-fetoprotein levels, and drinking alcohol, ascites, hepatorenal syndrome, infection and 〉i 2 complications. Multifactor logistic regression analysis showed that the activity of thrombinogen and the number of complications were related to the prognosis. CONCLUSION: Alcohol influences the patients' prognosis and condition. PTA and complications are independent factors that can be used for estimating the prognosis of HBV-related liver failure.展开更多
Soil degradation, including rocky desertification,of the karst regions in China is severe. Karst landscapes are especially sensitive to soil degradation as carbonate rocks are nutrient-poor and easily eroded. Understa...Soil degradation, including rocky desertification,of the karst regions in China is severe. Karst landscapes are especially sensitive to soil degradation as carbonate rocks are nutrient-poor and easily eroded. Understanding the balance between soil formation and soil erosion is critical for long-term soil sustainability, yet little is known about the initial soil forming processes on karst terrain. Herein we examine the initial weathering processes of several types of carbonate bedrock containing varying amounts of non-carbonate minerals in the SPECTRA Critical Zone Observatory, Guizhou Province, Southwest China. We compared the weathering mechanisms of the bedrock to the mass transfer of mineral nutrients in a soil profile developed on these rocks and found that soil formation and nutrient contents are strongly dependent upon the weathering of interbedded layers of more silicate-rich bedrock(marls). Atmospheric inputs from dust were also detected.展开更多
In this work, the authors aimed to detect the clonal relatedness of the isolated imipenem-susceptible and non-susceptible Acenitobacter baumanii. This study was conducted from September 2008 through August 2009 in Abo...In this work, the authors aimed to detect the clonal relatedness of the isolated imipenem-susceptible and non-susceptible Acenitobacter baumanii. This study was conducted from September 2008 through August 2009 in Aboelreech-Elmounira paediatric-Cairo University-teaching hospital in Egypt. All the isolated acenitobacter species were identified by standard laboratory procedures. The clonal relationship of the A. baumanii (the most common detected clinical type) was studied by biotyping and AST and then confirmed using rep-PCR with primers aimed at repetitive extragenic palindromic sequences and enterobacterial repetitive intergenic consensus sequences. A total of 100 A. baumanii isolates out of 104 acenitobacter species were recovered from different clinical samples. Sixty two percent of the isolates were resistant to imipenem. The resulting rep-PCR patterns oftheA, baumanii strains revealed 8 clones, 3 clones found in the imipenem resistant group, and 5 clones in imipenem sensitive group with statistically significant clonal distribution in both groups (P-value 0.00). Clonality was proved in imipenem resistant group with an alarming predominance of clone 1 representing 80.6% of IMP-R isolates. In accordance the prevalence of resistant acenitobacter strains seems to be correlated with inappropriate antibiotic use. These results call for strict compliance of coordinated strategy of infection control measures and judicious use of antimicrobials which is likely to effectively deal with this serious public health issue.展开更多
In view of the measurement difficulties of indexes recommended by the 50Items Experience of Coal Mine Gas Prevention in the process of the nonoutburst coalseam upgrade, this paper took the No.8 coal seam of Huainan Mi...In view of the measurement difficulties of indexes recommended by the 50Items Experience of Coal Mine Gas Prevention in the process of the nonoutburst coalseam upgrade, this paper took the No.8 coal seam of Huainan Mining Group as research object. Discussed the suitability of indexes and corresponding critical values, putforward method in determining the indexes and its critical values by analysis and investigation of the gas geological condition and the-spot tracking near position where anoutburst occurred combined with laboratory experiment, and established the indexesand its critical values of nonoutburst coal seam upgrade in No.8 coal seam of HuainanMining Group. The results show that it is suitable to take gas content and tectonic softcoal thickness easily to gain in routine production as primary upgrade indexes that itscritical values are 7.5 m^3/t and 0.8 m, respectively. In addition, takefvalue and Ap valueas auxiliary indexes.展开更多
Next-generation sequencing(NGS) has been rapidly integrated into molecular pathology, dramatically increasing the breadth genomic of information available to oncologists and their patients. This review will explore th...Next-generation sequencing(NGS) has been rapidly integrated into molecular pathology, dramatically increasing the breadth genomic of information available to oncologists and their patients. This review will explore the ways in which this new technology is currently applied to bolster care for patients with solid tumors and hematological malignancies, focusing on practices and guidelines for assessing the technical validity and clinical utility of DNA variants identified during clinical NGS oncology testing.展开更多
OBJECTIVE To study the clinicopathologic characteristics, changes in the nature and incidence of colorectal polyps in the Nanchang area, Jiangxi, Province. METHODS We retrospectively investigated the patients with col...OBJECTIVE To study the clinicopathologic characteristics, changes in the nature and incidence of colorectal polyps in the Nanchang area, Jiangxi, Province. METHODS We retrospectively investigated the patients with colorectal polyps who were diagnosed by colonoscopy and pathology in our hospital from 1990 to 2004. The analysis involved the incidence, average patient age, polyp location and pathological types. We recorded the changes of the polyp clinicopathologic features by comparing the clinicopathologic types of colorectal polyps over fi ve-year periods. RESULTS Of the 21,853 patients who received a colonoscopy, 2,889(13.2%) were diagnosed with colorectal polyps. Their average age was 46.6±16.5 years, with a male to female ratio of 1.8:1. The males were older than females (47.1±17.5 vs. 45.5±14.5, P<0.05). Location of the polyps: 41% in the rectum, 27.7% in the sigmoid colon, 35.8% in the left side verus 23.1% in the right side (P<0.05). Patients with polyps located in the transverse and ascending colon were older than those with polyps in the rectum and sigmoid colon (P<0.05). Adenomatous polyps comprised the most common type (67%) and the rectum was the most common site for each type, especially juvenile and retention polyps. Juvenile polyps were found in the youngest patients(12±4.8, P<0.05) and the adenomatous in the oldest (52±14, P<0.05). The ratio of patients with polyposis comprised 1.2%, and patients with polyps accompanied with colorectal cancer comprised 6.1%. Examination of the changes in the incidence, the average patient age, and adenomatous type showed that they had all increased, but the frequency of infl ammatory and retention polyps decreased. CONCLUSION Colorectal polyps are a common problem. The frequency is greater in males compared to females and the rectum and sigmoid colon had the highest incidence. Most juvenile and retention polyps were found in young patients, but most adenomatous occurred in adults. In recent years, the incidence of colorectal polyps, the average patient age, and the adenomatous type have increased in the Nanchang area, but inflammatory and retention types decreased.展开更多
基金supported by the Commonweal Program of Chinese Ministry of Water Resources( No.200901062)the National Natural Science Foundation of China ( No.50979033)the Research Fund of State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering ( No. 2009585812 and No. 2008491011)
文摘Using optimal interpolation data assimilation of observed wave spectrum around Northeast coast of Taiwan Island, the typhoon driven wave nowcasting model in Southeast China Sea is setup. The SWAN (simulating waves nearshore) model is used to calculate wave field and the input wind field is the QSCAT/NCEP (Quick Scatterometer/National Centers for Environmental Prediction) data. The two-dimensional wavelet transform is applied to analyze the X-band radar image of nearshore wave field and it reveals that the observed wave spectrum has shoaling characteristics in frequency domain. The reverse calculation approach of wave spectrum in deep water is proposed and validated with experimental tests. The two-dimensional digital low-pass filter is used to obtain the initialization wave field. Wave data during Typhoon Sinlaku is used to calibrate the data assimilation parameters and test the reverse calculation approach. Data assimilation corrects the significant wave height and the low frequency spectra energy evidently at Beishuang Station along Fujian Province coast, where the entire assimilation indexes are positive in verification moments. The nowcasting wave field shows that the present model can obtain more accurate wave predictions for coastal and ocean engineering in Southeast China Sea.
文摘In recent years, great progress has been made regarding the treatment of inflammatory bowel disease (IBD), particularly in the field of biological therapies. Nevertheless, the ultimate treatment is not in sight. With the development of new medication, it has become clear that we need a new understanding of IBD. Therapy needs to fit the different subtypes of IBD; e.g. mild disease in comparison to severe chronic active disease or Crohn's disease with or without fistulation or stenosis. The following article gives a practical overview of actual treatments for IBD. The intention of this article is not to provide a complete review of all new scientific developments, but to give a practical guideline for therapy of IBD.
基金supported by the National Natural Scientific Foundation of China(No.41571130071)
文摘Focusing on sustainability of water resources and ecology in the complex karst critical zone, we illustrated functions of the hydro-geochemical analysis on hydrology from the aspects of connection and interaction among hydrology–vegetation–soils/rock fractures along the karst subsurface profile. We reviewed isotopic and geochemical interpretations on tracing water sources for plant uptake, quantifying watershed outlet flow composition and residence times, and evaluating long-term evolution among climate–landscape–hydrology in the karst critical zone. In this paper, the application of the hydro-geochemical analysis on the above aspects in the karst areas of southwest China was summarized.
文摘Hospital Gunshots On the morning of April 17,2016,in front of the People’s Hospital of Linying County of Henan Province,a number of relatives of a dead child cried incessantly,hung banners and posted the child’s photos in front of the hospital.
基金funded by Fudan-Fuxing Nursing Research Funds(No.FNF201701)JBI Evidence Based Clinical Fellowship Pro-gram Funds(No.FNF201861)from Fudan University,China.
文摘Objective:To standardize the distress management of gastric cancer patients receiving chemotherapy,the adapted Cancer-related Distress Management Guidelines were implemented in nursing practice among gastric cancer patients receiving chemotherapy based on A Guideline Adaptation and Implementation Planning Resource(CAN-IMPLEMENT).Methods:Based on the theoretical framework of CAN-IMPLEMENT,A multidisciplinary team was established,barriers and facilitators obstacles of guidelines implementation in medical oncology units were assessed,corresponding solutions were formulated,the guidelines implementation process was monitored,and implementation results were evaluated.Results:The multidisciplinary team developed review criteria,standardized work paths,assessment tools,training manuals for healthcare professionals,education manuals for patients and their caregivers.After guidelines implementation,the completion rate of the distress management record came up to 97.9%(189/193).From September 2017 to December 2018,the compliance of medical staff on most items in the audit checklist was improved,ranging from 57.1%(100/175)to 100.0%(193/193).The positive distress rate of gastric cancer patients receiving chemotherapy was decreased from 22.7%(32/141)to 9.3%(18/193)(P<0.05),and the Median(range)of the distress score declined from 2(0e9)to 0(0e7)(P<0.001).Conclusions:The implementation of guidelines based on CAN-IMPLEMENT promotes the establishment of a distress management system in the medical oncology units.The review standards,standardized work paths,and evaluation tools for distress in cancer patients formulated by the multidisciplinary team had clinical applicability and effectiveness.Quality control in the practice of distress management was effective.The compliance of healthcare professionals with distress management was improved.The distress of gastric cancer patients receiving chemotherapy was alleviated effectively.
基金Supported by The National Basic Research Program of China(973 Program 2007CB512903)the State Key Project of China in HBV-related severe hepatitis (2008ZX10002-005)
文摘AIM: To examine the epidemiologic and clinical characteristics of hepatitis B virus (HBV) related liver failure in patients in China. METHODS: This study was conducted with a retro- spective design to examine 1066 patients with HBV- related liver failure in the southwest of China. RESULTS: There were more male than female patients. Young and middle-aged people comprised most of the patients. Farmers and laborers comprised the larg- est proportion (63.09%). Han Chinese accounted for 98.12%, while minority ethnic groups only accounted for 0.88% of patients. A total of 43.47% patients had a family history of HBV-related liver failure and 56.66% patients had a history of drinking alcohol. A total of 42.59% patients with HBV-related liver failure had defi- nite causes. With regard to the clinical manifestation of HBV-related liver failure, the symptoms were: hypodynamia, anorexia and abdominal distension. Total bilirubin (TBIL) and alanine aminotransferase (ALT) levels were altered in 46.23% of patients with evident damage of the liver. Univariate logistic regression analysis showed that the patients' prognoses were correlated with ALT, aspartate aminotransferase, albumin, TBIL, prothrombin activity (PTA), and alpha-fetoprotein levels, and drinking alcohol, ascites, hepatorenal syndrome, infection and 〉i 2 complications. Multifactor logistic regression analysis showed that the activity of thrombinogen and the number of complications were related to the prognosis. CONCLUSION: Alcohol influences the patients' prognosis and condition. PTA and complications are independent factors that can be used for estimating the prognosis of HBV-related liver failure.
基金supported by the National Environmental Research Council of the UK(Grant Nos.NE/N007530/1 and NE/N007603/1)the National Science Foundation of China(Grant No.41571130042)
文摘Soil degradation, including rocky desertification,of the karst regions in China is severe. Karst landscapes are especially sensitive to soil degradation as carbonate rocks are nutrient-poor and easily eroded. Understanding the balance between soil formation and soil erosion is critical for long-term soil sustainability, yet little is known about the initial soil forming processes on karst terrain. Herein we examine the initial weathering processes of several types of carbonate bedrock containing varying amounts of non-carbonate minerals in the SPECTRA Critical Zone Observatory, Guizhou Province, Southwest China. We compared the weathering mechanisms of the bedrock to the mass transfer of mineral nutrients in a soil profile developed on these rocks and found that soil formation and nutrient contents are strongly dependent upon the weathering of interbedded layers of more silicate-rich bedrock(marls). Atmospheric inputs from dust were also detected.
文摘In this work, the authors aimed to detect the clonal relatedness of the isolated imipenem-susceptible and non-susceptible Acenitobacter baumanii. This study was conducted from September 2008 through August 2009 in Aboelreech-Elmounira paediatric-Cairo University-teaching hospital in Egypt. All the isolated acenitobacter species were identified by standard laboratory procedures. The clonal relationship of the A. baumanii (the most common detected clinical type) was studied by biotyping and AST and then confirmed using rep-PCR with primers aimed at repetitive extragenic palindromic sequences and enterobacterial repetitive intergenic consensus sequences. A total of 100 A. baumanii isolates out of 104 acenitobacter species were recovered from different clinical samples. Sixty two percent of the isolates were resistant to imipenem. The resulting rep-PCR patterns oftheA, baumanii strains revealed 8 clones, 3 clones found in the imipenem resistant group, and 5 clones in imipenem sensitive group with statistically significant clonal distribution in both groups (P-value 0.00). Clonality was proved in imipenem resistant group with an alarming predominance of clone 1 representing 80.6% of IMP-R isolates. In accordance the prevalence of resistant acenitobacter strains seems to be correlated with inappropriate antibiotic use. These results call for strict compliance of coordinated strategy of infection control measures and judicious use of antimicrobials which is likely to effectively deal with this serious public health issue.
基金Supported by the National Key Basic Research Development Program of China (973 program) (2005CB221501)the National Key Technologies Research and Development Program of China during the Eleventh Five-Year Plan Period(2006BAK03B01)Program for Changjiang Scholars and Innovative Research Team in University(IRT0618)
文摘In view of the measurement difficulties of indexes recommended by the 50Items Experience of Coal Mine Gas Prevention in the process of the nonoutburst coalseam upgrade, this paper took the No.8 coal seam of Huainan Mining Group as research object. Discussed the suitability of indexes and corresponding critical values, putforward method in determining the indexes and its critical values by analysis and investigation of the gas geological condition and the-spot tracking near position where anoutburst occurred combined with laboratory experiment, and established the indexesand its critical values of nonoutburst coal seam upgrade in No.8 coal seam of HuainanMining Group. The results show that it is suitable to take gas content and tectonic softcoal thickness easily to gain in routine production as primary upgrade indexes that itscritical values are 7.5 m^3/t and 0.8 m, respectively. In addition, takefvalue and Ap valueas auxiliary indexes.
文摘Next-generation sequencing(NGS) has been rapidly integrated into molecular pathology, dramatically increasing the breadth genomic of information available to oncologists and their patients. This review will explore the ways in which this new technology is currently applied to bolster care for patients with solid tumors and hematological malignancies, focusing on practices and guidelines for assessing the technical validity and clinical utility of DNA variants identified during clinical NGS oncology testing.
文摘OBJECTIVE To study the clinicopathologic characteristics, changes in the nature and incidence of colorectal polyps in the Nanchang area, Jiangxi, Province. METHODS We retrospectively investigated the patients with colorectal polyps who were diagnosed by colonoscopy and pathology in our hospital from 1990 to 2004. The analysis involved the incidence, average patient age, polyp location and pathological types. We recorded the changes of the polyp clinicopathologic features by comparing the clinicopathologic types of colorectal polyps over fi ve-year periods. RESULTS Of the 21,853 patients who received a colonoscopy, 2,889(13.2%) were diagnosed with colorectal polyps. Their average age was 46.6±16.5 years, with a male to female ratio of 1.8:1. The males were older than females (47.1±17.5 vs. 45.5±14.5, P<0.05). Location of the polyps: 41% in the rectum, 27.7% in the sigmoid colon, 35.8% in the left side verus 23.1% in the right side (P<0.05). Patients with polyps located in the transverse and ascending colon were older than those with polyps in the rectum and sigmoid colon (P<0.05). Adenomatous polyps comprised the most common type (67%) and the rectum was the most common site for each type, especially juvenile and retention polyps. Juvenile polyps were found in the youngest patients(12±4.8, P<0.05) and the adenomatous in the oldest (52±14, P<0.05). The ratio of patients with polyposis comprised 1.2%, and patients with polyps accompanied with colorectal cancer comprised 6.1%. Examination of the changes in the incidence, the average patient age, and adenomatous type showed that they had all increased, but the frequency of infl ammatory and retention polyps decreased. CONCLUSION Colorectal polyps are a common problem. The frequency is greater in males compared to females and the rectum and sigmoid colon had the highest incidence. Most juvenile and retention polyps were found in young patients, but most adenomatous occurred in adults. In recent years, the incidence of colorectal polyps, the average patient age, and the adenomatous type have increased in the Nanchang area, but inflammatory and retention types decreased.