博宁联合化疗治疗骨转移癌的疗效分析

目的 :分析单纯化疗与博守联合化疗对实体瘤骨转移引起疼痛治疗的效果。方法 :42例病人随机分为单纯化疗组和化疗联合博宁组 ,对疼痛缓解程度和活动能力改善等进行对照研究。结果 :化疗联合应用博宁组疼痛缓解率及肿瘤变化方面明显优于单纯联合化疗组 (P <0 .0 5 ) ,而在活动能力改善方面则无明显差别。结论

博宁及博宁联合化疗治疗骨转移引起疼痛的疗效观察

目的：观察博宁单独使用与博宁联合化疗对实体瘤骨转移引起疼痛的疗效。方法：对４４ 例实体瘤骨转移患者随机分为治疗组（ 博宁单独应用） 与对照组（ 博宁联合化疗） 静脉滴注博宁９０ｍ ｇ ，２ 至４ 周重复，对照组于次日行常规方案化疗（２ 周期） 。结果：治疗组１８ 例，显效８ 例，有效６ 例，无效４ 例，总有效率７７ ．８ ％ （１４／１８） ，一周内取得疗效占５０ ％ （９／１８） ，毒副反应２ 例占１１ ．１ ％ （２／１８） 。对照组２６ 例，显效１２ 例，有效１１ 例，无效３ 例，总有效率８８ ．５ ％ （２３／２６） ，一周内取得疗效占５７ ．７ ％ （１５／２６） ，毒副反应４ 例占１５ ．４ ％ （４／２６） 。结论：博宁单独使用与博宁联合化疗治疗骨转移的疼痛均具有良好的止痛效果。

Combined chemotherapy with Boning in the treatment of pain due to bone metasta ses from malignant tumors

Objective To investigate the effect of Boning o n pain due to bone metastases from mal ignant tumors.Method From De-cember,1998to December,2000,86pa tients with pathologically proved b one metastases from malignant tumors were randomly divided into two groups,study group(combined chemotherapy with boning),control group(simple chemotherapy).Boning(60mg )dissolved in saline solution(500ml )were given IV for consecutive 3days.Then 60mg Boning was given every half-month .Patients in control group accepted simple chemotherapy.Results Efficacy in study group was 88.37%which was significantly superior to th at in control group(66.47%).Boning could repair injured bone.Adverse r eaction associated with Boning was weak.Boning quickly relieved sympto ms for a long time.Conclusion Effect of large-dose Boning for reli eving pain due to bone metastases fro m malignant tumors is satisfying.At the same time,Boning play im-portant role in repair of destructed bone.