In the past, celiac disease was believed to be a chronic enteropathy, almost exclusively affecting people of European origin. The availability of new, simple, very sensitive and specific serological tests （anti-gliad...In the past, celiac disease was believed to be a chronic enteropathy, almost exclusively affecting people of European origin. The availability of new, simple, very sensitive and specific serological tests （anti-gliadin, anti- endomysium and anti-transglutaminase antibody assays） have shown that celiac disease is common not only in Europe and in people of European ancestry but also in the developing countries where the major staple diet is wheat （Southern Asia, the Middle East, North West and East Africa, South America）, both in the general population and in the groups at risk. Gluten intolerance thus appears to be a widespread public health problem and an increased level of awareness and clinical suspicion are needed in the New World where physicians must learn to recognize the variable clinical presentations （classical, atypical and silent forms） of celiac disease. In the developing countries, both serological screening in the general population and serological testing in groups at risk are necessary for an early identification of celiac patients. The gluten-free diet poses a challenging public health problem in the developing countries, especially since commercial gluten-free products are not available.展开更多
Diverticular disease(DD) is an age-related disorder of the large bowel which may affect half of the population over the age of 65 in the UK.This high prevalence ranks it as one of the most common bowel disorders in we...Diverticular disease(DD) is an age-related disorder of the large bowel which may affect half of the population over the age of 65 in the UK.This high prevalence ranks it as one of the most common bowel disorders in western nations.The majority of patients remain asymptomatic but there are associated life-threatening co-morbidities, which, given the large numbers of people with DD, translates into a considerable number of deaths per annum.Despite this public health burden, relatively little seems to be known about either the mechanisms of development or causality.In the 1970s, a model of DD formulated the concept that diverticula occur as a consequence of pressureinduced damage to the colon wall amongst those with a low intake of dietary fiber.In this review, we have examined the evidence regarding the influence of ageing, diet, inflammation and genetics on DD development.We argue that the evidence supporting the barotrauma hypothesis is largely anecdotal.We have also identified several gaps in the knowledge base which need to be filled before we can complete a model for the etiology of diverticular disease.展开更多
In the last two years, we have seen a remarkable intensification in the response to AIDS in China. A number of organizations have joined and contributed to the efforts of the Chinese government in responding the AIDS ...In the last two years, we have seen a remarkable intensification in the response to AIDS in China. A number of organizations have joined and contributed to the efforts of the Chinese government in responding the AIDS epidemic in China. This article specifically describes the role of the United Nations in supporting and strengthening those responses. Achievements of the United Nations （UN） highlighted in the article include： strengthened leadership and political commitment to respond to AIDS; improved HIV/AIDS surveillance and information; expanded prevention efforts; improved treatment, care and support to people living with HIV and increased resources for AIDS programs. Additional roles of the United Nations system in the near future include strengthening national leadership by supporting the ‘three ones＇, i. e., one national plan on AIDS; one national coordinating authority for AIDS; and one monitoring and evaluation system for AIDS. In addition, the UN system is expected to strengthen alignment and harmonization of activities of all international organizations and improved accountability and oversight. Remaining challenges identified include increasing awareness of AIDS and reducing stigma and discrimination; reducing vulnerability and risk behaviour among specific groups; providing improved treatment, care and support for people living with HIV; promoting stronger engagement by civil society, and; addressing the gender dimensions of AIDS.展开更多
The Belt and Road Initiative is an important decision for the great rejuvenation of the Chinese nation. Maritime security has a significant place in this process. In recent years, there have been frequent violent terr...The Belt and Road Initiative is an important decision for the great rejuvenation of the Chinese nation. Maritime security has a significant place in this process. In recent years, there have been frequent violent terrorist incidents at sea, including piracy, armed hijackings and terrorist attacks, posing a dire threat to both international and Chinese maritime transport interests and seriously challenging the fulfillment of the maritime part of the ＂Belt and Road Initiative.＂ Five direct measures can be taken to protect ocean shipping from violence at sea. One example is the defensive measures taken against the Somali pirates. The employment of armed guards from professional security companies on board ship is an effective model for guaranteeing maritime security; it not only meets the standards of international law, but is also legally permitted in many developed countries and regions, and is thus strategically significant for overall Chinese maritime security. In the Chinese context, this model carries its own legal risks. We should embrace a new approach to national security law, strengthen legal guarantees and make concerted efforts to provide warship （military aircraft） escorts to jointly build an optimum model of Chinese maritime security in order to ensure the realization of core Chinese maritime interests.展开更多
This paper examines the widely acclaimed Barefoot Doctor campaign in China. The Barefoot Doctor campaign has come to symbolise the success of Chinese health care to the extent that it has become a model for WHO public...This paper examines the widely acclaimed Barefoot Doctor campaign in China. The Barefoot Doctor campaign has come to symbolise the success of Chinese health care to the extent that it has become a model for WHO public health strategy. Yet little has been done to understand how or whether it worked on the ground and what difficulties and contradictions emerged in its implementation. Using previously unexplored party archives as well as newly collected oral interviews, this paper moves away from a narrow focus on party politics and policy formulation by examining the reality of health care at the local level and the challenges faced by local authorities and individuals as the campaigns evolved.展开更多
文摘In the past, celiac disease was believed to be a chronic enteropathy, almost exclusively affecting people of European origin. The availability of new, simple, very sensitive and specific serological tests （anti-gliadin, anti- endomysium and anti-transglutaminase antibody assays） have shown that celiac disease is common not only in Europe and in people of European ancestry but also in the developing countries where the major staple diet is wheat （Southern Asia, the Middle East, North West and East Africa, South America）, both in the general population and in the groups at risk. Gluten intolerance thus appears to be a widespread public health problem and an increased level of awareness and clinical suspicion are needed in the New World where physicians must learn to recognize the variable clinical presentations （classical, atypical and silent forms） of celiac disease. In the developing countries, both serological screening in the general population and serological testing in groups at risk are necessary for an early identification of celiac patients. The gluten-free diet poses a challenging public health problem in the developing countries, especially since commercial gluten-free products are not available.
基金Supported by Food Standards Agency, N12105Northumbria Colorectal Research Funds
文摘Diverticular disease(DD) is an age-related disorder of the large bowel which may affect half of the population over the age of 65 in the UK.This high prevalence ranks it as one of the most common bowel disorders in western nations.The majority of patients remain asymptomatic but there are associated life-threatening co-morbidities, which, given the large numbers of people with DD, translates into a considerable number of deaths per annum.Despite this public health burden, relatively little seems to be known about either the mechanisms of development or causality.In the 1970s, a model of DD formulated the concept that diverticula occur as a consequence of pressureinduced damage to the colon wall amongst those with a low intake of dietary fiber.In this review, we have examined the evidence regarding the influence of ageing, diet, inflammation and genetics on DD development.We argue that the evidence supporting the barotrauma hypothesis is largely anecdotal.We have also identified several gaps in the knowledge base which need to be filled before we can complete a model for the etiology of diverticular disease.
文摘In the last two years, we have seen a remarkable intensification in the response to AIDS in China. A number of organizations have joined and contributed to the efforts of the Chinese government in responding the AIDS epidemic in China. This article specifically describes the role of the United Nations in supporting and strengthening those responses. Achievements of the United Nations （UN） highlighted in the article include： strengthened leadership and political commitment to respond to AIDS; improved HIV/AIDS surveillance and information; expanded prevention efforts; improved treatment, care and support to people living with HIV and increased resources for AIDS programs. Additional roles of the United Nations system in the near future include strengthening national leadership by supporting the ‘three ones＇, i. e., one national plan on AIDS; one national coordinating authority for AIDS; and one monitoring and evaluation system for AIDS. In addition, the UN system is expected to strengthen alignment and harmonization of activities of all international organizations and improved accountability and oversight. Remaining challenges identified include increasing awareness of AIDS and reducing stigma and discrimination; reducing vulnerability and risk behaviour among specific groups; providing improved treatment, care and support for people living with HIV; promoting stronger engagement by civil society, and; addressing the gender dimensions of AIDS.
文摘The Belt and Road Initiative is an important decision for the great rejuvenation of the Chinese nation. Maritime security has a significant place in this process. In recent years, there have been frequent violent terrorist incidents at sea, including piracy, armed hijackings and terrorist attacks, posing a dire threat to both international and Chinese maritime transport interests and seriously challenging the fulfillment of the maritime part of the ＂Belt and Road Initiative.＂ Five direct measures can be taken to protect ocean shipping from violence at sea. One example is the defensive measures taken against the Somali pirates. The employment of armed guards from professional security companies on board ship is an effective model for guaranteeing maritime security; it not only meets the standards of international law, but is also legally permitted in many developed countries and regions, and is thus strategically significant for overall Chinese maritime security. In the Chinese context, this model carries its own legal risks. We should embrace a new approach to national security law, strengthen legal guarantees and make concerted efforts to provide warship （military aircraft） escorts to jointly build an optimum model of Chinese maritime security in order to ensure the realization of core Chinese maritime interests.
文摘This paper examines the widely acclaimed Barefoot Doctor campaign in China. The Barefoot Doctor campaign has come to symbolise the success of Chinese health care to the extent that it has become a model for WHO public health strategy. Yet little has been done to understand how or whether it worked on the ground and what difficulties and contradictions emerged in its implementation. Using previously unexplored party archives as well as newly collected oral interviews, this paper moves away from a narrow focus on party politics and policy formulation by examining the reality of health care at the local level and the challenges faced by local authorities and individuals as the campaigns evolved.
