Helicobacter pylori (H. pylori), discovered in 1982, is a microaerophilic, spiral-shaped gram-negative bacterium that is able to colonize the human stomach. Nearly half of the world’s population is infected by this p...Helicobacter pylori (H. pylori), discovered in 1982, is a microaerophilic, spiral-shaped gram-negative bacterium that is able to colonize the human stomach. Nearly half of the world’s population is infected by this pathogen. Its ability to induce gastritis, peptic ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma has been confirmed. The susceptibility of an individual to these clinical outcomes is multifactorial and depends on H. pylori virulence, environmental factors, the genetic susceptibility of the host and the reactivity of the host immune system. Despite the host immune response, H. pylori infection can be difficult to eradicate. H. pylori is categorized as a group I carcinogen since this bacterium is responsible for the highest rate of cancer-related deaths worldwide. Early detection of cancer can be lifesaving. The 5-year survival rate for gastric cancer patients diagnosed in the early stages is nearly 90%. Gastric cancer is asymptomatic in the early stages but always progresses over time and begins to cause symptoms when untreated. In 97% of stomach cancer cases, cancer cells metastasize to other organs. H. pylori infection is responsible for nearly 60% of the intestinal-type gastric cancer cases but also influences the development of diffuse gastric cancer. The host genetic susceptibility depends on polymorphisms of genes involved in H. pylori-related inflammation and the cytokine response of gastric epithelial and immune cells. H. pylori strains differ in their ability to induce a deleterious inflammatory response. H. pylori-driven cytokines accelerate the inflammatory response and promote malignancy. Chronic H. pylori infection induces genetic instability in gastric epithelial cells and affects the DNA damage repair systems. Therefore, H. pylori infection should always be considered a pro-cancerous factor.展开更多
AIM:To evaluate the difference in diagnostic performance of hydro-stomach computed tomography(CT) to detect early gastric cancer(EGC) between blinded and unblinded analysis and to assess independent factors affecting ...AIM:To evaluate the difference in diagnostic performance of hydro-stomach computed tomography(CT) to detect early gastric cancer(EGC) between blinded and unblinded analysis and to assess independent factors affecting visibility of cancer foci.METHODS:Two radiologists initially blinded and then unblinded to gastroscopic and surgical-histological findings independently reviewed hydro-stomach CT images of 110 patients with single EGC.They graded the visibility of cancer foci for each of three gastric segments(upper,middle and lower thirds) using a 4-point scale(1:definitely absent,2:probably absent,3:probably present,and 4:definitely present).The sensitivity and specificity for detecting an EGC were calculated.Intraobserver and interobserver agreements were analyzed.The visibility of an EGC was evaluated with regard to tumor size,invasion depth,gastric segments,histological type and gross morphology using univariate and multivariate analysis.RESULTS:The respective sensitivities and specificities [reviewer 1:blinded,20%(22/110) and 98%(215/220);unblinded,27%(30/110) and 100%(219/220)/reviewer 2:blinded,19%(21/110) and 98%(216/220);unblinded,25%(27/110) and 98%(215/220)] were not significantly different.Although intraobserver agreements were good(weighted κ = 0.677 and 0.666),interobserver agreements were fair(blinded,0.371) or moderate(unblinded,0.558).For both univariate and multivariate analyses,the tumor size and invasion depth were statistically significant factors affecting visibility.CONCLUSION:The diagnostic performance of hydrostomach CT to detect an EGC was not significantly different between blinded and unblinded analysis.The tumor size and invasion depth were independent factors for visibility.展开更多
A catastrophic landslide occurred at Xinmo village in Maoxian County, Sichuan Province,China, on June 24, 2017. A 2.87×106 m3 rock mass collapsed and entrained the surface soil layer along the landslide path. Eig...A catastrophic landslide occurred at Xinmo village in Maoxian County, Sichuan Province,China, on June 24, 2017. A 2.87×106 m3 rock mass collapsed and entrained the surface soil layer along the landslide path. Eighty-three people were killed or went missing and more than 103 houses were destroyed. In this paper, the geological conditions of the landslide are analyzed via field investigation and high-resolution imagery. The dynamic process and runout characteristics of the landslide are numerically analyzed using a depth-integrated continuum method and Mac Cormack-TVD finite difference algorithm.Computational results show that the evaluated area of the danger zone matchs well with the results of field investigation. It is worth noting that soil sprayed by the high-speed blast needs to be taken into account for such kind of large high-locality landslide. The maximum velocity is about 55 m/s, which is consistent with most cases. In addition, the potential danger zone of an unstable block is evaluated. The potential risk area evaluated by the efficient depthintegrated continuum method could play a significant role in disaster prevention and secondary hazard avoidance during rescue operations.展开更多
A potential energy framework for assessment of grid vulnerability was presented.In the framework,the branch potential energy function model was constructed.Two indexes,current vulnerability and forecasting vulnerabili...A potential energy framework for assessment of grid vulnerability was presented.In the framework,the branch potential energy function model was constructed.Two indexes,current vulnerability and forecasting vulnerability,were calculated.The current vulnerability was used to identify the current vulnerable area through calculating the distance between the current transmitted power and initial transmitted power;and the forecast vulnerability under variation of power injection was used to predict the vulnerable area of next step and verify the current vulnerable area.Numerical simulation was performed under variant operating conditions with IEEE-30 bus system,which shows that almost area of 90% overlaps between current vulnerable area and forecasting vulnerable area,the overlapped area is termed as inherent vulnerable area of grid.When considering N-1 contingency,the assessment results of this method proposed agree with those of optimal power flow.When considering N-2 contingency,optimal power flow fails to obtain correct results,while the method based on energy framework gives reliable results.展开更多
In this article, clustered recurrent gap time is investigated. A marginal additive haz- ards model is proposed without specifying the association of the individuals within the same cluster. The relationship among the ...In this article, clustered recurrent gap time is investigated. A marginal additive haz- ards model is proposed without specifying the association of the individuals within the same cluster. The relationship among the gap times for the same individual is also left unspecified. An estimating equation-based inference procedure is developed for the model parameters, and the asymptotic proper- ties of the resulting estimators are established. In addition, a lack-of-fit test is presented to assess the adequacy of the model. The finite sample behavior of the proposed estimators is evaluated through simulation studies, and an application to a clinic study on chronic granulomatous disease （CGD） is illustrated.展开更多
The concept of Koszul differential graded (DG for short) algebra is introduced in [8].Let A be a Koszul DG algebra.If the Ext-algebra of A is finite-dimensional,i.e.,the trivial module A k is a compact object in the d...The concept of Koszul differential graded (DG for short) algebra is introduced in [8].Let A be a Koszul DG algebra.If the Ext-algebra of A is finite-dimensional,i.e.,the trivial module A k is a compact object in the derived category of DG A-modules,then it is shown in [8] that A has many nice properties.However,if the Ext-algebra is infinitedimensional,little is known about A.As shown in [15] (see also Proposition 2.2),A k is not compact if H(A) is finite-dimensional.In this paper,it is proved that the Koszul duality theorem also holds when H(A) is finite-dimensional by using Foxby duality.A DG version of the BGG correspondence is deduced from the Koszul duality theorem.展开更多
基金supported by a pilot grant(PI:Feng) from the Clinical and Translational Sciences Institute at the University of Rochester Medical Center(UR-CTSI GR500208)
文摘Helicobacter pylori (H. pylori), discovered in 1982, is a microaerophilic, spiral-shaped gram-negative bacterium that is able to colonize the human stomach. Nearly half of the world’s population is infected by this pathogen. Its ability to induce gastritis, peptic ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma has been confirmed. The susceptibility of an individual to these clinical outcomes is multifactorial and depends on H. pylori virulence, environmental factors, the genetic susceptibility of the host and the reactivity of the host immune system. Despite the host immune response, H. pylori infection can be difficult to eradicate. H. pylori is categorized as a group I carcinogen since this bacterium is responsible for the highest rate of cancer-related deaths worldwide. Early detection of cancer can be lifesaving. The 5-year survival rate for gastric cancer patients diagnosed in the early stages is nearly 90%. Gastric cancer is asymptomatic in the early stages but always progresses over time and begins to cause symptoms when untreated. In 97% of stomach cancer cases, cancer cells metastasize to other organs. H. pylori infection is responsible for nearly 60% of the intestinal-type gastric cancer cases but also influences the development of diffuse gastric cancer. The host genetic susceptibility depends on polymorphisms of genes involved in H. pylori-related inflammation and the cytokine response of gastric epithelial and immune cells. H. pylori strains differ in their ability to induce a deleterious inflammatory response. H. pylori-driven cytokines accelerate the inflammatory response and promote malignancy. Chronic H. pylori infection induces genetic instability in gastric epithelial cells and affects the DNA damage repair systems. Therefore, H. pylori infection should always be considered a pro-cancerous factor.
文摘AIM:To evaluate the difference in diagnostic performance of hydro-stomach computed tomography(CT) to detect early gastric cancer(EGC) between blinded and unblinded analysis and to assess independent factors affecting visibility of cancer foci.METHODS:Two radiologists initially blinded and then unblinded to gastroscopic and surgical-histological findings independently reviewed hydro-stomach CT images of 110 patients with single EGC.They graded the visibility of cancer foci for each of three gastric segments(upper,middle and lower thirds) using a 4-point scale(1:definitely absent,2:probably absent,3:probably present,and 4:definitely present).The sensitivity and specificity for detecting an EGC were calculated.Intraobserver and interobserver agreements were analyzed.The visibility of an EGC was evaluated with regard to tumor size,invasion depth,gastric segments,histological type and gross morphology using univariate and multivariate analysis.RESULTS:The respective sensitivities and specificities [reviewer 1:blinded,20%(22/110) and 98%(215/220);unblinded,27%(30/110) and 100%(219/220)/reviewer 2:blinded,19%(21/110) and 98%(216/220);unblinded,25%(27/110) and 98%(215/220)] were not significantly different.Although intraobserver agreements were good(weighted κ = 0.677 and 0.666),interobserver agreements were fair(blinded,0.371) or moderate(unblinded,0.558).For both univariate and multivariate analyses,the tumor size and invasion depth were statistically significant factors affecting visibility.CONCLUSION:The diagnostic performance of hydrostomach CT to detect an EGC was not significantly different between blinded and unblinded analysis.The tumor size and invasion depth were independent factors for visibility.
基金Financial support from National Nature Science Foundation of China (Grant No. 41572303, 41520104002)Chinese Academy of Sciences “Light of West China” Program and Youth Innovation Promotion Association
文摘A catastrophic landslide occurred at Xinmo village in Maoxian County, Sichuan Province,China, on June 24, 2017. A 2.87×106 m3 rock mass collapsed and entrained the surface soil layer along the landslide path. Eighty-three people were killed or went missing and more than 103 houses were destroyed. In this paper, the geological conditions of the landslide are analyzed via field investigation and high-resolution imagery. The dynamic process and runout characteristics of the landslide are numerically analyzed using a depth-integrated continuum method and Mac Cormack-TVD finite difference algorithm.Computational results show that the evaluated area of the danger zone matchs well with the results of field investigation. It is worth noting that soil sprayed by the high-speed blast needs to be taken into account for such kind of large high-locality landslide. The maximum velocity is about 55 m/s, which is consistent with most cases. In addition, the potential danger zone of an unstable block is evaluated. The potential risk area evaluated by the efficient depthintegrated continuum method could play a significant role in disaster prevention and secondary hazard avoidance during rescue operations.
基金Project(51007006) supported by the National Natural Science Foundation of ChinaProject(20090185120023) supported by the Ph.D Programs Foundation for New Teacher of Ministry of Education of China
文摘A potential energy framework for assessment of grid vulnerability was presented.In the framework,the branch potential energy function model was constructed.Two indexes,current vulnerability and forecasting vulnerability,were calculated.The current vulnerability was used to identify the current vulnerable area through calculating the distance between the current transmitted power and initial transmitted power;and the forecast vulnerability under variation of power injection was used to predict the vulnerable area of next step and verify the current vulnerable area.Numerical simulation was performed under variant operating conditions with IEEE-30 bus system,which shows that almost area of 90% overlaps between current vulnerable area and forecasting vulnerable area,the overlapped area is termed as inherent vulnerable area of grid.When considering N-1 contingency,the assessment results of this method proposed agree with those of optimal power flow.When considering N-2 contingency,optimal power flow fails to obtain correct results,while the method based on energy framework gives reliable results.
基金supported by the National Natural Science Foundation of China under Grant Nos.11501037,11771431,and 11690015
文摘In this article, clustered recurrent gap time is investigated. A marginal additive haz- ards model is proposed without specifying the association of the individuals within the same cluster. The relationship among the gap times for the same individual is also left unspecified. An estimating equation-based inference procedure is developed for the model parameters, and the asymptotic proper- ties of the resulting estimators are established. In addition, a lack-of-fit test is presented to assess the adequacy of the model. The finite sample behavior of the proposed estimators is evaluated through simulation studies, and an application to a clinic study on chronic granulomatous disease （CGD） is illustrated.
基金supported by the National Natural Science Foundation of China (Nos. 10801099,10731070)the Doctoral Program Foundation of the Ministry of Education of China (No. 20060246003)
文摘The concept of Koszul differential graded (DG for short) algebra is introduced in [8].Let A be a Koszul DG algebra.If the Ext-algebra of A is finite-dimensional,i.e.,the trivial module A k is a compact object in the derived category of DG A-modules,then it is shown in [8] that A has many nice properties.However,if the Ext-algebra is infinitedimensional,little is known about A.As shown in [15] (see also Proposition 2.2),A k is not compact if H(A) is finite-dimensional.In this paper,it is proved that the Koszul duality theorem also holds when H(A) is finite-dimensional by using Foxby duality.A DG version of the BGG correspondence is deduced from the Koszul duality theorem.
