The use of bionic non-smooth surfaces is a popular approach for saving energy because of their drag reduction property. Conventional non-smooth structures include riblets and dimples. Inspired by sand dunes, a novel v...The use of bionic non-smooth surfaces is a popular approach for saving energy because of their drag reduction property. Conventional non-smooth structures include riblets and dimples. Inspired by sand dunes, a novel variable ovoid non-smooth structure is proposed in this study. The body of the variable ovoid dimple was designed based on three size parameters, the radius, semimajor, and depth, and a 3D model was created based on UG software. The constructed variable dimples were placed in a rectangular array on the bottom of a square tube model. Following ANSYS meshing, the grid model was imported into FLUENT, where the flow characteristics were calculated. Results of skin friction reduction were achieved and the effect of the design parameters on different variable ovoid dimples was obtained by orthogonal testing. Various aspects of the skin friction reduction mechanism were discussed including the distribution of velocity vectors, variation in boundary layer thickness, and pressure distribution.展开更多
Ovarian cancer is one of the most deadly female genital malignant tumors in many regions while an effective early screening strategy can save numerous lives.CA125 and HE4 are tumor markers validated efficacious as wel...Ovarian cancer is one of the most deadly female genital malignant tumors in many regions while an effective early screening strategy can save numerous lives.CA125 and HE4 are tumor markers validated efficacious as well as most commonly used in recent screening research of ovarian cancer.In this paper,the authors construct a change-point and mixture model on the basis of longitudinal CA125 and HE4 levels and estimated parameters using maximum likelihood method with the preclinical duration assumed right-censored,which is more adaptive and yields comparable results in comparison to the Bayesian approach raised by Skates.Consistency of estimators is proved.The authors also run a 5-year simulation of sequential screening by calculating the risk of cancer and hypothesis testing the true incidence time respectively.Results show that diagnosis based on hypothesis test performs better in early detection.展开更多
基金Project supported by the National Natural Science Foundation of China （No. 51375439）
文摘The use of bionic non-smooth surfaces is a popular approach for saving energy because of their drag reduction property. Conventional non-smooth structures include riblets and dimples. Inspired by sand dunes, a novel variable ovoid non-smooth structure is proposed in this study. The body of the variable ovoid dimple was designed based on three size parameters, the radius, semimajor, and depth, and a 3D model was created based on UG software. The constructed variable dimples were placed in a rectangular array on the bottom of a square tube model. Following ANSYS meshing, the grid model was imported into FLUENT, where the flow characteristics were calculated. Results of skin friction reduction were achieved and the effect of the design parameters on different variable ovoid dimples was obtained by orthogonal testing. Various aspects of the skin friction reduction mechanism were discussed including the distribution of velocity vectors, variation in boundary layer thickness, and pressure distribution.
基金supported by the Ph.D. Programs Foundation of Ministry of Education of China under Grant No.20090001110005the National Natural Science Foundation of China under Grant No.11171007
文摘Ovarian cancer is one of the most deadly female genital malignant tumors in many regions while an effective early screening strategy can save numerous lives.CA125 and HE4 are tumor markers validated efficacious as well as most commonly used in recent screening research of ovarian cancer.In this paper,the authors construct a change-point and mixture model on the basis of longitudinal CA125 and HE4 levels and estimated parameters using maximum likelihood method with the preclinical duration assumed right-censored,which is more adaptive and yields comparable results in comparison to the Bayesian approach raised by Skates.Consistency of estimators is proved.The authors also run a 5-year simulation of sequential screening by calculating the risk of cancer and hypothesis testing the true incidence time respectively.Results show that diagnosis based on hypothesis test performs better in early detection.
