Primary age-related tauopathy(PART)is characterized by the presence of tau neurofibrillary tangles(NFTs)which are typically observed in Alzheimer’s disease(AD)brains,with few or withoutβ-amyloid(Aβ)plaques.The diag...Primary age-related tauopathy(PART)is characterized by the presence of tau neurofibrillary tangles(NFTs)which are typically observed in Alzheimer’s disease(AD)brains,with few or withoutβ-amyloid(Aβ)plaques.The diagnosis of PART can be categorized into“definite”or“possible”depending on the amount of Aβplaques.Definite PART is diagnosed when NFTs are observed and the Braak stage is≤IV,with Thal AβPhase 0(Crary et al.,2014).According to the neuropathological diagnostic criteria,we reported reported that PART was frequently observed in the Chinese population according to our findings from specimens in our brain bank,with 47%of brain bank subjects meeting the criteria for PART.There is no consensus on the nature of PART.It remains to be elucidated whether PART is an early form of AD or a novel tauopathy(Duyckaerts et al.,2015;Jellinger et al.,2015).展开更多
基金Project supported by the National Natural Science Foundation of China(Nos.91632109 and 81971184)the Zhejiang Provincial Natural Science Foundation of China(No.LY16H090013)the Zhejiang Medical and Health Science and Technology Plan Project(No.WKJ2013-2-009),China.
文摘Primary age-related tauopathy(PART)is characterized by the presence of tau neurofibrillary tangles(NFTs)which are typically observed in Alzheimer’s disease(AD)brains,with few or withoutβ-amyloid(Aβ)plaques.The diagnosis of PART can be categorized into“definite”or“possible”depending on the amount of Aβplaques.Definite PART is diagnosed when NFTs are observed and the Braak stage is≤IV,with Thal AβPhase 0(Crary et al.,2014).According to the neuropathological diagnostic criteria,we reported reported that PART was frequently observed in the Chinese population according to our findings from specimens in our brain bank,with 47%of brain bank subjects meeting the criteria for PART.There is no consensus on the nature of PART.It remains to be elucidated whether PART is an early form of AD or a novel tauopathy(Duyckaerts et al.,2015;Jellinger et al.,2015).
