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应用原子力显微镜实时观察oxLDL对大鼠脑微血管内皮细胞膜结构的影响 被引量:3
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作者 李宗信 黄小波 +5 位作者 李斌 游云 韩东 马万云 李文 廖福龙 《中国血液流变学杂志》 CAS 2004年第3期315-316,323,共3页
目的 应用原子力显微镜 (AFM)实时观察体外培养的内皮细胞膜表面超微结构 ,并观察氧化低密度脂蛋白 (oxLDL)的影响。方法 以体外培养的大鼠脑微血管内皮细胞为材料 ,用AFM观察 80 μg/mloxLDL对细胞膜的影响。 结果 AFM可以观察内皮... 目的 应用原子力显微镜 (AFM)实时观察体外培养的内皮细胞膜表面超微结构 ,并观察氧化低密度脂蛋白 (oxLDL)的影响。方法 以体外培养的大鼠脑微血管内皮细胞为材料 ,用AFM观察 80 μg/mloxLDL对细胞膜的影响。 结果 AFM可以观察内皮细胞表面纳米超微结构 ,oxLDL可引起超微结构改变。结论 首次用AFM观察oxLDL对微血管内皮膜的影响 ,AFM在高脂血症实验研究中有应用前景。 展开更多
关键词 原子力显微镜实 OXLDL 大鼠 脑微血管 内皮细胞膜 氧化低密度脂蛋白 超微结构 高脂血症
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Investigation of loading and force sensing properties of a probe-type microforce sensor with force-distance curves 被引量:3
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作者 SUN Chen SU DongChuan LI XiDe 《Science China(Technological Sciences)》 SCIE EI CAS 2011年第6期1362-1370,共9页
In this paper,the force-distance curves have been employed to investigate the force sensing properties of the probe-type microforce sensors.In the preliminary studies,two kinds of probe-type microforce sensors have be... In this paper,the force-distance curves have been employed to investigate the force sensing properties of the probe-type microforce sensors.In the preliminary studies,two kinds of probe-type microforce sensors have been used to load the objects with dry and wetted surfaces.One is a developed piezoresistive cantilever force sensor with sensitivity of 35 μN/V and the other an atomic force microscope(AFM) cantilever beam probe with sensitivity of 10.4 nN/V.The force outputs corresponding to the regimes of approaching,indenting,and loading are obtained,and the properties of the stability in the approaching regime of the sensors,local mechanical behavior of the tested objects in the indenting regime,and the force sensing of the global samples are analyzed.Experimental results of this analysis are also presented. 展开更多
关键词 force sensor PROBE force-distance curve mechanical behavior surface effects
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Experimental Study of Perfectly Patterned Silica-Titania Optical Waveguide 被引量:1
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作者 Rimlee DEB ROY Devika SIL +2 位作者 Sunirmal JANA Prasanta Kumar BISWAS Shyamal Kumar BHADRA 《Photonic Sensors》 SCIE EI CAS 2012年第1期81-91,共11页
Inorganic silica-titania thin films with thicknesses 150 nm-200 nm are deposited on high purity and polished silicon wafer and silica glass substrates by sol-gel dipping process and are patterned by capillary force li... Inorganic silica-titania thin films with thicknesses 150 nm-200 nm are deposited on high purity and polished silicon wafer and silica glass substrates by sol-gel dipping process and are patterned by capillary force lithography technique. Subsequently grating structure is embossed in green stage. The patterned gel films are subjected to stepwise heat treatment to 500 ℃ and above in pure oxygen atmosphere in order to achieve major conversion of mixed-gel to oxide optical films which are characterized by Ellipsometry, Fourier transform infrared spectroscopy (FTIR) and atomic force microscopy (AFM) to optimize the fabrication parameters and to get perfectly matched film. Removal of organics and formation of perfectly inorganic silica-titania network at optimized heat treatment in controlled environment are ensured by FTIR spectral study. The difference in refractive indices between the substrate and coated film as developed waveguides for operating wavelength show the planar waveguide behavior of the films. calculated theoretically matches exactly with the (632.8 nm) and the measured optical properties 展开更多
关键词 Optical properties sol-gel technique thin films OXIDES
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