The paper aims to study agricultural land suitability in typical agricultural area in Huanghuaihai plain by the comprehensive evaluation of natural factors and environmental conditions of agricultural land with Liaoch...The paper aims to study agricultural land suitability in typical agricultural area in Huanghuaihai plain by the comprehensive evaluation of natural factors and environmental conditions of agricultural land with Liaocheng area in Shangdong Province in the center of Huanghuaihai plain as a case.The results suggested that the land quality in Liaocheng was above the average and accorded with the local practical situation.The authors validated the scientificity of agricultural land suitability study by using GIS technology and proposed some suggestions on analysis results.展开更多
The flexibility of MIP technology to meet market demand is mainly introduced in this study. Their commercial application and technical principle are analyzed too. The MIP technology with wide feed adaptability can for...The flexibility of MIP technology to meet market demand is mainly introduced in this study. Their commercial application and technical principle are analyzed too. The MIP technology with wide feed adaptability can form a good combination with other technologies. The MIP technology has been applied extensively in China. Based on this platform, the CGP, MIP-LTG and MIP-DCR technologies have been developed, which can further improve the flexibility of MIP technology. Based on its novel reaction control technique with a sole sequential two-zone riser, the MIP users can easily switch to different operating modes between producing either more clean gasoline and propylene or diesel through changing the catalysts and varying the operating conditions. That offers MIP users with enough production flexibility and a rational production arrangement to meet the market demand. The MIP-DCR technology with less dry gas and coke yields can provide a more flexible operating mode since the catalysts to oil ratio has become an independent variable.展开更多
The paper conducts analysis on the causes of dangerous goods road transportation accidents by applying analytic technique of security system science - Event Tree Analysis (ETA). By computing minimum cut and minimal ...The paper conducts analysis on the causes of dangerous goods road transportation accidents by applying analytic technique of security system science - Event Tree Analysis (ETA). By computing minimum cut and minimal path set of event tree and the important level of elementary event, the paper elicits the results that the factors of causing road transportation accident are multiple and its hazard is great while the paper also elicits the sorting of structural important level of elementary event. The paper offers the security countermeasures for dangerous goods road transportation which plays a vital role in safeguarding dangerous goods road transportation security.展开更多
The magnesium has some excellent properties such as ligh quality, high specific strength and stiffness, high damp and reeoverd easily compared with steel, aluminium, engineering plastic. So the application and exploit...The magnesium has some excellent properties such as ligh quality, high specific strength and stiffness, high damp and reeoverd easily compared with steel, aluminium, engineering plastic. So the application and exploitation of magnesium arose extensive attention of the public.展开更多
Parameters of the power source used to control PV-10 piezoelectric crystal valve are following DC output voltage: 0 - 120 V, continuously controllable, linear enlargement factor of input direct current voltage: appr...Parameters of the power source used to control PV-10 piezoelectric crystal valve are following DC output voltage: 0 - 120 V, continuously controllable, linear enlargement factor of input direct current voltage: approximate 25 times, the accuracy of DC output voltage: ±5%, manual control and automatic control.展开更多
Abstract: Malaria, where the causative agent Plasmodium is rapidly gaining resistance to practically all the antimalarial drugs in clinical use, requires the identification of new drug targets to enable the discovery...Abstract: Malaria, where the causative agent Plasmodium is rapidly gaining resistance to practically all the antimalarial drugs in clinical use, requires the identification of new drug targets to enable the discovery of novel, more effective and safer drugs to treat the disease. Advancements in molecular techniques have provided the proof of existence of autophagy in Plasmodium; however, its role(s) in malaria is only becoming to be understood. Nevertheless, some of the recently explored dimensions of autophagy in Plasmodium have indicated its fairly larger role in parasite survival and growth. But then, autophagy is also essential for host cell survival and defence. There is thus need to explore chemotherapeutic strategies to specifically target autophagy in both the parasite and host. This review focuses on autophagy pathways in Plasmodium and in host with a view to identify autophagy-related new drug targets for the discovery of novel antimalarial drugs.展开更多
The Centennial Hall was designed as a monumental building entirely of reinforced concrete. Soon it became a model for modernist buildings of that era. During the years 2009-2011, the biggest renovation since its compl...The Centennial Hall was designed as a monumental building entirely of reinforced concrete. Soon it became a model for modernist buildings of that era. During the years 2009-2011, the biggest renovation since its completion took place. All activities described in the following paper aimed to put the Centennial Hall into good repair and adjust it to the applicable requirements of modem public buildings. The primary aim is to preserve the authenticity of the original materials used in construction through the use of remedial technologies, thereby maintaining the historical integrity of the building.展开更多
The current need to fasten the implementation of renewable energies greatly depends on the development of competitive storage devices, and while there is not a single technology which is likely capable to competitivel...The current need to fasten the implementation of renewable energies greatly depends on the development of competitive storage devices, and while there is not a single technology which is likely capable to competitively cover the wide range of possible demands, electrochemical technologies are one of the most promising for many of them. For the realization of this promise, new materials fulfilling criteria such as high energy density, high power density, competitive cost, reliability, and environmental compatibility need to be developed in the near future. Electrochemical energy storage devices can be classified into two main technologies: supercapacitors and batteries (including redox flow batteries). Materials and applications for these technologies are discussed and compared, listing current status, technical and strategic challenges.展开更多
Deforestation to reclaim land often triggers severe soil erosion in the Guizhou Karst Plateau. 137Cs dating of the deposited sediments in the karst depression bottom was used to estimate soil losses by surface erosion...Deforestation to reclaim land often triggers severe soil erosion in the Guizhou Karst Plateau. 137Cs dating of the deposited sediments in the karst depression bottom was used to estimate soil losses by surface erosion since deforestation started in 1979 on hillslopes in the Shirenzhai catchment, Puding County, Guizhou Province. The catchment has a drainage area of 0.054 km2. The average 137Cs contents of the top and peak layers in five cores of the depression bottom (with an area of 2652 m2), collected in 2009, were 2.35 and 7.25 Bq kg-1, respectively. The medium depths in the depression (which ranged between 84 cm and 113.5 cm with a mean value of 92.1 cm) showed the presence of sediments deposited in 1979. The total volume and weight of the deposited sediments since 1979 were estimated to be 1965 m3 and 2496 t, respectively. The depression bottom can be treated as a temporary impoundment and its sediment trapping efficiency was estimated to be 0.7. The relevant average soil erosion rate on the hillslopes was 2315 t km-2 yr-1 since 1979. The mean 137Cs inventory of the five cores was 7693 Bq m-2, which was ~10 times the local reference inventory of 782 Bq m-2. The total 137Cs activity of the sediments in the bottom was 20.4×106 Bq, and the relevant 137Cs inventory loss from the hillslopes was 358 Bq m-2 (since 1954), which accounted for 45.8% of the reference inventory. As soil erosion was not severe before and after the period of deforestation and following cultivation in 1979-1990, the erosion rates on the hillslopes could potentially reach 7000 t km-2 yr-1.展开更多
Exposure to cigarette smoke is a major risk factor for cancer and cardiovascular disease. Thrombosis is regarded as the main reason for smoking-related car- diovascular disease. However, the detail mechanism of how sm...Exposure to cigarette smoke is a major risk factor for cancer and cardiovascular disease. Thrombosis is regarded as the main reason for smoking-related car- diovascular disease. However, the detail mechanism of how smoking promotes thrombosis is not fully under- stood. In this work, we investigated the impacts of one major cigarette carcinogens 4-(methylnitrosamino)-l-(3- pyridyl)-l-butanone (NNK) as well as its metabolite 4-(methylnitrosamino)- 1-(3-pyridyl)- 1-butanol (NNAL) on a key process in thrombosis regulation: thrombin- thrombomodulin (TM) binding. Atomic force microscopy based single-molecule force spectroscopy was applied to measure both in vitro and in vivo binding force of thrombin to TM in the absence and presence of NNK and NNAL respectively. The results revealed that NNK and NNAL can reduce the binding probability of TM and thrombin. The inhibition effect and underlying mechanism was further studied by molecular simulation. As indicated by our results, the cigarette carcinogens could cause a higher risk of thrombosis through the disruption of TM- thrombin interaction.展开更多
Induced pluripotent stem cells (iPSCs) are an attractive cell source for regenerative medicine through cell therapy or drug screening. But application of iPSCs in regenerative medicine requires rapid and accurate ch...Induced pluripotent stem cells (iPSCs) are an attractive cell source for regenerative medicine through cell therapy or drug screening. But application of iPSCs in regenerative medicine requires rapid and accurate charac- terization of iPSCs. Here, we demonstrate the detection of multiple antigens present in iPSC lysate using rapid, label- free surface plasmon resonance imaging (SPRi) assay. Validation of pluripotency is an important aspect of iPSC research. In this study, we fabricated antibody array against pluripotency biomarkers and found that our array suc- cessfully detect corresponding antigens in stem cell lysate. Each antibody recognized its specific antigens presented in iPSC lysates and a certain degree of variability was observed in comparison with other cell lysates. The results suggested that SPRi is a versatile technology feasible for the detection of multiple antigens presented in iPSC lysate. Further extension of this method may be applied in the characterization and high-throughput biomarker profiling of iPSCs.展开更多
基金Support by Research of Comprehensive Evaluation of Agricultural Land Suitability in Typical Area of Huanghuahai Plain based on GIS(X0810025)~~
文摘The paper aims to study agricultural land suitability in typical agricultural area in Huanghuaihai plain by the comprehensive evaluation of natural factors and environmental conditions of agricultural land with Liaocheng area in Shangdong Province in the center of Huanghuaihai plain as a case.The results suggested that the land quality in Liaocheng was above the average and accorded with the local practical situation.The authors validated the scientificity of agricultural land suitability study by using GIS technology and proposed some suggestions on analysis results.
文摘The flexibility of MIP technology to meet market demand is mainly introduced in this study. Their commercial application and technical principle are analyzed too. The MIP technology with wide feed adaptability can form a good combination with other technologies. The MIP technology has been applied extensively in China. Based on this platform, the CGP, MIP-LTG and MIP-DCR technologies have been developed, which can further improve the flexibility of MIP technology. Based on its novel reaction control technique with a sole sequential two-zone riser, the MIP users can easily switch to different operating modes between producing either more clean gasoline and propylene or diesel through changing the catalysts and varying the operating conditions. That offers MIP users with enough production flexibility and a rational production arrangement to meet the market demand. The MIP-DCR technology with less dry gas and coke yields can provide a more flexible operating mode since the catalysts to oil ratio has become an independent variable.
文摘The paper conducts analysis on the causes of dangerous goods road transportation accidents by applying analytic technique of security system science - Event Tree Analysis (ETA). By computing minimum cut and minimal path set of event tree and the important level of elementary event, the paper elicits the results that the factors of causing road transportation accident are multiple and its hazard is great while the paper also elicits the sorting of structural important level of elementary event. The paper offers the security countermeasures for dangerous goods road transportation which plays a vital role in safeguarding dangerous goods road transportation security.
文摘The magnesium has some excellent properties such as ligh quality, high specific strength and stiffness, high damp and reeoverd easily compared with steel, aluminium, engineering plastic. So the application and exploitation of magnesium arose extensive attention of the public.
文摘Parameters of the power source used to control PV-10 piezoelectric crystal valve are following DC output voltage: 0 - 120 V, continuously controllable, linear enlargement factor of input direct current voltage: approximate 25 times, the accuracy of DC output voltage: ±5%, manual control and automatic control.
文摘Abstract: Malaria, where the causative agent Plasmodium is rapidly gaining resistance to practically all the antimalarial drugs in clinical use, requires the identification of new drug targets to enable the discovery of novel, more effective and safer drugs to treat the disease. Advancements in molecular techniques have provided the proof of existence of autophagy in Plasmodium; however, its role(s) in malaria is only becoming to be understood. Nevertheless, some of the recently explored dimensions of autophagy in Plasmodium have indicated its fairly larger role in parasite survival and growth. But then, autophagy is also essential for host cell survival and defence. There is thus need to explore chemotherapeutic strategies to specifically target autophagy in both the parasite and host. This review focuses on autophagy pathways in Plasmodium and in host with a view to identify autophagy-related new drug targets for the discovery of novel antimalarial drugs.
文摘The Centennial Hall was designed as a monumental building entirely of reinforced concrete. Soon it became a model for modernist buildings of that era. During the years 2009-2011, the biggest renovation since its completion took place. All activities described in the following paper aimed to put the Centennial Hall into good repair and adjust it to the applicable requirements of modem public buildings. The primary aim is to preserve the authenticity of the original materials used in construction through the use of remedial technologies, thereby maintaining the historical integrity of the building.
文摘The current need to fasten the implementation of renewable energies greatly depends on the development of competitive storage devices, and while there is not a single technology which is likely capable to competitively cover the wide range of possible demands, electrochemical technologies are one of the most promising for many of them. For the realization of this promise, new materials fulfilling criteria such as high energy density, high power density, competitive cost, reliability, and environmental compatibility need to be developed in the near future. Electrochemical energy storage devices can be classified into two main technologies: supercapacitors and batteries (including redox flow batteries). Materials and applications for these technologies are discussed and compared, listing current status, technical and strategic challenges.
基金supported by National Basic Research Program of China (Grant No. 2006CB403200)National Natural Science Foundation of China (Grant No. 41001162)+3 种基金Knowledge Innovation Project of the Chinese Academy of Sciences (Grant No. KZCX2-YW-306)National Key Technology R&D Program (Grant Nos. 2006BAC01A09 and 2008BAD98B07)Provincial Governor Foundation of Guizhou (Grant No. 2010-95)Opening Fund of State Key Laboratory of Environmental Geochemistry (Grant No. SKLEG9008)
文摘Deforestation to reclaim land often triggers severe soil erosion in the Guizhou Karst Plateau. 137Cs dating of the deposited sediments in the karst depression bottom was used to estimate soil losses by surface erosion since deforestation started in 1979 on hillslopes in the Shirenzhai catchment, Puding County, Guizhou Province. The catchment has a drainage area of 0.054 km2. The average 137Cs contents of the top and peak layers in five cores of the depression bottom (with an area of 2652 m2), collected in 2009, were 2.35 and 7.25 Bq kg-1, respectively. The medium depths in the depression (which ranged between 84 cm and 113.5 cm with a mean value of 92.1 cm) showed the presence of sediments deposited in 1979. The total volume and weight of the deposited sediments since 1979 were estimated to be 1965 m3 and 2496 t, respectively. The depression bottom can be treated as a temporary impoundment and its sediment trapping efficiency was estimated to be 0.7. The relevant average soil erosion rate on the hillslopes was 2315 t km-2 yr-1 since 1979. The mean 137Cs inventory of the five cores was 7693 Bq m-2, which was ~10 times the local reference inventory of 782 Bq m-2. The total 137Cs activity of the sediments in the bottom was 20.4×106 Bq, and the relevant 137Cs inventory loss from the hillslopes was 358 Bq m-2 (since 1954), which accounted for 45.8% of the reference inventory. As soil erosion was not severe before and after the period of deforestation and following cultivation in 1979-1990, the erosion rates on the hillslopes could potentially reach 7000 t km-2 yr-1.
基金supported by the National Basic Research Program of China (2013CB933701, 2013CB933704)the National Natural Science Foundation of China (21127901)
文摘Exposure to cigarette smoke is a major risk factor for cancer and cardiovascular disease. Thrombosis is regarded as the main reason for smoking-related car- diovascular disease. However, the detail mechanism of how smoking promotes thrombosis is not fully under- stood. In this work, we investigated the impacts of one major cigarette carcinogens 4-(methylnitrosamino)-l-(3- pyridyl)-l-butanone (NNK) as well as its metabolite 4-(methylnitrosamino)- 1-(3-pyridyl)- 1-butanol (NNAL) on a key process in thrombosis regulation: thrombin- thrombomodulin (TM) binding. Atomic force microscopy based single-molecule force spectroscopy was applied to measure both in vitro and in vivo binding force of thrombin to TM in the absence and presence of NNK and NNAL respectively. The results revealed that NNK and NNAL can reduce the binding probability of TM and thrombin. The inhibition effect and underlying mechanism was further studied by molecular simulation. As indicated by our results, the cigarette carcinogens could cause a higher risk of thrombosis through the disruption of TM- thrombin interaction.
基金partly supported by the National Natural Science Foundation of China(31171381)the National Basic Research Program of China,2012CB966701the core facility of the Tsinghua-Peking Center for Life Sciences
文摘Induced pluripotent stem cells (iPSCs) are an attractive cell source for regenerative medicine through cell therapy or drug screening. But application of iPSCs in regenerative medicine requires rapid and accurate charac- terization of iPSCs. Here, we demonstrate the detection of multiple antigens present in iPSC lysate using rapid, label- free surface plasmon resonance imaging (SPRi) assay. Validation of pluripotency is an important aspect of iPSC research. In this study, we fabricated antibody array against pluripotency biomarkers and found that our array suc- cessfully detect corresponding antigens in stem cell lysate. Each antibody recognized its specific antigens presented in iPSC lysates and a certain degree of variability was observed in comparison with other cell lysates. The results suggested that SPRi is a versatile technology feasible for the detection of multiple antigens presented in iPSC lysate. Further extension of this method may be applied in the characterization and high-throughput biomarker profiling of iPSCs.