The antibacterial effect of the crude methanol extracts and purified fractions of Ctadophora glomerata （Linnaeus） Kutzing （Cladophoraceae） against multidrug resistant human pathogen were investigated. The test bac...The antibacterial effect of the crude methanol extracts and purified fractions of Ctadophora glomerata （Linnaeus） Kutzing （Cladophoraceae） against multidrug resistant human pathogen were investigated. The test bacterial strains were Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus faecalis, Escherichia coli and S. typhimurium. Ethanol extract （0.5 mg/mL） of Cladophora glomerata inhibited growth of all the test organisms. Primary detection of active compounds showed that maeroalgae （Cladophora glomerata） containing flavonoids, alkaloids, phenols and tannins. Gas Chromatography-Mass Spectrometry was used to know the compounds which responsible of antibacterial activity and they were g-Pentadecanone that was found to be a major compound （42.67%） followed by 8-Octadecanone （22.43%） and Salicylic acid （20.04%） in addition to 10-hexadecaden （8.01%）. These findings suggest the possibility of using the Cladophora glomerata as a novel source of natural antimicrobial agents in pharmaceutical industries.展开更多
文摘The antibacterial effect of the crude methanol extracts and purified fractions of Ctadophora glomerata （Linnaeus） Kutzing （Cladophoraceae） against multidrug resistant human pathogen were investigated. The test bacterial strains were Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus faecalis, Escherichia coli and S. typhimurium. Ethanol extract （0.5 mg/mL） of Cladophora glomerata inhibited growth of all the test organisms. Primary detection of active compounds showed that maeroalgae （Cladophora glomerata） containing flavonoids, alkaloids, phenols and tannins. Gas Chromatography-Mass Spectrometry was used to know the compounds which responsible of antibacterial activity and they were g-Pentadecanone that was found to be a major compound （42.67%） followed by 8-Octadecanone （22.43%） and Salicylic acid （20.04%） in addition to 10-hexadecaden （8.01%）. These findings suggest the possibility of using the Cladophora glomerata as a novel source of natural antimicrobial agents in pharmaceutical industries.
