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参力保对家兔心肌缺血再灌注损伤的保护作用 被引量:1
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作者 董淑雯 宋海滨 +1 位作者 单迅 金毅 《青岛大学医学院学报》 CAS 2008年第2期99-102,共4页
目的观察参力保对家兔心肌缺血再灌注损伤的保护作用。方法结扎兔冠状动脉左前降支(LAD)30min,再灌注120min后制备家兔心肌缺血再灌注模型。56只家兔,随机分为7组,生理盐水对照组:假手术组,模型组(给予溶媒8.58mg/kg),参力... 目的观察参力保对家兔心肌缺血再灌注损伤的保护作用。方法结扎兔冠状动脉左前降支(LAD)30min,再灌注120min后制备家兔心肌缺血再灌注模型。56只家兔,随机分为7组,生理盐水对照组:假手术组,模型组(给予溶媒8.58mg/kg),参力保高剂量组(22.36mg/kg,内含5.2mg/kg人参皂苷Rg2),参力保中剂量组(11.18mg/kg,内含2.6mg/kg人参皂苷Rg2),参力保低剂量组(5.59mg/kg,内含1.3mg/kg人参皂苷Rg2),阳性对照组(给予盐酸尼卡地平注射液),测定血浆磷酸激酸同工酶(CK—MB)、乳酸脱氢酶(LDH)、天门冬氨酸转氨酶(AST)和心肌组织中超氧化物歧化酶(SOD)活性、丙二醛(MDA)及游离脂肪酸(NFFA)含量;高效液相法测定心肌组织去甲肾上腺素(NE)含量。结果参力保能显著降低血浆CK—MB和LDH、AST的活性,与模型组相比有显著差异(F=13.031~32.604,P〈0.05、0.01)。参力保3个剂量组与模型组比较可明显降低心肌MDA含量,提高SOD活性和NE的含量(F=2.880~15.927,q=5.249~12.510,P〈0.05);参力保高、中、低剂量组NFFA与模型组比较,差异有显著性(Z1=Z2=Z3=-2.329,P〈0.05)。结论参力保对家兔心肌缺血再灌注损伤有保护作用,其机制与清除自由基抑制脂质过氧化反应有关。 展开更多
关键词 参力保 再灌注损伤 心肌 脂质过氧化损伤
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参力保与二氮嗪对家兔心肌缺血再灌注损伤的保护作用 被引量:1
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作者 董淑雯 《中国老年学杂志》 CAS CSCD 北大核心 2016年第18期4428-4429,共2页
目的比较参力保与二氮嗪对家兔心肌缺血再灌注损伤的保护作用及机制。方法结扎兔冠状动脉左前降支(LAD)30 min,复灌120 min后复制家兔心肌缺血再灌注模型。40只家兔,随机分为5组,假手术组、模型组、参力保组、二氮嗪组、参力保+5-羟葵酸... 目的比较参力保与二氮嗪对家兔心肌缺血再灌注损伤的保护作用及机制。方法结扎兔冠状动脉左前降支(LAD)30 min,复灌120 min后复制家兔心肌缺血再灌注模型。40只家兔,随机分为5组,假手术组、模型组、参力保组、二氮嗪组、参力保+5-羟葵酸(5-HD)组。测定左室收缩压(LVSP)、左室舒张末期压(LVDEP)、缺血区面积、梗死区面积、血肌钙蛋白I(CTn I)活性。结果参力保与二氮嗪均升高LVSP、降低LVDEP,与模型组和参力保+5-HD组相比,有显著差异(P<0.05);参力保与二氮嗪组显著降低血浆CTn I的活性,与模型组和参力保+5-HD组相比有显著差异(P<0.01);并降低心肌梗死面积,与模型组和参力保+5-HD组相比有显著差异(P<0.05);而参力保组与二氮嗪组上述所有指标比较差异无统计学意义(P>0.05),参力保+5-HD组与模型组上述所有指标比较差异无显著性(P>0.05)。结论参力保与二氮嗪对家兔心肌缺血再灌注损伤的保护作用相似,其保护作用能被线粒体ATP敏感性钾通道阻滞剂5-HD所阻断,其机制可能与开放线粒体ATP敏感钾通道通道有关。 展开更多
关键词 参力保 二氮嗪 心肌缺血再灌注损伤 ATP敏感性钾通道
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Eco-drainage Pond in Non Irrigated Land for the Conservation of Land and Water Based on Community Participation
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作者 Dwi Tjahjanto Sriyana +3 位作者 Sobri Harun Zulhilmi Ismail Arien Heryansyah Muhamad Askari 《Journal of Environmental Science and Engineering(A)》 2012年第1期92-99,共8页
There are some bad impacts from a critical land such as flood in rainy season and dryness in dry season. Long dryness could cause shortage of water for human consumption, industry and agriculture. Prevention has been ... There are some bad impacts from a critical land such as flood in rainy season and dryness in dry season. Long dryness could cause shortage of water for human consumption, industry and agriculture. Prevention has been made to avoid the both bad impacts by building hydraulic structures like reservoirs and ponds in order to reduce the peak flow during the rainy season and to store the water for use during the dry season. However, they gradually become full of sediment. This will make them work insufficiently and will cause high maintenance cost. Moreover, wells in agriculture field used as retention also suffer dryness to make crop failure. This study aims to develop a model of pond for conservation of land and water in non irrigated land. Community participation is crucial in order to solve the flood and dryness problems. The community, especially the farmers will participate actively in the implementation and maintenance of the model. There are benefits in using the pond model such as: (1) to control sediment transport to the rivers, reservoir or other hydraulic structures; (2) to reduce flood rate; (3) to increase ground water recharge; (4) to contain water for agriculture and (5) to control the fertility of land. The cost of making a unit of model (sedrainpond) of 1.5 m diameter and 1.5 meter depth is relatively cheap between $10 to $20 (US), and the maintenance is done by the farmers. When the pond model becomes functional, besides containing water in the rainy season, the water can be used to sustain water for agriculture in the dry season to avoid any crop failure. When the pond becomes dry, the farmers can harvest the suspended load sediment such as clay or silt to spread onto their land to keep its fertility. 展开更多
关键词 Model of drain eco-drainage system model of pond.
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