The development of green open spaces is the key component for cities built for the people and a major initiative to enhance the core competitiveness of Chinese cities.This paper summarizes the research on green open s...The development of green open spaces is the key component for cities built for the people and a major initiative to enhance the core competitiveness of Chinese cities.This paper summarizes the research on green open spaces in international metropolitan cities,focusing on public participation,funding mix,and governmental actions.It focuses on the alignment of interests between public,private,and community sectors in New York City's green open space development in a series of case studies.It draws lessons from New York's experience and applies them to Chinese cities and proposes that:private non-government organizations should be introduced to improve the mechanism of major development and governance;real estate development incentives should be optimized to guide the private capital to provide public welfare;and policy innovation in land and property development is imperative in fiscal health and sustainability.展开更多
Objective: To investigate the role of TIP30 in the apoptotic signal pathwayin HepG2, and Hep3B and Hu-7 hepatoblastoma cell lines. Methods: In order to confirm whether TIP30conducted Bcl-2 family was involved in apopt...Objective: To investigate the role of TIP30 in the apoptotic signal pathwayin HepG2, and Hep3B and Hu-7 hepatoblastoma cell lines. Methods: In order to confirm whether TIP30conducted Bcl-2 family was involved in apoptosis signal pathway, MTT assay, in situ 3' end labellingof DNA assay and Western blot were carried out to detect the diverse apoptotic function of TIP30and the regulation of Bcl-2 family. Results: TIP30 induced apoptosis as evidenced by morphologicalchanges in hepatoblastoma cells, which was accompanied by up-regulating Bax and Bad proteins andstimulating them from cytoplasm to mitochondria, and down-regulating Bcl-xl, while it had no effecton the level of Bak protein. Conclusion: TIP30 induced apoptosis partly by modulating the proteinlevels of members of Bcl-2 family in hepatoblastoma cells. Elucidating the mechanism by which TIP30induces cell death might establish it as an anticancer factor.展开更多
Objective： To evaluate clinical effects of Shenqi Fuzheng Injection （参芪抉正注射液） in the neoadjuvant chemotherapy for local advanced breast cancer and the effects on T-lymphocyte subsets. Methods： During the pe...Objective： To evaluate clinical effects of Shenqi Fuzheng Injection （参芪抉正注射液） in the neoadjuvant chemotherapy for local advanced breast cancer and the effects on T-lymphocyte subsets. Methods： During the period from 2000 to 2005, 126 patients with local advanced breast cancer were treated with the neoadjuvant chemotherapy. They were randomly divided into the following two groups： a control group of 61 cases treated by chemotherapy alone and a study group of 65 cases treated by chemotherapy plus Shenqi Fuzheng Injection, All the cases of both groups were given the CEF （CTX 500 mg/m^2, d1, 8; EP140 mg/m^2, d1, 8; and 5-Fu 500 mg/m^2, d1,8） regimen. The clinical effects, the effects on T-lymphocyte subgroup and NK cells, and the toxic side effects were observed. Results： All the patients completed two cycles of the chemotherapy, and the efficacy and the toxic side effects were evaluated. For the primary tumor in the breast, the total effective rate was 69.2% （45/65） in the study group and 49.2% （30/61） in the control group with a statistically significant difference in the intergroup comparison （x^2=5.251, P=0.022, 〈 0.05）. There was no progression of the disease in both the groups, and there were no grade IV toxic side effects in the two groups. The major toxic responses were myelosuppression and gastrointestinal reaction, which were milder in the study group than the control group, and with a shorter recovery course in the former than the latter. Besides, an obvious rise of the T-lymphocyte subgroup and NK cells was found in the study group after the neoadjuvant chemotherapy, with a very significant difference from the controls （P〈0.01）. Conclusions： Shenqi Fuzheng Injection can improve and regulate immune function of the patients with local advanced breast cancer given the neoadjuvant chemotherapy, and therefore it can enhance the curative effect and reduce the side effect as well.展开更多
Studied on multi-component combustible gas,methane mainly,explosion char- acteristics of high gas mine,obtained the rules of gas explosive limit that influenced by environment temperature,pressure,concentration of oxy...Studied on multi-component combustible gas,methane mainly,explosion char- acteristics of high gas mine,obtained the rules of gas explosive limit that influenced by environment temperature,pressure,concentration of oxygen,other combustible gas,coal dust,energy of fire source,and the inert gas,proposed a new method of divide gas explo- sive triangle partition,and gave new partition linear equations.The gas explosive triangle and its new partition has important directive significance in distinguishing if the fire area has a gas explosion when sealing or opening fire area,or fire extinguishing in sealed fire area,and judging if there will be a gas explosion or other trend while fire extinguishing with inert gas.展开更多
文摘The development of green open spaces is the key component for cities built for the people and a major initiative to enhance the core competitiveness of Chinese cities.This paper summarizes the research on green open spaces in international metropolitan cities,focusing on public participation,funding mix,and governmental actions.It focuses on the alignment of interests between public,private,and community sectors in New York City's green open space development in a series of case studies.It draws lessons from New York's experience and applies them to Chinese cities and proposes that:private non-government organizations should be introduced to improve the mechanism of major development and governance;real estate development incentives should be optimized to guide the private capital to provide public welfare;and policy innovation in land and property development is imperative in fiscal health and sustainability.
文摘Objective: To investigate the role of TIP30 in the apoptotic signal pathwayin HepG2, and Hep3B and Hu-7 hepatoblastoma cell lines. Methods: In order to confirm whether TIP30conducted Bcl-2 family was involved in apoptosis signal pathway, MTT assay, in situ 3' end labellingof DNA assay and Western blot were carried out to detect the diverse apoptotic function of TIP30and the regulation of Bcl-2 family. Results: TIP30 induced apoptosis as evidenced by morphologicalchanges in hepatoblastoma cells, which was accompanied by up-regulating Bax and Bad proteins andstimulating them from cytoplasm to mitochondria, and down-regulating Bcl-xl, while it had no effecton the level of Bak protein. Conclusion: TIP30 induced apoptosis partly by modulating the proteinlevels of members of Bcl-2 family in hepatoblastoma cells. Elucidating the mechanism by which TIP30induces cell death might establish it as an anticancer factor.
文摘Objective： To evaluate clinical effects of Shenqi Fuzheng Injection （参芪抉正注射液） in the neoadjuvant chemotherapy for local advanced breast cancer and the effects on T-lymphocyte subsets. Methods： During the period from 2000 to 2005, 126 patients with local advanced breast cancer were treated with the neoadjuvant chemotherapy. They were randomly divided into the following two groups： a control group of 61 cases treated by chemotherapy alone and a study group of 65 cases treated by chemotherapy plus Shenqi Fuzheng Injection, All the cases of both groups were given the CEF （CTX 500 mg/m^2, d1, 8; EP140 mg/m^2, d1, 8; and 5-Fu 500 mg/m^2, d1,8） regimen. The clinical effects, the effects on T-lymphocyte subgroup and NK cells, and the toxic side effects were observed. Results： All the patients completed two cycles of the chemotherapy, and the efficacy and the toxic side effects were evaluated. For the primary tumor in the breast, the total effective rate was 69.2% （45/65） in the study group and 49.2% （30/61） in the control group with a statistically significant difference in the intergroup comparison （x^2=5.251, P=0.022, 〈 0.05）. There was no progression of the disease in both the groups, and there were no grade IV toxic side effects in the two groups. The major toxic responses were myelosuppression and gastrointestinal reaction, which were milder in the study group than the control group, and with a shorter recovery course in the former than the latter. Besides, an obvious rise of the T-lymphocyte subgroup and NK cells was found in the study group after the neoadjuvant chemotherapy, with a very significant difference from the controls （P〈0.01）. Conclusions： Shenqi Fuzheng Injection can improve and regulate immune function of the patients with local advanced breast cancer given the neoadjuvant chemotherapy, and therefore it can enhance the curative effect and reduce the side effect as well.
基金the National Natural Science Fund of China(50474010)the National"Eleventh Five-year Plan"Science and Technology Support Plan of China(2006BAK03B0503)+1 种基金the Fund of Education Department Liaoning Province(05L-174)the Fund of Education Department Liaoning Province(20060389)
文摘Studied on multi-component combustible gas,methane mainly,explosion char- acteristics of high gas mine,obtained the rules of gas explosive limit that influenced by environment temperature,pressure,concentration of oxygen,other combustible gas,coal dust,energy of fire source,and the inert gas,proposed a new method of divide gas explo- sive triangle partition,and gave new partition linear equations.The gas explosive triangle and its new partition has important directive significance in distinguishing if the fire area has a gas explosion when sealing or opening fire area,or fire extinguishing in sealed fire area,and judging if there will be a gas explosion or other trend while fire extinguishing with inert gas.
