Objective: To investigate the predictability of MRI and the possiblebiological markers of cavernous sinus invasion of pituitary adenomas associated with fourphenomenas: angiogenesis, cell proliferation, apoptosis and ...Objective: To investigate the predictability of MRI and the possiblebiological markers of cavernous sinus invasion of pituitary adenomas associated with fourphenomenas: angiogenesis, cell proliferation, apoptosis and matrix metalloproteinase. Methods: Weevaluated 45 patients with pituitary adenoma according to the MRI, surgical findings and theimmunohistochemistry staining of tumor tissues. Results: The results have shown that the sensitivityof MRI for predicting cavernous sinus invasion in this prospective study was 60%, its specificity85%, its positive predictive value 83.33%, negative predictive value 62.96%. 45 specimens ofpituitary adenomas were analyzed for expression of F8, VEGF, Ki-67, c-myc, Bcl-2, nm23 and MMP-9immunoreactivity using immunoperoxidase staining. MVD was assessed using F8-related antigen. Theresults have shown that MVD of invasive pituitary adenomas was significantly higher than that ofnoninvasive (P 【 0.001). There was an association between the invasion of pituitary adenomas andKi-67 LI (P = 0.039) or the expression of VEGF (P 【 0.001) and MMP-9 (P 【 0.001). But c-myc LI andBcl-2 expression have no association with invasiveness of pituitary adenomas (P = 0.061 versus P =0.201). On the other hand, there is an inverse relationship between nm23 expression and tumorinvasion (P 【 0.001). Conclusion: Parasellar extension of pituitary adenomas through the medial wallof the cavernous sinus is diagnosed at surgery, and with sensitive gadolinium-enhanced MRI, itsextent can be partly determined by radiology. Although our study has shown that MVD and theexpression of VEGF, Ki-67, nm23 and MMP-9 have associations with invasiveness of pituitary adenomas,they are lack of specificity. These markers can only provide some useful information.展开更多
In the conventional stochastic inversion method,the spatial structure information of underground strata is usually characterized by variograms.However,effectively characterizing the heterogeneity of complex strata is ...In the conventional stochastic inversion method,the spatial structure information of underground strata is usually characterized by variograms.However,effectively characterizing the heterogeneity of complex strata is difficult.In this paper,multiple parameters are used to fully explore the underground formation information in the known seismic reflection and well log data.The spatial structure characteristics of complex underground reservoirs are described more comprehensively using multiple statistical characteristic parameters.We propose a prestack seismic stochastic inversion method based on prior information on statistical characteristic parameters.According to the random medium theory,this method obtains several statistical characteristic parameters from known seismic and logging data,constructs a prior information model that meets the spatial structure characteristics of the underground strata,and integrates multiparameter constraints into the likelihood function to construct the objective function.The very fast quantum annealing algorithm is used to optimize and update the objective function to obtain the fi nal inversion result.The model test shows that compared with the traditional prior information model construction method,the prior information model based on multiple parameters in this paper contains more detailed stratigraphic information,which can better describe complex underground reservoirs.A real data analysis shows that the stochastic inversion method proposed in this paper can effectively predict the geophysical characteristics of complex underground reservoirs and has a high resolution.展开更多
The new CDF II measurement of W-boson mass shows a 7σdeviation from the standard model(SM)prediction,while the recent FNAL measurement of the muon g-2 shows a 4.2σdeviation(combined with the BNL result)from the SM.B...The new CDF II measurement of W-boson mass shows a 7σdeviation from the standard model(SM)prediction,while the recent FNAL measurement of the muon g-2 shows a 4.2σdeviation(combined with the BNL result)from the SM.Both of them strongly indicate new physics beyond the SM.In this work,we study the implication of both measurements on low energy supersymmetry.With an extensive exploration of the parameter space of the minimal supersymmetric standard model(MSSM),we find that in the parameter space allowed by current experimental constraints from colliders and dark matter detections,the MSSM can simultaneously explain both measurements on the edge of 2σlevel,taking theoretical uncertainties into consideration.The favored parameter space,characterized by a compressed spectrum between bino,wino and stau,with the stop being around 1 TeV,may be covered in the near future LHC searches.展开更多
We present an analysis of π-^20Ne elastic scattering at intermediate energy basing on the α＋^16O model of the ^20Ne nucleus and in the framework of Glauber multiple scattering theory. Satisfactory agreement with th...We present an analysis of π-^20Ne elastic scattering at intermediate energy basing on the α＋^16O model of the ^20Ne nucleus and in the framework of Glauber multiple scattering theory. Satisfactory agreement with the general features of the experimental data of pion elastic scattering on the neighboring 4N-type nuclei is obtained without any free parameters. Compared with the experimental angular distributions of pion elastic scattering on ^12 C, ^16O, ^24Mg, and ^28Si nuclei, the diffractive patterns and the positions of the dips and peaks in the angular distributions of ^π-^20Ne elastic scattering are reasonably predicted by the calculations.展开更多
文摘Objective: To investigate the predictability of MRI and the possiblebiological markers of cavernous sinus invasion of pituitary adenomas associated with fourphenomenas: angiogenesis, cell proliferation, apoptosis and matrix metalloproteinase. Methods: Weevaluated 45 patients with pituitary adenoma according to the MRI, surgical findings and theimmunohistochemistry staining of tumor tissues. Results: The results have shown that the sensitivityof MRI for predicting cavernous sinus invasion in this prospective study was 60%, its specificity85%, its positive predictive value 83.33%, negative predictive value 62.96%. 45 specimens ofpituitary adenomas were analyzed for expression of F8, VEGF, Ki-67, c-myc, Bcl-2, nm23 and MMP-9immunoreactivity using immunoperoxidase staining. MVD was assessed using F8-related antigen. Theresults have shown that MVD of invasive pituitary adenomas was significantly higher than that ofnoninvasive (P 【 0.001). There was an association between the invasion of pituitary adenomas andKi-67 LI (P = 0.039) or the expression of VEGF (P 【 0.001) and MMP-9 (P 【 0.001). But c-myc LI andBcl-2 expression have no association with invasiveness of pituitary adenomas (P = 0.061 versus P =0.201). On the other hand, there is an inverse relationship between nm23 expression and tumorinvasion (P 【 0.001). Conclusion: Parasellar extension of pituitary adenomas through the medial wallof the cavernous sinus is diagnosed at surgery, and with sensitive gadolinium-enhanced MRI, itsextent can be partly determined by radiology. Although our study has shown that MVD and theexpression of VEGF, Ki-67, nm23 and MMP-9 have associations with invasiveness of pituitary adenomas,they are lack of specificity. These markers can only provide some useful information.
基金the National Science Foundation of China(No.42074136 and U19B2008)the Major National Science and Technology Projects(No.2016ZX05027004-001 and 2016ZX05002-005-009)+1 种基金the Fundamental Research Funds for the Central Universities(No.19CX02007A)China Postdoctoral Science Foundation(No.2020M672170).
文摘In the conventional stochastic inversion method,the spatial structure information of underground strata is usually characterized by variograms.However,effectively characterizing the heterogeneity of complex strata is difficult.In this paper,multiple parameters are used to fully explore the underground formation information in the known seismic reflection and well log data.The spatial structure characteristics of complex underground reservoirs are described more comprehensively using multiple statistical characteristic parameters.We propose a prestack seismic stochastic inversion method based on prior information on statistical characteristic parameters.According to the random medium theory,this method obtains several statistical characteristic parameters from known seismic and logging data,constructs a prior information model that meets the spatial structure characteristics of the underground strata,and integrates multiparameter constraints into the likelihood function to construct the objective function.The very fast quantum annealing algorithm is used to optimize and update the objective function to obtain the fi nal inversion result.The model test shows that compared with the traditional prior information model construction method,the prior information model based on multiple parameters in this paper contains more detailed stratigraphic information,which can better describe complex underground reservoirs.A real data analysis shows that the stochastic inversion method proposed in this paper can effectively predict the geophysical characteristics of complex underground reservoirs and has a high resolution.
基金supported by the National Natural Science Foundation of China(11821505,12075300,and 12105248)the Key Research Project of Henan Education Department for Colleges and Universities(21A140025)+4 种基金Peng-Huan-Wu Theoretical Physics Innovation Center(12047503)the CAS Center for Excellence in Particle Physics(CCEPP)the CAS Key Research Program of Frontier Scienceshe Key R&D Program of Ministry of Science and Technology of the People’s Republic of China(2017YFA0402204)the Key Research Program of the Chinese Academy of Sciences(XDPB15)。
文摘The new CDF II measurement of W-boson mass shows a 7σdeviation from the standard model(SM)prediction,while the recent FNAL measurement of the muon g-2 shows a 4.2σdeviation(combined with the BNL result)from the SM.Both of them strongly indicate new physics beyond the SM.In this work,we study the implication of both measurements on low energy supersymmetry.With an extensive exploration of the parameter space of the minimal supersymmetric standard model(MSSM),we find that in the parameter space allowed by current experimental constraints from colliders and dark matter detections,the MSSM can simultaneously explain both measurements on the edge of 2σlevel,taking theoretical uncertainties into consideration.The favored parameter space,characterized by a compressed spectrum between bino,wino and stau,with the stop being around 1 TeV,may be covered in the near future LHC searches.
基金Supported by National Natural Science Foundation of China under Grant No.11265004
文摘We present an analysis of π-^20Ne elastic scattering at intermediate energy basing on the α＋^16O model of the ^20Ne nucleus and in the framework of Glauber multiple scattering theory. Satisfactory agreement with the general features of the experimental data of pion elastic scattering on the neighboring 4N-type nuclei is obtained without any free parameters. Compared with the experimental angular distributions of pion elastic scattering on ^12 C, ^16O, ^24Mg, and ^28Si nuclei, the diffractive patterns and the positions of the dips and peaks in the angular distributions of ^π-^20Ne elastic scattering are reasonably predicted by the calculations.
