目的探讨二甲双胍血糖控制不佳的2型糖尿病患者联合沙格列汀或吡格列酮的疗效。方法选择2015年1月至2016年1月安徽医科大第二附属医院内分泌门诊符合入选条件的2型糖尿病患者70例,随机被分为两组,观察组35例采用沙格列汀+二甲双胍治疗,...目的探讨二甲双胍血糖控制不佳的2型糖尿病患者联合沙格列汀或吡格列酮的疗效。方法选择2015年1月至2016年1月安徽医科大第二附属医院内分泌门诊符合入选条件的2型糖尿病患者70例,随机被分为两组,观察组35例采用沙格列汀+二甲双胍治疗,对照组35例患者采用吡格列酮+二甲双胍治疗,观察两组治疗前后的空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、空腹血清胰岛素水平、胰岛素抵抗指数(HOMA-IR)、体质指数(BMI)等。结果与治疗前比较,治疗16周后观察组、对照组患者的FPG、餐后2 h PG与Hb A1c明显降低,HOMA-IR改善,差异有统计学意义(P<0.05);但两组间差异无统计学意义(P>0.05)。与治疗前比较,治疗16周后观察组BMI无明显变化,差异无统计学意义(P>0.05),对照组患者BMI明显上升,差异有统计学意义(P<0.05),两组间差异有统计学意义(P<0.05)。结论沙格列汀或吡格列酮联合二甲双胍可有效控制2型糖尿病患者血糖、改善胰岛素敏感性,沙格列汀不增加体质量且不良反应小,联合二甲双胍治疗是一种安全可靠的治疗方法。展开更多
A new ligand 1,4-bis(2-hydroxymethylphenyl)-1,4-dioxabutane was synthesized by reducing 1,4-bis(2-formylphenyl)-1,4-dioxabutane with NaBH4 in absolute methanol solution. The crystal structure of the title compound C16...A new ligand 1,4-bis(2-hydroxymethylphenyl)-1,4-dioxabutane was synthesized by reducing 1,4-bis(2-formylphenyl)-1,4-dioxabutane with NaBH4 in absolute methanol solution. The crystal structure of the title compound C16H18O4 has been determined by single-crystal X-ray diffraction. The ligand crystallizes in the orthorhombic system, space group Pbcn with a = 13.777(1), b = 11.731(1), c = 9.076(8) ? V = 1466.8(2) ?, Mr = 274.30, Z = 4, F(000) = 548, Dc = 1.24 g/cm3, T = 293 K, m = 8.9 cm-1 and l = 0.71073 ? The structure was refined to R = 0.0324 and wR = 0.1025 for 1112 observed reflections with I > 2s(I). The two benzene rings are not on the same plane, and the dihedral angle between them is 60.6? The ligand has C2 symmetry axis which passes through the center of C(8)C(8a). The molecules are linked to each other by hydrogen bonding network to form supramolecular chain. The ligands connect to each other through the hydrogen bonds to form one-dimensional chains which further connect through the hydrogen bonds to form two- and three-dimensional structures.展开更多
文摘目的探讨二甲双胍血糖控制不佳的2型糖尿病患者联合沙格列汀或吡格列酮的疗效。方法选择2015年1月至2016年1月安徽医科大第二附属医院内分泌门诊符合入选条件的2型糖尿病患者70例,随机被分为两组,观察组35例采用沙格列汀+二甲双胍治疗,对照组35例患者采用吡格列酮+二甲双胍治疗,观察两组治疗前后的空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、空腹血清胰岛素水平、胰岛素抵抗指数(HOMA-IR)、体质指数(BMI)等。结果与治疗前比较,治疗16周后观察组、对照组患者的FPG、餐后2 h PG与Hb A1c明显降低,HOMA-IR改善,差异有统计学意义(P<0.05);但两组间差异无统计学意义(P>0.05)。与治疗前比较,治疗16周后观察组BMI无明显变化,差异无统计学意义(P>0.05),对照组患者BMI明显上升,差异有统计学意义(P<0.05),两组间差异有统计学意义(P<0.05)。结论沙格列汀或吡格列酮联合二甲双胍可有效控制2型糖尿病患者血糖、改善胰岛素敏感性,沙格列汀不增加体质量且不良反应小,联合二甲双胍治疗是一种安全可靠的治疗方法。
基金The project was supported by the state key laboratory of Suzhou University and the foundation of Science Committee of Jiangsu Province
文摘A new ligand 1,4-bis(2-hydroxymethylphenyl)-1,4-dioxabutane was synthesized by reducing 1,4-bis(2-formylphenyl)-1,4-dioxabutane with NaBH4 in absolute methanol solution. The crystal structure of the title compound C16H18O4 has been determined by single-crystal X-ray diffraction. The ligand crystallizes in the orthorhombic system, space group Pbcn with a = 13.777(1), b = 11.731(1), c = 9.076(8) ? V = 1466.8(2) ?, Mr = 274.30, Z = 4, F(000) = 548, Dc = 1.24 g/cm3, T = 293 K, m = 8.9 cm-1 and l = 0.71073 ? The structure was refined to R = 0.0324 and wR = 0.1025 for 1112 observed reflections with I > 2s(I). The two benzene rings are not on the same plane, and the dihedral angle between them is 60.6? The ligand has C2 symmetry axis which passes through the center of C(8)C(8a). The molecules are linked to each other by hydrogen bonding network to form supramolecular chain. The ligands connect to each other through the hydrogen bonds to form one-dimensional chains which further connect through the hydrogen bonds to form two- and three-dimensional structures.
