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散发性阿尔茨海默病患者BDNF基因G196A和C270T单体型及双体型分析
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作者 钱云 张志珺 +5 位作者 张晓斌 袁勇贵 宇辉 施咏梅 柏峰 谢春明 《东南大学学报(医学版)》 CAS 2008年第3期161-165,共5页
目的:探讨脑源性神经营养因子(BDNF)基因G196A和C270T单核苷酸多态性(SNPs)在散发性阿尔茨海默病(sAD)发病机制中的作用。方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,对105例sAD患者和105例健康对照者BDNF基因、载脂蛋... 目的:探讨脑源性神经营养因子(BDNF)基因G196A和C270T单核苷酸多态性(SNPs)在散发性阿尔茨海默病(sAD)发病机制中的作用。方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,对105例sAD患者和105例健康对照者BDNF基因、载脂蛋白E(ApoE)基因多态性进行分析。结果:(1)sAD患者C270T但非G196A基因型及等位基因频率与对照组相比差异有统计学意义(P=0.034,P=0.011)。(2)BDNF G196A和C270T单体型分析发现,4种单体型在sAD组和对照组间差异有统计学意义(P=0.048)。对照组H4单体型频率显著高于sAD组,差异有统计学意义(P=0.024);按ApoEε4分层后,在非ApoEε4携带者中,该差异仍有统计学意义(P=0.023)。对照组基于H4的双体型频率显著高于sAD组,差异有统计学意义(P=0.029);按ApoEε4分层后,在非ApoEε4携带者中,该差异仍有统计学意义(P=0.040)。结论:BDNF C270T位点的SNP可能与sAD的易感性相关,H4单体型及其构成的双体型是sAD的遗传保护因素,对非ApoEε4携带者而言尤其如此。 展开更多
关键词 阿尔茨海默病 脑源性神经营养因子 载脂蛋白E 体型 双体型
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双体型-同源染色体中配对的单体型对–在基因-疾病中的关联分析中的应用(英文) 被引量:2
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作者 左玲郡 王克胜 罗星光 《上海精神医学》 2014年第3期165-170,共6页
等位基因,基因型和单体型(等位基因组合)已被广泛应用于基因-疾病的关联研究。最近,使用双体型(同源染色体单体型对)的关联研究已经越来越普遍。本文综述了四种关联分析类型的基本原理,并探讨了为什么以双体型为基础的关联分析比其他类... 等位基因,基因型和单体型(等位基因组合)已被广泛应用于基因-疾病的关联研究。最近,使用双体型(同源染色体单体型对)的关联研究已经越来越普遍。本文综述了四种关联分析类型的基本原理,并探讨了为什么以双体型为基础的关联分析比其他类型的关联分析更高效。单体型关联分析比基于等位基因的关联分析更高效,以双体型为基础的关联分析比基于基因型的关联分析更高效。在标记之间没有交互作用并且符合Hardy-Weinberg平衡(HWE)标准的情况下,以等位基因和单体型为基础的关联分析样本量较大、自由度较小,使它们分别比基因型和双体型为基础的关联分析更高效。然而,在某些情况下以双体型为基础的关联分析比单体型关联分析更高效。 展开更多
关键词 双体型 体型 关联分析 基因型 交互作用 Hardy—Weinberg平衡
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双体型渡船太阳能动力系统设计 被引量:1
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作者 曹雪玲 常卓 +3 位作者 陈爱国 苏泽彬 刘金辉 黄鸿霓 《广州航海学院学报》 2020年第3期1-5,46,共6页
本文在太阳能光伏发电理论的基础下,设计了一套在目标船(双体型渡船)上运用的太阳能动力系统和蓄电池组件方阵系统.该设计合理选用太阳能电池板和蓄电池,并对其进行串并联设计,得出了双体型渡船太阳能动力系统设计的最佳方案.采用太阳... 本文在太阳能光伏发电理论的基础下,设计了一套在目标船(双体型渡船)上运用的太阳能动力系统和蓄电池组件方阵系统.该设计合理选用太阳能电池板和蓄电池,并对其进行串并联设计,得出了双体型渡船太阳能动力系统设计的最佳方案.采用太阳能板和蓄电池分别串并联方阵有效延长了蓄电池的使用寿命,增加了太阳能的能源利用率,有利于我国光伏发电和绿色船舶的多向发展. 展开更多
关键词 双体型渡船 太阳能动力 蓄电池方阵 绿色船舶
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南亚高压的多模态特征及其与新疆夏季降水的联系 被引量:23
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作者 王前 赵勇 +2 位作者 陈飞 杨青 黄安宁 《高原气象》 CSCD 北大核心 2017年第5期1209-1220,共12页
基于欧洲中期天气预报中心(ECMWF)的Interim再分析资料(ERA-Interim)和新疆88个观测站点降水资料,分析了1979—2013年夏季(7月和8月)南亚高压多模态特征及其与新疆夏季降水的关系。结果表明,南亚高压除了青藏高压型和伊朗高压型外,还存... 基于欧洲中期天气预报中心(ECMWF)的Interim再分析资料(ERA-Interim)和新疆88个观测站点降水资料,分析了1979—2013年夏季(7月和8月)南亚高压多模态特征及其与新疆夏季降水的关系。结果表明,南亚高压除了青藏高压型和伊朗高压型外,还存在双体型。伊朗高压型和双体型分布产生的降水占新疆夏季总降水的70%~90%,青藏高压型分布产生的降水相对较少,占10%~30%。南亚高压的多模态分布对新疆降水有不同影响,伊朗高压型时,北疆部分地区和东疆降水偏多,塔里木盆地降水偏少;青藏高压型时,除塔里木盆地西南部降水偏多外,新疆其余地方降水均偏少。南亚高压双体型对塔里木盆地夏季降水影响最为突出,当夏季南亚高压呈双体型分布时,塔里木盆地降水偏多。合成分析发现,南亚高压双体型中心位置变化对环流和水汽输送产生不同影响,因而对应的塔里木盆地夏季降水也存在一定差异。当两个中心位置同时偏西时,塔里木盆地中西部地区降水偏多,水汽分两步进入塔里木盆地。当两个中心位置同时偏北时,整个塔里木盆地降水增加,水汽沿着青藏高原东侧绕流进入塔里木盆地。 展开更多
关键词 南亚高压 双体型 夏季降水 新疆
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Single-and Two-band Transport Properties Crossover in Bi_(2)Te_(3)Based Thermoelectrics
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作者 MENG Yuting WANG Xuemei +2 位作者 ZHANG Shuxian CHEN Zhiwei PEI Yanzhong 《无机材料学报》 SCIE EI CAS CSCD 北大核心 2024年第11期1283-1291,共9页
Based on Peltier effect,Bi_(2)Te_(3)-based alloy is widely used in commercial solid-state refrigeration at room temperature.The mainstream strategies for enhancing room-temperature thermoelectric performance in Bi_(2)... Based on Peltier effect,Bi_(2)Te_(3)-based alloy is widely used in commercial solid-state refrigeration at room temperature.The mainstream strategies for enhancing room-temperature thermoelectric performance in Bi_(2)Te_(3)focus on band and microstructure engineering.However,a clear understanding of the modulation of band structure and scattering through such engineering remains still challenging,because the minority carriers compensate partially the overall transport properties for the narrow-gap Bi_(2)Te_(3)at room temperature(known as the bipolar effect).The purpose of this work is to model the transport properties near and far away from the bipolar effect region for Bi_(2)Te_(3)-based thermoelectric material by a two-band model taking contributions of both majority and minority carriers into account.This is endowed by shifting the Fermi level from the conduction band to the valence band during the modeling.A large amount of data of Bi_(2)Te_(3)-based materials is collected from various studies for the comparison between experimental and predicted properties.The fundamental parameters,such as the density of states effective masses and deformation potential coefficients,of Bi_(2)Te_(3)-based materials are quantified.The analysis can help find out the impact factors(e.g.the mobility ratio between conduction and valence bands)for the improvement of thermoelectric properties for Bi_(2)Te_(3)-based alloys.This work provides a convenient tool for analyzing and predicting the transport performance even in the presence of bipolar effect,which can facilitate the development of the narrow-gap thermoelectric semiconductors. 展开更多
关键词 thermoelectric material Bi_(2)Te_(3)-based alloy two-band model narrow-gap thermoelectric semiconductor
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水翼艇性能的小系列试验研究 被引量:2
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作者 周俊麟 董祖舜 董文才 《船舶》 北大核心 2004年第2期15-19,共5页
水翼艇由于其具有优异的快速性及其它性能 ,已在军事上和民用交通方面得到广泛应用。为了开发和研制适合于中国水运市场的新艇型 ,本文以“单体”和“双体”两种截然不同的艇型作为比较对象 ,进行了一系列性能试验研究 ,在探求“双体”... 水翼艇由于其具有优异的快速性及其它性能 ,已在军事上和民用交通方面得到广泛应用。为了开发和研制适合于中国水运市场的新艇型 ,本文以“单体”和“双体”两种截然不同的艇型作为比较对象 ,进行了一系列性能试验研究 ,在探求“双体”带来的利弊量值大小的情况下 ,权衡其采用的可能性。 展开更多
关键词 水翼艇 体型线 双体型线 船舶试验 型线参数 船型参数 水翼形式
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积液型两相流分配器的性能与优化 被引量:3
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作者 徐博 张驰 +2 位作者 陈江平 孙西辉 马小魁 《上海交通大学学报》 EI CAS CSCD 北大核心 2015年第1期91-95,100,共6页
试验研究了带有复杂入口管的积液型两相流分液器在不同干度和质量流量条件下的分液均匀性.结果表明:当干度增大时,分液器的分液均匀性下降;当质量流量增大时,分液器的分液均匀性得到改善;各工况下分液器分液的流体质量流量标准偏差(STD... 试验研究了带有复杂入口管的积液型两相流分液器在不同干度和质量流量条件下的分液均匀性.结果表明:当干度增大时,分液器的分液均匀性下降;当质量流量增大时,分液器的分液均匀性得到改善;各工况下分液器分液的流体质量流量标准偏差(STD)的平均值为2.80%.同时,对复杂入口管进行了计算流体动力学模拟,提出了一种能够有效降低入口管形式影响的新型双筒体型分液器,并通过试验加以验证.验证试验结果表明,在各工况下,双筒体型分液器分液的STD的平均值为2.36%,比积液型分液器的分液均匀性提高了15.7%. 展开更多
关键词 分液器 计算流体动力学模拟 入口条件 体型
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王甫洲泄水闸导堤设计与试验研究 被引量:1
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作者 田士豪 翁建良 邓和云 《水利水电技术》 CSCD 北大核心 2000年第4期52-54,共3页
王甫洲水利枢纽是汉江干流上的一座大型水利枢纽 ,泄水闸承担渲泄洪水、控制上游水位的任务 .泄水闸布置在主河道的左岸滩地上 ,最大下泄流量 2 0 80 0 m3/ s.其左右导堤是保证泄水闸安全运行的重要建筑物 ,特别是右导堤的作用更为显著 ... 王甫洲水利枢纽是汉江干流上的一座大型水利枢纽 ,泄水闸承担渲泄洪水、控制上游水位的任务 .泄水闸布置在主河道的左岸滩地上 ,最大下泄流量 2 0 80 0 m3/ s.其左右导堤是保证泄水闸安全运行的重要建筑物 ,特别是右导堤的作用更为显著 .试验研究比较了土堤方案和混凝土墙方案 .混凝土墙的水流条件好 ,投资省 ,施工期短 . 展开更多
关键词 水利枢纽 水闸 导流堤 设计 试验 抛物线体型
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SiGe HBT Class AB Power Amplifier for Wireless Communications 被引量:1
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作者 贾宏勇 刘志农 +1 位作者 李高庆 钱佩信 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2002年第9期921-924,共4页
Good performance SiGe power amplifiers applicable to wireless communications are demonstrated.The output power can reach more than 30dBm in class B mode.And in class AB mode,the output power at 1dB compression point (... Good performance SiGe power amplifiers applicable to wireless communications are demonstrated.The output power can reach more than 30dBm in class B mode.And in class AB mode,the output power at 1dB compression point ( P 1dB ) is 24dBm,the output third order intercept (TOI) power is 39dBm under V cc of 4V.The highest power added efficiency (PAE) and PAE at 1dB compression point are 34% and 25%,respectively.The adjacent channel power rejection for CDMA signal is more than 42dBc,which complies with IS95 specification. 展开更多
关键词 SIGE HBT microwave power amplifier
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A monolithic InGaP/GaAs HBT power amplifier for W-CDMA applications 被引量:1
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作者 黄继伟 王志功 +2 位作者 廖英豪 陈志坚 方志坚 《Journal of Southeast University(English Edition)》 EI CAS 2011年第2期132-135,共4页
A monolithic microwave integrated circuit (MMIC) power amplifier (PA) is proposed. It adopts a new on-chip bias circuit, which not only avoids the instability of the direct current bias caused by the change in the... A monolithic microwave integrated circuit (MMIC) power amplifier (PA) is proposed. It adopts a new on-chip bias circuit, which not only avoids the instability of the direct current bias caused by the change in the power supply and temperature, but also compensates deviations caused by the increase in input power. The bias circuit is a current-mirror configuration, and the feedback circuit helps to maintain bias voltage at a constant level. The gain of the feedback circuit is improved by the addition of a non-inverting amplifier within the feedback circuit. A shunt capacitor at the base node of the active bias transistor enhances the linearity of the PA. The chip is fabricated in an InGaP/GaAs heterojunction bipolar transistor (HBT) process. Measured results exhibit a 26. 6-dBm output compression point, 33.6% power-added efficiency (PAE) and - 40.2 dBc adjacent channel power ratio (ACPR) for wide-band code division multiple access (W-CDMA) applications. 展开更多
关键词 power amplifier wide-band code division multipleaccess(W-CDMA) heterojunction bipolar transistor (HBT) bias circuit gain compression
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A 162GHz Self-Aligned InP/InGaAs Heterojunction Bipolar Transistor
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作者 于进勇 严北平 +5 位作者 苏树兵 刘训春 王润梅 徐安怀 齐 鸣 刘新宇 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2006年第10期1732-1736,共5页
An emitter self-aligned InP-based single heterojunction bipolar transistor with a cutoff frequency (fT) of 162GHz is reported. The emitter size is 0.8μm × 12μm, the maximum DC gain is 120, the offset voltage ... An emitter self-aligned InP-based single heterojunction bipolar transistor with a cutoff frequency (fT) of 162GHz is reported. The emitter size is 0.8μm × 12μm, the maximum DC gain is 120, the offset voltage is 0.10V,and the typical breakdown voltage at Ic = 0. 1μA is 3.8V. This device is suitable for high-speed low-power applications,such as OEIC receivers and analog-to-digital converters. 展开更多
关键词 INP HBT SELF-ALIGNED
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InP/InGaAs Heterojunction Bipolar Transistor with Base μ-Bridge and Emitter Air-Bridge
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作者 于进勇 刘新宇 +3 位作者 苏树兵 王润梅 徐安怀 齐鸣 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2007年第2期154-158,共5页
An InP-based single-heterojunction bipolar transistor (SHBT) with base μ-bndge and emitter air-bridge is reported. Because those bridges reduce parasitic capacitance greatly, the cutoff frequency fT of the 2μm ... An InP-based single-heterojunction bipolar transistor (SHBT) with base μ-bndge and emitter air-bridge is reported. Because those bridges reduce parasitic capacitance greatly, the cutoff frequency fT of the 2μm ×12.5μm InP SHBT without de-embedding reaches 178GHz. It is critical in high-speed low power applications,such as OEIC receivers and analog-to-digital converters. 展开更多
关键词 InP HBT μ-bridge air-bridges self-aligning
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Super Performance InGaP/GaAs Heterojunction Bipolar Transistor with Hexagonal Emitter
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作者 刘洪刚 袁志鹏 +1 位作者 和致经 吴德馨 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2003年第11期1135-1139,共5页
Super performance InGaP/GaAs heterojunction bipolar transistors (HBTs) with hexagonal emitter are described.The fabricated HBT shows excellent DC characteristics with low V CE offset voltage (<0 15V) and ... Super performance InGaP/GaAs heterojunction bipolar transistors (HBTs) with hexagonal emitter are described.The fabricated HBT shows excellent DC characteristics with low V CE offset voltage (<0 15V) and low knee voltage (<0 5V).Over 14V of the collector base breakdown voltage BV CBO and over 9V of the collector emitter breakdown voltage BV CEO are obtained.For a self aligned InGaP/GaAs HBT with 2μm×10μm emitter area,the f T is extrapolated to 92GHz and f max is extrapolated to 105GHz.These great values are obtained due to the hexagonal emitter and laterally etched undercut (LEU) of collector,indicating the great potential of InGaP/GaAs HBTs for high speed digital circuit and microwave power applications. 展开更多
关键词 HBT INGAP/GAAS hexagonal emitter
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Alloy Temperature Dependence of Offset Voltage and Ohmic Contact Resistance in Thin Base InGaP/GaAs HBTs
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作者 杨威 刘训春 +2 位作者 朱旻 王润梅 申华军 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2006年第5期765-768,共4页
The alloy temperature dependence of Voffset and Rcontact is studied, and an optimal alloy temperature range for the best trade-off between Voffset and Rcontact, is given for thin base HBTs. In addition,the reason for ... The alloy temperature dependence of Voffset and Rcontact is studied, and an optimal alloy temperature range for the best trade-off between Voffset and Rcontact, is given for thin base HBTs. In addition,the reason for the high Voffset at high alloy temperature is interpreted using Schottky clamped theory. The lower Voffset of our U-shaped emitter HBT than that of traditional strip emitter HBTs is explained. 展开更多
关键词 heterojunction bipolar transistor U-shaped emitter ALLOY offset voltage
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The Bipolar Field-Effect Transistor:Ⅰ.Electrochemical Current Theory(Two-MOS-Gates on Pure-Base)
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作者 薩支唐 揭斌斌 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2007年第11期1661-1673,共13页
This paper describes the bipolar field-effect transistor (BiFET) and its theory. Analytical solution is ob- tained from partitioning the two-dimensional transistor into two one-dimensional transistors. The analysis ... This paper describes the bipolar field-effect transistor (BiFET) and its theory. Analytical solution is ob- tained from partitioning the two-dimensional transistor into two one-dimensional transistors. The analysis employs the parametric surface-electric-potential and the electrochemical (quasi-Fermi) potential-gradient driving force to compute the current. Output and transfer D. C. current and conductance versus voltage are presented over practi- cal ranges of terminal D. C. voltages and device parameters. Electron and hole surface channel currents are pres- ent simultaneously, a new feature which could provide circuit functions in one physical transistor such as the CMOS inverter and SRAM memory. 展开更多
关键词 bipolar field-effect transistor theory MOS field-effect transistor bipolar junction transistor simul-taneous hole and electron surface channel~ volume channel surface potential
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The Bipolar Field-Effect Transistor:II.Drift-Diffusion Current Theory(Two-MOS-Gates on Pure-Base)
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作者 薩支唐 揭斌斌 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2007年第12期1849-1859,共11页
This paper describes the drift-diffusion theory of the bipolar field-effect transistor (BiFET) with two identical and connected metal-oxide-silicon-gates (MOS-gates) on a thin-pure-base. Analytical solution is obt... This paper describes the drift-diffusion theory of the bipolar field-effect transistor (BiFET) with two identical and connected metal-oxide-silicon-gates (MOS-gates) on a thin-pure-base. Analytical solution is obtained by partitioning the two-dimensional transistor into two one-dimensional problems coupled by the parametric sur- face-electric-potential. Total and component output and transfer currents and conductances versus D. C. voltages from the drift-diffusion theory, and their deviations from the electrochemical (quasi-Fermi) potential-gradient theory,are presented over practical ranges of thicknesses of the silicon base and gate oxide. A substantial contri- bution from the longitudinal gradient of the square of the transverse electric field is shown. 展开更多
关键词 bipolar field-effect transistor theory MOS field-effect transistor simultaneous electron and holesurface and volume channels surface potential~ longitudinal gradient of transverse electric field
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沿海作战需求特种舰船
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作者 于大海 左文锵 《国外舰船工程》 2003年第11期47-48,共2页
关键词 沿海作战 特种舰船 沿海快艇 浅水区 双体型战斗舰 船型
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Numerical Simulation and Analysis of Bipolar Junction Photogate Transistor for CMOS Image Sensor
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作者 金湘亮 陈杰 仇玉林 《Journal of Semiconductors》 EI CAS CSCD 北大核心 2003年第3期250-254,共5页
A new photodetector--bipolar junction photogate transistor is presented for CMOS image sensor and its analytical model is also established.With the technical parameter of the 0.6μm CMOS process,the bipolar junction p... A new photodetector--bipolar junction photogate transistor is presented for CMOS image sensor and its analytical model is also established.With the technical parameter of the 0.6μm CMOS process,the bipolar junction photogate transistor is analyzed and simulated.The simulated results illustrate that the bipolar junction photogate transistor has the similar characteristics of the traditional photogate transistor.The photocurrent density of the bipolar junction photogate transistor increases exponentially with the incidence light power due to introducing the injection p+n junction.Its characteristic of blue response is rather improved compared to the traditional photogate transistor that benefits to increase the color photograph made up of the red,the green,and the blue. 展开更多
关键词 bipolar junction photogate transistor PHOTODETECTOR CMOS image sensor
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我国首艘全天候“不晕船”交付
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《军民两用技术与产品》 2004年第3期17-17,共1页
关键词 双体型 耐波性能 水面接触面 设计 “新世纪一号” 中国
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液体型双试剂在生化分析仪上应用的体会
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作者 蒋仁礼 《临床检验信息导报》 1995年第4期124-124,126,共2页
关键词 生化分析仪 体型试剂
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