Objective To evaluate the efficacy of medroxyprogesterone acetate(MA)plus metformin as the primary fertility-sparing treatment for atypical endometrial hyperplasia(AEH)and early-stage grade 1 endometrial adenocarcinom...Objective To evaluate the efficacy of medroxyprogesterone acetate(MA)plus metformin as the primary fertility-sparing treatment for atypical endometrial hyperplasia(AEH)and early-stage grade 1 endometrial adenocarcinoma(G1 EAC)and the recurrence rate after treatment.Methods Sixty patients(aged 20-42 years)with AEH and/or grade 1 EAC limited to the endometrium were enrolled prospectively and randomized into two groups(n=30)to receive oral MA treatment at the daily dose of 160 mg(control)or MA plus oral metformin(850 mg,twice a day)for at least 6 months.The treatment could extend to 12 months until a complete response(CR)was achieved,and follow-up hysteroscopy and curettage were performed every 3 months.For all the patients who achieved CR,endometrial expressions of IGFBP-rP1,p-Akt and p-AMPK were detected immunohistochemically.Results A total of 58 patients completed the treatment.After 9 months of treatment,23(76.7%)patients in the combined treatment group and 20(71.4%)in the control group achieved CR;two patients in the control group achieved CR after converting to the combined treatment.The recurrence rate did not differ significantly between the control group and combined treatment group(30.0%vs 22.7%,P>0.05).Ten(35.7%)patients in the control group experienced significant weight gain of 5.7±6.1 kg,while none of the patients receiving the combined treatment exhibited significant body weight changes.Compared with the control group,the patients receiving the combined treatment showed enhanced endometrial expressions of IGFBP-rP1 and p-AMPK with lowered p-Akt expression.Conclusion Metformin combined with MA may provide an effective option for fertility-sparing treatment of AEH and grade 1 stage IA EAC,and the clinical benefits of metformin for controlling MA-induced weight gain and promoting endometrial expressions of IGFBP-rP1 and p-AMPK while inhibiting p-Akt expression warrants further study.展开更多
In order to more effectively apply an artifact removal melhod in an online brain-computer interface （BCI） system, a new method based on canonical correlation analysis （CCA） and two-channel eleetroeneephalography ...In order to more effectively apply an artifact removal melhod in an online brain-computer interface （BCI） system, a new method based on canonical correlation analysis （CCA） and two-channel eleetroeneephalography （EEG） recordings to quickly remove ocular artifacts （OA） is proposed in this paper. Considering both the formation of EEG signals contaminated by OA and the spread of OA, vertical electrooculo~＇aphy （VEOG） was appropriately introduced in CCA, and the blind source separation （BSS~ method based on CCA was used in a new way during the OA removal process. Both experimental and comparison with ICA and SOBI results show that the new method with simple calculation and fast processing speed can effectively separate and remove OA using only two-channel EEG recordings, with retaining useful EEG signals. Hence, this method used in an online BCI system will be more effective.展开更多
文摘Objective To evaluate the efficacy of medroxyprogesterone acetate(MA)plus metformin as the primary fertility-sparing treatment for atypical endometrial hyperplasia(AEH)and early-stage grade 1 endometrial adenocarcinoma(G1 EAC)and the recurrence rate after treatment.Methods Sixty patients(aged 20-42 years)with AEH and/or grade 1 EAC limited to the endometrium were enrolled prospectively and randomized into two groups(n=30)to receive oral MA treatment at the daily dose of 160 mg(control)or MA plus oral metformin(850 mg,twice a day)for at least 6 months.The treatment could extend to 12 months until a complete response(CR)was achieved,and follow-up hysteroscopy and curettage were performed every 3 months.For all the patients who achieved CR,endometrial expressions of IGFBP-rP1,p-Akt and p-AMPK were detected immunohistochemically.Results A total of 58 patients completed the treatment.After 9 months of treatment,23(76.7%)patients in the combined treatment group and 20(71.4%)in the control group achieved CR;two patients in the control group achieved CR after converting to the combined treatment.The recurrence rate did not differ significantly between the control group and combined treatment group(30.0%vs 22.7%,P>0.05).Ten(35.7%)patients in the control group experienced significant weight gain of 5.7±6.1 kg,while none of the patients receiving the combined treatment exhibited significant body weight changes.Compared with the control group,the patients receiving the combined treatment showed enhanced endometrial expressions of IGFBP-rP1 and p-AMPK with lowered p-Akt expression.Conclusion Metformin combined with MA may provide an effective option for fertility-sparing treatment of AEH and grade 1 stage IA EAC,and the clinical benefits of metformin for controlling MA-induced weight gain and promoting endometrial expressions of IGFBP-rP1 and p-AMPK while inhibiting p-Akt expression warrants further study.
基金National Science Foundation of China grant number: 61172108,61139001 and 60872122+1 种基金Shanghai Dianji University Leading Academic Discipine Project grant number: 10xkf01
文摘In order to more effectively apply an artifact removal melhod in an online brain-computer interface （BCI） system, a new method based on canonical correlation analysis （CCA） and two-channel eleetroeneephalography （EEG） recordings to quickly remove ocular artifacts （OA） is proposed in this paper. Considering both the formation of EEG signals contaminated by OA and the spread of OA, vertical electrooculo~＇aphy （VEOG） was appropriately introduced in CCA, and the blind source separation （BSS~ method based on CCA was used in a new way during the OA removal process. Both experimental and comparison with ICA and SOBI results show that the new method with simple calculation and fast processing speed can effectively separate and remove OA using only two-channel EEG recordings, with retaining useful EEG signals. Hence, this method used in an online BCI system will be more effective.
