期刊文献+
共找到22篇文章
< 1 2 >
每页显示 20 50 100
用双功能性离子液体[A336][P204]从硫酸体系中萃取钼 被引量:2
1
作者 刘泉 陆明杰 +5 位作者 汪慧刚 于立策 徐红娟 彭逸超 钱铖镕 杨华玲 《湿法冶金》 CAS 北大核心 2020年第6期507-510,共4页
研究了以正庚烷为稀释剂、双功能性离子液体[A336][P204]为萃取剂萃取分离钼。结果表明:钼萃取率与萃取时间、水相酸度、盐析剂Na2SO4浓度及萃取剂浓度有关;与传统的P204和P204+TBP体系对比,双功能性离子液体[A336][P204]对钼的萃取率更... 研究了以正庚烷为稀释剂、双功能性离子液体[A336][P204]为萃取剂萃取分离钼。结果表明:钼萃取率与萃取时间、水相酸度、盐析剂Na2SO4浓度及萃取剂浓度有关;与传统的P204和P204+TBP体系对比,双功能性离子液体[A336][P204]对钼的萃取率更高,反萃取效果更好;[A336][P204]在硫酸体系中萃取钼的最佳条件为:萃取时间15 min,水相pH=2.12,盐析剂Na2SO4浓度0.07 mol/L,[A336][P204]浓度0.1 mol/L,此条件下,钼萃取率达97%,萃取效果较好。 展开更多
关键词 双功能性离子液体 [A336][P204] 溶剂萃取
下载PDF
双功能性离子液体溶胶-凝胶法制备介孔SiO_2 被引量:1
2
作者 葛倪林 张迪 +1 位作者 魏海兵 丁运生 《功能材料》 EI CAS CSCD 北大核心 2014年第20期20068-20073,共6页
首先合成了一种新型双功能性离子液体1-甲基-3-(3'-磺酸丙基)咪唑十二烷基磺酸盐([PMIM(SO3H)][C12SO3]),并采用FT-IR、1H NMR和13C NMR对其结构进行了表征;进一步以该离子液体为模板剂和酸源,以正硅酸乙酯(TEOS)为硅源,通过溶胶-... 首先合成了一种新型双功能性离子液体1-甲基-3-(3'-磺酸丙基)咪唑十二烷基磺酸盐([PMIM(SO3H)][C12SO3]),并采用FT-IR、1H NMR和13C NMR对其结构进行了表征;进一步以该离子液体为模板剂和酸源,以正硅酸乙酯(TEOS)为硅源,通过溶胶-凝胶法制备出介孔SiO2,利用TGA和FT-IR研究了介孔材料的形成过程,采用SAXRD、SEM、TEM和氮气等温吸附-脱附等手段对介孔材料的结构形貌进行了表征,并研究了其对Pb2+的吸附性能。结果显示,以[PMIM(SO3H)][C12SO3]为模板剂和酸源制备的介孔SiO2其比表面积、孔容、平均孔径大小分别为1 010m2/g、0.95 cm3/g、3.25 nm,其对重金属Pb2+有很好的吸附性能。 展开更多
关键词 双功能性离子液体 模板剂 溶胶-凝胶 介孔材料 吸附性能
下载PDF
新型双功能性超支化聚合物的制备及表征 被引量:5
3
作者 刘兴亮 罗静 +1 位作者 李小杰 刘晓亚 《功能高分子学报》 CAS CSCD 北大核心 2018年第2期147-152,共6页
首先以烯丙基缩水甘油醚与N-氨乙基哌嗪反应合成新型B_3单体,然后分别以六亚甲基二异氰酸酯和1,6-己二硫醇为A_2单体与上述B_3单体反应,利用异氰酸-羟基以及巯基-烯的反应,合成了同时含有羟基和烯丙基的双功能性超支化聚(氨酯-胺)和聚(... 首先以烯丙基缩水甘油醚与N-氨乙基哌嗪反应合成新型B_3单体,然后分别以六亚甲基二异氰酸酯和1,6-己二硫醇为A_2单体与上述B_3单体反应,利用异氰酸-羟基以及巯基-烯的反应,合成了同时含有羟基和烯丙基的双功能性超支化聚(氨酯-胺)和聚(硫醚-胺)。研究了单体种类及投料比与合成的超支化聚合物的化学与拓扑结构的关系。通过红外吸收光谱、核磁共振氢谱和凝胶渗透色谱表征了超支化聚合物的分子结构和化学组成。结果表明:该B_3单体同时带有3个羟基与3个烯丙基,当A_2和B_3单体投料比(物质的量之比)为0.825∶1时,可以成功制备较高分子量的双功能性超支化聚合物。 展开更多
关键词 双功能性 超支化聚(氨酯-胺) 超支化聚(硫醚-胺)
下载PDF
前交叉韧带功能性双束重建与传统单束重建的临床疗效对比 被引量:1
4
作者 罗毅 马壮 +2 位作者 董溢海 徐宁 韩敦鑫 《医学研究与战创伤救治》 CAS 北大核心 2023年第3期286-289,共4页
目的评估前交叉韧带(ACL)功能性双束重建与传统单束重建的临床疗效。方法回顾性分析2018年1月至2020年12月在联勤保障部队970医院骨科接受ACL重建手术的80例患者临床资料。根据前交叉重建方式不同分为传统单束重建组(n=40)和功能性双束... 目的评估前交叉韧带(ACL)功能性双束重建与传统单束重建的临床疗效。方法回顾性分析2018年1月至2020年12月在联勤保障部队970医院骨科接受ACL重建手术的80例患者临床资料。根据前交叉重建方式不同分为传统单束重建组(n=40)和功能性双束重建组(n=40)。于术后1个月、3个月、6个月时对比IKDC评分、Lysholm评分、查体评分,评估膝关节功能恢复情况。结果所有患者术后切口均无感染,无横穿钉断裂,失效以及血管神经损伤发生。术后3个月,功能性双束重建组膝关节活动范围优于传统单束重建组(P<0.05)。术后3个月和6个月,功能性双束重建组较传统单束重建组更好的膝关节稳定性(P<0.05)。功能性双束重建组Lysholm评分、IKDC评分优于传统单束重建组(P<0.05)。结论ACL功能性双束重建术中期具有更好的本体稳定觉,在对抗膝关节重建术后的前后向稳定性,尤其是旋转稳定性上具有一定优势和临床意义。 展开更多
关键词 前交叉韧带 功能性束重建 回顾性分析 疗效评估 单束重建
下载PDF
四瓣法功能性双侧唇裂修复术
5
作者 程代薇 王玉明 +2 位作者 王达利 周妮娅 袁习萍 《贵州医药》 CAS 2001年第7期586-587,共2页
目的对双侧唇裂修复手术方法进行改进,以改善术后前唇组织薄弱、平坦及唇中部唇红不丰满等缺陷。方法设计四瓣,用前唇上部内侧粘膜瓣(A瓣)加深唇龈沟,用下方的粘膜及红唇瓣(B瓣)重建唇珠,用两侧唇的皮肤粘膜瓣(C、D瓣)衬... 目的对双侧唇裂修复手术方法进行改进,以改善术后前唇组织薄弱、平坦及唇中部唇红不丰满等缺陷。方法设计四瓣,用前唇上部内侧粘膜瓣(A瓣)加深唇龈沟,用下方的粘膜及红唇瓣(B瓣)重建唇珠,用两侧唇的皮肤粘膜瓣(C、D瓣)衬垫子前唇内侧以加固、加厚前唇;并将两侧唇肌肉缝合并固定于前唇上。结果18例均获良好效果,术后上唇丰厚而无过紧、过短及塌陷畸形,唇红丰满美观唇珠形态好,动态畸形矫不明显。结论此改进后的术式主要适合前唇前突严重者。 展开更多
关键词 唇裂 修复 皮瓣 四瓣法功能性侧唇裂修复术
下载PDF
功能性弹力小提花面料的设计
6
作者 张会青 王秀燕 +2 位作者 李梅 王静 贺欣欣 《毛纺科技》 CAS 北大核心 2016年第8期19-22,共4页
论述采用CAD系统将具有流行元素的图像转为组织点描述的织物设计方法,结合环保功能性新材料的使用,使面料设计更加符合市场流行趋势,提高产品附加值。以平纹地组织小提花纬弹毛呢面料的设计为例,阐述织物设计思路、设计方法及上机工艺... 论述采用CAD系统将具有流行元素的图像转为组织点描述的织物设计方法,结合环保功能性新材料的使用,使面料设计更加符合市场流行趋势,提高产品附加值。以平纹地组织小提花纬弹毛呢面料的设计为例,阐述织物设计思路、设计方法及上机工艺参数设计,采用"基于图像处理的组织设计"思路,借助于CAD软件的强大功能,花型变化建立在省综法的基础上;采用对称设计,实现了花型创新设计。并根据面料设计特点,解决关键工序的工艺问题,为小提花面料的设计与生产提供新思路。 展开更多
关键词 织物CAD软件 Beccy纤维/蛋白/羊绒功能性混纺纱 对称设计 上机参数
下载PDF
双颌垫功能性矫治器对安氏Ⅱ类错[牙合]畸形青少年上气道及舌骨位置变化的影响
7
作者 刘莎莎 刘宏历 孙岳 《医药论坛杂志》 2024年第16期1745-1749,共5页
目的分析安氏Ⅱ类错[牙合]畸形青少年应用双颌垫功能性矫治器的效果。方法采用回顾性分析,将在开封市口腔医院救治的62例安氏Ⅱ类错[牙合]畸形患者作为研究对象,病例收集时间为2019年1月—2024年1月,根据治疗方法不同将其分为两组,即观... 目的分析安氏Ⅱ类错[牙合]畸形青少年应用双颌垫功能性矫治器的效果。方法采用回顾性分析,将在开封市口腔医院救治的62例安氏Ⅱ类错[牙合]畸形患者作为研究对象,病例收集时间为2019年1月—2024年1月,根据治疗方法不同将其分为两组,即观察组(31例,采用TB功能性矫治器)和对照组(31例,采用标准方丝弓矫治器)。比较两组上气道形态功能[上齿槽座角(sella-nasion-A point,SNA)、下齿槽座角(sella-nasion-B point,SNB)、上下齿槽座角(angle's A-point over B-point,ANB)、软腭后气道矢状径(maxillary pharyngeal segment,MPS)、咽后壁与软腭之间的距离(soft palate to posterior pharyngeal space distance,SPPS)、第二颈椎最下点与上气道后壁矢状径(inter-pedicular space,IPS)、后鼻腔高度(posterior nasal passage heigh,S-PNS)、鼻咽全长(base to posterior nasal spine,BA-PNS)、舌骨到颈椎的矢状向距离(hyoid-vertebral level,H-VL)、舌骨到蝶鞍中心点的矢状向距离(hyoid point-sella,H-S)、舌骨到眶耳平面的垂直距离(hyoid point-frankfort horizontal,H-FH)、舌骨到下颌面的垂直距离(hyoid point-mandibular plane,H-MP)、氧减指数(oxygen desaturation index,ODI)、平均血氧饱和度(mean blood oxygen saturation,MSaO_(2))、最低血氧饱和度(lowest oxygen saturation,LSaO_(2))]、侧貌变化(下唇基角、颊唇沟角、软组织颊凸角、下唇凸点-H线距离)、正畸效果。结果正畸12周后,观察组SNB、下唇基角、颊唇沟角均相比对照组较大;MPS、IPS、S-PNS、Ba-PNS均相比对照组较长;SNA、ANB、软组织颊凸角均相比对照组较小;SPPS、下唇凸点-H线距离均相比对照组较短;H-S、H-FH、H-MP、MSaO_(2)、LSaO_(2)均相比对照组较高;H-VL、ODI均相比对照组较低;差异有统计学意义(P<0.05)。观察组总有效率(93.55%)相比对照组总有效率(74.19%)较高,差异有统计学意义(χ^(2)=4.292,P<0.05)。结论安氏Ⅱ类错[牙合]畸形青少年应用TB功能性矫治器,效果明确,不仅能有效改善上气道形态功能,调节舌骨位置,降低对侧貌的影响,还能优化睡眠情况。 展开更多
关键词 颌垫功能性矫治器 安氏Ⅱ类错[牙合]畸形 青少年 上气道变化 舌骨位置
原文传递
自体红细胞凝集试验研究进展 被引量:2
8
作者 邵长利 吕茂民 +1 位作者 史利军 章金刚 《生物技术通讯》 CAS 2007年第5期840-842,共3页
自体红细胞凝集试验是一种快速、简便,成本低廉的免疫学检测方法。用于自体红细胞凝集试验的主要成分是一种双功能性抗体。介绍了自体红细胞凝集试验的基本原理和主要特点,以及如何建立自体红细胞凝集试验检测体系;简要综述了双功能性... 自体红细胞凝集试验是一种快速、简便,成本低廉的免疫学检测方法。用于自体红细胞凝集试验的主要成分是一种双功能性抗体。介绍了自体红细胞凝集试验的基本原理和主要特点,以及如何建立自体红细胞凝集试验检测体系;简要综述了双功能性抗体的活性、稳定性、特异性、敏感性等方面的研究进展,以及自体红细胞凝集试验检测方法的应用前景。 展开更多
关键词 红细胞 凝集试验 双功能性抗体
下载PDF
指令类言外行为作用下的语用原则
9
作者 张玉上 《湖南经济管理干部学院学报》 2002年第1期99-101,共3页
本文分析了在实施指令类言外行为的过程中,人们对语用原则的选择,归纳了二者之间的辩证关系,对人们在言语交流中顺利实施指令类言外行为,达到预期的效果具有参照作用。
关键词 指令类言外行为 语用原则 辩证关系 语言交际 双功能性
下载PDF
NEWS
10
《分析化学》 SCIE EI CAS CSCD 北大核心 2010年第11期1687-1687,共1页
构建最蛋近白,同质济阵大列学对化生学物系传田感阳器课、题蛋组白报质道组了学一、组种织基工于程蛋学白、质生微物阵电列子,器具件有等选的择发性展吸具附有、原重位要培的养作细用胞。
关键词 分析化学 蛋白质 双功能性活细胞微阵列 小分子 一体化
下载PDF
白垩纪伤齿龙竖直成对螺旋排列产卵方式
11
作者 钱迈平 段政 +4 位作者 马雪 陈荣 张翔 余明刚 赵倩 《地质学刊》 CAS 2021年第2期138-142,共5页
伤齿龙类(troodontids)与其他恐龙不同,生蛋时将蛋竖直插入巢穴内松软泥沙里。此窝产自中国浙江天台盆地上白垩统赤城山组地层的恐龙蛋化石,显示该种恐龙每次产2枚蛋,从巢穴中心开始,向外依次螺旋排列,每窝可超过20枚。暗示雌性伤齿龙... 伤齿龙类(troodontids)与其他恐龙不同,生蛋时将蛋竖直插入巢穴内松软泥沙里。此窝产自中国浙江天台盆地上白垩统赤城山组地层的恐龙蛋化石,显示该种恐龙每次产2枚蛋,从巢穴中心开始,向外依次螺旋排列,每窝可超过20枚。暗示雌性伤齿龙类与雌性盗蛋龙类一样,有1对均具输卵功能的输卵管,一次又一次地在一个固定巢穴生蛋,并时常照看这些蛋。此外,伤齿龙类恐龙的蛋壳像某些现代鸟类的蛋壳一样坚固,足以承受其插入泥沙时的压力。而其他一些恐龙的蛋壳更像某些现代爬行类的蛋壳,是韧性的,在重力作用下往往呈扁球形。 展开更多
关键词 伤齿龙类 蛋化石 筑巢行为 功能性输卵管 浙江天台
下载PDF
Controllable synthesis of a self-assembled ultralow Ru,Ni-doped Fe_(2)O_(3) lily as a bifunctional electrocatalyst for large-current-density alkaline seawater electrolysis 被引量:1
12
作者 Tong Cui Xuejun Zhai +5 位作者 Lili Guo Jing-Qi Chi Yu Zhang Jiawei Zhu Xuemei Sun Lei Wang 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2022年第8期2202-2211,共10页
Highly efficient and stable bifunctional electrocatalysts that can be used for large-current-density electrolysis of alkaline seawater are highly desirable for carbon-neutral economies,but their facile and controllabl... Highly efficient and stable bifunctional electrocatalysts that can be used for large-current-density electrolysis of alkaline seawater are highly desirable for carbon-neutral economies,but their facile and controllable synthesis remains a challenge.Here,self-assembled ultralow Ru,Ni-doped Fe_(2)O_(3) with a lily shaped morphology was synthesized on iron foam(RuNi-Fe_(2)O_(3)/IF)via a facile one-step hydrothermal process,in which the intact lily shaped RuNi-Fe_(2)O_(3)/IF was obtained by adjusting the ratio of Ru/Ni.Benefitting from the Ru/Ni chemical substitution,the as-synthesized RuNi-Fe_(2)O_(3)/IF can act as free-standing dual-function electrodes that are applied to electrocatalysis for the hydrogen evolution(HER)and oxygen evolution reactions(OER)in 1.0 mol L^(-1) KOH,requiring an overpotential of 75.0 mV to drive 100 mA cm^(-2) for HER and 329.0 mV for OER.Moreover,the overall water splitting catalyzed by RuNi-Fe_(2)O_(3)/IF only demands ultralow cell voltages of 1.66 and 1.73 V to drive 100 mA cm^(-2) in 1.0 mol L^(-1) KOH and 1.0 mol L^(-1) KOH seawater electrolytes,respectively.The electrodes show remarkable long-term durability,maintaining current densities exceeding 100 mA cm^(-2) for more than 100 h and thus outperforming the two-electrode system composed of noble catalysts.This work provides an efficient,economical method to synthesize self-standing bifunctional electrodes for large-current-density alkaline seawater electrolysis,which is of significant importance for ecological protection and energy exploitation. 展开更多
关键词 RuNi-Fe_(2)O_(3)/IF Lily shape Bifunctional electrocatalyst Alkaline seawater splitting Large current density
下载PDF
Acid‐promoted Ir‐La‐S/AC‐catalyzed methanol carbonylation on single atomic active sites 被引量:4
13
作者 Zhou Ren Yuan Lyu +2 位作者 Siquan Feng Xiangen Song Yunjie Ding 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 北大核心 2018年第6期1060-1069,共10页
Highly active Ir‐La‐S/AC catalyst was successfully prepared by co‐impregnation of an activated carbon(AC) carrier with a sulfuric acid solution of Ir and La species and compared with a tradition‐ally prepared Ir... Highly active Ir‐La‐S/AC catalyst was successfully prepared by co‐impregnation of an activated carbon(AC) carrier with a sulfuric acid solution of Ir and La species and compared with a tradition‐ally prepared Ir‐La/AC catalyst. High angle annular dark‐field‐scanning transmission electron mi‐croscopy(HAADF‐STEM) measurement results show that most of the Ir species on Ir‐La‐S/AC exist as single atomic sites, while those on Ir‐La/AC exist as nanoparticles with an average diameter of 1.5 nm. Evaluation of Ir‐La‐S/AC as a catalyst for heterogeneous carbonylation of methanol to acetyl gave a maximum TOF (turn‐over‐frequency) of 2760 h^–1, which was distinctly higher than that achieved by the Ir‐La/AC catalyst(approximately 1000 h^-1). Temperature‐programmed desorption of ammonia(NH3‐TPD) result shows that the addition of sulfuric acid during the preparation pro‐cedure results in significantly more acidic sites on Ir‐La‐S/AC than those on Ir‐La/AC, which plays a key role in the enhancement of CO insertion as the rate‐determining step. Tempera‐ture‐programmed reduction(TPR) and in situ X‐ray photoelectron spectroscopy reveal that Ir spe‐cies are more reducible, and that more Ir^+ might be formed by activation of Ir‐La‐S/AC than those on the Ir‐La/AC catalyst, which is thought to be beneficial for reductive elimination of AcI from Ir^3+ species as an essential step for CH3I regeneration and acetyl formation. 展开更多
关键词 Heterogeneous METHANOL carbonylationIr‐La‐S/ACcatalyst BIFUNCTIONAL catalyst Single‐atomic active site Co‐impregnation
下载PDF
Certificateless Proxy Identity-Based Signcryption Scheme Without Bilinear Pairings 被引量:7
14
作者 亓延峰 唐春明 +2 位作者 娄裕 徐茂智 郭宝安 《China Communications》 SCIE CSCD 2013年第11期37-41,共5页
Signcryption, which was introduced by ZHEN~ is a cryptographic primitive that fulfils the functions of both digital signature and encryption and guarantees confidentiality, integrity and non-repudiation in a more effi... Signcryption, which was introduced by ZHEN~ is a cryptographic primitive that fulfils the functions of both digital signature and encryption and guarantees confidentiality, integrity and non-repudiation in a more effi- cient way. Certificateless signcryption and pro- xy signcryption in identity-based cryptography were proposed for different applications. Most of these schemes are constructed by bilinear pairings from elliptic curves. However, some schemes were recently presented without pai- rings. In this paper, we present a certificateless proxy identity-based signcryption scheme with- out bilinear pairings, which is efficient and secure. 展开更多
关键词 certificateless signcryption iden-tity-based cryptography proxy signcryption elliptic curve discrete logarithm problem
下载PDF
Analysis on the Fast Excitation System of Composite Magnetic Controllable Reactor
15
作者 Cuizhi WANG 《International English Education Research》 2014年第10期40-42,共3页
The fast excitation system of a composite magnetic controllable reactor is introduced. In this excitation system, a bidirectional function (i.e. fast forward excitation and backward forcible demagnetization) is avai... The fast excitation system of a composite magnetic controllable reactor is introduced. In this excitation system, a bidirectional function (i.e. fast forward excitation and backward forcible demagnetization) is available, which can significantly improve the response speed, performances, and application scope of magnetic controllable reactor. 展开更多
关键词 COMPOSITE FAST EXCITATION Magnetic Control REACTOR
下载PDF
下咽癌及近端食管癌外科治疗价值的探讨 被引量:5
16
作者 傅剑华 黄植藩 +2 位作者 戎铁华 张诠 郭朱明 《中华胃肠外科杂志》 CAS 2004年第3期202-204,共3页
目的探讨下咽癌及近端食管癌外科治疗的价值。方法回顾性分析1987年以来14例下咽癌及近端食管癌的外科治疗结果,其中下咽癌6例,近端食管癌8例。结果全组均行下咽、全喉、全食管切除,咽胃吻合术,其中3例并行双侧功能性颈清扫术。患者出... 目的探讨下咽癌及近端食管癌外科治疗的价值。方法回顾性分析1987年以来14例下咽癌及近端食管癌的外科治疗结果,其中下咽癌6例,近端食管癌8例。结果全组均行下咽、全喉、全食管切除,咽胃吻合术,其中3例并行双侧功能性颈清扫术。患者出院后全部随访。术后1例双肺感染,1例医院内死亡,1例吻合口狭窄;患者均能经口进食,日常生活自理;2例应用电子喉可进行交流。13例已死亡,中位生存期20个月。结论下咽、全喉、全食管切除,胃咽吻合术治疗下咽癌及近端食管癌方法可行,但预后差,生活质量欠满意,应探索更加有效的治疗方法。 展开更多
关键词 下咽癌 近端食管癌 外科治疗 咽胃吻合术 功能性颈清扫术 全食管切除术
原文传递
Extraction mechanism of rare earths from chloride acidic solution with ammonium-bifunctionalized ionic liquid extractants 被引量:2
17
作者 Hualing Yang Ji Chen +3 位作者 Wei Wang Hongmin Cui Wengang Liu Yu Liu 《Science China Chemistry》 SCIE EI CAS CSCD 2016年第5期532-537,共6页
A series of ammonium-bifunctionalized ionic liquid extractants (ammonium-Bif-ILEs) combined with a number of anions, in- cluding carboxylic acids and 1,3-diketonates, have been prepared and studied in this report. T... A series of ammonium-bifunctionalized ionic liquid extractants (ammonium-Bif-ILEs) combined with a number of anions, in- cluding carboxylic acids and 1,3-diketonates, have been prepared and studied in this report. Their extraction behavior and properties toward rare earth ions (REs(III)) are systematically investigated in chloride media as a function of important param- eters such as aqueous phase pH, salting-out agent concentrations, and extraction temperature. The separation performance of ammonium-Bif-ILEs toward REs(III) are systematically discussed. The results demonstrate that ammonium-Bif-ILEs have a synergistic effect between the cation and anions in separation of REs(III). The influences of different anions on separation fac- tor (β) values are further studied. By comparison, ammonium-Bif-ILEs containing 1,3-diketonates have more potential appli- cations in La(III)/RE(III) separation than those containing carboxylic acids. 展开更多
关键词 ammonium-bifunctional ionic liquids separation rare earths
原文传递
Design,synthesis and evaluation of spermine-based pH-sensitive amphiphilic gene delivery systems: Multifunctional non-viral gene carriers 被引量:5
18
作者 XU RongZuo LU Zheng-Rong 《Science China Chemistry》 SCIE EI CAS 2011年第2期359-368,共10页
Design and development of efficient non-viral gene delivery systems is critical to overcome various barriers for effective intracellular gene delivery.Eight new spermine-based protonatable surfactants were designed,sy... Design and development of efficient non-viral gene delivery systems is critical to overcome various barriers for effective intracellular gene delivery.Eight new spermine-based protonatable surfactants were designed,synthesized and evaluated as non-viral pH-sensitive gene carriers.These carriers formed stable complexes with plasmid DNA at an N/P ratio as low as 2.The sizes of the carrier/pDNA nanoparticles (N/P = 12) were in the range of 90–130 nm,smaller than that of Lipofectamine2000/pDNA nanoparticles.The pDNA nanoparticles of the carriers exhibited substantially increased hemolysis when pH decreased from 7.4 to 5.5.The DNA nanoparticles had low cytotocixity,similar to that of Lipofectamine-2000/pDNA nanoparticles.The pH-sensitive gene carriers with no helper lipids resulted in much higher intracellular transfection and gene expression in U87 cells than Lipofectamine-2000.[N,N′-Bis(oleoylcysteinyl)(β-alanyl-α-lysyl)]-spermine monoamide (SKACO) resulted in the highest luciferase transfection efficiency,more than 400 times higher than that of Lipofectamine-2000,and GFP expression in 71% of transfected U87 cells.SKACO was identified as a promising lead carrier for efficient gene delivery.These spermine-based pH-sensitive amphiphilic carriers have a potential to be further developed as efficient non-viral multifunctional gene delivery systems. 展开更多
关键词 gene delivery plasmid DNA pH sensitive MULTIFUNCTIONAL
原文传递
Preparation of stable micropatterns of gold on cell-adhesion-resistant hydrogels assisted by a hetero-bifunctional macromonomer linker 被引量:3
19
作者 SUN JianGuo GRAETER Stefan V +7 位作者 TANG Jian HUANG JingHuan LIU Peng LAI YuXiao YU Lin MAJER Günter SPATZ Joachim P DING JianDong 《Science China Chemistry》 SCIE EI CAS 2014年第4期645-653,共9页
Surface patterning is very useful in biomaterial studies, yet it is not easy to prepare a micropattern with cell-adhesion contrast that is stable in a wet environment. Recently, a platform technique of transfer photol... Surface patterning is very useful in biomaterial studies, yet it is not easy to prepare a micropattern with cell-adhesion contrast that is stable in a wet environment. Recently, a platform technique of transfer photolithography was invented to fabricate stable metal microarrays on the surface of a cell-adhesion resistant and mechanically biomimetic poly(ethylene glycol) hydrogel; the linker is the key chemical in such a transfer strategy. This article reports the design and synthesis of a hetero-bifunctional macromonomer linker with a thiol group at one end and an acryloyl group at the other end. The bifunctional linker was char- acterized by GPC and ~H NMR, and the average number of thiol groups in the bifunctional linker was detected by Ellman's reagent. The regent stability under wet conditions was also confirmed by the model reactants. The resultant micropatterned surfaces are meaningful for future studies of cell behaviors on mechanically biomimetic matrixes. 展开更多
关键词 biomaterials HYDROGELS MICROPATTERN MACROMONOMER cell adhesion
原文传递
Pt embedded Ni3Se2@NiOOH core-shell dendrite-like nanoarrays on nickel foam as bifunctional electrocatalysts for overall water splitting 被引量:11
20
作者 Xuerong Zheng Yanhui Cao +6 位作者 Xiaopeng Han Hui Liu Jihui Wang Zhijia Zhang Xianwen Wu Cheng Zhong Wenbin Hu 《Science China Materials》 SCIE EI CSCD 2019年第8期1096-1104,共9页
Developing high-performance bifunctional catalysts toward hydrogen evolution reaction(HER) and oxygen evolution reaction(OER) is essential to enhance water splitting efficiency for large-scale hydrogen production. Nei... Developing high-performance bifunctional catalysts toward hydrogen evolution reaction(HER) and oxygen evolution reaction(OER) is essential to enhance water splitting efficiency for large-scale hydrogen production. Neither noble metal Pt nor transition metal compounds show satisfactory performances for both HER and OER simultaneously. Here, we prepared a three-dimensional Pt-Ni3 Se2@NiOOH/NF(PNOF) hybrid catalyst via in-situ growth strategy. Benefitting from the self-supported structure and oxygen vacancies on the surface of NiOOH nanosheets, the PNOF electrode shows remarkably catalytic performance for dual HER and OER. The overall water electrolyzer using PNOF as anode and cathode can achieve a current density of10 mA cm^-2 at a low voltage of 1.52 V with excellent long-term stability, which is superior to precious metal catalysts of Pt/C and Ir/C. This study provides a promising strategy for preparing bifunctional catalysts with high performance. 展开更多
关键词 Pt-Ni3Se2@NiOOH/NF bifunctional catalyst oxygen vacancy overall water splitting
原文传递
上一页 1 2 下一页 到第
使用帮助 返回顶部