肿瘤受体显像剂^(99)Tc^m-octreotide的放化纯度分析

采用高压液相色谱分析(HPLC)和双层析结合银染色两种方法,对新型肿瘤受体显像剂^(99)Tc^m-oc-treotide的放化纯度进行分析。结果表明,双层析法结合银染色可以准确、有效地分离^(99)Tc^m-octreotide及其它放射性组分,可以较精确地计算出显像剂的放化纯度。为Octreotide及其它多肽类显像剂的放化纯度测定提供了一种简捷、准确的新手段。

心肌显像剂^(99)Tc^mN(NOEt)_2放化纯度的分析

采用单层析与双层析法分别对新型心肌显像剂 99Tcm N(NOEt) 2 的放化纯度进行了分析。结果表明 ,双层析法对 99Tcm N(NOEt) 2 及杂质的分离较为迅速、准确 ,可作为 99Tcm N(NOEt) 2 放化纯度分析的较佳方法。

原油非烃化合物结构与含量的馏分分离及联用色谱信息获取通用方法

用正己烷将沥青质从油样中分离 ,再根据类组分之间极性差别 ,用中性氧化铝 硅胶双层析柱将原油样其余部分分成脂肪烃、芳香烃和 7个非烃馏分。各馏分回收完全。用色 质联用技术 ,将非烃馏分再分离并获取实验数据 ,为原油非烃结构和含量测定奠定有关的信息基础。不同油井样品研究和重复实验表明 ,方法对各种原油非烃化合物分离和信息测定有很好的重现性。

Seismic imaging of the middle and upper crust by double-difference tomography:the Haicheng earthquake (Ms 7.3) in Liaoning Province

The Haicheng earthquake （Ms 7.3） occurred in Liaoning Province （39°N-43°N, 120°E-126°E ）, China on February 4, 1975. The mortality rate was only 0.02% owing to the first timely and accurate prediction, although the area affected by the earthquake was 9200 km^2 and covered cities with a population density of 1000 p/km^2. In this study, the double- difference （DD） tomography method was used to obtain high-resolution three-dimensional （3D） P- and S-wave velocity （Vp and Vs） structures and Vp/Vs as well as the earthquake locations. Tomography results suggest that velocity structure at shallow depth coincides well with topography and sediment thickness. The earthquake locations form a northwest-striking zone associated with the Jinzhou（JZ） Fault and a northeast-striking zone associated with the Haichenghe-Dayanghe （HD） Fault, and suggest that the JZ Fault consists of three faults and the Ms 7.3 Haicheng earthquake originated at the intersection of the JZ and the Faults. Low- velocity zones （LVZs） with low Vp/Vs are observed at 15-20 km depth beneath the Haicheng （HC） region. We interpret the LVZs in the middle crust as regions of fluids, suggesting rock dehydration at high temperatures. The LVZs and low Vp/Vs in the upper crust are attributed to groundwater-filled cracks and pores. We believe that large crustal earthquakes in this area are caused by the combination of faulting and fluid movement in the middle crust.

liver and the defects of cholesterol and bile acids biosynthesis: rare disorders many diagnostic pitfalls

In recent decades, biotechnology produced a growth of knowledge on the causes and mechanisms of metabolic diseases that have formed the basis for their study, diagnosis and treatment. Unfortunately, it is well known that the clinical features of metabolic diseases can manifest themselves with very different characteristics and escape early detection. Also, it is well known that the prognosis of many metabolic diseases is excellent if diagnosed and treated early. In this editorial we briefly summarized two groups of inherited metabolic diseases, the defects of cholesterol biosynthesis and those of bile acids. Both groups show variable clinical manifestations but some clinical signs and symptoms are common in both the defects of cholesterol and bile acids. The differential diagnosis can be made analyzing sterol profiles in blood and/or bile acids in blood and urine by chromatographic techniques(GC-MS and LC-MS/MS). Several defects of both biosynthetic pathways are treatable so early diagnosis is crucial. Unfortunately their diagnosis is made too late, due either to the clinical heterogeneity of the syndromes(severe, mild and very mild) that to the scarcity of scientific dissemination of these rare diseases. Therefore, the delay in diagnosis leads the patient to the medical observation when the disease has produced irreversible damages to the body. Here, we highlighted simple clinical and laboratory descriptions that can potentially make you to suspect a defect in cholesterol biosynthesis and/or bile acids, as well, we suggest appropriate request of the laboratory tests that along with common clinical features can help to diagnose these defects.

Three-dimensional crustal velocity structure and activity characteristics of the Madoi Ms7.4 earthquake in 2021

In this paper,using natural earthquake P-wave arrival time data recorded by the seismic network in the surrounding area of Madoi,the three-dimensional fine P-wave crustal velocity structure at depths above 60 km in the epicenter of the Madoi Ms7.4 earthquake was inverted using the double-difference seismic tomography method.On the basis of the relocation of the source of the aftershock sequence,we summarized the strip-shaped distribution characteristics along the strike of the Jiangcuo fault,revealing the significant heterogeneity of the crustal velocity structure in the source area.Research has found that most of the Madoi Ms7.4 aftershocks were located in the weak area of the high-speed anomaly in the upper crust.The focal depth changed with the velocity structure,showing obvious fluctuation and segmentation characteristics.There was a good correspondence between the spatial distribution and the velocity structure.The high-velocity bodies of the upper crust in the hypocenter area provided a medium environment for earthquake rupture,the low-velocity bodies of the middle crust formed the deep material,and the migration channel and the undulating shape of the high-speed body in the lower crust corroborated the strong pushing action in the region.The results confirmed that under the continuous promotion of tectonic stress in the Madoi area,the high-speed body of the Jiangcuo fault blocked the migration of weak materials in the middle crust.When the stress accumulation exceeded the limit,the Madoi Ms7.4 earthquake occurred.Meanwhile,the nonuniform velocity structure near the fault plane determined the location of the main shock and the spatiotemporal distribution of the aftershock sequence.

Three-dimensional velocity structure and tectonic characteristics of earthquake area in Yibin

In this study,on the basis of absolute first-arrival times of 84756 P-and S-waves from 6085 earthquakes recorded at 56 fixed stations in Yibin and surrounding areas in China from January 2009 to January 2019,focal parameters and three-dimensional(3 D)body-wave high-resolution velocity structures at depths of 0–30 km were retrieved by double-difference tomography.Results show that there is a good correspondence between the spatial distribution of the relocated earthquakes and velocity structures,which were concentrated mainly in the high-velocity-anomaly region or edge of high-velocity region.Velocity structure of P-and S-waves in the Yibin area clearly shows lateral inhomogeneity.The distribution characteristics of the P-and S-waves near the surface are closely related to the geomorphology and geologic structure.The low-velocity anomaly appears at the depth of 15–25 km,which is affected by the lower crust current.The Junlian–Gongxian and Gongxian–Changning earthquake areas,which are the two most earthquake-prone areas in the Yibin region,clearly differ in earthquake distribution and tectonic characteristics.We analyzed the structural characteristics of the Junlian–Gongxian and Gongxian–Changning earthquake areas on the basis of the 3 D bodywave velocity structures in the Yibin region.We found that although most seismicity in the Yibin area is caused by fluid injection,the spatial position of seismicity is controlled by the velocity structures of the middle and upper crust and local geologic structure.Fine-scale 3 D velocity structures in the Yibin area provide important local reference information for further understanding the crustal medium,seismogenic structure,and seismicity.

Unveiling the active sites of ultrathin Co-Fe layered double hydroxides for the oxygen evolution reaction

Two-dimensional layered double hydroxides(LDHs)have been identified as promising electrocatalysts for the oxygen evolution reaction(OER);however,the simple and effective synthesis of high-quality LDHs remains extremely challenging and the active sites have not been clarified.Herein,we report a facile solution-reaction method for preparing an ultrathin(thickness<2 nm)nonprecious CoFe-based LDH.Co_(1)Fe_(0.2) LDH delivers a current density of 10 mA cm^(-2) and a high turnover frequency of 0.082 s^(-1) per total 3d metal atoms at a low overpotential of 256 mV.Its mass activity is 277.9 A g^(-1) at an overpotential of 300 mV for the OER.Kinetic studies reveal the Co site as the main active center for the OER.The doped Fe lowers the reaction barrier by accelerating the charge-transfer process.Theoretical calculations reveal that the surface Co sites adjacent to Fe atoms are the active centers for the OER and the subsurface Fe dopants excessively weaken the OH^(*)adsorption,thus increasing the energy barrier of the rate-determining step.This study can guide the rational design of high-performance CoFe-based LDHs for water splitting.

Tuning the oxygen evolution electrocatalysis on NiFe-layered double hydroxides via sulfur doping

We report a facile way to prepare sulfur(S) doped Ni4/5 Fe1/5-layered double hydroxide(LDH) electrocatalysts for oxygen evolution reaction(OER). The influence of S doping amount on the OER activity of the resulted Ni Fe-LDHs was studied and the optimal surface S content was ca. 0.43 at%. The developed S-doped Ni Fe-LDH exhibits excellent OER catalyst activity in 1.0 M KOH with overpotential of only 257 m V at the current density of 10 m A cm^-2. Moreover, the catalyst could maintain high activity after 30 h stability test. The high activity of the S-doped Ni Fe-LDH catalysts may originate from the synergistic effect between S and the Fe sites. This work provides a simple but efficient way to improve the OER performance of transition metal oxides/(oxy)hydroxides.

Variation analysis of ultimate pullout capacity of shallow horizontal strip anchor plate with 2-layer overlying soil based on nonlinear M-C failure criterion

Based on the nonlinear Mohr-Coulomb failure criterion and an associated flow rule,a kinematic admissible velocity field of failure mechanism of the 2-layer soil above a shallow horizontal strip anchor plate is constructed.The ultimate pull-out force and its corresponding failure mechanism through the upper bound limit analysis according to a variation principle are deduced.When the 2-layer overlying soil is degraded into single-layer soil,the model of ultimate pullout force could also be degraded into the model of single-layer soil.And the comparison between results of single-layer soil variation method and those calculated by rigid limit analysis method proves the correctness of our method.Based on that,the influence of changes of geotechnical parameters on ultimate pullout forces and failure mechanism of a shallow horizontal strip anchor with the 2-layer soil above are analyzed.The results show that the ultimate pull-out force and failure mechanism of a shallow horizontal strip anchor with the 2-layer soil above are affected by the nonlinear geotechnical parameters greatly.Thus,it is very important to obtain the accurate geotechnical parameters of 2-layer soil for the evaluation of the ultimate pullout capacity of the anchor plate.

Electronic structure regulation on layered double hydroxides for oxygen evolution reaction

Oxygen evolution reactions(OERs)as core components of energy conversion and storage technology systems,such as water splitting and rechargeable metal–air batteries,have attracted considerable attention in recent years.Transition metal compounds,particularly layered double hydroxides(LDHs),are considered as the most promising electrocatalysts owing to their unique two-dimensional layer structures and tunable components.However,heir poor intrinsic electrical conductivities and the limited number of active sites hinder their performances.The regulation of the electronic structure is an effective approach to improve the OER activity of LDHs,including cationic and anionic regulation,defect engineering,regulation of intercalated anions,and surface modifications.In this review,we summarize recent advances in the regulation of the electronic structures of LDHs used as electrocatalysts in OERs.In addition,we discuss the effects of each regulation type on OER activities.This review is expected to shed light on the development and design of effective OER electrocatalysts by summarizing various electronic structure regulation pathways and the effects on their catalytic performances.

The AHP analysis on Quality Evaluation oriented to Bilingual Teaching Practices in Yunnan＇ s Universities

A number of studies show that bilingual education in private universities is worth studying in recent years, but its feasibility causes many debates at the same time which students are not as superior in both English proficiency and expertise as what we have expect- ed.However, it is undeniable that teaching process of teachers becomes significant influence on students＇ learning results. In my research I focus on the comprehensive view and procedures of teaching and set up the index system for evaluation of bilingual teaching process from teachers＇ perspective. In addition, I calculate the weighted value of each index at each level by using the root method, and determine the key success factors which affecting the quality of bilingual teaching process. Lastly, taking Oxbridge college as an example, I try to study what types of factors that constitutes conditions and limitations for a successful effect for bilingual teaching and to propose the solutions for improving and self-supervising in bilingual teaching process.

Aerodynamic drag analysis of double-deck container vehicles with different structures

To study the aerodynamic performance of a new six-axis X2K double-deck container vehicle, numerical simulation was done based on three-dimensional, steady Navier-Stokes equations and k-e turbulence model. The results show that the pressure on the front surface of vehicle is positive, and others are negative. The maximum negative one appears as a ＂gate＂ shape on front surfaces. The pressure on vehicle increases with train speed, and pressure on vehicles with cross-loaded structure is smaller than that without it. The airflow around vehicles is symmetrical about train vertical axis, and the flow velocity decreases gradually along the axis to ground. Airflow around vehicles with cross-loaded structure is weaker than that without the structure. The aerodynamic drag increases linearly with the train speed, and it is minimum for the mid-vehicle. The linear coefficient for mid-vehicle without cross-loaded structure is 29.75, nearly one time larger than that with the structure valued as 15.425. So, from the view-point of aerodynamic drag, the cross-loaded structure is more reasonable for the six-axis X2K double-deck container vehicle.

RESIDUAL A POSTERIORI ERROR ESTIMATE OF A NEW TWO-LEVEL METHOD FOR STEADY NAVIER-STOKES EQUATIONS

Residual-based a posteriori error estimate for conforming finite element solutions of incompressible Navier-Stokes equations, which is computed with a new two-level method that is different from Volker John, is derived. A posteriori error estimate contains additional terms in comparison to the estimate for the solution obtained by the standard finite element method. The importance of the additional terms in the error estimates is investigated by studying their asymptotic behavior. For optimal scaled meshes, these bounds are not of higher order than the convergence of discrete solution. The two-level method aims to solve the nonlinear problem on a coarse grid with less computational work, then to solve the linear problem on a fine grid, which is superior to the usual finite element method solving a similar nonlinear problem on the fine grid.

Evaluation of the hepatoprotective and antioxidant activities of Rubus parvifolius L.

The hepatoprotective and antioxidant activities of the n-butanol extract of Rubus parvifolius L. （RPL）, a widely used medicinal plant, were evaluated. Results demonstrated that RPL extract possessed pronounced hepatoprotective effects against carbon tetrachloride （CCI4）-induced hepatic injury in mice, which was at least partially attributed to its strong antioxidant capacity. Treatment with RPL extract markedly attenuated the increases in serum alanine ami- notransferase （ALT） and aspartate aminotransferase （AST） levels caused by CCI4 intoxication. It also significantly prevented the decrease in superoxide dismutase （SOD） activity and the increase in malondialdehyde （MDA） content of liver tissue. Meanwhile, histopathological changes of hepatic damage were also remarkably ameliorated. Phytochemical analysis based on high-performance liquid chromatography/tandem mass spectrometry （HPLC-MS/MS） revealed the presence of various phenolic compounds, including caffeic acid conjugates, ellagic acid glycosides, and flavonol glycosides, which might be responsible for the hepatoprotective and antioxidant activities of RPL.

Analysis of 19-nortestosterone residue in animal tissues by ion-trap gas chromatography-tandem mass spectrometry

A rapid sample treatment procedure for the gas chromatography-tandem mass spectrometry （GC-MS） determination of 19-nortestosterone （19-NT） in animal tissues has been developed. In our optimized procedures, enzymatic hydrolysis with β-glucuronidase from Escherichia coliwas performed in an acetate buffer （pH 5.2, 0.2 mol/L） Next, the homogenate was mixed with methanol and heated at 60℃ for 15 min, then placed in an ice-bath at -18℃ for 2 h. After liquid-liquid extraction with n-hexane, the analytes were subjected to a normal-phase solid phase ex- traction （SPE） C18 cartridge for clean-up. The dded organic extracts were derivatized with heptafluorobutydc anhydride （HFBA）, and then the products were injected into GC-MS. Using electron impact mass spectrometry （El-MS） with positive chemical ionization （PCI）, four diagnostic ions （mlz 666, 453, 318, and 306） were determined. A standard calibration curve over the concentration range of 1-20 ng/g was reached, with Y=467084X-68354 （R^2=0.9997） for 19-NT, and the detection limit was 0.3 ng. When applied to spiked samples collected from bovine and ovine, the recoveries ranged from 63% to 101% with relative standard deviation （RSD） between 2.7% and 8.9%. The procedure is a highly efficient, sensitive, and more economical method which offers considerable potential to resolve cases of suspected nandrolone doping in husbandry animals.

Penetration of disk fragments following impact on thin plate

To investigate the ballistic resistance and failure pattern of aeroengine casing following the impact of disk fragments, and to determine the optimum case structure, the phenomena of a 1/3rd disk fragment impact on single and double-layered thin plate targets were simulated using nonlinear dynamical analysis software MSC.Dytran. Strain rate effect was introduced in a Johnson-Cook (JC) material model for the disk fragment and the plate. Impact modeling was based on the Arbitrary Lagrange-Eulerian method, and simulated using explicit finite element method (FEM). Simulation results showed that the major failure pattern of the plate is shearing and tensile fracture with large plastic deformation. It was also concluded that the ballistic limit velocity increases with the standoff distance when it is beyond a certain value, and that greater resistance is obtained when the front plate has either a proportionately low or high thickness. The impact resistance of a double-layered plate may exceed that of a single plate if the thicknesses and standoff distance of the two plates are set appropriately.

Highly efficient overall urea electrolysis via single-atomically active centers on layered double hydroxide

Anodic urea oxidation reaction(UOR)is an intriguing half reaction that can replace oxygen evolution reaction(OER)and work together with hydrogen evolution reaction(HER)toward simultaneous hydrogen fuel generation and urea-rich wastewater purification;however,it remains a challenge to achieve overall urea electrolysis with high efficiency.Herein,we report a multifunctional electrocatalyst termed as Rh/Ni V-LDH,through integration of nickel-vanadium layered double hydroxide(LDH)with rhodium single-atom catalyst(SAC),to achieve this goal.The electrocatalyst delivers high HER mass activity of0.262 A mg^(-1) and exceptionally high turnover frequency(TOF)of 2.125 s^(-1) at an overpotential of100 m V.Moreover,exceptional activity toward urea oxidation is addressed,which requires a potential of 1.33 V to yield 10 mA cm^(-2),endorsing the potential to surmount the sluggish OER.The splendid catalytic activity is enabled by the synergy of the Ni V-LDH support and the atomically dispersed Rh sites(located on the Ni-V hollow sites)as evidenced both experimentally and theoretically.The selfsupported Rh/Ni V-LDH catalyst serving as the anode and cathode for overall urea electrolysis(1 mol L^(-1) KOH with 0.33 mol L^(-1) urea as electrolyte)only requires a small voltage of 1.47 V to deliver 100 mA cm^(-2) with excellent stability.This work provides important insights into multifunctional SAC design from the perspective of support sites toward overall electrolysis applications.