提出一种有效的快速细化算法,包括两个步骤:首先通过建立w e igh t-va lue的概念对模板进行分类,然后按照分类后的模板对象素进行删除,使之成为由双层点或单层点构成的子图像;为保证能将双层点细化为单层点,提出两个模板,依据这两个模...提出一种有效的快速细化算法,包括两个步骤:首先通过建立w e igh t-va lue的概念对模板进行分类,然后按照分类后的模板对象素进行删除,使之成为由双层点或单层点构成的子图像;为保证能将双层点细化为单层点,提出两个模板,依据这两个模板进行并行细化从而得到单象素骨架.实验证明这个方法是快速有效的.展开更多
Overlay multicast has become one of the most promising multicast solutions for IP network,and Neutral Network(NN) has been a good candidate for searching optimal solutions to the constrained shortest routing path in v...Overlay multicast has become one of the most promising multicast solutions for IP network,and Neutral Network(NN) has been a good candidate for searching optimal solutions to the constrained shortest routing path in virtue of its powerful capacity for parallel computation. Though traditional Hopfield NN can tackle the optimization problem,it is incapable of dealing with large scale networks due to the large number of neurons. In this paper,a neural network for overlay multicast tree com-putation is presented to reliably implement routing algorithm in real time. The neural network is constructed as a two-layer recurrent architecture,which is comprised of Independent Variable Neurons(IDVN) and Dependent Variable Neurons(DVN) ,according to the independence of the decision variables associated with the edges in directed graph. Compared with the heuristic routing algorithms,it is characterized as shorter computational time,fewer neurons,and better precision.展开更多
The objectives of this present investigation were to develop and formulate nimesulide bilayer tablets by using different polymer combinations and fillers, to optimize the formulations for different drug release variab...The objectives of this present investigation were to develop and formulate nimesulide bilayer tablets by using different polymer combinations and fillers, to optimize the formulations for different drug release variables by orthogonal design and central composite design-surface methodology and to evaluate drug release pattern of the optimized product. The bilayer tablet containing a fast release layer（FRL） and a sustained release layer（SRL） provided an initial burst release of nimesulide, followed by the sustained release for a period of time. The optimal formulation obtained was as follows：（I） the formulation of FRL： nimesulide, 50 mg; lactose, 92 mg; starch, 22 mg; CCMC-Na, 14 mg; PVP K30, 1 mg; micronized silica gel, 1 mg; magnesium stearate, 0.9 mg; and iron oxide red, 0.1 mg; and（II） the formulation of SRL： nimesulide, 150 mg; HPMC K100LV, 26 mg; HPMC K4M, 33 mg; lactose, 54 mg; PVP K30, 1 mg; micronized silica gel, 1 mg; and magnesium stearate, 0.9 mg. According to the optimal formulation, the biphasic type of release was identified. The in vitro drug dissolution from the bilayer tablets was sustained for about 16 h after releasing 15% of drug in the first 10 min. The developed nimesulide bilayer tablets with improved efficacy can perform therapeutically better than the conventional tablets.展开更多
This paper describes a bi-level programming model that seeks to simultaneously optimize location and design decisions of facilities in a distribution system in order to realize company's maximal total profit subje...This paper describes a bi-level programming model that seeks to simultaneously optimize location and design decisions of facilities in a distribution system in order to realize company's maximal total profit subject to the constraints on the facility capacity and the investment budget.In the upper-level problem,twoechelon integrated competitive/uncompetitive capacitated facility location model,which involves facility location and design,is presented.In the lower-level problem,customer is assumed to patronize store based on facility utility which is expressed by service time cost in the store and its travel cost to customer.Customer's facility choice behavior is presented by a stochastic user equilibrium assignment model with elastic demand.Since such a distribution system design problem belongs to a class of NP-hard problem,a genetic algorithm(GA)-based heuristic procedure is presented.Finally,a numerical example is used to illustrate the application of the proposed model and some parameter sensitivity analyses are presented.展开更多
文摘提出一种有效的快速细化算法,包括两个步骤:首先通过建立w e igh t-va lue的概念对模板进行分类,然后按照分类后的模板对象素进行删除,使之成为由双层点或单层点构成的子图像;为保证能将双层点细化为单层点,提出两个模板,依据这两个模板进行并行细化从而得到单象素骨架.实验证明这个方法是快速有效的.
基金the High-tech Project of Jiangsu Province (No.BG2003001).
文摘Overlay multicast has become one of the most promising multicast solutions for IP network,and Neutral Network(NN) has been a good candidate for searching optimal solutions to the constrained shortest routing path in virtue of its powerful capacity for parallel computation. Though traditional Hopfield NN can tackle the optimization problem,it is incapable of dealing with large scale networks due to the large number of neurons. In this paper,a neural network for overlay multicast tree com-putation is presented to reliably implement routing algorithm in real time. The neural network is constructed as a two-layer recurrent architecture,which is comprised of Independent Variable Neurons(IDVN) and Dependent Variable Neurons(DVN) ,according to the independence of the decision variables associated with the edges in directed graph. Compared with the heuristic routing algorithms,it is characterized as shorter computational time,fewer neurons,and better precision.
基金Important National Science & Technology Specific Projects of China(Grant No.2012ZX09301003-001-009)
文摘The objectives of this present investigation were to develop and formulate nimesulide bilayer tablets by using different polymer combinations and fillers, to optimize the formulations for different drug release variables by orthogonal design and central composite design-surface methodology and to evaluate drug release pattern of the optimized product. The bilayer tablet containing a fast release layer（FRL） and a sustained release layer（SRL） provided an initial burst release of nimesulide, followed by the sustained release for a period of time. The optimal formulation obtained was as follows：（I） the formulation of FRL： nimesulide, 50 mg; lactose, 92 mg; starch, 22 mg; CCMC-Na, 14 mg; PVP K30, 1 mg; micronized silica gel, 1 mg; magnesium stearate, 0.9 mg; and iron oxide red, 0.1 mg; and（II） the formulation of SRL： nimesulide, 150 mg; HPMC K100LV, 26 mg; HPMC K4M, 33 mg; lactose, 54 mg; PVP K30, 1 mg; micronized silica gel, 1 mg; and magnesium stearate, 0.9 mg. According to the optimal formulation, the biphasic type of release was identified. The in vitro drug dissolution from the bilayer tablets was sustained for about 16 h after releasing 15% of drug in the first 10 min. The developed nimesulide bilayer tablets with improved efficacy can perform therapeutically better than the conventional tablets.
基金the 2009 Science Foundation for Youths of the Department of Education of Jiangxi Province (No.GJJ09558)the 2009 Humanities and Social Science found of College of Jiangxi Province (No.GL0911)
文摘This paper describes a bi-level programming model that seeks to simultaneously optimize location and design decisions of facilities in a distribution system in order to realize company's maximal total profit subject to the constraints on the facility capacity and the investment budget.In the upper-level problem,twoechelon integrated competitive/uncompetitive capacitated facility location model,which involves facility location and design,is presented.In the lower-level problem,customer is assumed to patronize store based on facility utility which is expressed by service time cost in the store and its travel cost to customer.Customer's facility choice behavior is presented by a stochastic user equilibrium assignment model with elastic demand.Since such a distribution system design problem belongs to a class of NP-hard problem,a genetic algorithm(GA)-based heuristic procedure is presented.Finally,a numerical example is used to illustrate the application of the proposed model and some parameter sensitivity analyses are presented.
