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1,4萘醌和1,2萘醌化合物对肌质网钙通道Ryanodine受体的调节作用 被引量:1
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作者 夏若虹 《航天医学与医学工程》 CAS CSCD 1999年第1期42-45,共4页
目的研究萘醌钙通道蛋白(NQRyR)的作用机制。方法对NQ旋的1,4NQ、1,4NQ2sulfonate(1,4NQ2S)、1,2NQ、1,2NQ4sulfonate(1,2NQ4S)、2CH31,... 目的研究萘醌钙通道蛋白(NQRyR)的作用机制。方法对NQ旋的1,4NQ、1,4NQ2sulfonate(1,4NQ2S)、1,2NQ、1,2NQ4sulfonate(1,2NQ4S)、2CH31,4NQ和2OH1,4NQ等6种NQ与骨骼肌肌质网(SR)RyR的相互作用进行了观察和比较。结果所有NQ都不同程度地激活钙通道引起钙流释放;1,4NQ、1,2NQ、1,2NQ、1,4NQ2S和1,2NQ4S对RyR的调节表现出强烈的浓度依赖性的双相作用性;NQ通过氧化还原作用调控RyR的门控机制;NQ在氧化还原循环中产生的超氧等伴生物没有参与RyR的相互作用。结论NQ对RyR的调控是通过氧化还原作用调节通道蛋白的门控状态。 展开更多
关键词 萘醌 钙通道 双相性行为 骨骼肌肌质网
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Thermal-mechanical and springback behavior of dual-phase steel at warm temperatures
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作者 LIN Qi-quan WANG Zhen-zhu +2 位作者 DONG Wen-zheng BU Gen HUANG Jin-shan 《Journal of Central South University》 SCIE EI CAS CSCD 2022年第6期1895-1905,共11页
For non-quenchable dual-phase(DP)steel sheet,the warm forming process can effectively reduce the amount of springback,and the mechanical parameters that influence its elastic and inelastic recovery to decrease exhibit... For non-quenchable dual-phase(DP)steel sheet,the warm forming process can effectively reduce the amount of springback,and the mechanical parameters that influence its elastic and inelastic recovery to decrease exhibit a strong temperature dependence,especially under cyclic loading conditions.In this paper,the monotonic and cyclic loading tests of DP980 steel sheets are conducted at the temperatures ranging from 25℃ to 500℃.The temperature-dependent flow stress,nonlinear elastic recovery,and Bauschinger effect are investigated.The results demonstrate that both the elastic modulus and Bauschinger effect show an exponential law with pre-strain,and decrease with the increase of forming temperature,while there will be an abnormal phenomenon of rebound due to the influence of dynamic strain aging effect.Meanwhile,a linear relationship between the Bauschinger effect and inelastic strain is observed at various temperatures,and the weight of the Bauschinger effect in the total strain reduces with temperature increasing,which indicates that the springback is dominated by linear elastic recovery.Furthermore,the U-draw bending tests are carried out to clarify the influence of Vickers hardness distribution and martensite size effect on the springback behavior. 展开更多
关键词 warm forming dual-phase steel springback behavior nonlinear elastic recovery Bauschinger effect
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