Purpose: One assumption of the uniocular drug trial in glaucoma management is that fellow-eye pairs exhibit symmetric intraocular pr essure (IOP) responseswhen both eyes are treated with the same topical IOP-lowe ring...Purpose: One assumption of the uniocular drug trial in glaucoma management is that fellow-eye pairs exhibit symmetric intraocular pr essure (IOP) responseswhen both eyes are treated with the same topical IOP-lowe ring medication. The purpose of this study was to determine if this assumption i s true. Design: Observational case series. Participants and Controls: Fortythree patients with bilateral glaucoma or ocular hypertension who underwent bilateral treatment with a topical IOP-lowering medication. Methods: Patients were on 0 (81%) or 1 (19%)-IOP-lowering medication at the time the medication was adde d in this study. Baseline IOP was the IOP at the treatment initiation visit, and IOP on treatment was assessed in both eyes on the first visit after addition of the medication. Linear regression of right-eye versus left-eye IOP reductions was performed. Main Outcome Measure: Correlation of right-eye and left-eye IOP responses to therapy. Results: Right eyes demonstrated a 5.0-mmHg (26.9%) red uction, and left eyes demonstrated a 4.3-mmHg (23.7%) reduction. Linear regres sion of right-eye IOP reduction against left-eye IOP reduction gave a slope of 0.77 (Pearson correlation coefficient, r=0.84; r2=0.70; P < 0.0001). Conclusion s: Fellow-eye pairs exhibited marked symmetry in IOP responses to IOP-lowering medications.展开更多
患者,女性,60岁。自述双眼视物模糊5年,近期加重,5年前曾于外地诊治时发现左眼＂视神经病变＂,未能明确诊断。专科检查：双眼裸眼视力：右眼0.5,左眼0.3,验光矫正：OD：＋0.75 DS矫正至1.0,OS：＋0.5 DS矫正至1.0。双眼眼压：OD：14 mm...患者,女性,60岁。自述双眼视物模糊5年,近期加重,5年前曾于外地诊治时发现左眼＂视神经病变＂,未能明确诊断。专科检查：双眼裸眼视力：右眼0.5,左眼0.3,验光矫正：OD：＋0.75 DS矫正至1.0,OS：＋0.5 DS矫正至1.0。双眼眼压：OD：14 mm Hg（1 mm Hg=0.133 k Pa,OS：15 mmHg。眼前节检查：双眼结膜充血（＋）,角膜透明,房水清,展开更多
Purpose: To investigate the effects of sildenafil, a popular new drug in the t reatment of erectile dysfunction, on ocular blood flow. Methods: This study was designed as a prosp ective, double-blind, placebo-controll...Purpose: To investigate the effects of sildenafil, a popular new drug in the t reatment of erectile dysfunction, on ocular blood flow. Methods: This study was designed as a prosp ective, double-blind, placebo-controlled study. Twenty participants with ere ctile dysfunction were given a single oral dose of 100 mg sildenafil, while 10 p articipants with erectile dysfunction were given placebo. All the participants u nderwent routine systemic and ophthalmological examinations. Intraocular pressur e, systolic and diastolic blood pressure and ocular blood flow (ophthalmic, cent ral retinal, short posterior ciliary arteries) were measured in both eyes before and 1 hour after the dose of sildenafil or placebo. Ocular blood flow measureme nts were performed using colour Doppler ultrasonography. Results: None of the pa rameters were significantly different between the groups before study drug intak e. Although central retinal artery velocitieswere not changed,ophthalmic artery and short posterior ciliary artery peak systolic velocity,end-diastolic velocit y, and mean velocity values were significantly increased 1 hour after drug intak e in the sildenafil group compared to the placebo group (p < 0.05). Conclusion: Sildenafil causes a significant increase in blood flow in these arteries. A poss ible role of inhibition of phosphodiesterase-5 in vascular smooth muscles by si ldenafil is implicated. Further studies are needed to investigate the effects of sildenafil on ocular blood flow in patients with senile macular degeneration, d iabetic retinopathy and glaucoma.展开更多
文摘Purpose: One assumption of the uniocular drug trial in glaucoma management is that fellow-eye pairs exhibit symmetric intraocular pr essure (IOP) responseswhen both eyes are treated with the same topical IOP-lowe ring medication. The purpose of this study was to determine if this assumption i s true. Design: Observational case series. Participants and Controls: Fortythree patients with bilateral glaucoma or ocular hypertension who underwent bilateral treatment with a topical IOP-lowering medication. Methods: Patients were on 0 (81%) or 1 (19%)-IOP-lowering medication at the time the medication was adde d in this study. Baseline IOP was the IOP at the treatment initiation visit, and IOP on treatment was assessed in both eyes on the first visit after addition of the medication. Linear regression of right-eye versus left-eye IOP reductions was performed. Main Outcome Measure: Correlation of right-eye and left-eye IOP responses to therapy. Results: Right eyes demonstrated a 5.0-mmHg (26.9%) red uction, and left eyes demonstrated a 4.3-mmHg (23.7%) reduction. Linear regres sion of right-eye IOP reduction against left-eye IOP reduction gave a slope of 0.77 (Pearson correlation coefficient, r=0.84; r2=0.70; P < 0.0001). Conclusion s: Fellow-eye pairs exhibited marked symmetry in IOP responses to IOP-lowering medications.
文摘患者,女性,60岁。自述双眼视物模糊5年,近期加重,5年前曾于外地诊治时发现左眼＂视神经病变＂,未能明确诊断。专科检查：双眼裸眼视力：右眼0.5,左眼0.3,验光矫正：OD：＋0.75 DS矫正至1.0,OS：＋0.5 DS矫正至1.0。双眼眼压：OD：14 mm Hg（1 mm Hg=0.133 k Pa,OS：15 mmHg。眼前节检查：双眼结膜充血（＋）,角膜透明,房水清,
文摘Purpose: To investigate the effects of sildenafil, a popular new drug in the t reatment of erectile dysfunction, on ocular blood flow. Methods: This study was designed as a prosp ective, double-blind, placebo-controlled study. Twenty participants with ere ctile dysfunction were given a single oral dose of 100 mg sildenafil, while 10 p articipants with erectile dysfunction were given placebo. All the participants u nderwent routine systemic and ophthalmological examinations. Intraocular pressur e, systolic and diastolic blood pressure and ocular blood flow (ophthalmic, cent ral retinal, short posterior ciliary arteries) were measured in both eyes before and 1 hour after the dose of sildenafil or placebo. Ocular blood flow measureme nts were performed using colour Doppler ultrasonography. Results: None of the pa rameters were significantly different between the groups before study drug intak e. Although central retinal artery velocitieswere not changed,ophthalmic artery and short posterior ciliary artery peak systolic velocity,end-diastolic velocit y, and mean velocity values were significantly increased 1 hour after drug intak e in the sildenafil group compared to the placebo group (p < 0.05). Conclusion: Sildenafil causes a significant increase in blood flow in these arteries. A poss ible role of inhibition of phosphodiesterase-5 in vascular smooth muscles by si ldenafil is implicated. Further studies are needed to investigate the effects of sildenafil on ocular blood flow in patients with senile macular degeneration, d iabetic retinopathy and glaucoma.
