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Study on Galloping Stability Mechanism of Conductor and Its Application to Anti-Galloping of Transmission Lines 被引量:1
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作者 YouChuanyong 《Electricity》 2005年第1期26-30,共5页
Galloping of conductor is a major hazard to safe operation of transmission lines. This paper introduces the basic galloping stability mechanism of conductor, design method of anti-galloping and the application of anti... Galloping of conductor is a major hazard to safe operation of transmission lines. This paper introduces the basic galloping stability mechanism of conductor, design method of anti-galloping and the application of anti-galloping double pendulum and integral eccentric pendulum in China. Galloping stability mechanism of conductor was established based on vertical galloping mechanism developed by Den Hartog and torsional galloping mechanism developed by O. Nigel. A design method of anti-galloping was derived and anti-galloping double pendulum and integral eccentric pendulum were developed. Applications to several transmission lines including a 500 kV transmission line of large span indicated that they have played important roles in anti-galloping. 展开更多
关键词 galloping of conductor stability mechanism transmission line anti-galloping double pendulum integral eccentric pendulum
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A New Approach to Calculate Parameters of Induction Generator with Double Windings
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作者 刘长红 姚若萍 《Journal of Shanghai Jiaotong university(Science)》 EI 2005年第2期186-189,共4页
The accuracy prediction for the performance of an induction generator depends much on the parameters of the equivalent circuit. This paper presented a new way for calculating these parameters of induction generator wi... The accuracy prediction for the performance of an induction generator depends much on the parameters of the equivalent circuit. This paper presented a new way for calculating these parameters of induction generator with double windings. The method is based on 2D time-dependent magnetic field coupled with electric circuit. An application example of a 12-phase self-excited induction generator (SEIG) was provided to demonstrate the effectiveness of the presented approach. Some of the calculated results show good coincidence with the experiment values. 展开更多
关键词 equivalent parameters self-excited induction generators double windings FEM
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Effects of polyaniline on electrochemical properties of composite inert anodes used in zinc electrowinning 被引量:4
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作者 詹鹏 徐瑞东 +2 位作者 黄利平 陈步明 周建峰 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2012年第7期1693-1700,共8页
In order to search for a suitable anode material used in zinc electrowinning in place of Pb-Ag alloy,Al/Pb-PANI(polyaniline)-WC(tungsten carbide) composite inert anodes were prepared on aluminum alloy substrate by... In order to search for a suitable anode material used in zinc electrowinning in place of Pb-Ag alloy,Al/Pb-PANI(polyaniline)-WC(tungsten carbide) composite inert anodes were prepared on aluminum alloy substrate by double pulse electrodeposition(DPE) of PANI and WC particles with Pb2+ from an original plating bath.Thereafter,anodic polarization curves,cyclic voltammetry curves and Tafel polarization curves for the composite inert anodes obtained under different PANI concentrations in the original plating bath were measured,and the microstructural features were also investigated by scanning electron microscopy(SEM).The results show that Al/Pb-PANI-WC composite inert anode obtained under PANI concentration of 20 g/L in the original plating bath possesses uniform microstructures and composition distributions,higher electrocatalytic activity,better reversibility of electrode reaction and corrosion resistance in a synthetic zinc electrowinning electrolyte of 50 g/L Zn2+,150 g/L H2SO4 at 35 °C.Compared with Pb-1%Ag alloy,the overpotential of oxygen evolutions for the composite inert anode are decreased by 185 mV and 166 mV,respectively,under 500 A/m2 and 1000 A/m2. 展开更多
关键词 composite inert anodes double pulse electrodeposition anodic polarization curves cyclic voltammetry curves Tafel polarization curves MICROSTRUCTURES
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Robust Digital Non-Linear Self-Interference Cancellation in Full Duplex Radios with Maximum Correntropy Criterion 被引量:3
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作者 Zhirong Luan Hua Qu +1 位作者 Jihong Zhao Badong Chen 《China Communications》 SCIE CSCD 2016年第9期53-59,共7页
Full duplex radio increases the frequency efficiency but its performance is limited by the self-interference (SI). We first analyze the multiple noises in the full duplex radio system and model such noises as an α ... Full duplex radio increases the frequency efficiency but its performance is limited by the self-interference (SI). We first analyze the multiple noises in the full duplex radio system and model such noises as an α - stable distribution. Then we formulate a novel non-Gaussian SI problem. Under the maximum correntropy criterion (MCC), a robust digital non-linear self-interference cancellation algorithm is proposed for the SI channel estimation. A gradient descent based algorithm is derived to search the optimal solution. Simulation results show that the proposed algorithm can achieve a smaller estimation error and a higher pseudo signal to interference plus noise ratio (PSINR) than the well-known least mean square (LMS) algorithm and least square (LS) algorithm. 展开更多
关键词 full duplex radio robust estimation digital non-linear self-interference can- cellation a-stable noise correntropy
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Negatons, Positons, and Complexiton Solutions of Higher Order for a Non-isospectral KdV Equation
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作者 ZHANG Yuan-Yuan WANG Qi ZHANG Hong-Qing 《Communications in Theoretical Physics》 SCIE CAS CSCD 2007年第3X期411-414,共4页
In this paper, negatons, positons, and complexiton solutions of higher order for a non-isospectral KdV equation, the KdV equation with loss and non-uniformity terms are obtained through the bilinear Baicklund transfor... In this paper, negatons, positons, and complexiton solutions of higher order for a non-isospectral KdV equation, the KdV equation with loss and non-uniformity terms are obtained through the bilinear Baicklund transformation. Further, the properties of some solutions are shown by some figures made by using Maple. 展开更多
关键词 bilinear Backlund transformation negatons positons complexiton solutions
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Dual-Wavelength Linearization of Radio-over-Fiber Link for Broadband Access and Ubiquitous Sensing
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作者 Wu Zhongle Lv Qiang +1 位作者 Dai Yitang Lin Jintong 《China Communications》 SCIE CSCD 2012年第1期20-24,共5页
Radio-over-Fiber (RoF) technologies have been considered to be a promising solution to broadband access and ubiquitous sensing. We present a novel approach using dual-wavelength lights to suppress the nonlinear inte... Radio-over-Fiber (RoF) technologies have been considered to be a promising solution to broadband access and ubiquitous sensing. We present a novel approach using dual-wavelength lights to suppress the nonlinear intermodulation distortion in intensity-modulated RoF link both theoretically and experimentally. The system we proposed rminly consists of two Laser Diodes (LDs) at different wavelengths, a commercial available Mach-Zehnder Modulator (MZM) and a Photo Detector (PD). More than 25 dB suppression of the Third-order Interrnodulation Distortion (IMD3) is achieved by adjusting the wavelength and opti- cal power of the laser. Besides, the output of the MZM is then sent to the photodetector via a single fiber, which simplifies the system complexity for distrbution of RF signals over long distances. 展开更多
关键词 ROF optical linearization IMD3 intensity modulator
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A New Auto-Backlund Transformation and Two-Soliton Solution for (3+l)-Dimensional Jimbo-Miwa Equation 被引量:1
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作者 刘春平 周玲 《Communications in Theoretical Physics》 SCIE CAS CSCD 2011年第2期213-216,共4页
Abstract By improving the extended homogeneous balance method, a general method is suggested to derive a new auto-Bgcklund transformation (BT) for (3-k l)-Dimensional Jimbo-Miwa (JM) equation. The auto-BT obtain... Abstract By improving the extended homogeneous balance method, a general method is suggested to derive a new auto-Bgcklund transformation (BT) for (3-k l)-Dimensional Jimbo-Miwa (JM) equation. The auto-BT obtained by using our method only involves one quadratic homogeneity equation written as a bilinear equation. Based on the auto-BT, two-soliton solution of the (3+1)-Dimensional JM equation is obtained. 展开更多
关键词 extended homogeneous balance method (3+1)-Dimensional Jimbo-Miwa equation auto-Backlund transformation exact solution
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Rebamipide suppresses diclofenac-induced intestinal permeability via mitochondrial protection in mice 被引量:8
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作者 Lei Diao Qiao Mei +5 位作者 Jian-Ming Xu Xiao-Chang Liu Jing Hu Juan Jin Qiang Yao Mo-Li Chen 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第10期1059-1066,共8页
AIM: To investigate the protective effect and mechanism of rebamipide on small intestinal permeability induced by diclofenac in mice. METHODS: Diclofenac (2.5 mg/kg) was administered once daily for 3 d orally. A contr... AIM: To investigate the protective effect and mechanism of rebamipide on small intestinal permeability induced by diclofenac in mice. METHODS: Diclofenac (2.5 mg/kg) was administered once daily for 3 d orally. A control group received the vehicle by gavage. Rebamipide (100 mg/kg, 200 mg/kg, 400 mg/kg) was administered intragastrically once a day for 3 d 4 h after diclofenac administration. Intestinal permeability was evaluated by Evans blue and the FITC-dextran method. The ultrastructure of the mucosal barrier was evaluated by transmission electron microscopy (TEM). Mitochondrial function including mitochondrial swelling, mitochondrial membrane potential, mitochondrial nicotinamide adenine dinucleotide-reduced (NADH) levels, succinate dehydrogenase (SDH) and ATPase activities were measured. Small intestinal mucosa was collected for assessment of malondialdehyde (MDA) content and myeloperoxidase (MPO) activity. RESULTS: Compared with the control group, intestinal permeability was significantly increased in the diclofenac group, which was accompanied by broken tight junctions, and significant increases in MDA content and MPO activity. Rebamipide significantly reduced intestinal permeability, improved inter-cellular tight junctions, and was associated with decreases in intestinal MDA content and MPO activity. At the mitochondrial level, rebamipide increased SDH and ATPase activities, NADH level and decreased mitochondrial swelling. CONCLUSION: Increased intestinal permeability induced by diclofenac can be attenuated by rebamipide, which partially contributed to the protection of mitochondrial function. 展开更多
关键词 Intestinal mucosal permeability MITOCHONDRIA Non-steroid anti-inflammatory drugs Oxidative damage REBAMIPIDE Tight junction
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Cooperative spectrum sensing algorithm based on bilateral threshold selection against Byzantine attack
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作者 Zhu Hancheng Song Tiecheng +2 位作者 Wu Jun Li Xi Hu Jing 《Journal of Southeast University(English Edition)》 EI CAS 2018年第4期439-443,共5页
To deal with Byzantine attacks in 5 G cognitive radio networks,a bilateral threshold selection-based algorithm is proposed in the spectrum sensing process. In each round,secondary uses( SUs) first submit the energy va... To deal with Byzantine attacks in 5 G cognitive radio networks,a bilateral threshold selection-based algorithm is proposed in the spectrum sensing process. In each round,secondary uses( SUs) first submit the energy values and instantaneous detection signal-to-noise ratios( SNRs) to the fusion center( FC). According to detection SNRs,the FC conducts normalization calculations on the energy values. Then,the FC makes a sort operation for these normalized energy values and traverses all the possible mid-points between these sorted normalized energy values to maximize the classification accuracy of each SU. Finally,by introducing the recognition probability and misclassification probability,the distributions of the normalized energy values are analyzed and the bilateral threshold of classification accuracy is obtained via a target misclassification probability. Hence,the blacklist of malicious secondary users( MSUs) is obtained. Simulation results show that the proposed scheme outperforms the current mainstream schemes in correct sensing probability,false alarm probability and detection probability. 展开更多
关键词 cognitive radio Byzantine attack bilateral threshold misclassification probability recognition probability
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Downlink/Uplink Identification of Time-Division Duplexing-OFDMA Systems for Cognitive Radios
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作者 饶毓 陈巍 曹志刚 《China Communications》 SCIE CSCD 2013年第6期68-78,共11页
When coexisting with dual-link primary systems,secondary systems in cognitive radios should first distinguish between the primary downlinks and uplinks in order to efficiently explore their respective spectrum opportu... When coexisting with dual-link primary systems,secondary systems in cognitive radios should first distinguish between the primary downlinks and uplinks in order to efficiently explore their respective spectrum opportunities.Because of the assumptive prior knowledge about the time-frequency locations of primary downlinks and uplinks,this procedure is usually not considered in the design of cognitive radios.In this paper,a cooperative method is proposed for the downlink/uplink identification of time-division duplex-based orthogonal frequency-division multiple access systems.In this method,the power level of the primary link is extracted as the key feature,which also contributes to the subsequent cognitive behaviours.The effects of the primary and secondary systems and the effects of the detection parameters on the identification accuracy are all analysed in detail.The simulation results show that the proposed method can identify the primary links precisely and quickly with low complexity. 展开更多
关键词 cognitive radios downlink/uplink identification cooperative detection time-division duplex orthogonal frequency-division multiple access
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Electromagnetic Environmental Impact of 500-kV Double -Circuit Transmission Lines
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作者 Qi Jianzhao, Zhang Guohua, Wu Xiaoyan Hebei Electric Power Design & Research Institute Zhang Jianping 《Electricity》 2011年第1期24-28,共5页
The strength of the power frequency electric intensity and magnetic field of the 500-kV double circuit transmission lines was calculated by using the equivalent charge method and the Ampere's Law, and the environm... The strength of the power frequency electric intensity and magnetic field of the 500-kV double circuit transmission lines was calculated by using the equivalent charge method and the Ampere's Law, and the environmental impact factors of the fields were evaluated. By optimizing the phase sequence, the frequency electric intensity and magnetic field strength can be reduced. Within a distance of 25 m from the center of the transmission line, the power frequency electric intensity and magnetic field strength fall off sharply with the distance increase. Finally, the best phase sequence and the minimum ground clearance of the transmission lines were obtained to meet the requirements of the least impact on envionment. 展开更多
关键词 transmission line frequency electric field intensity frequency magnetic field strength
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Predictive current control system of PMSM based on LADRC 被引量:1
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作者 Wang Xiaopeng Zhao Jun +1 位作者 Wang Bohui Li Baomin 《Journal of Southeast University(English Edition)》 EI CAS 2022年第3期227-234,共8页
For a permanent magnet synchronous motor(PMSM)model predictive current control(MPCC)system,when the speed loop adopts proportional-integral(PI)control,speed regulation is easily affected by motor parameters,resulting ... For a permanent magnet synchronous motor(PMSM)model predictive current control(MPCC)system,when the speed loop adopts proportional-integral(PI)control,speed regulation is easily affected by motor parameters,resulting in the inability to balance the system robustness and dynamic performance.A PMSM optimal control strategy combining linear active disturbance rejection control(LADRC)and two-vector MPCC(TV-MPCC)is proposed.Firstly,a mathematical model of a PMSM is presented,and the PMSM TV-MPCC model is developed in the synchronous rotation coordinate system.Secondly,a first-order LADRC controller composed of a linear extended state observer and linear state error feedback is designed to reduce the complexity of parameter tuning while linearly simplifying the traditional active disturbance rejection control(ADRC)structure.Finally,the conventional PI speed regulator in the motor speed control system is replaced by the designed LADRC controller.The simulation results show that the speed control system using LADRC can effectively deal with the changes in motor parameters and has better robustness and dynamic performance than PI control and similar methods.The system has a fast motor speed response,small overshoot,strong anti-interference,and no steady-state error,and the total harmonic distortion is reduced. 展开更多
关键词 permanent magnet synchronous motor(PMSM) two-vector model predictive current control linear active disturbance rejection control speed control system
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In Situ Synchrotron X-ray Diffraction Studies of Single-walled Carbon Nanotubes for Electric Double-layer Capacitors
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作者 Yukihiro Yoshida Masato Tsutsui +2 位作者 Ayar Al-zubaidi Yosuke Ishii Shinji Kawasaki 《Journal of Chemistry and Chemical Engineering》 2015年第8期509-513,共5页
In situ synchrotron X-ray diffraction experiments of SWCNT (single-walled carbon nanotube) electrode in alkali halide aqueous electrolyte at several applied potentials were performed, and the change in the diffracti... In situ synchrotron X-ray diffraction experiments of SWCNT (single-walled carbon nanotube) electrode in alkali halide aqueous electrolyte at several applied potentials were performed, and the change in the diffraction pattern of SWCNTs was observed. It was found that the position of the 100 diffraction peak does not change with applied potential while the peak intensity decreases with anion adsorption. It was concluded that the space inside the tube would be the important ion adsorption site for the well-gown SWCNT bundles. 展开更多
关键词 Carbon nanotubes synchrotron X-ray EDLC
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Calculation of optimal current density of double side permanent magnet linear synchronous motor
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作者 JANG Ki-Bong AN Ho-Jin KIM Gyu-Tak 《Journal of Central South University》 SCIE EI CAS 2011年第1期165-170,共6页
The use of design method considering a coil temperature to maximize the thrust density of a double side coreless permanent magnet linear synchronous motor(PMLSM) was presented.The optimal current density where the coi... The use of design method considering a coil temperature to maximize the thrust density of a double side coreless permanent magnet linear synchronous motor(PMLSM) was presented.The optimal current density where the coil temperature reaches an allowable temperature with heat analysis was applied to a magnetic circuit design.Changing optimal current density is verified whenever the design parameters of the motor are altered.The design parameters of the motor were applied to thrust calculation.In this way,the optimal model,which is a reversal of the existing design method,is deduced.The results were compared with the experimental data to verify their validity.When the convection heat transfer coefficient is applied to other models,the results of the analysis and test values show good concordance.The method proposed has some limitations. 展开更多
关键词 permanent magnet linear synchronous motor current density heat transfer temperature thickness of coil
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海西:跨入动车时代
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作者 姚森 吴建彬 《报林》 2009年第12期72-77,共6页
2009年9月28日上午7时44分,首趟时速250公里的D3102次"和谐号"动车组徐徐驶离福州站台,标志着福建省结束了只有单线和低速铁路的历史,温福铁路正式开通。自此,每天有13对动车组往返于这条新线之上。据介绍,温福铁路于2004年1... 2009年9月28日上午7时44分,首趟时速250公里的D3102次"和谐号"动车组徐徐驶离福州站台,标志着福建省结束了只有单线和低速铁路的历史,温福铁路正式开通。自此,每天有13对动车组往返于这条新线之上。据介绍,温福铁路于2004年12月动工建设,自浙江省温州市至福建省福州市,全长298.4公里,为铁道部、福建省和浙江省合资建设的国家I级双线电气化铁路,是我国《中长期铁路网规划》"四纵四横"主通道沿海客运专线的重要组成部分。温福铁路通车后,从福州出发到温州,将由目前的中转换乘15个小时缩短至约100分钟,福州至杭州由目前的9个半小时缩短至4个半小时,福州至上海由11个小时缩短至约6小时。该条铁路还将与甬台温铁路以及在建的福州至厦门铁路和厦门至深圳铁路共同形成一条长三角经闽通往珠三角的快速通道,让中国三大经济圈联系更趋紧密。11月中旬,本刊记者带着向往与憧憬踏上了海西的沃土。此行我们的任务是用眼睛观察福建,用心灵感受福建,在动车开行之后,这个"福地"是否也在涌动着新一轮的经济大提速?一周的时间里,我们跑遍了福州、泉州、石狮、厦门以及浙南温州地区的苍南等地,深入到数十家企业体验交流,切身感受到温福高铁带来的包括物质与心灵两方面的变化。 展开更多
关键词 温福铁路 合资建设 福建省福州市 甬台温铁路 客运专线 浙江省温州市 圣达 苍南 国际时装周 双线电
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Impact of TID on response to pulsed X-ray irradiation in the bipolar operational amplifier 被引量:2
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作者 LI Rui Bin WANG Gui Zhen +7 位作者 CHEN Wei MA Qiang LIU Yan LIN Dong Sheng YANG ShanChao BAI XiaoYan QI Chao JIN XiaoMing 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2015年第2期390-396,共7页
Groups of a typical operational amplifier-μA741 were irradiated in a cobalt unit, each group accumulating a different total ionizing dose (TID). The results showed that the TID caused power consumption current and ... Groups of a typical operational amplifier-μA741 were irradiated in a cobalt unit, each group accumulating a different total ionizing dose (TID). The results showed that the TID caused power consumption current and slew rate (SR) to degenerate in ultra-linearity, owing to a severe reduction in the current gain of the internal LPNP transistors. Pulsed X-ray irradiation experiments were carried out on the μA741 groups with different values, and the results revealed that the impact on the response to the pulsed X-ray irradiation was greater when the devices absorbed more TID. The mechanism for this is explained on the basis of the circuit construction of the μA741; the sensitive parameters of the circuit were obtained via simulation on SP1CE. The simulation results additionally showed that if the sensitive parameters were optimized, the duration of interruption caused by the pulsed X-ray irradiation would be reduced significantly. In addition, several proposals are provided for hardening the devices. 展开更多
关键词 TID pulsed X-ray irradiation operational amplifier simulation
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PdPb bimetallic nanowires as electrocatalysts for enhanced ethanol electrooxidation 被引量:3
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作者 Ning Ma Shuqing Wang +4 位作者 Xuehua Liu Yunchang Sun Yanru Yin Lian Ying Zhang Peizhi Guo 《Science China Materials》 SCIE EI CSCD 2020年第10期2040-2049,共10页
Less-expensive but efficient electrocatalysts are essential to accelerate the commercialization of fuel cells.Herein,ultrathin PdPb nanowires(PdPb NWs)with a diameter of around 3.5 nm were prepared by using a one-step... Less-expensive but efficient electrocatalysts are essential to accelerate the commercialization of fuel cells.Herein,ultrathin PdPb nanowires(PdPb NWs)with a diameter of around 3.5 nm were prepared by using a one-step hydrothermal method.The introduction of Pb in Pd-based bimetallic nanostructures produced high differences in the morphology from Pd nanoparticles(NPs)to various PdPb NWs.All the as-prepared PdPb NWs exhibited better electrocatalytic activity and durability than Pd NPs due to the synergistic effect.Especially,Pd65Pb35 possessed the highest current density of about 3460 mA mgPd^−1 for the ethanol electrooxidation which was around 6.3 times higher than commercial Pd/C.The high-performance of Pd65Pb35 is attributed to the defect-rich and stable nanowire structure with optimized surface atomic arrangement,as evidenced by high resolution transmission electron microscopy measurements and long-time treatment in an acidic media.The differences in the morphologies and electrocatalytic activities of PdPb NWs with varied Pb contents have also been discussed and analyzed. 展开更多
关键词 PdPb nanowires electronic structure lattice defects ELECTROCATALYSIS ethanol electrooxidation
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Polaron Effect of a Two Electron Parabolic Quantum Dot 被引量:5
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作者 S.Saravana Kumar A.John Peter Chang Kyoo Yoo 《Communications in Theoretical Physics》 SCIE CAS CSCD 2013年第6期763-768,共6页
Polaron induced double electron in a quantum dot is investigated using the exact diagonalization techniques and the compact density-matrix approach. The dependence of nonlinear optical processes on the incident photon... Polaron induced double electron in a quantum dot is investigated using the exact diagonalization techniques and the compact density-matrix approach. The dependence of nonlinear optical processes on the incident photon energies and the polaronic effect are brought out. The linear, third order non-linear optical absorption coefficients and the refractive index changes of singlet and triplet states as a function of photon energy are obtained with and without the inclusion of polaronic effect. It is found that the geometrical confinement and the effect of polaron have great influence on the optical properties of dots. 展开更多
关键词 parabolic quantum dot correlation energy SEMICONDUCTOR
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The Fourier space restricted Hartree-Fock method for the electronic structure calculation of linear poly(tetrafluoroethylene)
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作者 FRIPIAT Joseph G. HARRIS Frank E. 《Science China Chemistry》 SCIE EI CAS 2014年第10期1355-1362,共8页
Building on the pioneering work of Jean-Marie Andre and working in the laboratory he founded, the authors have developed a code called FT-1D to make Hartree-Fock electronic structure computations for stereoregular pol... Building on the pioneering work of Jean-Marie Andre and working in the laboratory he founded, the authors have developed a code called FT-1D to make Hartree-Fock electronic structure computations for stereoregular polymers using Ewald-type con- vergence acceleration methods. That code also takes full advantage of all line-group symmetries to calculate only the minimal set of two-electron integrals and to optimize the computation of the Fock matrix. The present communication reports a bench- mark study of the FT-1D code using polytetrafluoroethylene (PTFE) as a test case. Our results not only confirm the algorith- mic correctness of the code through agreement with other studies where they are applicable, but also show that the use of con- vergence acceleration enables accurate results to be obtained in situations where other widely-used codes (e.g., PLH and Crys- tal) fail. It is also found that full attention to the line-group symmetry of the PTFE polymer leads to an increase of between one and two orders of magnitude in the speed of computation. The new code can therefore be viewed as extending the range of electronic-structure computations for stereoregular polymers beyond the present scope of the successful and valuable code Crystal. 展开更多
关键词 poly(tetrafluoroethylene) band structure Fourier-space Hartree-Fock lattice sum Ewaid
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Self-assemblies of plasmonic gold/layered double hydroxides with highly efficient antiviral effect against the hepatitis B virus 被引量:5
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作者 Gabriela Carja Elena Florentina Grosu +1 位作者 Catalina Petrarean Norica Nichita 《Nano Research》 SCIE EI CAS CSCD 2015年第11期3512-3523,共12页
Engineering complex nanocomposites that specifically target the hepatitis B virus (HBV) and overcome the limitations of current therapies such as limited efficacy and serious side effects is very challenging. Here, ... Engineering complex nanocomposites that specifically target the hepatitis B virus (HBV) and overcome the limitations of current therapies such as limited efficacy and serious side effects is very challenging. Here, for the first time, the antiviral effect of engineered plasmonic gold and layered double hydroxide self-assemblies (AuNPs/LDHs) is demonstrated, using HBV as a model virus and hepatoma-derived HepG2.2.215 ceils for viral replication, assembly, and secretion of infectious virions and subviral particles. AuNPs/LDHs were obtained by a simple, cost-effective procedure in which small AuNPs (-3.5 nm) were directly obtained and organized on the surface of larger LDH nanoparticles (-150 nm) by exploiting the capability of MgLDH, ZnLDH, and MgFeLDH to manifest their "structural memory" in the aqueous solution of Au(O2CCH3)3. The self-assembly approach of AuNPs and LDHs was assessed by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), powder X-ray diffraction (PXRD), and UV-Vis analysis (UV-Vis). All AuNPs/LDHs tested reduced the amount of viral and subviral particles released from treated cells by up to 80% and exhibited good cytocompatibility. AuNPs/MgFeLDH showed the highest antiviral HBV response with more than 90% inhibition of HBV secretion for the whole concentration range. Preliminary studies on the mechanism of HBV inhibition reveals that in the presence of AuNPs/LDHs, HBV particles are sequestered within the treated cells. The antiviral and low cytotoxic plasmonic properties of these Au/LDH nanocomposites indicate that they hold significant potential to be tailored as novel efficient therapeutics for the treatment of hepatitis B. 展开更多
关键词 plasmonic gold layered double hydroxides layered double hydroxide (LDH) antiviral effect HBV HEPATITIS CYTOTOXICITY
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