The dry friction and wear behaviors of co-continuous composites SiC/Fe–40Cr against SiC/Al 2618 alloy were investigated on a ring-on-ring friction and wear tester at sliding speed of 30-105 m/s under the load of 1.0-...The dry friction and wear behaviors of co-continuous composites SiC/Fe–40Cr against SiC/Al 2618 alloy were investigated on a ring-on-ring friction and wear tester at sliding speed of 30-105 m/s under the load of 1.0-2.5 MPa. The experimental result reveals that the characteristic of two body abrasive wear and oxidation wear mechanisms are present for SiCn/2618 Al composite under higher load and sliding speed. SiC ceramic continuous network as the reinforcement can avoid composite from the third body wear that usually occurs in traditional particle reinforced composite. The mechanically mixed layer (MML) controls greatly the wear rate and friction coefficient of the composites. The composites tested at higher sliding speed exhibit higher value of friction coefficient and fluctuation, which is associated with the intermittent formation and removal of the MML. The wear and stress—strain behaviors of SiCn/Fe–40Cr against SiCn/Al 2168 at 30-105 m/s under 1.0-2.5 MPa were analyzed by finite element method with the software Solidwork2012 Simulation, respectively. The wear and stress–strain behavior of the composite predicted by the FEM correlated well with the experimental results.展开更多
Objective. To study the effects of two kinds of Chinese herbal medicine, Radix angelicae sinensis(RAS)(当归)and Shuanghuanglian(SHL)(双黄连) on chronic Pseudomonas aeruginosa(PA)lung infection in a rat model mimicking...Objective. To study the effects of two kinds of Chinese herbal medicine, Radix angelicae sinensis(RAS)(当归)and Shuanghuanglian(SHL)(双黄连) on chronic Pseudomonas aeruginosa(PA)lung infection in a rat model mimicking cystic fibrosis(CF). Methods.Rats were divided into RAS, SHL and control groups. All rats were challenged intratracheally with alginate embedded PA and the treatments with herbal medicine started on the same day of challenge. The drugs were administered subcutaneously once a day for ten days and the control group was treated with sterile saline.The rats were sacrificed two weeks after challenge. Results. Significantly improved lung bacterial clearance(P<005, P<001) and milder macroscopic lung pathology (P<0005) were found in the two treated groups compared to the control group. In the SHL treated group, the neutrophil percent in the peripheral blood leukocytes(P<005), the antiPA IgG level in serum (P<005), the incidence of lung abscesses(P<0005) and the incidence of acute lung inflammation(P<005) were significantly lower than in the control group. The RAS treatment reduced fever(P<005), decreased the incidence of lung abscesses(P<0005) and lung mast cell number (P<005), and lowered antiPA IgG1 level in serum(P<005) when compared to the control group. The antiPA bacterial activity test in SHL was weakly positive whereas in RAS it was negative. Conclusion.The treatment with both herbal medicines could increase the resistance of the rats against PA lung infection and they therefore might be potential promising drugs for stimulation of the immune system in CF patients with chronic PA lung infection.展开更多
The method of numerical solving of nonlinear model problems of theory of a complex quasi-potential in doubly-connected nonlinear-layered curvilinear domains considering inverse influence function of flow on a conducti...The method of numerical solving of nonlinear model problems of theory of a complex quasi-potential in doubly-connected nonlinear-layered curvilinear domains considering inverse influence function of flow on a conductivity coefficient of medium was developed on the basis of synthesis of numerical methods of the quasi-conformal mappings and summary representations in conjunction with domain decomposition by method Schwartz. The proposed algorithm allows finding the potential of the quasiideals field, construction a motion grid (fluid-flow grid) simultaneously defining the flow lines that separate of sub-domains constancy of coefficient conductivity and identification the piecewise-constant values of coefficient conductivity, the local flows for the known measurements on boundary of domain.展开更多
This paper presents a further development of the dual reciprocity boundary element method(DRBEM) with stepwise updating to pave the way for the introduction of boundary element mesh into the discontinuous deformation ...This paper presents a further development of the dual reciprocity boundary element method(DRBEM) with stepwise updating to pave the way for the introduction of boundary element mesh into the discontinuous deformation analysis(DDA). The advantage of the proposed method lies in its adoption of static fundamental solutions and reduction in the size of the governing equations by transforming the inertial term domain integrals to boundary integrals in the dynamic large displacement analysis. The unconditionally stable Newmark-β time integration method involving numerical damping to enhance the numerical stability is implemented for the dynamic analysis. In order to be coupled with the DDA to improve the deformability of the DDA block domains, a stepwise updating algorithm of the system variables is introduced. The stress updating in the analysis involved in the calculation of a domain integral and internal cells are used for the integration of the initial stress term. Several examples are used to verify the geometry-updated DRBEM model and satisfactory results have been obtained.展开更多
基金Project (2012BAE06B01) supported by the Key Technology R&D Program During the 12th Five-Year Plan Period, ChinaProjects(21201030, 51272039, 51032007) supported by the National Natural Science Foundation of ChinaProject (1099043) supported by the Science and Technology in Guangxi Province, China
文摘The dry friction and wear behaviors of co-continuous composites SiC/Fe–40Cr against SiC/Al 2618 alloy were investigated on a ring-on-ring friction and wear tester at sliding speed of 30-105 m/s under the load of 1.0-2.5 MPa. The experimental result reveals that the characteristic of two body abrasive wear and oxidation wear mechanisms are present for SiCn/2618 Al composite under higher load and sliding speed. SiC ceramic continuous network as the reinforcement can avoid composite from the third body wear that usually occurs in traditional particle reinforced composite. The mechanically mixed layer (MML) controls greatly the wear rate and friction coefficient of the composites. The composites tested at higher sliding speed exhibit higher value of friction coefficient and fluctuation, which is associated with the intermittent formation and removal of the MML. The wear and stress—strain behaviors of SiCn/Fe–40Cr against SiCn/Al 2168 at 30-105 m/s under 1.0-2.5 MPa were analyzed by finite element method with the software Solidwork2012 Simulation, respectively. The wear and stress–strain behavior of the composite predicted by the FEM correlated well with the experimental results.
文摘Objective. To study the effects of two kinds of Chinese herbal medicine, Radix angelicae sinensis(RAS)(当归)and Shuanghuanglian(SHL)(双黄连) on chronic Pseudomonas aeruginosa(PA)lung infection in a rat model mimicking cystic fibrosis(CF). Methods.Rats were divided into RAS, SHL and control groups. All rats were challenged intratracheally with alginate embedded PA and the treatments with herbal medicine started on the same day of challenge. The drugs were administered subcutaneously once a day for ten days and the control group was treated with sterile saline.The rats were sacrificed two weeks after challenge. Results. Significantly improved lung bacterial clearance(P<005, P<001) and milder macroscopic lung pathology (P<0005) were found in the two treated groups compared to the control group. In the SHL treated group, the neutrophil percent in the peripheral blood leukocytes(P<005), the antiPA IgG level in serum (P<005), the incidence of lung abscesses(P<0005) and the incidence of acute lung inflammation(P<005) were significantly lower than in the control group. The RAS treatment reduced fever(P<005), decreased the incidence of lung abscesses(P<0005) and lung mast cell number (P<005), and lowered antiPA IgG1 level in serum(P<005) when compared to the control group. The antiPA bacterial activity test in SHL was weakly positive whereas in RAS it was negative. Conclusion.The treatment with both herbal medicines could increase the resistance of the rats against PA lung infection and they therefore might be potential promising drugs for stimulation of the immune system in CF patients with chronic PA lung infection.
文摘The method of numerical solving of nonlinear model problems of theory of a complex quasi-potential in doubly-connected nonlinear-layered curvilinear domains considering inverse influence function of flow on a conductivity coefficient of medium was developed on the basis of synthesis of numerical methods of the quasi-conformal mappings and summary representations in conjunction with domain decomposition by method Schwartz. The proposed algorithm allows finding the potential of the quasiideals field, construction a motion grid (fluid-flow grid) simultaneously defining the flow lines that separate of sub-domains constancy of coefficient conductivity and identification the piecewise-constant values of coefficient conductivity, the local flows for the known measurements on boundary of domain.
基金supported by the International Postgraduate Research Scholarship(IPRS)Australian Postgraduate Award(APA)sponsored by the Australian Government via the University of Western Australiathe National Natural Science Foundation of China(Grant Nos.41130751&51178012)
文摘This paper presents a further development of the dual reciprocity boundary element method(DRBEM) with stepwise updating to pave the way for the introduction of boundary element mesh into the discontinuous deformation analysis(DDA). The advantage of the proposed method lies in its adoption of static fundamental solutions and reduction in the size of the governing equations by transforming the inertial term domain integrals to boundary integrals in the dynamic large displacement analysis. The unconditionally stable Newmark-β time integration method involving numerical damping to enhance the numerical stability is implemented for the dynamic analysis. In order to be coupled with the DDA to improve the deformability of the DDA block domains, a stepwise updating algorithm of the system variables is introduced. The stress updating in the analysis involved in the calculation of a domain integral and internal cells are used for the integration of the initial stress term. Several examples are used to verify the geometry-updated DRBEM model and satisfactory results have been obtained.