Traditionally, fluid substitutions are often conducted on log data for calculating reservoir elastic properties with different pore fluids. Their corresponding seismic responses are computed by seismic forward modelin...Traditionally, fluid substitutions are often conducted on log data for calculating reservoir elastic properties with different pore fluids. Their corresponding seismic responses are computed by seismic forward modeling for direct gas reservoir identification. The workflow provides us with the information about reservoir and seismic but just at the well. For real reservoirs, the reservoir parameters such as porosity, clay content, and thickness vary with location. So the information from traditional fluid substitution just at the well is limited. By assuming a rock physics model linking the elastic properties to porosity and mineralogy, we conducted seismic forward modeling and AVO attributes computation on a three-layer earth model with varying porosity, clay content, and formation thickness. Then we analyzed the relations between AVO attributes at wet reservoirs and those at the same but gas reservoirs. We arrived at their linear relations within the assumption framework used in the forward modeling. Their linear relations make it possible to directly conduct fluid substitution on seismic AVO attributes. Finally, we applied these linear relations for fluid substitution on seismic data and identified gas reservoirs by the cross-plot between the AVO attributes from seismic data and those from seismic data after direct fluid substitution.展开更多
Gonadotropin-releasing hormone (GnRH) is a crucial peptide for the regulation of reproduction. Using immunological techniques, we investigated the presence of GnRH in horseshoe crab Tachypleus tridentatus. Octopus G...Gonadotropin-releasing hormone (GnRH) is a crucial peptide for the regulation of reproduction. Using immunological techniques, we investigated the presence of GnRH in horseshoe crab Tachypleus tridentatus. Octopus GnRH-like immunoreactivity, tunicate GnRH-like immunoreactivity, and lamprey GnRH-I-like immunoreactivity were detected in the neurons and fibers of the protocerebrum. However, no mammal GnRH-like immunoreactivity or lamprey GnRH-LII-like immunoreactivity was observed. Our results suggest that a GnRH-like factor, an ancient peptide, existed in the brain of T. tridentatus and may be involved in the reproductive endocrine system.展开更多
Toll-like receptors (TLRs) are probably the most important class of pattern-recognition receptors. Members of the TLR family play key roles in the both innate and adaptive immune responses. Recognition of pathogen-a...Toll-like receptors (TLRs) are probably the most important class of pattern-recognition receptors. Members of the TLR family play key roles in the both innate and adaptive immune responses. Recognition of pathogen-associated molecular patterns (PAMPs) by TLRs, either alone or in heterodimedzation with other TLR or non-TLR receptors, induces the production of signals that are responsible for the activation of genes important for an effective host defense, especially those of proinflammatory cytokines. Thus, TLRs are involved in the development of many pathological conditions including infectious diseases, tissue damage, and cancer especially. In this review, the contribution of TLRs to tumorgenesis is evaluated. We hope to provide new insight into the progression of cancer and more importantly into the potential for TLRs as targets of therapeutics.展开更多
基金sponsored by the National Natural Science Foundation of China (No.41074098)
文摘Traditionally, fluid substitutions are often conducted on log data for calculating reservoir elastic properties with different pore fluids. Their corresponding seismic responses are computed by seismic forward modeling for direct gas reservoir identification. The workflow provides us with the information about reservoir and seismic but just at the well. For real reservoirs, the reservoir parameters such as porosity, clay content, and thickness vary with location. So the information from traditional fluid substitution just at the well is limited. By assuming a rock physics model linking the elastic properties to porosity and mineralogy, we conducted seismic forward modeling and AVO attributes computation on a three-layer earth model with varying porosity, clay content, and formation thickness. Then we analyzed the relations between AVO attributes at wet reservoirs and those at the same but gas reservoirs. We arrived at their linear relations within the assumption framework used in the forward modeling. Their linear relations make it possible to directly conduct fluid substitution on seismic AVO attributes. Finally, we applied these linear relations for fluid substitution on seismic data and identified gas reservoirs by the cross-plot between the AVO attributes from seismic data and those from seismic data after direct fluid substitution.
基金Supported by the National Natural Science Foundation of China(No.41076081)
文摘Gonadotropin-releasing hormone (GnRH) is a crucial peptide for the regulation of reproduction. Using immunological techniques, we investigated the presence of GnRH in horseshoe crab Tachypleus tridentatus. Octopus GnRH-like immunoreactivity, tunicate GnRH-like immunoreactivity, and lamprey GnRH-I-like immunoreactivity were detected in the neurons and fibers of the protocerebrum. However, no mammal GnRH-like immunoreactivity or lamprey GnRH-LII-like immunoreactivity was observed. Our results suggest that a GnRH-like factor, an ancient peptide, existed in the brain of T. tridentatus and may be involved in the reproductive endocrine system.
文摘Toll-like receptors (TLRs) are probably the most important class of pattern-recognition receptors. Members of the TLR family play key roles in the both innate and adaptive immune responses. Recognition of pathogen-associated molecular patterns (PAMPs) by TLRs, either alone or in heterodimedzation with other TLR or non-TLR receptors, induces the production of signals that are responsible for the activation of genes important for an effective host defense, especially those of proinflammatory cytokines. Thus, TLRs are involved in the development of many pathological conditions including infectious diseases, tissue damage, and cancer especially. In this review, the contribution of TLRs to tumorgenesis is evaluated. We hope to provide new insight into the progression of cancer and more importantly into the potential for TLRs as targets of therapeutics.