Aim A simple, sensitive and rapid RP HPLC method with pre column derivatization has been developed for the determination of sulphonylurea glimepiride in dog serum. Methods The sulphonylurea glimepiride was extract...Aim A simple, sensitive and rapid RP HPLC method with pre column derivatization has been developed for the determination of sulphonylurea glimepiride in dog serum. Methods The sulphonylurea glimepiride was extracted from the dog serum using dichlromethane followed by derivatization with DNBF for 20 min at 100℃. The solvent was then evaporated at 60℃ under nitrogen, and the residue was taken up in 100 μL of mobile phase consisting of acetonitrile water (75∶30, v/v). The separation was performed on a Hypersil BDS C18 column with a flow rate of 0 8 mL·min -1 , and the ultraviolet detector wavelength was set at 350 nm. Results Extraction recovery ranged from 75.9% to 83.2%, and methodological recovery was between 96.5% and 109.3%. Within day RSD ranged from 1.5% to 6.3%, and inter day RSD was between 2 9% and 14.8%. The method showed good linearity (R=0.9998). Conclusion The method was simple, convenient and sensitive. The reaction of derivatization was reproducible.展开更多
A pre-column derivatization HPLC method for the determination of peimine(P)and peiminine(PE)in Bulbus Fritillariae has been developed. Under the derivatization conditions optimized,the calibration curve is Y1=-3.83...A pre-column derivatization HPLC method for the determination of peimine(P)and peiminine(PE)in Bulbus Fritillariae has been developed. Under the derivatization conditions optimized,the calibration curve is Y1=-3.83×103+1.33 ×105X1,r=0.998 for P and Y2=-7.86 × 102+6.33 × 104X2,r=0995 for PE,where Y is the peak area and X is the weight of the alkaloid; the average recovery is 98.0%(n=5, RSD=2.1%) for P and 101.0%(n=5,RSD=4.1%)for PE,the linear range is from 0.504 μg to 3.126μg for P and from 0.520μgto 3.328μgfor PE,respectively. Results of the determination of the two alkaloids in several samples of different Fritillaria species from various parts ofthe country are presented.The results suggest that P and PE are two major chemical constituents in bulbs of different Fritillaria species,and that the method developed is generally appli-cable to the determination of the hydroxy group on aliphatic fused ring systems without steric hin-drance.展开更多
Aim A liquid chromatographic method for the determination ofcandicidin/FR-008 and related components in fermentation broth has been developed. Methods Therewere four major components in the candicidin/FR-008 complex, ...Aim A liquid chromatographic method for the determination ofcandicidin/FR-008 and related components in fermentation broth has been developed. Methods Therewere four major components in the candicidin/FR-008 complex, which were separated by HPLC under thefollowing conditions: SB-C8 column (4.6 mm x 250 mm, 5 μm) was used, the mobile phase consisted ofacetonitrileam-monium acteate (20 mmol·L^(-1) , pH 4.0) (40:60, V/V) , with a flow rate of 1 .0mL·min^(-1) , the UV detection wavelength was 380 nm, and the whole process was performed at 25℃ .Results The linearity was obtained in the range of 6.25 - 500 μg· mL^(-1) candicidin/FR-008 withthe regression equation of Y = 20 461 x + 30 748 and the correlation coefficient of 0.999 1. Theinstrument precision was 1.84% and the method precision was 3.8%. Conclusion This method isaccurate, rapid and simple; it can be used for determination of candicidin/FR-008 and relatedcomponents in fermentation broth.展开更多
To find a reasonable way to prepare the designed CPP32 inhibitors. Method Ugifour-component condensation reaction was used to synthesize peptide mimic CPP32 inhibitors; ResultsA key isocyanide component (aspartate-der...To find a reasonable way to prepare the designed CPP32 inhibitors. Method Ugifour-component condensation reaction was used to synthesize peptide mimic CPP32 inhibitors; ResultsA key isocyanide component (aspartate-derived isocyanide 3) and one of the designed CPP32inhibitors 4 (as a template) were synthesized; Conclusion The CPP32 inhibitor 4 was synthesized bythe newly developed procedure, which is an Ugi four-component condensation reaction based onaspartate-derived isocyanide 3. This method can be used to build up the CPP32 inhibitor library.展开更多
A series of 2 (E) (4 hydroxy 3 methoxybenzylidene) 5 (N substituted ami nomethyl) cyclopentanones was synthesized and evaluated for the anti inflammatory activity. All of the target compounds were confirmed ...A series of 2 (E) (4 hydroxy 3 methoxybenzylidene) 5 (N substituted ami nomethyl) cyclopentanones was synthesized and evaluated for the anti inflammatory activity. All of the target compounds were confirmed by spectral analysis and elemental analysis. Preliminary pharmacological tests showed that several compounds exerted appreciable inhibitory effect on xylene induced ear edema in mice and that alteration of the substituents of anilines had significant influence in anti inflammatory potency.展开更多
A basic ionic liquid, namely 1,1＇-（butane-1,4-diyl）bis（1,4-diazabicyclo [2.2.2]octan-1-ium） hydrox-ide, was prepared and characterized using Fourier-transform infrared spectroscopy, XH nuclear magnetic...A basic ionic liquid, namely 1,1＇-（butane-1,4-diyl）bis（1,4-diazabicyclo [2.2.2]octan-1-ium） hydrox-ide, was prepared and characterized using Fourier-transform infrared spectroscopy, XH nuclear magnetic resonance spectroscopy, and pH measurements. The ionic liquid was used for efficient promotion of the synthesis of pyrano[2,3-d]pyrimidinone and pyrido[2,3-d]pyrimidine derivatives at room temperature under grinding conditions. A simple procedure, short reaction time, high yields, non-column chromatographic separation, commercial availability of the starting materials, and recyclability of the catalyst are attractive features of this process.展开更多
A type of visible light photocatalyst Bi2WO6 was prepared from Bi(NO3)3.5H2O and Na2WO4.2H2O by means of hydrothermal method and was characterized by UV-vis diffuse reflectance spectrometry and XRD.Oxidative desulfuri...A type of visible light photocatalyst Bi2WO6 was prepared from Bi(NO3)3.5H2O and Na2WO4.2H2O by means of hydrothermal method and was characterized by UV-vis diffuse reflectance spectrometry and XRD.Oxidative desulfurization via photocatalysis was investigated using thiophene dissolved in octane as the model compound,with hydrogen peroxide used as the oxidant.The effects of hydrogen peroxide mass fraction,irradiation time,dosage of photocatalyst Bi2WO6 on the desulfurization efficiency were also investigated.Under suitable conditions,the desulfurization rate of model compound reached over 70%.展开更多
Aim To determine the structure of the by-product produced in Grignard reaction for preparing mifepristone derivatives, and elucidate the reaction mechanism.Methods The structure of the by-product was determined with e...Aim To determine the structure of the by-product produced in Grignard reaction for preparing mifepristone derivatives, and elucidate the reaction mechanism.Methods The structure of the by-product was determined with elemental analysis, one- and two-dimension spectra NMR (DEPT, 1H-1Hcosy, HMQC, HMBC) and compared with those of mifepristone.Results The main by-product was 11,17-di-addition product of Grignard reagent of N, N-dimethylamino phenyl bromide.Conclusion This is the first complete assignment of 1H NMR and 13C NMR of compound (3).展开更多
A multilayer perceptron neural network system is established to support the diagnosis for five most common heart diseases (coronary heart disease, rheumatic valvular heart disease, hypertension, chronic cor pulmonale ...A multilayer perceptron neural network system is established to support the diagnosis for five most common heart diseases (coronary heart disease, rheumatic valvular heart disease, hypertension, chronic cor pulmonale and congenital heart disease). Momentum term, adaptive learning rate, the forgetting mechanics, and conjugate gradients method are introduced to improve the basic BP algorithm aiming to speed up the convergence of the BP algorithm and enhance the accuracy for diagnosis. A heart disease database consisting of 352 samples is applied to the training and testing courses of the system. The performance of the system is assessed by cross-validation method. It is found that as the basic BP algorithm is improved step by step, the convergence speed and the classification accuracy of the network are enhanced, and the system has great application prospect in supporting heart diseases diagnosis.展开更多
Some new 2-thioxo thiazole, 2-thioxo 1,3,4- thiadiazole and 3-thioxo-1,3,4-triazole derivatives （3-17） have been synthesized through ring closure reactions ofdithioic formic acid hydrazones 2 with functional reagent...Some new 2-thioxo thiazole, 2-thioxo 1,3,4- thiadiazole and 3-thioxo-1,3,4-triazole derivatives （3-17） have been synthesized through ring closure reactions ofdithioic formic acid hydrazones 2 with functional reagents in different medium. Former structures of the products have been established by the help of elemental and spectral analysis. Most of the obtained targets showed a moderate activity towards some microbes in comparison with two antibiotics Pipercillin and Mycostatine.展开更多
Cs0.35V2O5 was successfully synthesized as cathode material for lithium secondary battery by the rheological phase reaction method from Cs2CO3 and NH4VO3. The Cs0.35V2O5/Cu composite material was prepared by the displ...Cs0.35V2O5 was successfully synthesized as cathode material for lithium secondary battery by the rheological phase reaction method from Cs2CO3 and NH4VO3. The Cs0.35V2O5/Cu composite material was prepared by the displacement reaction in CuSO4 solution using zinc powder as a reductant. The structure and electrochemical property of the so-prepared powders were characterized by means of XRD （powder X-ray diffraction） and the galvanostatic discharge-charge techniques. The results show that the electrochemical property of Cs0.35V2O5/Cu composite material is significantly improved compared to the bulk Cs0.35V2O5 material. The Cs0.35V2O5/Cu composite material exhibits the first discharge capacity as high as 164.3 mAh.g -1 in the range of 4.2-1.8V at a current rate of 10 mA.g-1 and remains at a stable discharge capacity of about 110 mAh.g-1 within 40 cycles.展开更多
AIM:To investigate the role of CXC chemokine receptor-4 (CXCR4) and stromal cell-derived factor-1 (SDF-1) in lymph node metastasis of gastric carcinoma.METHODS:In 40 cases of gastric cancer,expression of CXCR4 mRNA in...AIM:To investigate the role of CXC chemokine receptor-4 (CXCR4) and stromal cell-derived factor-1 (SDF-1) in lymph node metastasis of gastric carcinoma.METHODS:In 40 cases of gastric cancer,expression of CXCR4 mRNA in cancer and normal mucous membrane and SDF-1 mRNA in lymph nodes around the stomach was detected using quantitative polymerase chain reaction (PCR) (TaqMan) and immunohistochemistric assay.SGC-7901 and MGC80-3 cancer cells were used to investigate the effect of SDF-1 on cell proliferation and migration.RESULTS:Quantitative reverse transcription PCR and immunohistochemistry revealed that the expression level of CXCR4 in gastric cancer was significantly higher than that in normal mucous membrane (1.6244 ± 1.3801 vs 1.0715 ± 0.5243,P < 0.05).The expression level of CXCR4 mRNA in gastric cancer with lymph node metastasis was also significantly higher than that without lymph node metastasis (0.823 ± 0.551 vs 0.392 ± 0.338,P < 0.05).CXCR4 expression was significantly related to poorly differentiated,high tumor stage and lymph node metastasis.Significant differences in the expression level of SDF-1 mRNA were found between lymph nodes in metastatic gastric cancer and normal nodes (0.5432 ± 0.4907 vs 0.2640 ± 0.2601,P < 0.05).The positive expression of SDF-1 mRNA in lymph nodes of metastatic gastric cancer was consistent with the positive expression of CXCR4 mRNA in gastric cancer (r=0.776,P < 0.01).Additionally,human gastric cancer cell lines expressed CXCR4 and showed vigorous proliferation and migratory responses to SDF-1.AMD3100 (a specific CXCR4 antagonist) was also found to effectively reduce the migration of gastric cancer cells.CONCLUSION:The CXCR4/SDF-1 axis is involved in the lymph node metastasis of gastric cancer.CXCR4 is considered as a potential therapeutic target in the treatment of gastric cancer.展开更多
The electroless nickel plating on the surface of carbon fibers was prepared by pretreating the carbon fibers in order to increase their conductivity,and consequently enhance the EMI shielding effectiveness of the comp...The electroless nickel plating on the surface of carbon fibers was prepared by pretreating the carbon fibers in order to increase their conductivity,and consequently enhance the EMI shielding effectiveness of the composites.The relationship between the performance of depositing coat and pH value,temperature,reaction time and the way of agitation was studied.Results show that the depositing quality is stable under pH between 4.5 and 5.0,temperature between 75 ℃ and 85 ℃,reaction time for 10 min and air agitation.The uniform and compact nickel layer deposited on carbon fibers was proved by XRD and SEM,and the electrical resistivity of carbon fibers with nickel coating was tested.Results indicate that the electrical resistivity of carbon fibers with electroless nickel plating is decreased by an order of magnitude compared with that of carbon fibers.It means that nickel coating can greatly improve the electromagnetic interference shielding properties of carbon fibers.展开更多
Two series of molybdenum-containing MCM-41 catalysts were prepared for oxidative desulfurization ofdibenzothiophene （DBT） using t-butylhydroperoxide （TBHP） as the oxidant. The electronic properties, pore dimension...Two series of molybdenum-containing MCM-41 catalysts were prepared for oxidative desulfurization ofdibenzothiophene （DBT） using t-butylhydroperoxide （TBHP） as the oxidant. The electronic properties, pore dimension and hydrophilic properties of the catalysts were studied by XRD, BET, and 1R spectrometry. The Mo-Al2O3 catalyst and TiMCM-3% were also studied for comparison. The two series of MCM-41 zeolite with MoO3 in the framework or impregnated on the surface exhibited considerable activities at low MoO3 content and both were faxbetter than the Mo-Al2O3 catalyst, but had lower activities as compared to the TiMCM-3% catalyst. The catalysts with the highest activity were evaluated in a fixed-bed reactor. The concentration of DBT in model diesel upon oxidative desulfurization was successfully reduced from 5000 ppm to less than 150 ppm, but the catalysts were deactivated very fast. The probable reason was the high affinity of DBTO2 to the MCM-41 skeleton, especially to MoO3. The catalysts could restore most of its original activity by treating with alcohol.展开更多
文摘Aim A simple, sensitive and rapid RP HPLC method with pre column derivatization has been developed for the determination of sulphonylurea glimepiride in dog serum. Methods The sulphonylurea glimepiride was extracted from the dog serum using dichlromethane followed by derivatization with DNBF for 20 min at 100℃. The solvent was then evaporated at 60℃ under nitrogen, and the residue was taken up in 100 μL of mobile phase consisting of acetonitrile water (75∶30, v/v). The separation was performed on a Hypersil BDS C18 column with a flow rate of 0 8 mL·min -1 , and the ultraviolet detector wavelength was set at 350 nm. Results Extraction recovery ranged from 75.9% to 83.2%, and methodological recovery was between 96.5% and 109.3%. Within day RSD ranged from 1.5% to 6.3%, and inter day RSD was between 2 9% and 14.8%. The method showed good linearity (R=0.9998). Conclusion The method was simple, convenient and sensitive. The reaction of derivatization was reproducible.
文摘A pre-column derivatization HPLC method for the determination of peimine(P)and peiminine(PE)in Bulbus Fritillariae has been developed. Under the derivatization conditions optimized,the calibration curve is Y1=-3.83×103+1.33 ×105X1,r=0.998 for P and Y2=-7.86 × 102+6.33 × 104X2,r=0995 for PE,where Y is the peak area and X is the weight of the alkaloid; the average recovery is 98.0%(n=5, RSD=2.1%) for P and 101.0%(n=5,RSD=4.1%)for PE,the linear range is from 0.504 μg to 3.126μg for P and from 0.520μgto 3.328μgfor PE,respectively. Results of the determination of the two alkaloids in several samples of different Fritillaria species from various parts ofthe country are presented.The results suggest that P and PE are two major chemical constituents in bulbs of different Fritillaria species,and that the method developed is generally appli-cable to the determination of the hydroxy group on aliphatic fused ring systems without steric hin-drance.
文摘Aim A liquid chromatographic method for the determination ofcandicidin/FR-008 and related components in fermentation broth has been developed. Methods Therewere four major components in the candicidin/FR-008 complex, which were separated by HPLC under thefollowing conditions: SB-C8 column (4.6 mm x 250 mm, 5 μm) was used, the mobile phase consisted ofacetonitrileam-monium acteate (20 mmol·L^(-1) , pH 4.0) (40:60, V/V) , with a flow rate of 1 .0mL·min^(-1) , the UV detection wavelength was 380 nm, and the whole process was performed at 25℃ .Results The linearity was obtained in the range of 6.25 - 500 μg· mL^(-1) candicidin/FR-008 withthe regression equation of Y = 20 461 x + 30 748 and the correlation coefficient of 0.999 1. Theinstrument precision was 1.84% and the method precision was 3.8%. Conclusion This method isaccurate, rapid and simple; it can be used for determination of candicidin/FR-008 and relatedcomponents in fermentation broth.
文摘To find a reasonable way to prepare the designed CPP32 inhibitors. Method Ugifour-component condensation reaction was used to synthesize peptide mimic CPP32 inhibitors; ResultsA key isocyanide component (aspartate-derived isocyanide 3) and one of the designed CPP32inhibitors 4 (as a template) were synthesized; Conclusion The CPP32 inhibitor 4 was synthesized bythe newly developed procedure, which is an Ugi four-component condensation reaction based onaspartate-derived isocyanide 3. This method can be used to build up the CPP32 inhibitor library.
文摘A series of 2 (E) (4 hydroxy 3 methoxybenzylidene) 5 (N substituted ami nomethyl) cyclopentanones was synthesized and evaluated for the anti inflammatory activity. All of the target compounds were confirmed by spectral analysis and elemental analysis. Preliminary pharmacological tests showed that several compounds exerted appreciable inhibitory effect on xylene induced ear edema in mice and that alteration of the substituents of anilines had significant influence in anti inflammatory potency.
基金the University of Guilan Research Council for the partial support of this work
文摘A basic ionic liquid, namely 1,1＇-（butane-1,4-diyl）bis（1,4-diazabicyclo [2.2.2]octan-1-ium） hydrox-ide, was prepared and characterized using Fourier-transform infrared spectroscopy, XH nuclear magnetic resonance spectroscopy, and pH measurements. The ionic liquid was used for efficient promotion of the synthesis of pyrano[2,3-d]pyrimidinone and pyrido[2,3-d]pyrimidine derivatives at room temperature under grinding conditions. A simple procedure, short reaction time, high yields, non-column chromatographic separation, commercial availability of the starting materials, and recyclability of the catalyst are attractive features of this process.
基金support provided by the Shaanxi Provincial Education Project (09JK816)
文摘A type of visible light photocatalyst Bi2WO6 was prepared from Bi(NO3)3.5H2O and Na2WO4.2H2O by means of hydrothermal method and was characterized by UV-vis diffuse reflectance spectrometry and XRD.Oxidative desulfurization via photocatalysis was investigated using thiophene dissolved in octane as the model compound,with hydrogen peroxide used as the oxidant.The effects of hydrogen peroxide mass fraction,irradiation time,dosage of photocatalyst Bi2WO6 on the desulfurization efficiency were also investigated.Under suitable conditions,the desulfurization rate of model compound reached over 70%.
文摘Aim To determine the structure of the by-product produced in Grignard reaction for preparing mifepristone derivatives, and elucidate the reaction mechanism.Methods The structure of the by-product was determined with elemental analysis, one- and two-dimension spectra NMR (DEPT, 1H-1Hcosy, HMQC, HMBC) and compared with those of mifepristone.Results The main by-product was 11,17-di-addition product of Grignard reagent of N, N-dimethylamino phenyl bromide.Conclusion This is the first complete assignment of 1H NMR and 13C NMR of compound (3).
基金the Natural Science Foundation of China (No. 30070211).
文摘A multilayer perceptron neural network system is established to support the diagnosis for five most common heart diseases (coronary heart disease, rheumatic valvular heart disease, hypertension, chronic cor pulmonale and congenital heart disease). Momentum term, adaptive learning rate, the forgetting mechanics, and conjugate gradients method are introduced to improve the basic BP algorithm aiming to speed up the convergence of the BP algorithm and enhance the accuracy for diagnosis. A heart disease database consisting of 352 samples is applied to the training and testing courses of the system. The performance of the system is assessed by cross-validation method. It is found that as the basic BP algorithm is improved step by step, the convergence speed and the classification accuracy of the network are enhanced, and the system has great application prospect in supporting heart diseases diagnosis.
文摘Some new 2-thioxo thiazole, 2-thioxo 1,3,4- thiadiazole and 3-thioxo-1,3,4-triazole derivatives （3-17） have been synthesized through ring closure reactions ofdithioic formic acid hydrazones 2 with functional reagents in different medium. Former structures of the products have been established by the help of elemental and spectral analysis. Most of the obtained targets showed a moderate activity towards some microbes in comparison with two antibiotics Pipercillin and Mycostatine.
文摘Cs0.35V2O5 was successfully synthesized as cathode material for lithium secondary battery by the rheological phase reaction method from Cs2CO3 and NH4VO3. The Cs0.35V2O5/Cu composite material was prepared by the displacement reaction in CuSO4 solution using zinc powder as a reductant. The structure and electrochemical property of the so-prepared powders were characterized by means of XRD （powder X-ray diffraction） and the galvanostatic discharge-charge techniques. The results show that the electrochemical property of Cs0.35V2O5/Cu composite material is significantly improved compared to the bulk Cs0.35V2O5 material. The Cs0.35V2O5/Cu composite material exhibits the first discharge capacity as high as 164.3 mAh.g -1 in the range of 4.2-1.8V at a current rate of 10 mA.g-1 and remains at a stable discharge capacity of about 110 mAh.g-1 within 40 cycles.
基金Supported by The National Natural Science Foundation of China, No. 30772542
文摘AIM:To investigate the role of CXC chemokine receptor-4 (CXCR4) and stromal cell-derived factor-1 (SDF-1) in lymph node metastasis of gastric carcinoma.METHODS:In 40 cases of gastric cancer,expression of CXCR4 mRNA in cancer and normal mucous membrane and SDF-1 mRNA in lymph nodes around the stomach was detected using quantitative polymerase chain reaction (PCR) (TaqMan) and immunohistochemistric assay.SGC-7901 and MGC80-3 cancer cells were used to investigate the effect of SDF-1 on cell proliferation and migration.RESULTS:Quantitative reverse transcription PCR and immunohistochemistry revealed that the expression level of CXCR4 in gastric cancer was significantly higher than that in normal mucous membrane (1.6244 ± 1.3801 vs 1.0715 ± 0.5243,P < 0.05).The expression level of CXCR4 mRNA in gastric cancer with lymph node metastasis was also significantly higher than that without lymph node metastasis (0.823 ± 0.551 vs 0.392 ± 0.338,P < 0.05).CXCR4 expression was significantly related to poorly differentiated,high tumor stage and lymph node metastasis.Significant differences in the expression level of SDF-1 mRNA were found between lymph nodes in metastatic gastric cancer and normal nodes (0.5432 ± 0.4907 vs 0.2640 ± 0.2601,P < 0.05).The positive expression of SDF-1 mRNA in lymph nodes of metastatic gastric cancer was consistent with the positive expression of CXCR4 mRNA in gastric cancer (r=0.776,P < 0.01).Additionally,human gastric cancer cell lines expressed CXCR4 and showed vigorous proliferation and migratory responses to SDF-1.AMD3100 (a specific CXCR4 antagonist) was also found to effectively reduce the migration of gastric cancer cells.CONCLUSION:The CXCR4/SDF-1 axis is involved in the lymph node metastasis of gastric cancer.CXCR4 is considered as a potential therapeutic target in the treatment of gastric cancer.
文摘The electroless nickel plating on the surface of carbon fibers was prepared by pretreating the carbon fibers in order to increase their conductivity,and consequently enhance the EMI shielding effectiveness of the composites.The relationship between the performance of depositing coat and pH value,temperature,reaction time and the way of agitation was studied.Results show that the depositing quality is stable under pH between 4.5 and 5.0,temperature between 75 ℃ and 85 ℃,reaction time for 10 min and air agitation.The uniform and compact nickel layer deposited on carbon fibers was proved by XRD and SEM,and the electrical resistivity of carbon fibers with nickel coating was tested.Results indicate that the electrical resistivity of carbon fibers with electroless nickel plating is decreased by an order of magnitude compared with that of carbon fibers.It means that nickel coating can greatly improve the electromagnetic interference shielding properties of carbon fibers.
文摘Two series of molybdenum-containing MCM-41 catalysts were prepared for oxidative desulfurization ofdibenzothiophene （DBT） using t-butylhydroperoxide （TBHP） as the oxidant. The electronic properties, pore dimension and hydrophilic properties of the catalysts were studied by XRD, BET, and 1R spectrometry. The Mo-Al2O3 catalyst and TiMCM-3% were also studied for comparison. The two series of MCM-41 zeolite with MoO3 in the framework or impregnated on the surface exhibited considerable activities at low MoO3 content and both were faxbetter than the Mo-Al2O3 catalyst, but had lower activities as compared to the TiMCM-3% catalyst. The catalysts with the highest activity were evaluated in a fixed-bed reactor. The concentration of DBT in model diesel upon oxidative desulfurization was successfully reduced from 5000 ppm to less than 150 ppm, but the catalysts were deactivated very fast. The probable reason was the high affinity of DBTO2 to the MCM-41 skeleton, especially to MoO3. The catalysts could restore most of its original activity by treating with alcohol.
