Transfer RNA plays a fundamental role in the protein biosynthesis as an adaptor molecule by functioning as a biological link between the genetic nucleotide sequence in the mRNA and the amino acid sequence in the prote...Transfer RNA plays a fundamental role in the protein biosynthesis as an adaptor molecule by functioning as a biological link between the genetic nucleotide sequence in the mRNA and the amino acid sequence in the protein.To perform its role in protein biosynthesis,it has to be accurately recognized by aminoacyl-tRNA synthetases(aaRSs)to generate aminoacyl-tRNAs(aa-tRNAs).The correct pairing between an amino acid with its cognate tRNA is crucial for translational quality control.Production and utilization of mis-charged tRNAs are usually detrimental for all the species,resulting in cellular dysfunctions.Correct aa-tRNAs formation is collectively controlled by aaRSs with distinct mechanisms and/or other trans-factors.However,in very limited instances,mis-charged tRNAs are intermediate for specific pathways or essential components for the translational machinery.Here,from the point of accuracy in tRNA charging,we review our understanding about the mechanism ensuring correct aa-tRNA generation.In addition,some unique mis-charged tRNA species necessary for the organism are also briefly described.展开更多
We establish Talagrand＇s T2-transportation inequalities for infinite dimensional dissipative diffusions with sharp constants, through Galerkin type＇s approximations and the known results in the finite dimensional ca...We establish Talagrand＇s T2-transportation inequalities for infinite dimensional dissipative diffusions with sharp constants, through Galerkin type＇s approximations and the known results in the finite dimensional case. Furthermore in the additive noise case we prove also logarithmic Sobolev inequalities with sharp constants. Applications to Reaction- Diffusion equations are provided.展开更多
基金supported by the National Natural Science Foundation of China(31270852,31000355)the National Key Basic Research Program of China(2012CB911000)
文摘Transfer RNA plays a fundamental role in the protein biosynthesis as an adaptor molecule by functioning as a biological link between the genetic nucleotide sequence in the mRNA and the amino acid sequence in the protein.To perform its role in protein biosynthesis,it has to be accurately recognized by aminoacyl-tRNA synthetases(aaRSs)to generate aminoacyl-tRNAs(aa-tRNAs).The correct pairing between an amino acid with its cognate tRNA is crucial for translational quality control.Production and utilization of mis-charged tRNAs are usually detrimental for all the species,resulting in cellular dysfunctions.Correct aa-tRNAs formation is collectively controlled by aaRSs with distinct mechanisms and/or other trans-factors.However,in very limited instances,mis-charged tRNAs are intermediate for specific pathways or essential components for the translational machinery.Here,from the point of accuracy in tRNA charging,we review our understanding about the mechanism ensuring correct aa-tRNA generation.In addition,some unique mis-charged tRNA species necessary for the organism are also briefly described.
基金Project supported by the Yangtze Scholarship Program
文摘We establish Talagrand＇s T2-transportation inequalities for infinite dimensional dissipative diffusions with sharp constants, through Galerkin type＇s approximations and the known results in the finite dimensional case. Furthermore in the additive noise case we prove also logarithmic Sobolev inequalities with sharp constants. Applications to Reaction- Diffusion equations are provided.
