Objective To observe the influence of acupuncture on hypothalamus-pituitary-ovary axis (HPOA) in rats with primary dysmenorrhea, and to explore its mechanisms. Methods Effects of acupuncture on the concentration lev...Objective To observe the influence of acupuncture on hypothalamus-pituitary-ovary axis (HPOA) in rats with primary dysmenorrhea, and to explore its mechanisms. Methods Effects of acupuncture on the concentration level of β-endorphin (β-EP), hypothalamic hormone (gonadotropin-releasing hormone, GnRH), pituitary hormone (GnRH receptor GnRH-R, follicle stimulating hormone FSH, luteinizing hormone LH) and ovarian hormone (estrodiol E2, estrodiol receptor ER, progesterone P and progesterone receptor PR) were observed in dysmenorrheic rats. Results After receiving acupuncture treatment, the levels of 13- EP, GnRH, GnRH-R, FSH, LH, E2, ER, P and PR were changed, and this suggested that acupuncture had a regulative action on HPOA in dysmenorrheic rats. Conclusion The mechanism of acupuncture acting on the HPOA with primary dysmenorrhea might be its regulating role to the gonadal hormone of HPOA and its corresponding receptor expression.展开更多
The objective of this research was to study the effect of ECS on cumulus expansion and rate of nucleus maturation of bovine oocytes. Media maturation were used: (1) TCM 199 + FCS 10%; (2) TCM 199 + FCS 10% + E...The objective of this research was to study the effect of ECS on cumulus expansion and rate of nucleus maturation of bovine oocytes. Media maturation were used: (1) TCM 199 + FCS 10%; (2) TCM 199 + FCS 10% + ECS 5%; (3) TCM 199 + FCS 10% + ECS 7, 5%; (4) TCM 199 + FCS 10% + ECS 10%; (5) TCM 199 + ECS 10%. Supplementation of ECS had significantly difference (P 〈 0.05) on expansion of cumulus cells and rate of nucleus maturation. Supplementation of ECS 5% was the best result in expanded cumulus cells and metaphase II rate: 82% and 72% respectively. It was concluded that medium of TCM 199 + FCS 10%o + ECS 5% was the best maturation medium展开更多
The reasonable development and utilization of mountainous regions closely relates to local economic development and ecological security. The wine production region in the eastern foothills of the Helan Mountains in Ni...The reasonable development and utilization of mountainous regions closely relates to local economic development and ecological security. The wine production region in the eastern foothills of the Helan Mountains in Ningxia, Ningxia Hui Autonomous Region, with its excellent terroir, is emerging as one of China's three major geographical attractions. Based on surveys of tourism resources and spatial analysis for this wine producing region, we propose a highly representative and practicable path for wine tourism development. Based on China's national standard in Classification, Investigation and Evaluation of Tourism Resources(GB/T 18972-2003), which recommended the types and grades of tourism resources in one area, we conduct an analysis of resource characteristics and the current state of development. Using Arc GIS software, spatialautocorrelation analysis, average nearest neighbor analysis, as well as clustering and outlier analysis, we are able to derive the spatial distribution characteristics of tourism resources. Our survey showed that tourism resources in this area are relatively abundant and have good quality and clear combination advantages. Nonetheless, there are resources shortage for wine tourism and poor integration of wine production with the tourism industry. Regarding the spatial distribution of resources, we revealed the current states of and issues surrounding regions with concentrated resources, as well as characteristics of this clustering. Finally, we proposed a development path for wine tourism in this region based on the five dimensions of management mode, industrial path, product development, spatial optimization, and market development.展开更多
Through studies of the practical reasons for the Charter of Machu Picchu, this paper interprets the core ideas of the Charter, analyzes its historical limitations and proposes several suggestions for current urban and...Through studies of the practical reasons for the Charter of Machu Picchu, this paper interprets the core ideas of the Charter, analyzes its historical limitations and proposes several suggestions for current urban and rural planning.展开更多
Current methods that utilize simple data or models to judge whether soil fertility can selfdevelop are not sufficiently rigorous. A new framework has been set up using catastrophe theory, laboratory experiment, field ...Current methods that utilize simple data or models to judge whether soil fertility can selfdevelop are not sufficiently rigorous. A new framework has been set up using catastrophe theory, laboratory experiment, field work, and 3S(Geographic information system, Global positioning system, and Remote sensing) to explore soil fertility catastrophe under ecological restoration, discriminate whether soil fertility can self-develop, and propose adjustment of ecological restoration measures in the Zhuxi watershed of Changting County, Fujian Province, China, which is a typical representative of the red soil hilly region of China. The results show that: 1) the soil fertility is obviously improved through the four ecological restoration measures, which impels soil fertility catastrophe. Among 89 soil samples, catastrophic soil samples and stable soil samples account for 26(29.21%) and 63(70.79%) of the samples, respectively. The four ecological restoration measures are listed in the order lowquality forest improvement > arbor–bush–herb mixed plantation > orchard improvement > closing measures according to the proportions of catastrophic soil samples. A typical soil sample in Bashilihe that can self-develop is selected as the criterion to judge the upper lobe and lower lobe of soil fertility in the process surface of the Cusp catastrophe model. Twenty-six(29.21%) were in the middle lobe, 10(11.24%) were in the upper lobe, and 53(70.79%) were in the lower lobe. The catastrophic direction of 26 catastrophic soil samples is to the upper lobe according to soil and water loss change as well as fieldwork. There is a significant positive correlation of Δ with soil and water loss change, and the lower soil and water loss relates to higher catastrophic probability. 2) Soil fertility self-development could be regionalized as "Soil fertility can self-develop" whose area was 12.74 km2(28.33%) distributed mainly in the leftmost and rightmost parts, "Soil fertility tends to self-develop" whose area was 11.63 km2(25.89%) distributed mainly in the middle part, and "Soil fertility cannot self-develop" whose area was 20.58 km2(45.78%) distributed mainly between the above two types. 3) There is no need to take ecological restoration measures and excessive human interference should be avoided in the future in regions of "Soil fertility can self-develop" and "Soil fertility tends to self-develop," and ecological restoration measures should be taken in region of "Soil fertility cannot self-develop." 4) We suggest withdrawal and implementation of ecological restoration measures should be incorporated into the evaluation criteria of ecological restoration to avoid misuse of funds.展开更多
Urochondra setulosa (Trin.) C.E. Hubbard is a coastal halophytic grass thriving on the coastal dunes along the Pakistani seashore. This grass could be useful in coastal sand dune stabilization using seawater irrigat...Urochondra setulosa (Trin.) C.E. Hubbard is a coastal halophytic grass thriving on the coastal dunes along the Pakistani seashore. This grass could be useful in coastal sand dune stabilization using seawater irrigation. The purpose of this investigation was to test the hypothesis that Ca^2+ (0.0, 2.5, 5.0, 10.0 and 50.0 mmol/L) alleviates the adverse effects of KC1, MgSO4, NaC1 and Na2SO4 at 0, 200, 400, 600, 800 and 1000 mmol/L on the germination of Urochondra setulosa. Seed germination was inhibited with increase in salt concentration with few seeds germinated at and above 400 mmol/L concentration. No seed germinated in any of the KC1 treatments. Inclusion of CaC12 substantially alleviated the inhibitory effects of all salts. Germination was higher under photoperiod in comparison to those seeds germinated under complete darkness. Among the CaC12 concentrations used, 10 mmol/L was most effective in alleviating salinity effects and allowing few seeds to germinate at 1000 mmol/L KC1, MgSO4, NaC1 and Na2SO4 solution.展开更多
In order to describe the magnetic resonance imaging (MRI) findings in hypothalamic-pituitary area and its clinical relevance in patients with idiopathic growth hormone deficiency (IGHD), the MR imagings of 26 patients...In order to describe the magnetic resonance imaging (MRI) findings in hypothalamic-pituitary area and its clinical relevance in patients with idiopathic growth hormone deficiency (IGHD), the MR imagings of 26 patients with IGHD were analyzed. On MRI, 24 out of 26 cases (92. 3%) showed apparent pituitary upper margin depression; 8 out of 26 cases (30. 8%) showed definite pituitary stalk transection; 22 out of 26 cases (84. 6%) showed absence of the normal posterior pituitary bright spot. The bright lipidlike signal on T1W1 images at the median eminence distal to the breaking point (so-called ectopic posterior lobe) was found in 4 out of 26 cases (15. 4%). According to the MRI findings of the pituitary stalks, the 26 cases were divided into three groups; group A of 8 cases (31%) characterized by the definite transaction of stalk; group B of 13 cases (50%) defined by the possible stalk transection; and group C of 5 cases (19%) with no definite stalk transection.MRI findings were consistent with the clinical and endocrine tests. The stalk transection was statistically significantly difference in insulin test, L-dopa/p test, and height standard deviation score (P< 0.05). The MRI of hypothalamic-pituitary area may differentiate partial IGHD form stalk-transected, doubtful transection and without transection.展开更多
To determine whether the cyclic adenosine monophosphate (cAMP) mediated protein kinase signal transduction pathway is involved in the pyrogenic action of corticotropin releasing hormone (CRH) in rats.Methods Corticot...To determine whether the cyclic adenosine monophosphate (cAMP) mediated protein kinase signal transduction pathway is involved in the pyrogenic action of corticotropin releasing hormone (CRH) in rats.Methods Corticotropin releasing hormone, 2', 3 '-dideoxyadenosine (DDA) and adenosine-3', 5'(cyclic) monophosphorothionate, Rp-lsomer (Rp-cAMPS), were administered intracerebroventricularly (i.c.v.). The colonic temperature was measured using a thermistor, and the content of cAMP in the hypothalamus was determined by radioimmunoassay. Hypethalemic incubation was used to assess the effects of CRH on the content of cAMP in the hypothalamus in vitro.Results Microinjection (i.c.v.) of CRH (2.5 μg, 5.0 μg and 10 μg) caused increases in colonic temperature and the hypothalemus cAMP level in conscious rats. CRH increased hypothalemus cAMP level in vitro. The pyrogenic effects of CRH were abolished or markedly inhibited by prior injection (i. c. v. ) of an adenylate cyclase inhibitor, DDA (30 μg), or an inhibitor of cAMP-dependent protein kinase, Rp-cAMPS (15 μg).Conclusion cAMP mediates the pyrogenic action of centrally administered of CRH in rats, and protein kinase A may play an important role in the central CRH-induced fever. The cAMP-dependent protein kinase signal transduction pathway may be involved in the central mechanisms of the pyrogenic action of CRH in rats.展开更多
Objective: To evaluate the clinical effect of acupuncture in managing thalamic pain syndrome. Methods: Eighty patients with thalamic pain syndrome were randomly allocated into two groups, with 40 cases in the treatm...Objective: To evaluate the clinical effect of acupuncture in managing thalamic pain syndrome. Methods: Eighty patients with thalamic pain syndrome were randomly allocated into two groups, with 40 cases in the treatment group receiving combined scalp and body acupuncture treatment and 40 cases in the control group receiving single body acupuncture treatment. The intervention was given for 28 d in total, and the effects were evaluated after 14-day and 28-day treatments. Results: The inner-group comparison of McGill Pain Questionnaire (MPQ) showed significant differences after the treatment d 14 in both of the two groups (P〈0.05), and after the treatment d 28, the differences were even more significant (P〈0.01). After 28-day treatment, compared with pre-treatment, the Transcranial Doppler (TCD) test detected significant changes in the two groups (P〈0.05). The total effective rate was 72.5% in the treatment group versus 47.5% in the control group, and the difference was statistically significant (P〈0.05). The 3-month follow-up study found the relapse rate was 0 in the treatment group and 15.8% in the control group, and the difference was significant (P〈0.05). Conclusion: Acupuncture is effective in treating thalamic pain syndrome and combined scalp and body acupuncture can achieve even better results.展开更多
OBJECTIVE: To test the reliability and validity of dermatology life quality index(DLQI) in simplified Chinese language by assessing the quality of life(QoL) in HIV(human immunodeficiency virus)/AIDS(Acquired immunodef...OBJECTIVE: To test the reliability and validity of dermatology life quality index(DLQI) in simplified Chinese language by assessing the quality of life(QoL) in HIV(human immunodeficiency virus)/AIDS(Acquired immunodeficiency syndrome) patients with pruritic papular eruption(PPE). METHODS: A study of simplified-Chinese-versiond from10 questions with the principal component analysis and the contribution rate of the 3 common factors was 59.95%. CONCLUSION: The simplified-Chinese-version DIQL is an acceptable and valid scale for HIV/AIDS patients with PPE. It can be used to evaluate the QoL of HIV/AIDS patients with PPE in China.展开更多
基金National Basic Research Program of China(973 program,No:2006CB504502)Chinese Na-tional Foundation of Natural Sciences.(No.90209009)
文摘Objective To observe the influence of acupuncture on hypothalamus-pituitary-ovary axis (HPOA) in rats with primary dysmenorrhea, and to explore its mechanisms. Methods Effects of acupuncture on the concentration level of β-endorphin (β-EP), hypothalamic hormone (gonadotropin-releasing hormone, GnRH), pituitary hormone (GnRH receptor GnRH-R, follicle stimulating hormone FSH, luteinizing hormone LH) and ovarian hormone (estrodiol E2, estrodiol receptor ER, progesterone P and progesterone receptor PR) were observed in dysmenorrheic rats. Results After receiving acupuncture treatment, the levels of 13- EP, GnRH, GnRH-R, FSH, LH, E2, ER, P and PR were changed, and this suggested that acupuncture had a regulative action on HPOA in dysmenorrheic rats. Conclusion The mechanism of acupuncture acting on the HPOA with primary dysmenorrhea might be its regulating role to the gonadal hormone of HPOA and its corresponding receptor expression.
文摘The objective of this research was to study the effect of ECS on cumulus expansion and rate of nucleus maturation of bovine oocytes. Media maturation were used: (1) TCM 199 + FCS 10%; (2) TCM 199 + FCS 10% + ECS 5%; (3) TCM 199 + FCS 10% + ECS 7, 5%; (4) TCM 199 + FCS 10% + ECS 10%; (5) TCM 199 + ECS 10%. Supplementation of ECS had significantly difference (P 〈 0.05) on expansion of cumulus cells and rate of nucleus maturation. Supplementation of ECS 5% was the best result in expanded cumulus cells and metaphase II rate: 82% and 72% respectively. It was concluded that medium of TCM 199 + FCS 10%o + ECS 5% was the best maturation medium
基金supported by the National Natural Science Foundation of China (Grant Nos. 41071110 41701620)
文摘The reasonable development and utilization of mountainous regions closely relates to local economic development and ecological security. The wine production region in the eastern foothills of the Helan Mountains in Ningxia, Ningxia Hui Autonomous Region, with its excellent terroir, is emerging as one of China's three major geographical attractions. Based on surveys of tourism resources and spatial analysis for this wine producing region, we propose a highly representative and practicable path for wine tourism development. Based on China's national standard in Classification, Investigation and Evaluation of Tourism Resources(GB/T 18972-2003), which recommended the types and grades of tourism resources in one area, we conduct an analysis of resource characteristics and the current state of development. Using Arc GIS software, spatialautocorrelation analysis, average nearest neighbor analysis, as well as clustering and outlier analysis, we are able to derive the spatial distribution characteristics of tourism resources. Our survey showed that tourism resources in this area are relatively abundant and have good quality and clear combination advantages. Nonetheless, there are resources shortage for wine tourism and poor integration of wine production with the tourism industry. Regarding the spatial distribution of resources, we revealed the current states of and issues surrounding regions with concentrated resources, as well as characteristics of this clustering. Finally, we proposed a development path for wine tourism in this region based on the five dimensions of management mode, industrial path, product development, spatial optimization, and market development.
文摘Through studies of the practical reasons for the Charter of Machu Picchu, this paper interprets the core ideas of the Charter, analyzes its historical limitations and proposes several suggestions for current urban and rural planning.
基金funded by the National Natural Science Foundation of China(Grant Nos.41371512,41001170)
文摘Current methods that utilize simple data or models to judge whether soil fertility can selfdevelop are not sufficiently rigorous. A new framework has been set up using catastrophe theory, laboratory experiment, field work, and 3S(Geographic information system, Global positioning system, and Remote sensing) to explore soil fertility catastrophe under ecological restoration, discriminate whether soil fertility can self-develop, and propose adjustment of ecological restoration measures in the Zhuxi watershed of Changting County, Fujian Province, China, which is a typical representative of the red soil hilly region of China. The results show that: 1) the soil fertility is obviously improved through the four ecological restoration measures, which impels soil fertility catastrophe. Among 89 soil samples, catastrophic soil samples and stable soil samples account for 26(29.21%) and 63(70.79%) of the samples, respectively. The four ecological restoration measures are listed in the order lowquality forest improvement > arbor–bush–herb mixed plantation > orchard improvement > closing measures according to the proportions of catastrophic soil samples. A typical soil sample in Bashilihe that can self-develop is selected as the criterion to judge the upper lobe and lower lobe of soil fertility in the process surface of the Cusp catastrophe model. Twenty-six(29.21%) were in the middle lobe, 10(11.24%) were in the upper lobe, and 53(70.79%) were in the lower lobe. The catastrophic direction of 26 catastrophic soil samples is to the upper lobe according to soil and water loss change as well as fieldwork. There is a significant positive correlation of Δ with soil and water loss change, and the lower soil and water loss relates to higher catastrophic probability. 2) Soil fertility self-development could be regionalized as "Soil fertility can self-develop" whose area was 12.74 km2(28.33%) distributed mainly in the leftmost and rightmost parts, "Soil fertility tends to self-develop" whose area was 11.63 km2(25.89%) distributed mainly in the middle part, and "Soil fertility cannot self-develop" whose area was 20.58 km2(45.78%) distributed mainly between the above two types. 3) There is no need to take ecological restoration measures and excessive human interference should be avoided in the future in regions of "Soil fertility can self-develop" and "Soil fertility tends to self-develop," and ecological restoration measures should be taken in region of "Soil fertility cannot self-develop." 4) We suggest withdrawal and implementation of ecological restoration measures should be incorporated into the evaluation criteria of ecological restoration to avoid misuse of funds.
基金Project supported by the 16th Pakistan-China Cooperation Project(Study on Sustainable Halophytes Utilization, No. 16-413)
文摘Urochondra setulosa (Trin.) C.E. Hubbard is a coastal halophytic grass thriving on the coastal dunes along the Pakistani seashore. This grass could be useful in coastal sand dune stabilization using seawater irrigation. The purpose of this investigation was to test the hypothesis that Ca^2+ (0.0, 2.5, 5.0, 10.0 and 50.0 mmol/L) alleviates the adverse effects of KC1, MgSO4, NaC1 and Na2SO4 at 0, 200, 400, 600, 800 and 1000 mmol/L on the germination of Urochondra setulosa. Seed germination was inhibited with increase in salt concentration with few seeds germinated at and above 400 mmol/L concentration. No seed germinated in any of the KC1 treatments. Inclusion of CaC12 substantially alleviated the inhibitory effects of all salts. Germination was higher under photoperiod in comparison to those seeds germinated under complete darkness. Among the CaC12 concentrations used, 10 mmol/L was most effective in alleviating salinity effects and allowing few seeds to germinate at 1000 mmol/L KC1, MgSO4, NaC1 and Na2SO4 solution.
文摘In order to describe the magnetic resonance imaging (MRI) findings in hypothalamic-pituitary area and its clinical relevance in patients with idiopathic growth hormone deficiency (IGHD), the MR imagings of 26 patients with IGHD were analyzed. On MRI, 24 out of 26 cases (92. 3%) showed apparent pituitary upper margin depression; 8 out of 26 cases (30. 8%) showed definite pituitary stalk transection; 22 out of 26 cases (84. 6%) showed absence of the normal posterior pituitary bright spot. The bright lipidlike signal on T1W1 images at the median eminence distal to the breaking point (so-called ectopic posterior lobe) was found in 4 out of 26 cases (15. 4%). According to the MRI findings of the pituitary stalks, the 26 cases were divided into three groups; group A of 8 cases (31%) characterized by the definite transaction of stalk; group B of 13 cases (50%) defined by the possible stalk transection; and group C of 5 cases (19%) with no definite stalk transection.MRI findings were consistent with the clinical and endocrine tests. The stalk transection was statistically significantly difference in insulin test, L-dopa/p test, and height standard deviation score (P< 0.05). The MRI of hypothalamic-pituitary area may differentiate partial IGHD form stalk-transected, doubtful transection and without transection.
基金ThisworkwassupportedbytheNationalNaturalScienceFoundationofChina (No 3970 0 0 5 5 )
文摘To determine whether the cyclic adenosine monophosphate (cAMP) mediated protein kinase signal transduction pathway is involved in the pyrogenic action of corticotropin releasing hormone (CRH) in rats.Methods Corticotropin releasing hormone, 2', 3 '-dideoxyadenosine (DDA) and adenosine-3', 5'(cyclic) monophosphorothionate, Rp-lsomer (Rp-cAMPS), were administered intracerebroventricularly (i.c.v.). The colonic temperature was measured using a thermistor, and the content of cAMP in the hypothalamus was determined by radioimmunoassay. Hypethalemic incubation was used to assess the effects of CRH on the content of cAMP in the hypothalamus in vitro.Results Microinjection (i.c.v.) of CRH (2.5 μg, 5.0 μg and 10 μg) caused increases in colonic temperature and the hypothalemus cAMP level in conscious rats. CRH increased hypothalemus cAMP level in vitro. The pyrogenic effects of CRH were abolished or markedly inhibited by prior injection (i. c. v. ) of an adenylate cyclase inhibitor, DDA (30 μg), or an inhibitor of cAMP-dependent protein kinase, Rp-cAMPS (15 μg).Conclusion cAMP mediates the pyrogenic action of centrally administered of CRH in rats, and protein kinase A may play an important role in the central CRH-induced fever. The cAMP-dependent protein kinase signal transduction pathway may be involved in the central mechanisms of the pyrogenic action of CRH in rats.
基金Projects of Chinese and Western Medicine of Tianjin Health Bureau (2005035)
文摘Objective: To evaluate the clinical effect of acupuncture in managing thalamic pain syndrome. Methods: Eighty patients with thalamic pain syndrome were randomly allocated into two groups, with 40 cases in the treatment group receiving combined scalp and body acupuncture treatment and 40 cases in the control group receiving single body acupuncture treatment. The intervention was given for 28 d in total, and the effects were evaluated after 14-day and 28-day treatments. Results: The inner-group comparison of McGill Pain Questionnaire (MPQ) showed significant differences after the treatment d 14 in both of the two groups (P〈0.05), and after the treatment d 28, the differences were even more significant (P〈0.01). After 28-day treatment, compared with pre-treatment, the Transcranial Doppler (TCD) test detected significant changes in the two groups (P〈0.05). The total effective rate was 72.5% in the treatment group versus 47.5% in the control group, and the difference was statistically significant (P〈0.05). The 3-month follow-up study found the relapse rate was 0 in the treatment group and 15.8% in the control group, and the difference was significant (P〈0.05). Conclusion: Acupuncture is effective in treating thalamic pain syndrome and combined scalp and body acupuncture can achieve even better results.
基金Supported by the National Special S&T Program on Major Infectious Diseases(No.2008ZX 10005-003,No.2012ZX10004905-003-003)Innovation Scientists and Technicians Troop Construction Projects of Zhengzhou City(No.10CXTD140)
文摘OBJECTIVE: To test the reliability and validity of dermatology life quality index(DLQI) in simplified Chinese language by assessing the quality of life(QoL) in HIV(human immunodeficiency virus)/AIDS(Acquired immunodeficiency syndrome) patients with pruritic papular eruption(PPE). METHODS: A study of simplified-Chinese-versiond from10 questions with the principal component analysis and the contribution rate of the 3 common factors was 59.95%. CONCLUSION: The simplified-Chinese-version DIQL is an acceptable and valid scale for HIV/AIDS patients with PPE. It can be used to evaluate the QoL of HIV/AIDS patients with PPE in China.