MicroRNAs （miRNAs） are endogenous -22 nucleofide-long noncoding RNAs. In this study, to investigate miRNA expression profiles and their functions in mammary gland development, we have used microarray as well as qRT-...MicroRNAs （miRNAs） are endogenous -22 nucleofide-long noncoding RNAs. In this study, to investigate miRNA expression profiles and their functions in mammary gland development, we have used microarray as well as qRT-PCR, to analyze the miRNA expression changes along the murine mammary cycle during pregnancy, particularly on transition from pregnancy to lactation. It shows that every developmental stage of the mammary gland has its own mjRNA expression pattern. Compared with virgin and involution, some miRNAs such as miR-138 and miR-431 are downregulated, whereas, some miRNAs such as miR-133 and miR-133a-133b are upregulated during pregnancy and lactation. These results indicate that miRNAs are functionally involved in mammary gland development.展开更多
Cell cycle kinetic activity in the cortical cells of the lentil (Lens culinaris Me-die. cv. Verte du Puy) primary root during germination was examined both temporally and spatially. Immunohistochemical and cytological...Cell cycle kinetic activity in the cortical cells of the lentil (Lens culinaris Me-die. cv. Verte du Puy) primary root during germination was examined both temporally and spatially. Immunohistochemical and cytological evidence indicated that DNA replication and cell division started in the cortical cells of tire lentil primary root after around 13 and 17 h of imbibition, respectively. The first cells in DNA synthesis and the First mitotic figures all appeared in the cortical cells about I mm front the root-cap junction, but these divided cells had synthesized their DNA during the maturity of seed instead of during germination. The kinetic pattern of activity of the first cell cycle showed that these cells were not activated synchronously, but re-entered the cell cycle in turn depending on their places in the root tip, However, the adjacent cells partially synchronously proceeded their cell cycle.展开更多
In this paper we discuss the anti-periodic problem for a class of abstractnonlinear second-order evolution equations associated with maximal monotone operators in Hilbertspaces and give some new assumptions on operato...In this paper we discuss the anti-periodic problem for a class of abstractnonlinear second-order evolution equations associated with maximal monotone operators in Hilbertspaces and give some new assumptions on operators. We establish the existence and uniqueness ofanti-periodic solutions, which improve andgeneralize the results that have been obtained. Finally weillustrate the abstract theory by discussing a simple example of an anti-periodic problem fornonlinear partial differential equations.展开更多
Since the automotive industry has many possible applications for semi-solid metal (SSM)-high-pressure die casting (HPDC) parts, the newly developed heat treatment cycles, as well as the traditional heat treatment cycl...Since the automotive industry has many possible applications for semi-solid metal (SSM)-high-pressure die casting (HPDC) parts, the newly developed heat treatment cycles, as well as the traditional heat treatment cycles, were applied to A356 brake calipers cast using a LK DCC630 HPDC machine.Vickers hardness measurements at a cross section of the brake calipers were performed, indicating that similar values can be obtained when using the significantly shorter heat treatment cycles.Finally, the typical tensile properties that can be obtained for SSM-HPDC A356 brake calipers are compared with those manufactured by gravity die casting.Results indicate that the differences in microstructures (globular or dendritic) do not have a noteworthy effect on the heat treatment response.This implies that the short heat treatment cycles originally developed for globular SSM-HPDC A356 castings can be successfully applied to dendritic liquid A356 castings too.展开更多
Recurrent acute pancreatitis(RAP) is defined based on the occurrence of two or more episodes of acute pancreatitis. The initial evaluation fails to detect the cause of RAP in 10%-30% of patients, whose condition is cl...Recurrent acute pancreatitis(RAP) is defined based on the occurrence of two or more episodes of acute pancreatitis. The initial evaluation fails to detect the cause of RAP in 10%-30% of patients, whose condition is classified as idiopathic RAP(IRAP). Idiopathic acute pancreatitis(IAP) is a diagnostic challenge for gastroenterologists. In view of associated morbidity and mortality, it is important to determine the aetiology of pancreatitis to provide early treatment and prevent recurrence. Endoscopic ultrasound(EUS) is an investigation of choice for imaging of pancreas and biliary tract. In view of high diagnostic accuracy and safety of EUS, a EUS based management strategy appears to be a reasonable approach for evaluation of patients with a single/recurrent idiopathic pancreatitis. The most common diagnoses by EUS in IAP is biliary tract disease. The present review aims to discuss the role of EUS in the clinical management and diagnosis of patients with IAP. It elaborates the diagnostic approach to IAP in relation to EUS and other different modalities. Controversial issues in IAP like when to perform EUS, whether to perform after first episode or recurrent episodes, comparison among different investigations and the latest evidence significance are detailed.展开更多
Exhaust hot water （EHW） is widely used for various industrial processes. However, the excess heat carried by EHW is typically ignored and discharged into the environment, resulting in heat loss and heat pollution. A...Exhaust hot water （EHW） is widely used for various industrial processes. However, the excess heat carried by EHW is typically ignored and discharged into the environment, resulting in heat loss and heat pollution. An organic Rankine cycle （ORC） is an attractive technology to recycle heat from low-temperature energy carriers. Herein, ORC was used to recycle the heat carried by EHW. To investigate the energy and exergy recovery effects of EHW, a mathematical model was developed and a parametric study was conducted. The energy efficiency and exergy efficiency of the EHW-driven ORC system were modeled with R245fa, Rl13 and R123 as the working fluids. The results demonstrate that the EHW and evaporation temperatures have significant effects on the energy and exergy efficiencies of the EHW-driven ORC system. Under given EHW conditions, an optimum evaporation temperature exists corresponding to the highest exergy efficiency. To further use the low-temperature EHW, a configuration retrofitted to the ORC by combining with flash evaporation （FE） was conducted. For an EHW at 120 ~C and 0.2 MPa, the maximum exergy efficiency of the FE-ORC system is 45.91% at a flash pressure of 0.088 MPa. The FE-ORC performs better in exergy efficiency than the basic FE and basic EHW-driven ORC.展开更多
It is desired to obtain the joint probability distribution(JPD) over a set of random variables with local data, so as to avoid the hard work to collect statistical data in the scale of all variables. A lot of work has...It is desired to obtain the joint probability distribution(JPD) over a set of random variables with local data, so as to avoid the hard work to collect statistical data in the scale of all variables. A lot of work has been done when all variables are in a known directed acyclic graph(DAG). However, steady directed cyclic graphs(DCGs) may be involved when we simply combine modules containing local data together, where a module is composed of a child variable and its parent variables. So far, the physical and statistical meaning of steady DCGs remain unclear and unsolved. This paper illustrates the physical and statistical meaning of steady DCGs, and presents a method to calculate the JPD with local data, given that all variables are in a known single-valued Dynamic Uncertain Causality Graph(S-DUCG), and thus defines a new Bayesian Network with steady DCGs. The so-called single-valued means that only the causes of the true state of a variable are specified, while the false state is the complement of the true state.展开更多
Germinal centers （GC） of secondary lymphoid tissues are critical to mounting a high-affinity humoral immune response. B cells within the GC undergo rapid clonal expansion and selection while diversifying their antib...Germinal centers （GC） of secondary lymphoid tissues are critical to mounting a high-affinity humoral immune response. B cells within the GC undergo rapid clonal expansion and selection while diversifying their antibody genes. Although it is generally believed that GC B cells employ a unique proliferative program to accommodate these processes, little is known about how the GC-associated cell cycle is orchestrated. The D-type cyclins constitute an important component of the cell cycle engine that enables the cells to respond to physiological changes. Cell type- and developmental stage-specific roles of D-type cyclins have been described but the cyclin D requirement during GC reaction has not been addressed. In this study, we report that cyclin D3 is largely dispensable for proliferation and Ig class switching of in vitro activated B cells. In contrast, GC development in Ccnd3^-/- mice is markedly impaired, as is the T cell-dependent antibody response. Within the GC, although both switched and unswitched B cells are affected by cyclin D3 inactivation, the IgM^- pool is more severely reduced. Interestingly, despite a compensatory increase in cyclln D2 expression, a significant number of Ccnd3^-/- GC B cells accumulate in quiescent GO state. Lastly, although cyclin D3 inactivation did not disrupt BCL6 expression in GC B cells, it completely blocked the GC promoting effect of BCL6 overexpression, suggesting that cyclin D3 acts downstream of BCL6 to regulate GC formation. This is the first demonstration that cyclin D3 plays an important and unique role at the GC stage of B cell development.展开更多
Along with the popularization of artificial intelligence and information technology, the development of automobile industry have been closely combined with information technology, environmental protection and energy s...Along with the popularization of artificial intelligence and information technology, the development of automobile industry have been closely combined with information technology, environmental protection and energy saving ideas, promotion and application of electronic control technology, which development cycle becoming shorter and shorter. In this paper, through the analysis of the present application situation and development trend of the automobile electronic technology at present, in order to provide a theoretical reference for the future development of the automobile electronic control technology.展开更多
In this paper, the Life Cycle of Urban Development was firstly analyzed, and the phases of Life Cycle Assessment applied to Urban Development (ULCA) were described. As a case study, ULCA was applied in the environment...In this paper, the Life Cycle of Urban Development was firstly analyzed, and the phases of Life Cycle Assessment applied to Urban Development (ULCA) were described. As a case study, ULCA was applied in the environmental impact assessment of the land readjustment project of Hyogo District of Saga, Japan. In addition, mitigation proposals for reducing CO2 were also presented and the relevant environmental ef-fects were simulated.展开更多
To adapt to the change in the demand of the oil refining market,two hydrocracking catalysts,RHC-1 and RHC-5,were developed to improve the quality of tail oil.The catalysts were designed based on the theory of selectiv...To adapt to the change in the demand of the oil refining market,two hydrocracking catalysts,RHC-1 and RHC-5,were developed to improve the quality of tail oil.The catalysts were designed based on the theory of selective ring-opening.By selecting more acidic molecular sieves,the problem of poor selectivity of conventional materials can be solved to properly match up to the hydrogenation performance of catalysts.Compared with the performance of previous catalysts,the quality of the tail oil achieved by the said catalysts is better,and the BMCI is reduced by 1—2 units.In the long cycle operation of the petroleum industry,the good quality of the tail oil has been verified and the adaptability of the process conditions is good.When the RHC-1 catalyst is used to process heavy feed under medium pressure,a BMCI value of about12 can be obtained along with a nearly 60%yield of tail oil.The total yield of chemical raw material(steaming cracking feed+catalytic reforming feed)can exceed 80%,and the hydrogen consumption has dropped by nearly 50%as compared to the conventional hydrocracking conversion rate.When processing a mixed CGO and VGO feed with the full conversion mode under a hydrogen pressure of 13.0 MPa,the RHC-5 catalyst can yield about 68.4%of heavy naphtha with a potential aromatic content of up to 50.6,while the total yield of chemical raw materials can reach more than 98%.The results of industrial application of these catalysts show that more than 30%of high quality tail oil can be obtained via processing of inferior quality feed,and its BMCI value can reach 10.7.The total yield of chemical raw materials can reach more than65%.The industrial operation process has implemented two operating cycles totaling 8 years.展开更多
基金This work was supported by the Doctor Study Project of Heilongjiang Education in 2005.
文摘MicroRNAs （miRNAs） are endogenous -22 nucleofide-long noncoding RNAs. In this study, to investigate miRNA expression profiles and their functions in mammary gland development, we have used microarray as well as qRT-PCR, to analyze the miRNA expression changes along the murine mammary cycle during pregnancy, particularly on transition from pregnancy to lactation. It shows that every developmental stage of the mammary gland has its own mjRNA expression pattern. Compared with virgin and involution, some miRNAs such as miR-138 and miR-431 are downregulated, whereas, some miRNAs such as miR-133 and miR-133a-133b are upregulated during pregnancy and lactation. These results indicate that miRNAs are functionally involved in mammary gland development.
文摘Cell cycle kinetic activity in the cortical cells of the lentil (Lens culinaris Me-die. cv. Verte du Puy) primary root during germination was examined both temporally and spatially. Immunohistochemical and cytological evidence indicated that DNA replication and cell division started in the cortical cells of tire lentil primary root after around 13 and 17 h of imbibition, respectively. The first cells in DNA synthesis and the First mitotic figures all appeared in the cortical cells about I mm front the root-cap junction, but these divided cells had synthesized their DNA during the maturity of seed instead of during germination. The kinetic pattern of activity of the first cell cycle showed that these cells were not activated synchronously, but re-entered the cell cycle in turn depending on their places in the root tip, However, the adjacent cells partially synchronously proceeded their cell cycle.
文摘In this paper we discuss the anti-periodic problem for a class of abstractnonlinear second-order evolution equations associated with maximal monotone operators in Hilbertspaces and give some new assumptions on operators. We establish the existence and uniqueness ofanti-periodic solutions, which improve andgeneralize the results that have been obtained. Finally weillustrate the abstract theory by discussing a simple example of an anti-periodic problem fornonlinear partial differential equations.
文摘Since the automotive industry has many possible applications for semi-solid metal (SSM)-high-pressure die casting (HPDC) parts, the newly developed heat treatment cycles, as well as the traditional heat treatment cycles, were applied to A356 brake calipers cast using a LK DCC630 HPDC machine.Vickers hardness measurements at a cross section of the brake calipers were performed, indicating that similar values can be obtained when using the significantly shorter heat treatment cycles.Finally, the typical tensile properties that can be obtained for SSM-HPDC A356 brake calipers are compared with those manufactured by gravity die casting.Results indicate that the differences in microstructures (globular or dendritic) do not have a noteworthy effect on the heat treatment response.This implies that the short heat treatment cycles originally developed for globular SSM-HPDC A356 castings can be successfully applied to dendritic liquid A356 castings too.
文摘Recurrent acute pancreatitis(RAP) is defined based on the occurrence of two or more episodes of acute pancreatitis. The initial evaluation fails to detect the cause of RAP in 10%-30% of patients, whose condition is classified as idiopathic RAP(IRAP). Idiopathic acute pancreatitis(IAP) is a diagnostic challenge for gastroenterologists. In view of associated morbidity and mortality, it is important to determine the aetiology of pancreatitis to provide early treatment and prevent recurrence. Endoscopic ultrasound(EUS) is an investigation of choice for imaging of pancreas and biliary tract. In view of high diagnostic accuracy and safety of EUS, a EUS based management strategy appears to be a reasonable approach for evaluation of patients with a single/recurrent idiopathic pancreatitis. The most common diagnoses by EUS in IAP is biliary tract disease. The present review aims to discuss the role of EUS in the clinical management and diagnosis of patients with IAP. It elaborates the diagnostic approach to IAP in relation to EUS and other different modalities. Controversial issues in IAP like when to perform EUS, whether to perform after first episode or recurrent episodes, comparison among different investigations and the latest evidence significance are detailed.
基金Projects（51704069, 51734004, 71403175） supported by the National Natural Science Foundation of China Project（N162504011） supported by the Fundamental Research Funds for the Central Universities, China
文摘Exhaust hot water （EHW） is widely used for various industrial processes. However, the excess heat carried by EHW is typically ignored and discharged into the environment, resulting in heat loss and heat pollution. An organic Rankine cycle （ORC） is an attractive technology to recycle heat from low-temperature energy carriers. Herein, ORC was used to recycle the heat carried by EHW. To investigate the energy and exergy recovery effects of EHW, a mathematical model was developed and a parametric study was conducted. The energy efficiency and exergy efficiency of the EHW-driven ORC system were modeled with R245fa, Rl13 and R123 as the working fluids. The results demonstrate that the EHW and evaporation temperatures have significant effects on the energy and exergy efficiencies of the EHW-driven ORC system. Under given EHW conditions, an optimum evaporation temperature exists corresponding to the highest exergy efficiency. To further use the low-temperature EHW, a configuration retrofitted to the ORC by combining with flash evaporation （FE） was conducted. For an EHW at 120 ~C and 0.2 MPa, the maximum exergy efficiency of the FE-ORC system is 45.91% at a flash pressure of 0.088 MPa. The FE-ORC performs better in exergy efficiency than the basic FE and basic EHW-driven ORC.
基金supported by the National Natural Science Foundation of China under Grant 71671103
文摘It is desired to obtain the joint probability distribution(JPD) over a set of random variables with local data, so as to avoid the hard work to collect statistical data in the scale of all variables. A lot of work has been done when all variables are in a known directed acyclic graph(DAG). However, steady directed cyclic graphs(DCGs) may be involved when we simply combine modules containing local data together, where a module is composed of a child variable and its parent variables. So far, the physical and statistical meaning of steady DCGs remain unclear and unsolved. This paper illustrates the physical and statistical meaning of steady DCGs, and presents a method to calculate the JPD with local data, given that all variables are in a known single-valued Dynamic Uncertain Causality Graph(S-DUCG), and thus defines a new Bayesian Network with steady DCGs. The so-called single-valued means that only the causes of the true state of a variable are specified, while the false state is the complement of the true state.
文摘Germinal centers （GC） of secondary lymphoid tissues are critical to mounting a high-affinity humoral immune response. B cells within the GC undergo rapid clonal expansion and selection while diversifying their antibody genes. Although it is generally believed that GC B cells employ a unique proliferative program to accommodate these processes, little is known about how the GC-associated cell cycle is orchestrated. The D-type cyclins constitute an important component of the cell cycle engine that enables the cells to respond to physiological changes. Cell type- and developmental stage-specific roles of D-type cyclins have been described but the cyclin D requirement during GC reaction has not been addressed. In this study, we report that cyclin D3 is largely dispensable for proliferation and Ig class switching of in vitro activated B cells. In contrast, GC development in Ccnd3^-/- mice is markedly impaired, as is the T cell-dependent antibody response. Within the GC, although both switched and unswitched B cells are affected by cyclin D3 inactivation, the IgM^- pool is more severely reduced. Interestingly, despite a compensatory increase in cyclln D2 expression, a significant number of Ccnd3^-/- GC B cells accumulate in quiescent GO state. Lastly, although cyclin D3 inactivation did not disrupt BCL6 expression in GC B cells, it completely blocked the GC promoting effect of BCL6 overexpression, suggesting that cyclin D3 acts downstream of BCL6 to regulate GC formation. This is the first demonstration that cyclin D3 plays an important and unique role at the GC stage of B cell development.
文摘Along with the popularization of artificial intelligence and information technology, the development of automobile industry have been closely combined with information technology, environmental protection and energy saving ideas, promotion and application of electronic control technology, which development cycle becoming shorter and shorter. In this paper, through the analysis of the present application situation and development trend of the automobile electronic technology at present, in order to provide a theoretical reference for the future development of the automobile electronic control technology.
文摘In this paper, the Life Cycle of Urban Development was firstly analyzed, and the phases of Life Cycle Assessment applied to Urban Development (ULCA) were described. As a case study, ULCA was applied in the environmental impact assessment of the land readjustment project of Hyogo District of Saga, Japan. In addition, mitigation proposals for reducing CO2 were also presented and the relevant environmental ef-fects were simulated.
基金the financial support from the SINOPEC(No.114016)
文摘To adapt to the change in the demand of the oil refining market,two hydrocracking catalysts,RHC-1 and RHC-5,were developed to improve the quality of tail oil.The catalysts were designed based on the theory of selective ring-opening.By selecting more acidic molecular sieves,the problem of poor selectivity of conventional materials can be solved to properly match up to the hydrogenation performance of catalysts.Compared with the performance of previous catalysts,the quality of the tail oil achieved by the said catalysts is better,and the BMCI is reduced by 1—2 units.In the long cycle operation of the petroleum industry,the good quality of the tail oil has been verified and the adaptability of the process conditions is good.When the RHC-1 catalyst is used to process heavy feed under medium pressure,a BMCI value of about12 can be obtained along with a nearly 60%yield of tail oil.The total yield of chemical raw material(steaming cracking feed+catalytic reforming feed)can exceed 80%,and the hydrogen consumption has dropped by nearly 50%as compared to the conventional hydrocracking conversion rate.When processing a mixed CGO and VGO feed with the full conversion mode under a hydrogen pressure of 13.0 MPa,the RHC-5 catalyst can yield about 68.4%of heavy naphtha with a potential aromatic content of up to 50.6,while the total yield of chemical raw materials can reach more than 98%.The results of industrial application of these catalysts show that more than 30%of high quality tail oil can be obtained via processing of inferior quality feed,and its BMCI value can reach 10.7.The total yield of chemical raw materials can reach more than65%.The industrial operation process has implemented two operating cycles totaling 8 years.
