Based on archaeological excavations, 217 samples were collected from the Luotuodun Site. Of them 63 samples from the section plane of the site layer were used for identification analysis of foraminifera, plant debris ...Based on archaeological excavations, 217 samples were collected from the Luotuodun Site. Of them 63 samples from the section plane of the site layer were used for identification analysis of foraminifera, plant debris and seed fossils, and four samples were used for 14C dating and relevant analysis. Through many kinds of experiments, we have drawn some conclusions. Firstly, benthic foraminifera, such as Ammonia compressiuscula and Ammonia cff. sobrina, are found in the lOth layer, indicating that between 7500 and 5400 BC, i.e. before the emergence of the Majiabang Culture, Luotuodun Site and its nearby regions had ever experienced a marine transgression event. Secondly, we have found 450 plant fossils in this site, such as Polygonum sp., Scripus sp., Najas sp., Physalis sp., which indicated lacustrine or swamp environment.展开更多
Natural products,as major resources for drug discovery historically,are gaining more attentions recently due to the advancement in genomic sequencing and other technologies,which makes them attractive and amenable to ...Natural products,as major resources for drug discovery historically,are gaining more attentions recently due to the advancement in genomic sequencing and other technologies,which makes them attractive and amenable to drug candidate screening.Collecting and mining the bioactivity information of natural products are extremely important for accelerating drug development process by reducing cost.Lately,a number of publicly accessible databases have been established to facilitate the access to the chemical biology data for small molecules including natural products.Thus,it is imperative for scientists in related fields to exploit these resources in order to expedite their researches on natural products as drug leads/candidates for disease treatment.PubChem,as a public database,contains large amounts of natural products associated with bioactivity data.In this review,we introduce the information system provided at PubChem,and systematically describe the applications for a set of PubChem web services for rapid data retrieval,analysis,and downloading of natural products.We hope this work can serve as a starting point for the researchers to perform data mining on natural products using PubChem.展开更多
基金National Science and Technology Project, No.2006BAK21B02The Open Foundation of the State Key Laboratory of Loess and Quaternary Geology from the Institute of Earth Environment, CAS, No.SKLLQG0817+2 种基金The Training Foundation of National Basis of Talents, No.J0630535Foundation of Doc-toral Program, No.20050284011Test Foundation of Modern Analyses Center of Nanjing University, No.0209001309
文摘Based on archaeological excavations, 217 samples were collected from the Luotuodun Site. Of them 63 samples from the section plane of the site layer were used for identification analysis of foraminifera, plant debris and seed fossils, and four samples were used for 14C dating and relevant analysis. Through many kinds of experiments, we have drawn some conclusions. Firstly, benthic foraminifera, such as Ammonia compressiuscula and Ammonia cff. sobrina, are found in the lOth layer, indicating that between 7500 and 5400 BC, i.e. before the emergence of the Majiabang Culture, Luotuodun Site and its nearby regions had ever experienced a marine transgression event. Secondly, we have found 450 plant fossils in this site, such as Polygonum sp., Scripus sp., Najas sp., Physalis sp., which indicated lacustrine or swamp environment.
基金supported by the Intramural Research Program of the National Institutes of Health,National Library of Medicine
文摘Natural products,as major resources for drug discovery historically,are gaining more attentions recently due to the advancement in genomic sequencing and other technologies,which makes them attractive and amenable to drug candidate screening.Collecting and mining the bioactivity information of natural products are extremely important for accelerating drug development process by reducing cost.Lately,a number of publicly accessible databases have been established to facilitate the access to the chemical biology data for small molecules including natural products.Thus,it is imperative for scientists in related fields to exploit these resources in order to expedite their researches on natural products as drug leads/candidates for disease treatment.PubChem,as a public database,contains large amounts of natural products associated with bioactivity data.In this review,we introduce the information system provided at PubChem,and systematically describe the applications for a set of PubChem web services for rapid data retrieval,analysis,and downloading of natural products.We hope this work can serve as a starting point for the researchers to perform data mining on natural products using PubChem.
