To investigate the association of viral infections and febrile seizures (FS). From April 1998 to April 2002, a prospective, population-based study was carrie d out among general practitioners to assess the incidence o...To investigate the association of viral infections and febrile seizures (FS). From April 1998 to April 2002, a prospective, population-based study was carrie d out among general practitioners to assess the incidence of FS in their practic es. Data thus obtained were compared with the incidence of common viral infectio ns recorded in a national registry. Poisson regression analysis was performed to investigate whether the season or the type of infection was associated with the variation observed in FS incidence. Throughout the 4-year period, 267 of 303 ( 88%) of general practitioners in the Dutch province of Friesland participated i n the study. The estimated observation period was approximately 160, 000 patient -years. We registered 654 cases of FS in 429 children. The estimated incidence of FS was 2.4 in 100 0 patient-years. Poisson regression analysis revealed a positive correlation be tween recurrent FS and influenza A (P =.01). Our study suggests a relation betw een recurrent FS and influenza A. Influenza vaccination should be considered in all children with a history of FS.展开更多
文摘To investigate the association of viral infections and febrile seizures (FS). From April 1998 to April 2002, a prospective, population-based study was carrie d out among general practitioners to assess the incidence of FS in their practic es. Data thus obtained were compared with the incidence of common viral infectio ns recorded in a national registry. Poisson regression analysis was performed to investigate whether the season or the type of infection was associated with the variation observed in FS incidence. Throughout the 4-year period, 267 of 303 ( 88%) of general practitioners in the Dutch province of Friesland participated i n the study. The estimated observation period was approximately 160, 000 patient -years. We registered 654 cases of FS in 429 children. The estimated incidence of FS was 2.4 in 100 0 patient-years. Poisson regression analysis revealed a positive correlation be tween recurrent FS and influenza A (P =.01). Our study suggests a relation betw een recurrent FS and influenza A. Influenza vaccination should be considered in all children with a history of FS.
