无锡市出生缺陷发生水平、模式和变化趋势

分析无锡市出生缺陷的发生水平、规模、模式及变化趋势。上世纪利用80年代以来公开发表的相关文献资料及2000～2004年无锡市出生缺陷监测和病残儿鉴定资料,综合分析这些资料,参考世界卫生组织对全球出生缺陷发生水平的估计,估计无锡市出生缺陷实际发生水平至少在50‰左右;无锡市发生的结构性出生缺陷主要包括先天性心脏病、唇腭裂和骨骼畸形,功能性出生缺陷主要包括先天智力低下和先天性聋哑;无锡市城镇结构性出生缺陷的发生率显著高于农村,这是无锡市出生缺陷发生分布最显著的特点,但一些功能性出生缺陷如智力低下,农村的发生水平可能要高于城镇。监测结果同时表明孕妇教育程度与其胎婴儿出生缺陷发生率存在明显的负向关系;在过去十几年中,无锡市出生缺陷监测发生水平相对稳定,考虑到出生缺陷产前诊断技术的不断发展和成熟,诊断时间逐渐提前,这表明“稳定”的出生缺陷发生率可能隐盖了出生缺陷实际发生水平的上升态势。这些结果为出生缺陷预防和控制提供了重要线索。

2012—2016年南宁市围生儿出生缺陷发生率及流行病学分析

目的:分析2012—2016年南宁市围生儿出生缺陷发生率及影响因素。方法:以医院为基础,调查孕妇为28周至产后7d住院分娩的活产、死胎、死产和7d内死亡的新生儿。收集2012—2016年南宁市出生缺陷医院监测系统的资料进行回顾性分析。结果:2012—2016年南宁市出生缺陷发生率为171.7/万,高于全国和广西出生缺陷发生率;南宁市出生缺陷发生率位于前10位的出生缺陷分别是先天性心脏病、多指(趾)、外耳畸形、总唇腭裂、马蹄足内翻、尿道下裂、并指(趾)、地中海贫血、胎儿水肿综合征、小耳畸形;男性围生儿出生缺陷发生率(186.74/万)明显高于女性围生儿(151.08/万)(P<0.05);出生缺陷发生率随产妇年龄增长而增高,尤其是35岁以上的产妇围生儿的出生缺陷发生率明显高于其他年龄段(P<0.05)。结论:2012—2016年南宁市围生儿出生缺陷发生率呈波动趋势,2015年围生儿出生缺陷率最高。应继续推行出生缺陷三级预防,多学科多部门协同合作,加强孕前优生遗传咨询和孕前保健工作,对高危人群进行健康教育及重点筛查,使重点人群自觉参与出生缺陷防治以减少出生缺陷的发生。

颠簸状态下制冷系统气液分离器性能的影响研究

主要针对混合工质两级喷射制冷系统在船舶出海条件下的运行稳定性进行了分析研究。气液分离器是喷射式制冷系统中一个较为重要的设备部件。内部液体的波动与飞溅,容易使得气液分离器出现出气带液的现象,而高压级喷射器引射的出气带液量对整个系统的工作性能会有一定的影响。本文通过数值模拟与试验研究的方法对系统中的气液分离器进行了研究,结果表明,25cm为内部最大安全液位。当分离器内部液位高于25 cm时,气液分离器的出气带液量会随着内部液面高度的上升而增加。另外,在分离器中增设挡板对内部液体的波动与飞溅有明显的抑制作用。

Study on the Occurrence and Epidemic Regularity and Region Division of Rice Blast in Nanchong City

With the aim to improve the level of monitoring and warning as well as the comprehensive control of rice blast disease, and to feasibly reduce the disease threat in Nanchong City, the methods of GPS and GIS, systematical monitoring and field survey, rice blast resistance identification, physiologic races of rice blast monitoring, and meteorological data analysis were performed to study the occurrence and epidemic region division, precise demarcation and occurrence and epidemic regularity of rice blast in Nanchong City. This study first completed the epidemic region division and precise demarcation; first clarified the initial affection（beginning period） locations, occurrence characteristics, epidemic trends and characteristics; explicated the existence of four epidemic peak periods of rice blast in the field, where the damage areas of first peak period played a decisive role during the blast epidemic years; in late May, the cumulative occurrence areas and annual occurrence areas presented higher positive correlation with the correlation coefficient of 0.817;and established a prediction model of occurrence areas per year based on the disease field rate at the end of boot stages and the diseased plant rate at dough stages. The results of investigation on the impact factors investigation of blast disease in Nanchong in recent years suggested that the internal causes were the decrease or loss of blast resistance of the rice cultivars, as well as the increase of physiological races with strong resistance to rice blast and the emergence of new virulent physiologic varieties; the external causes were suitable temperature, too much rainy, and sunlight shortage. Between 2010 and 2015, the short-term forecast accuracy for rice blast in Nanchong was up to 100%, and medium-and long-term forecast accuracy was also up to 98% and 95%, respectively, which increased by 5-15% than that before 1997, thereby making the control effect of rice blast in Nanchong increased by 15-30%.

Study on Epidemic Characteristics and Its Causes of Wheat Stripe Rust in Nanchong City

On basis of the research result of stripe rust for 16 years since 1999,the epidemic characteristics and trend of stripe rust in the city were determined.Namely,the earlier the initial stage appeared,the heavier the disease would be.Furthermore,stripe rust has two introduction infection peaks,of which the first peak plays a key role.In farmlands,there are one to three epidemic peaks,and the infection area of the first peak plays the key role on the epidemic area of that year.In addition,the accumulated areas of late January was in significantly positive correlation with annually total area,with a correlation coefficient of 0.769 2.In recent 16 years,the frequency of severe stripe rust was as high as 81.25% which was 50% higher than that before 1995.The slight stripe rust became just in 2013,with a frequency of 6.3%,which indicated that the city has become a region hit by severe stripe rust.The internal reason is the reduction or loss of wheat variety＇s resistance to tripe rust for a new physiological race of rust is becoming pathogenic stronger and be the major race.Big fluctuation of temperatures in warm winter and spring,foggy and dew days slants much would be the external reason.

Changes in Agricultural Biodiversity: Implications for Sustainable Livelihood in the Himalaya

Himalayan mountain system is distinguished globally for a rich biodiversity and for its role in regulating the climate of the South Asia. Traditional crop-livestock mixed farming in the Himalaya is highly dependent on forests for fodder and manure prepared from forest leaf litter and livestock excreta. Apart from sustaining farm production, forests provide a variety of other tangible and intangible benefits, which are critical for sustainable livelihood of not only 115 million mountain people, but also many more people living in the adjoining plains. Extension of agricultural land- use coupled with replacement of traditional staple food crops by cash crops and of multipurpose agroforestry trees by fruit trees are widespread changes. Cultivation of Fagopyrum esculentum, Fagopyrum tataricum, Panicum miliaceum, Setaria italica and Pisum arvense has been almost abandoned. Increasing stress on cash crops is driven by a socio-cultural change from subsistence to market economy facilitated by improvement in accessibility andsupplyofstaplefoodgrainsatsubsidizedpriceby the government. Farmers have gained substantial economic benefits from cash crops. However, loss of agrobiodiversity implies more risks to local livelihood in the events of downfall in market price/demand of cashcrops,terminationofsupplyofstaplefoodgrains at subsidized price, pest outbreaks in a cash crop dominated homogeneous landscape and abnormal climate years. Indigenous innovations enabling improvement in farm economy by conserving and/enhancing agrobiodiversity do exist, but are highly localized. The changes in agrobiodiversity are such that soil loss and run-off from the croplands have dramatically increased together with increase in local pressure on forests. As farm productivity is maintained with forest-based inputs, continued depletion of forest resources will result in poor economic returns from agriculture to local people, apart from loss of global benefits from Himalayan forests. Interventions including improvement in traditionalmanureandmanagementofon-farm trees, participatorydevelopmentofagroforestryindegraded forestlandsandpoliciesfavoringeconomicbenefitsto local people from non-timber forest products could reduce the risks of decline in agricultural biodiversity and associated threats to livelihoods and Himalayan ecosystems.

Single-cell analyses of circulating tumor cells

Circulating tumor cells(CTCs) are a population of tumor cells mediating metastasis, which results in most of the cancer related deaths. The number of CTCs in the peripheral blood of patients is rare, and many platforms have been launched for detection and enrichment of CTCs. Enumeration of CTCs has already been used as a prognosis marker predicting the survival rate of cancer patients. Yet CTCs should be more potential. Studies on CTCs at single cell level may help revealing the underlying mechanism of tumorigenesis and metastasis. Though far from developed, this area of study holds much promise in providing new clinical application and deep understanding towards metastasis and cancer development.

Assessment of the Ecological Security in the Three Gorges Reservoir Area by Using the Ecological Footprint Method

The ecological footprint concept and its calculation models are useful for the measurement of the sustainable level of social and economic development.The ecological security situation of the Three Gorges Reservoir Area(TGRA) was evaluated using this concept in this study.The construction of the Three Gorges Reservoir has led to the change in the ecology and immigration status of TGRA.The ecological footprint method is an important means to study the regional ecological security.Our results suggested that,by excluding the areas for biodiversity conservation(12% of the total land),the ecological footprint per capita was 0.57895 ha,which exceeded the ecological carrying capacity in TGRA.The total ecological deficit was found to be 11,522,193.34 ha,accounting for 95.02% of the ecological carrying capacity.These findings suggested that the ecological security of TGRA was not good.In order to compensate for the ecological deficit,it was essential to introduce natural resources from other regions.

Analysis on the synergistic effect of sustainable development of coal industry under 1.5 ℃ scenario

Based on the coal demand under the 1.5 ℃ scenario, the amount of coal production in China was estimated in this study. According to the mutual relationship between the factors influencing coal production, an econometric model was constructed based on simultaneous equations, and the synergistic effect of each factor on the coal industry was estimated under the 1.5 ℃ scenario. Then, predictions were respectively made in the five aspects： coal production, coal science and technology progress, employment number, safe production level, and occupational health level, in different scenarios from 2016 to 2050. The results showed that before 2040, the comprehensive negative effect of the 1.5 ℃ situation is more than or equals to the positive effect. The 1.5 ℃ scenario has the biggest negative impact on employment, whose solution should be the focus. By 2050, the positive effects of the 1.5℃ scenario exceed the negative effect because of the enhancement in technical level and in the attention given to the whole production. Safety is improved, and health defects decline and the most obvious positive effect is on the ecological environment. The decrease of coal production will reduce the ecological environmental damage and significantly improve the ecological environment. In general, the prediction of 1.5 ℃ scenario promotes the increase of scientific production capacity and promotes the orderly development of coal. It has strengthened the safety and health protection degree, made the coal industry more efficient and competitive, and avoided or reduced the impact of coal development on the ecological environment and achieved environmental friendliness. However, the 1.5 ℃ situation also increases the employment pressure of the society, which affects the economic development of the major coal producing areas, but the situation can be overcome through the transformation and upgrading of the region. Finally, the impacts of various factors under the 1.5 ℃ scenario were evaluated through a unified comparison of the synergistic effect monetization using the cost and payment willingness methods. Based on the research results, suggestions on the regulation of coal production were proposed relating to resettlement of workers, protection of the ecological environment, and improvement of workers＇ health.

Calcium Addition Affects Germination and Early Seedling Growth of Sweet Sorghum under Saline Conditions

[Objective] This study aimed to determine the interactive effects of supple- mental Ca amendment and salinity on germination of sweet sorghum seeds in saline solution culture medium, and investigate the effects of different combinations of Na/Ca ratio in saline soils on the early growth of sweet sorghum plants. [Method] A germi- nation test and a greenhouse pot experiment were conducted to assess the interac- tive effects of calcium addition to culture medium on the germination and seedling growth of sweet sorghum （Sorghum saccharatum Moench） in saline soils with a range of NaYCa ratios. In the germination test, seeds were treated with different combinations of five calcium levels [0, 5, 10, 15, and 20 mmol/L Ca（NO3）2] and five salinity levels （0, 50, 100, 150, and 200 mmol/L NaCI）. In the greenhouse experi- ment, seeds were sown in potting soils containing 3 salinity levels （2.3, 4.7 and 7.0 dS/m） and three Na：Ca ratios （10：0, 10：1, and 5：1）. [Result] In the germination test, Ca addition at 5 mmol/L promoted germination by 5.5%, 9.9%, and 17.0% at the 3.4, 6.7 and 10.1 dS/m salinity levels. The higher Ca level （10 mmol/L） also in- creased germination by 9.1% and 7.8% at the 3.4 and 6.7 dS/m salinity levels. Then even higher Ca addition at 15 and 20 mmol/L appeared to promote germina- tion when culture media had high salinity （10.1 and 13.4 dS/m）. In the greenhouse pot experiment, saline soil amended with supplemental Ca at the 2.3 and 4.7 dS/m salinity levels significantly promoted early seedling growth, with an increase of 6.8% to 28.2% in plant height and 14.3% to 67.9% in whole plant weight. From 28 to 42 d after seeding, the relative growth of seedling was increased by Ca addition, with a reduction of 49.5% to 66.0% in plant height and 4.8% to 61.9% in whole plant weight. From 42 to 56 d after seeding, however, the relative growth of seedling was significantly inhibited by Ca amendment. [Conclusion] Results of this study indicate that appropriate supplemental Ca could improve sorghum germination and early seedling growth in saline soils.

Effect of Different Calcium Levels on Growth,Yield and Fruit Quality of Tomatoes in Substrate Culture

Tomato seedlings were grown in substrate culture with pots. The formulation of Holland Greenhouse Horticulture Research Institute was used(as CK) and the effects of different Ca concentrations(LCa, CK and HCa)on growth, yield, and fruit quality(protein, Vitamin C, nitrates, organic acid and soluble sugar) of tomato were studied keeping concentrations of other nutrients unchanged in the nutrient solution. The results showed that parameters related to the growth of tomato(plant height and Stem diameter), changes of tomato yield per plant and quality of tomato fruits were the highest when the plants were grown at 20% Ca treatments. In the second study, increased EC concentrations of nutrient solution resulted in stronger plants with improved yields and quality. Four different concentration gradients of nutrient solution treatment were designed based on the results of the first research stage(EC=1.5, 2.5, 3.5, 4.5 m S/cm, respectively). The single tomato plant had the highest production which is 2 268.994 g/plant, when the nutrient solution strength was at EC=1.5 m S cm, whereas they have the best fruit quality when the solution strength at EC 4.5 m S/cm. This suggests the need for wide popularization of the nutrient solution formula in large areas to improve the tomato production.

The Study of Cholesterol Content in Synbiotic Fermented Dairy Products

The influence of prebiotics as lactulose as well inulin on the ability of Bifidobacterium lactis to reduce cholesterol in milk was studied during milk fermentation. Pasteurized milk, freeze-dried starter culture Bb-12 （Bifidobacterium lactis, Chr. Hansen, Denmark）, inulin--RAFTILINEHP （ORAFI, Belgium）, syrup of lactulose （Duphalac, the Netherlands） in following concentrations： 0, 1%, 2%, 3%, 4% and 5% were used for experiments. The fermentation process was realized at 37 ℃ for 16 h. The content of cholesterol was determined according to AOAC Official Method 976.26A. The results showed that it is possible considerable to lower the level of cholesterol in fermented milk using B. lactis. The ability of B. lactis to decrease the level of cholesterol in milk can be influenced with addition of prebiotics. The lower concentration of cholesterol was determined in fermented samples with 4% of lactulose （9.5 mg/100g） and with 1% of inulin （10.4 mg/100g）. Evaluating the influence of prebiotics on cholesterol content in fermented milk samples, it is obvious that the influence depends on the type of prebiotics （P 〉 0.05） and their concentrations （P 〈 0.05）.

Molecular cloning and function analysis of insulin-like growth factorbinding protein 1a in blunt snout bream(Megalobrama amblycephala)

Insulin-like growth factor-binding protein 1 （IGFBP-1）, a hypoxia-induced protein, is a member of the IGFBP family that regulates vertebrate growth and development. In this study, full-length IGFBP-la cDNA was cloned from a hypoxia-sensitive Cyprinidae fish species, the blunt snout bream （Megalobrama arnblycephala）. IGFBP-la was expressed in various organs of adult blunt snout bream, including strongly in the liver and weakly in the gonads. Under hypoxia, IGFBP-la mRNA levels increased sharply in the skin, liver, kidney, spleen, intestine and heart tissues of juvenile blunt snout bream, but recovered to normal levels after 24-hour exposure to normal dissolved oxygen. In blunt snout bream embryos, IGFBP-la mRNA was expressed at very low levels at both four and eight hours post-fertilization, and strongly at later stages. Embryonic growth and development rates decreased significantly in embryos injected with IGFBP-la mRNA. The average body length of IGFBP-la-overexpressed embryos was 82.4% of that of the control group, and somite numbers decreased to 85.2%. These findings suggest that hypoxia-induced IGFBP-la may inhibit growth in this species under hypoxic conditions.

Right to Health or the Human Right of Access to Essential Healthcare

The Universal Declaration of Human Rights refers to the human right to health and well-being including medical care, but for the majority of people whom are not covered by health insurance this is better said than done. Ensuring the access of all citizens to the needed medical care requires the provision of health insurance coverage to a population pool and gradually expanding the pool to the whole nation. The ethical perspective of pooling resources across various groups of people with different levels of income and different health risks associated with age, genetics, and lifestyle, may raise the issue of individual autonomy versus social solidarity. Governmental, social, private, and community-based healthcare coverage have been used in different countries with varying details in the sources of funding, pooling of contributions, and the purchase of the covered healthcare services; these models have had varying levels of success depending on not only the availability of funds, but also on the political commitment of the state and the social solidarity and cultural attitude of the population towards universal healthcare. Therefore, universal healthcare requires not only a certain level of economic development, but also a strong sense of solidarity among the people as well as a political commitment in their government. I argue that the statement regarding the right to health, well-being, and medical care needs to be rethought, and instead universal access to essential healthcare should be regarded as a basic human right.

Metacognitive Strategy and College English Listening Teaching

Metacognitive strategy, as one of the branches of learning strategy, can help students to consciously plan, monitor and evaluate their language learning, thus facilitate it. As a matter of fact, listeuing has long been regarded as an important linguistic skill to be developed in college English teaching. However, there are still some misunderstandings which exist among teachers and students. With the development of second language acquisition and listening comprehension, it becomes clear that listening is an active process in which the listener negotiates meanings in a conscious way. Therefore, if teachers can train students in metacognitive strategies in college English listening teaching, students can consciously plan, monitor and evaluate the entire listening process and become an active listener, thus improve their listening proficiency.

A multi-state weather generator for daily precipitation for the Torne River basin, northern Sweden/western Finland

This paper describes a new weather generator e the 10-state empirical model e that combines a 10-state, first-order Markov chain with a non-parametric precipitation amounts model. Using a doubly-stochastic transition-matrix results in a weather generator for which the overall precipitation distribution(including both wet and dry days) and the temporal-correlation can be modified independently for climate change studies. This paper assesses the ability of the 10-state empirical model to simulate daily area-average precipitation in the Torne River catchment in northern Sweden/western Finland in the context of 3 other models: a 10-state model with a parametric(Gamma) amounts model; a wet/dry chain with the empirical amounts model; and a wet/dry chain with the parametric amounts model. The ability to accurately simulate the distribution of multi-day precipitation in the catchment is the primary consideration.Results showed that the 10-state empirical model represented accumulated 2- to 14-day precipitation most realistically. Further, the distribution of precipitation on wet days in the catchment is related to the placement of a wet day within a wet-spell, and the 10-state models represented this realistically, while the wet/dry models did not. Although all four models accurately reproduced the annual and monthly averages in the training data, all models underestimated inter-annual and inter-seasonal variance. Even so, the 10-state empirical model performed best.We conclude that the multi-state model is a promising candidate for hydrological applications, as it simulates multi-day precipitation well, but that further development is required to improve the simulation of interannual variation.

Sustainability Aspects of the Wheat Sector

In the frame of the present study, we examined the wheat sector with respect to economic and social sustainability. Accordingly, two research questions were formulated： （1） Is wheat production sustainable in economic terms？ and （2） Is wheat production sustainable in social terms？ Our view is that the content of sustainability can be defined on a case-by-case basis, and in our case, wheat production provides this content. To answer the research questions, we collected statistical data on the production area, average yield, production volume, selling price, consumption of wheat, and evaluated the tendencies prevalent in the sector. We suppose that in social terms, sustainability means maintaining consumption at least at a constant level, knowing that this sector produces considerable share of the direct and indirect food raw materials. A chief dilemma is that world population is continuously growing, although the size of the cultivated area in the wheat sector has not indicated significant changes over the past few decades. Unless increasing the yields, severe decrease may occur in the per capita production of wheat in the long run. In this case, the current consumption level will not be sustainable in the medium run. In addition, in the long run, it may even have influence on the consumption level of other commodities.

基于智力城镇化的特色小镇产业培育探索——以辽宁通远堡镇为例

我国城镇化正处于劣势的体力城镇化阶段,特色小镇作为新型城镇化的主力军,体力化威胁仍不可避免。为缓解特色小镇体力化困境,文章基于智力城镇化的相关理论,以辽宁通远堡镇为例,围绕特色产业展开智力化培育的探索。结合链式产业思维,以智力投入、智力主体、智力产出三大环节为基础,以智力要素创新性地打造智力链条,构建可持续的特色产业,带动城镇化转型升级,以期为辽宁省乃至全国特色小镇培育提供借鉴。

A large-sized basal ankylopollexian from East Asia, shedding light on early biogeographic history of Iguanodontia

A presumably mostly quadrupedal ankylopollexian iguanodontian, Bayannurosaurus perfectus gen. et sp. nov., is reported here, and is represented by an excellently well-preserved skeleton from the Lower Cretaceous Bayingebi Formation of Inner Mongolia, China. The diagnosis of the taxon includes several autapomorphies, notably a dorsally directed, strap-like posterodorsal process of the jugal and a horizontally oriented preacetabular process of the ilium. The nearly complete caudal series retains eight posterior-most caudals with procoelous, trapezoidal centra in dorsal view, and the last three caudals are fully fused. The discovery ofB. perfectus opens a critical new window on the early evolution and intercontinental dispersal of lguanodontia. The skeleton displays a transitional morphology between nonbadrosauriform ankylopollexians and Hadrosauriformes. A phylogenetic analysis indicates that Bayannurosaurus is positioned higher on the tree than Hypselospinus, but below Ouranosaurus just outside of Hadrosauriformes. The tree topology of Iguanodontia with temporal and spatial constraints reveals a possible biogeographic scenario supported by the statistical dispersal-vicariance analysis： around the J/K boundary, non-hadrosauriform ankylopollexians experienced multiple dispersal events from Europe to Asia, accompanying the coeval fall of the global sea level.

喹硫平联合丙戊酸镁缓释片治疗双相情感障碍的疗效

探究喹硫平联合丙戊酸镁缓释片治疗双相情感障碍的效果。方法 随机抽取我院于2021年4月~2023年4月接诊的90例患者作为研究对象。应用随机抽签法均分为联合治疗组及基础组(n=45)。基础组行丙戊酸镁缓释片治疗,联合治疗组加用喹硫平治疗。比较相关指标。结果 联合治疗组认知功能中长时记忆(87.74±2.54 vs 84.58±2.63)分、短时记忆(88.55±2.64 vs 85.52±2.88)分、即刻记忆(88.39±2.73 vs 85.41±2.65)分、记忆商数(87.58±2.47 vs 84.61±2.56)分、语言智商(88.47±2.45 vs 85.62±2.38)分、操作智商(86.63±2.52 vs 83.47±2.66)分及智商(87.63±2.25 vs 84.74±2.37)分评分均高于基础组,组间数据比较存在统计学差异(P<0.05);联合治疗组临床症状评分(49.51±2.82 vs 53.69±2.77)分低于基础组,组间数据比较存在统计学差异(P<0.05);联合治疗组炎性因子水平中IL-4(2545.61±281.96 vs 3145.69±352.77)ng/ml、IL-1(998.84±207.35 vs 1836.65±311.54)ng/ml及TNF-(130.47±9.32 vs 151.83±11.37)pg/L水平均低于基础组,组间数据比较存在统计学差异(P<0.05);两组不良反应对比(13.33 vs 15.56)%无差异(P>0.05)。结论 喹硫平联合丙戊酸镁缓释片可以改善双相情感障碍患者的认知功能、临床症状,降低炎性因子水平,且无严重不良反应发生。