对子宫内胎儿双眼发育性白内障的诊断的临床病理研究

Background: We report a case of unusual, bilateral developmental cataracts in a fetus with a supernumerary chromosome. Methods: A 42- year-old woman presented during her 6th pregnancy for assessment of fetal karyotype. This showed a supernumerary chromosome derived from chromosome 21. Subsequently fetal ultrasound suggested the presence of bilateral cataracts and the pregnancy was terminated at 19 weeks and 3 days’ gestation. Both eyes were submitted for histopathological and electron microscopical examination. Results: Histopathological examination revealed unusual bilateral developmental cataracts with abnormal bladder-type cells lining the posterior aspect of the lens vesicle, a poorly formed nuclear bow and a central mass of fibrillar material associated with macrophages lying within an area of liquefaction. Transmission electron microscopy revealed the presence of peg and socket joints in both central and posterior regions and degenerate crystallins in the posterior region. Conclusions: We described an unusual case of developmental cataract diagnosed in utero by ultrasound. The morphological appearances suggest that the defect occurred during or after formation of the secondary lens fibres. Detailed descriptions of cases such as this one may contribute to our understanding of lens development and cataract formation.

谨防小儿白内障

白内障是老年人常见的一种眼病。是否小孩也会得白内障呢?回答是肯定的,例如,小儿先天性白内障、外伤性白内障等,并非罕见。

国民用眼现状调查——视觉之殇

面对无处不在、大大小小的电子屏幕,现代人几乎无可选择,全面沦陷。一方面,中国青少年近视患病率居高不下;另一方面,在人口老龄化的背景下,各类老年性视力缺陷患病年龄提前。当电子屏幕成为现代社会发展的重要符号,人们的眼睛也变得不堪一击。这是一个用眼过度的时代,视觉健康成为备受关注并亟待解决的社会命题。