甘肃省某三级甲等中医院2012—2016年护理论文发表现状分析与对策

目的:调查甘肃省某三级甲等中医院护理人员近5年论文发表情况,对存在的问题进行分析并提出对策,为中医院护理管理者提供护理科研管理思路及方法。方法:收集2012年1月至2016年12月甘肃省某三级甲等中医院护理人员发表论文,摘录相关信息(作者学历、职称、发表篇数、期刊级别、研究方向等),建立数据库进行统计分析。结果:共发表论文310篇,其中本科学历者发表论文267篇(86.12%);中级职称者发表论文149篇(48.06%);统计源期刊108篇(34.84%);涉及科研基金32篇(10.32%);发表4篇以上者29人,占总篇数的9.35%;中医特色护理80篇(25.80%)。结论:中医护理科研、论文现状与护理人员自身科研能力不足、缺乏规范化写作方法和技巧以及科研环境差有关,导致中医护理论文数量及质量不高,应加强护理科研管理、培训及内部政策引导,重视中医护理科研工作科学化发展。

国际发表针灸临床研究系统评价的现状分析

检索并分析PubMed、Cochrane和EMbase数据库从建库起至2020年12月31日发表的针灸系统评价(SR)文献,分析国际针灸SR的发表现状。共纳入717篇针灸SR文献,总体发文数量呈波动式上升趋势。共涉及15大类疾病,其中113篇认为针灸治疗有效,12篇不支持针灸治疗,其他结论尚不确定。建议采用循证医学标准规范针灸试验设计,提高临床研究水平;SR研究应参照PRISMA报告的原则和方法筛选符合标准的优质文献,为针灸疗法提供可靠的临床证据。

Effect of 2-(8-hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl) propionic acid in combination with carboplatin on gastric carcinoma growth in vivo

AIM： To investigate the effects of 2-（8-hydroxy-6- methoxy-l-oxo-lH-2-benzopyran-3-yl） propionic acid （NM-3） alone and in combination with carboplatin on tumor growth and apoptosis in mouse models of human gastric cancer constructed by subcutaneous implantation of histologically intact tumor tissue. METHODS： Human gastric cancer SGC-7901 tissues were implanted into the dorsal subcutis of nude mice. One week after tumors reached to a volume of 50-100 mm3 for around 1 wk, these mice were randomly divided into 8 groups （n = 10）. NM-3 was injected peritoneally at the dose of 10 mg/kg, 20 mg/kg or 40 mg/kg every other day for 5 wk, combined with carboplatin （5 mg/kg） every third day for 4 wk. As controls of combined treatment, another 4 groups of mice were injected with either NM-3 at 10 mg/kg, 20 mg/kg or 40 mg/kg, or with carboplatin alone （5 mg/kg）. The control mice received normal saline. Tumor weight, tumor growth inhibition （TGI）, and intratumoral microvessel density （MVD） were evaluated. Apoptosis of human gastric cancer was detected by TUNEL method and flow o/tometry analysis, respectively. RESULTS： The mean tumor volume （692.40 ± 58.43 mm3, 548.30 ± 66.02 mm3, 382.13 ± 43.52 mm3） after treatment with carboplatin combined NM-3 at the dose of 10 mg/kg, 20 mg/kg or 40 mg/kg was lower than that after treatment with either NM-3 at the dose of 10 mg/kg, 20 mg/kg or 40 mg/kg or with carboplatin alone. Compared with the normal saline group, NM-3 administered at 10 mg/kg, 20 mg/kg or 40 mg/kg significantly reduced the tumor weight in these groups （P 〈 0.05）. Carboplatin used alone at 5 mg/kg showed minimal effects. But NM-3 in combination with carboplatin had greater effects of tumor weight than either NM-3 or carboplatin alone. NM-3 alone at the dose 10 mg/kg or in combination with carboplatin had no obvious effects on body changes. Two mice died of diarrhea in each of the two groups treated with 40 mg/kg NM-3 or with 40 mg/kg NM-3 in combination with carboplatin. A significant increase in apoptosis was observed in the NM-3 treated groups, and the effect was more significant in the groups treated with carboplatin in combination with NM-3 at 10 mg/kg, 20 mg/kg and 40 mg/kg, than in the control group. The induction of apoptosis was positively associated with the dose of NM-3. NM-3 significantly reduced the neomicrovascular formation of gastric cancer. The MVD was lower in the groups treated with NM-3 or with NM-3 in combination with carboplatin than in the group treated with carboplatin or in the normal saline group （P 〈 0.05）. CONCLUSION： The results suggest that the inhibitory effect of NM-3 on gastric cancer growth is mediated through decreased angiogenesis and the increased induction of apoptosis. Furthermore, NM-3 alone at the dose of 10 mg/kg or in combination with carboplatin has no obvious effects on body changes, indicating that NM-3 in combination with carboplatin may be effective in the treatment of gastric cancer. The toxicity of NM-3 needs further studies.

Research on Effect of Biolatex Surface Sizing on Paper Properties

Biolatex, a new type of paper coating adhesive that has been developed in recent years, has mainly been used in pre-coating and middle coating, due to its advantages of decreasing the associated cost and pollution by partly replacing petro-latex. In this paper, application of biolatex as a surface sizing agent and effects of various factors, such as titanium dioxide addition, on the properties of the sized paper were compared. The results showed that, addition of titanium dioxide to biolatex could improve the whiteness, internal bond strength, and ink absorption. Furthermore, application of the No.4 biolatex resulted in better surface strength, bond strength, and ink absorption of the sized paper than application of polyvinyl alcohol.

MicroRNAs identification and bioinformatics analysis in large yellow croaker Larimichthys crocea using an integrated comparative and ab initio approach

MicroRNAs(miRNAs) are a group of small, endogenous, single-stranded non-coding RNAs that post-transcriptionally regulate gene expression levels. Previous studies have revealed that miRNAs play key roles in multiple biological processes, such as growth and development in both animals and plants. Computational identification is an efficient method for miRNA prediction in organisms with a reference genome before high-throughput miRNA sequencing experiments. In this study, we employed an integrated strategy combining the homology-based and ab initio approaches to predict miRNAs from the genome and transcriptome of large yellow croaker, one of the most commercially important marine fish in China and East Asia. A total of 418 miRNA molecules, including 287 miRNAs by the homology-based method and 131 miRNAs by the ab initio approach, were identified for large yellow croaker. Additionally, 16 053 target genes were predicted and annotated for Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) databases. Meanwhile, we analysed single nucleotide polymorphisms(SNPs) around large yellow croaker miRNA and found that the miRNA seed regions were significantly less prone to mutations, indicating that the miRNA sequences were under strict natural selection based on their essential regulation functions in living cells. Twenty-two SNPs were identified in large yellow croaker miRNA seed regions, which dramatically influenced the miRNA-gene regulation networks. This is the first reported miRNA detection from both the genome and transcriptome using the integrated strategy for large yellow croaker species, and the miRNA and SNP analyses in this work provide important resources and a reference for subsequent miRNA functional investigations in large yellow croaker.

Effects of Hydroxyl Groups in Organic Ammonium Counterions on the Properties of Fluorinated Surfactants

The surface tension, foaming and viscosity for C7F15COO^-N^＋H（C2H4OH）χ（C2Hs）3-x and C8F17SO3- N^＋H（C2H4OH）χ（C2H5）3-χ （x = 0, 1, 2, 3） were measured to systematically study the effects of hydroxyl groups in organic ammonium counterions on the properties of perfluorooctanoates and perfluorooctanesulfonates. The results showed that the critical micelle concentration （cmc） and the surface tension at cmc （γcmc） were both increased with the increase of number of hydroxyl groups （χ） in the two series. The perfluorooctanesulfonate had smaller cmc but higher γ=cmc than perfluorooctanoate with the same counterion. The minimum molecular area of surface adsorption （Amin） of C8F17zSO3^-N^＋H（C2H4OH）χ（C2H5）3-χ were 0.64, 0.57, 0.63 and 0.72 nm^2 while the Amin values of C7F15COO^-N^＋H（C2H4OH）χ（C2H5）3-χ were 0.61, 0.62, 0.61 and 0.71 nm^2 when χ = 0, 1, 2 and 3, respectively. For the investigated systems of surfactants, the results of foam expansion ratio agreed with those of surface activity, while the 25% drainage time were consistent with the results of viscosity.

Surface Performance Testing of Cardanol Polyoxyethylene Ether and Its Application in Detergent

Cardanol polyoxyethylene ether is a kind of nonionic surfactants based on natural raw materials, with good surface activity and resistance to hard water. At 25 ℃, the value of critical micelle concentration （CMC） is 6.09×10-6 mol/L, and the lowest surface tension （TcMc） is 38.08 mN/m. Moreover, cardanol polyoxyethylene ether has strong salt tolerance to monovalent inorganic salts; with the increase of concentration of divalent inorganic salt, the surface activity of cardanol polyoxyethylene ether is enhanced. The effect of monohydric alcohol on the surface activity of cardanol polyoxyethylene ether is complex： the ability of BGF-10 to form micelles increases and then decreases with the increase of the concentration of monohydric alcohol, cardanol polyoxyethylene ether has a synergistic effect with anionic, nonionic and cationic surfactants, especially with hexadecyltrimethylammonium bromide （CTAB）, and its critical micelle concentration is decreased by 2.52%, while the surface tension is decreased by 11.49%. Test results also show, comparing to nonylphenol polyoxyethylene ether, the emulsifying and the thickening performances of cardanol polyoxyethylene ether are better, and its foam performance is lower. Also, the cloud point of cardanol polyoxyethylene ether is higher than nonylphenol polyoxyethylene ether. In most case, the detergency of cardanol polyoxyethylene ether is better than or equivalent to nonylphenol polyoxyethylene ether. cardanol polyoxyethylene ether is an excellent alternative to nonylphenol polyoxyethylene ether in detergents.

Recent Development on Zero-Phosphate Spray Dried Detergent Powders Incorporated with Palm C16 Methyl Ester Sulfonates

Palm C16 methyl ester sulphonate （C16MES）is an anionic surfactant that has the potential as active ingredient in the production of laundry detergent powders. Although C16MES has been successfully applied in the production of high-density laundry detergent powders （HDDP）, it coulingd not be employed directly as it is in the spray drying process for the production of low-density laundry detergent powders （LDDP） without compromising the detergency and other significant properties. This research paper highlights the pilot-scale experimental study, which performed to produce phosphate-free laundry detergent （PFD） powders incorporated with binary anionic surfactants of C16MES and linear alkyl benzene sulphonic acid （LABSA）. Past laboratory experiments revealed that PFD powders resulted from C16MES/LABSA of 50：50 ratio and of pH 7-8 have good detergency stability upon one-week of continuous heating in an oven at 50~C with 85% relative humidity. Based on these laboratory results, subsequent experiments were carded in a 5 kg/hr capacity co-current pilot spray dryer using PFD formulations comprising six different ratios of C16MES/LABSA （0：100, 20：80, 40：60, 80：20 and 100：0） under the same pH condition. Three PFD formulations were selected for further evaluation based on their characteristics in the spray drying process. The cleaning properties and particle properties of the resulting spray dried detergent powders from these selected formulations were analyzed. Based on the overall evaluation, C16MES/LABSA in 40：60 ratio was selected as the ideal PFD formulation. Further tests confirmed that spray dried detergent powder （SDDP） from the ideal formulation has high level of biodegradability （60% in 13 d）, low eco-toxicity properties （LC50 of 11.3 mg/L） and moderate flowability charactedsUcs （Hausner ratio of 1.27 and Carr＇s index of 21.3）.