An optimal control strategy is proposed to improve the fermentation titer,which combines the support vector machine(SVM)with real code genetic algorithm(RGA).A prediction model is established with SVM for penicillin f...An optimal control strategy is proposed to improve the fermentation titer,which combines the support vector machine(SVM)with real code genetic algorithm(RGA).A prediction model is established with SVM for penicillin fermentation processes,and it is used in RGA for fitting function.A control pattern is proposed to overcome the coupling problem of fermentation parameters,which describes the overall production condition.Experimental results show that the optimal control strategy improves the penicillin titer of the fermentation process by 22.88%,compared with the routine operation.展开更多
Based on 1,3-propanediol production from batch fermentation of glycerol by Klebsiella pneurnoniae, a multistage dynamic system and its parameter identification are discussed in this paper. The batch fermentation proce...Based on 1,3-propanediol production from batch fermentation of glycerol by Klebsiella pneurnoniae, a multistage dynamic system and its parameter identification are discussed in this paper. The batch fermentation process is divided into three stages exhibiting different dynamic behaviors and characteristics, from which a corresponding nonlinear multistage dynamic system is built. We then propose a parameter identification optimization model whose objective function is the average relative error. The model is solved by particle swarm optimization weighted by inertia, and the result shows that the relative error of our proposed model is 2-10%smaller than those of existing models.展开更多
基金Supported by the National Natural Science Foundation of China（60704036）
文摘An optimal control strategy is proposed to improve the fermentation titer,which combines the support vector machine(SVM)with real code genetic algorithm(RGA).A prediction model is established with SVM for penicillin fermentation processes,and it is used in RGA for fitting function.A control pattern is proposed to overcome the coupling problem of fermentation parameters,which describes the overall production condition.Experimental results show that the optimal control strategy improves the penicillin titer of the fermentation process by 22.88%,compared with the routine operation.
基金Acknowledgments This work was supported by the National Natural Science Foundation of China （Grant No. 10871033）, ＂863＂ Program （No. 2007AA02Z208） and ＂973＂ Program （No. 2007CB71430c）.
文摘Based on 1,3-propanediol production from batch fermentation of glycerol by Klebsiella pneurnoniae, a multistage dynamic system and its parameter identification are discussed in this paper. The batch fermentation process is divided into three stages exhibiting different dynamic behaviors and characteristics, from which a corresponding nonlinear multistage dynamic system is built. We then propose a parameter identification optimization model whose objective function is the average relative error. The model is solved by particle swarm optimization weighted by inertia, and the result shows that the relative error of our proposed model is 2-10%smaller than those of existing models.
