A series of benzimidazoles containing furyl and aryl substituents at C-2 position have been synthesiszed by the reaction of 1,2,-phenylenediamine with corresponding carboxylic acids under microwave irradiation without...A series of benzimidazoles containing furyl and aryl substituents at C-2 position have been synthesiszed by the reaction of 1,2,-phenylenediamine with corresponding carboxylic acids under microwave irradiation without solvent,in which artificial zeolite and catalytic amounts of DMF were used as the catalyst and the energy transfer medium,respectively. With such microwave techniques,the reaction times are remarkably shorted and the products are obtained in higher yields and cleaner reactions with easier workup than compared to conventional heating methods.展开更多
Six title compounds were synthesized by the reaction of salicylic acid and 4 substituted phenylenediamine in the presence of pyridine and POCl 3 by microwave irradiation.The reactions took place easily with good yields.
In this study, alumina, zirconia, manganese oxide/alumina, and manganese oxide/zirconia have been investigated for their catalytic activity in the condensation reaction between o-phenylenediamine and an aldehyde or a ...In this study, alumina, zirconia, manganese oxide/alumina, and manganese oxide/zirconia have been investigated for their catalytic activity in the condensation reaction between o-phenylenediamine and an aldehyde or a ketone to synthesise 2-substituted benzimidazoles and 1,5-disubstituted benzodiazepines respectively. Surface area, surface acidity, and morphology of the catalysts have been analysed and correlated with their catalytic activity. The isolated yields of 2-substituted benzimidazoles and 1,5-disubstituted benzodiazepines are in the range of 30% to 95%. A good correlation between the amount of surface acid sites as well as the surface morphology of the catalysts and the catalytic activity has been observed. This method has been found to be simple and economical. The solid supports could be regenerated and reused without much loss in their activity. Further, the solid supports have been also found to be effective as general catalysts in the condensation of o-phenylenediamine with other substituted aldehydes and ketones.展开更多
文摘A series of benzimidazoles containing furyl and aryl substituents at C-2 position have been synthesiszed by the reaction of 1,2,-phenylenediamine with corresponding carboxylic acids under microwave irradiation without solvent,in which artificial zeolite and catalytic amounts of DMF were used as the catalyst and the energy transfer medium,respectively. With such microwave techniques,the reaction times are remarkably shorted and the products are obtained in higher yields and cleaner reactions with easier workup than compared to conventional heating methods.
文摘Six title compounds were synthesized by the reaction of salicylic acid and 4 substituted phenylenediamine in the presence of pyridine and POCl 3 by microwave irradiation.The reactions took place easily with good yields.
文摘In this study, alumina, zirconia, manganese oxide/alumina, and manganese oxide/zirconia have been investigated for their catalytic activity in the condensation reaction between o-phenylenediamine and an aldehyde or a ketone to synthesise 2-substituted benzimidazoles and 1,5-disubstituted benzodiazepines respectively. Surface area, surface acidity, and morphology of the catalysts have been analysed and correlated with their catalytic activity. The isolated yields of 2-substituted benzimidazoles and 1,5-disubstituted benzodiazepines are in the range of 30% to 95%. A good correlation between the amount of surface acid sites as well as the surface morphology of the catalysts and the catalytic activity has been observed. This method has been found to be simple and economical. The solid supports could be regenerated and reused without much loss in their activity. Further, the solid supports have been also found to be effective as general catalysts in the condensation of o-phenylenediamine with other substituted aldehydes and ketones.
