A small-signal equivalent circuit model and the ted. The equivalent lumped circuit, which takes the main extraction techniques for photodetector chips are presen- factors that limit a photodetector's RF performance i...A small-signal equivalent circuit model and the ted. The equivalent lumped circuit, which takes the main extraction techniques for photodetector chips are presen- factors that limit a photodetector's RF performance into consideration,is first determined based on the device's physical structure. The photodetector's S parameters are then on-wafer measured, and the measured raw data are processed with further calibration. A genetic algorithm is used to fit the measured data, thereby allowing us to calculate each parameter value of the model. Experimental resuits show that the modeled parameters are well matched to the measurements in a frequency range from 130MHz to 20GHz, and the proposed method is proved feasible. This model can give an exact description of the photodetector chip's high frequency performance,which enables an effective circuit-level prediction for photodetector and optoelectronic integrated circuits.展开更多
Shoulder lines are the most important landform demarcations for geographical analysis,soil erosion modeling and land use planning in the Loess Plateau area of China.This paper proposes an automatic,effective and accur...Shoulder lines are the most important landform demarcations for geographical analysis,soil erosion modeling and land use planning in the Loess Plateau area of China.This paper proposes an automatic,effective and accurate method of determining loess shoulder line from DEMs by integrating a hydrological D8 algorithm and a snake model.The watershed boundary line is adopted as the initial contour which evolves to identify the exact position of loess shoulder-line by the guidance of an external force of snake model from DEMs.Experiments show that the method overcomes the difficulties in both threshold selection for edge detection and the disconnecting issues in former extraction approaches.The accuracy evaluation of shoulder-line maps from the two test sites of the loess plateau area show obvious improvements in the extraction.The average contour matching distance of the new method is 12.0 m on 5 m resolution DEM,and shows improvement in the accuracy and continuity.The comparisons of accuracy evaluations of the two test sites show that the snake model method performs better in the loess plain area than in the area with high gully density.展开更多
In China′s Loess Plateau area, gully head is the most active zone of a drainage system in gully areas. The differentiation of loess gully head follows geospatial patterns and reflects the process of the loess landfor...In China′s Loess Plateau area, gully head is the most active zone of a drainage system in gully areas. The differentiation of loess gully head follows geospatial patterns and reflects the process of the loess landform development and evolution of its drainage system to some extent. In this study, the geomorphic meaning, basic characteristics, morphological structure and the basic types of loess gully heads were systematically analysed. Then, the loess gully head′s conceptual model was established, and an extraction method based on Digital Elevation Model(DEM) for loess gully head features and elements was proposed. Through analysing the achieved statistics of loess gully head features, loess gully heads have apparently similar and different characteristics depending on the different loess landforms where they are found. The loess head characteristics reflect their growth period and evolution tendency to a certain degree, and they indirectly represent evolutionary mechanisms. In addition, the loess gully developmental stages and the evolutionary processes can be deduced by using loess gully head characteristics. This study is of great significance for development and improvement of the theoretical system for describing loess gully landforms.展开更多
Glacier length is a key morphological element that has many glaciological applications; however, it is often difficult to determine, especially for glaciers that cover larger spatial areas or those that exhibit freque...Glacier length is a key morphological element that has many glaciological applications; however, it is often difficult to determine, especially for glaciers that cover larger spatial areas or those that exhibit frequent temporal change. In this paper, we describe a new Arc GIS-based method that can derive glacier flow lines for determining glacier length based on digital elevation model and glacier outlines. This method involves(1) extraction of the highest and lowest points on a glacier,(2) calculation of 10-m contour lines on the glacier from 10 m to 100 m height, and(3) connection of the midpoints of each contour line with the highest and the lowest points in order to create a flow line, which is subsequently smoothed. In order to assess the reliability of this method, we tested the algorithm's results against flow lines calculated using field measurements, analysing data from the Chinese Glacier Inventory, and manual interpretation. These data showed that the new automated method is effective in deriving glacier flow lines when contour lines are relatively large; in particular, when they are between 70 m and 100 m. Nonetheless, a key limitation of the algorithm is the requirement to automatically delete repeated and closed curves in the pre-treatment processes. In addition to calculating glacier flow lines for derivation of glacier length, this method also can be used to effectively determine glacier terminus change.展开更多
Biapenem, a new parenteral carbapenem, has been widely used for treating bacterial infections. A simple, effective and accurate method based on solid-phase extraction (SPE) and HPLC was developed for the quantitativ...Biapenem, a new parenteral carbapenem, has been widely used for treating bacterial infections. A simple, effective and accurate method based on solid-phase extraction (SPE) and HPLC was developed for the quantitative determination of biapenem in human plasma. Stability and feasibility of the method was validated through a series of experiments. Using Vitamin B6 as an internal standard, analyte was separated on a Capcell Pak C18 column after SPE on Oasis hydrophilic-lipophilic balance (HLB) cartridge. The mobile phase was comprised of 0.05 mol/L NaH2PO4 (pH 5.7) and methanol (98:2, v/v) at a flow rate of 1.0 mL/min. Ultraviolet absorbance was measured at 300 nm. The calibration curve was linear in the concentration range of 0.04-50.00 μg/mL, and the lower limit of quantification was as low as 0.04 μg/mL. Recovery rates of biapenem at 0.10, 5.00, and 25.00 μg/mL were about 70%. The validated method has been successfully applied for quantifying biapenem in human samples and a pharmacokinetic study of 12 healthy volunteers who received three different doses (150, 300 and 600 mg) of biapenem by intravenous infusion. Our method has featured good accuracy and precision, and the processed sample was stable. Therefore, it can be propagated for clinical use.展开更多
Cimicifugae Rhizome (RC) is one of many commonly used traditional Chinese medicines. This study used Box-Behnken Design (BBD), a widely used form of response surface methodology (RSM), to optimize the conditions...Cimicifugae Rhizome (RC) is one of many commonly used traditional Chinese medicines. This study used Box-Behnken Design (BBD), a widely used form of response surface methodology (RSM), to optimize the conditions of the ultrasound-assisted extraction (UAE) for the extraction of phenolic compounds from CimicifugaeRhizome. The influence of three independent variables, including ethanol concentration (%), extraction time (min) and solvent-to-material ratio (mL/g), on the extraction yields of phenolic compounds were examined. The results demonstrated that the optimal ultrasound-assisted extraction (UAE) conditions were as follows: ethanol concentration of 68%, an extraction time of 19 min, and solvent-to-material ratio of 30 mL/g for the extraction of caffeic acid, cimicifugoside, ferulic acid, isoferulicacid, cimifugin, 4′-O-β-glucopyranosyl-5-O-methylvisamminol. These results demonstrated the suitability of UAE for the extraction of phenolic compounds from CimicifugaeRhizome.展开更多
This paper reports the extraction of aloe-emodin from aloe by microwave-assisted extraction. The effects of various factors, including the solvent, the ratio (mL/g) of the solvent to the sample, microwave irradiatio...This paper reports the extraction of aloe-emodin from aloe by microwave-assisted extraction. The effects of various factors, including the solvent, the ratio (mL/g) of the solvent to the sample, microwave irradiation time and microwave power, were discussed in the experiments. The yield of aloe-emodin was determined by HPLC. The optimized conditions for micro- wave-assisted extraction of aloe-emodin were concluded as follows: the solvent is 80% ethanol (V/V) solution, microwave ir- radiation time is 3 rain and microwave power is 340 W. Additionally, HPLC fingerprint was developed for consistency evalua- tion of aloe. The similarities of 3 aloe samples obtained by microwave-assisted extraction, ultrasound-assisted extraction and Soxhlet extraction were more than 0.9, indicating that 3 aloe samples were consistent. Compared with Soxhlet extraction and ultrasound-assisted extraction, microwave extraction is a rapid method with higher yield and less solvent consumption. Aloe samples treated by microwave-assisted extraction, ultrasound-assisted extraction and Soxhlet extraction were observed using transmission electronic microscopy. The micrographs provide evidence of more breakage of chloroplasts treated by micro- wave-assisted extraction as compared to Soxhlet extraction and ultrasound-assisted extraction.展开更多
CaBi2Nb2O9 (CBNO) ceramics was prepared at 1050℃ using regular flake-like CBNO powders as the precursor, and synthe-sized by the molten salts synthesis method. The tropism degree and microstructure of the ceramics we...CaBi2Nb2O9 (CBNO) ceramics was prepared at 1050℃ using regular flake-like CBNO powders as the precursor, and synthe-sized by the molten salts synthesis method. The tropism degree and microstructure of the ceramics were analyzed, and the die-lectric, ferroelectric and piezoelectric properties were characterized. Compared with conventional methods, the properties of CBNO ceramics by the new preparation method were found to be better. As the sinter temperature decreases, the grain growth becomes regular with textured features. The polarization process becomes easy to be realized at room temperature. Moreover, the dielectric loss decreases and the piezoelectric constant increases significantly.展开更多
Generalized morphological operator can generate less statistical bias in the output than classical morphological operator. Comprehensive utilization of spectral and spatial information of pixels, an endmember extracti...Generalized morphological operator can generate less statistical bias in the output than classical morphological operator. Comprehensive utilization of spectral and spatial information of pixels, an endmember extraction algorithm based on generalized morphology is proposed. For the limitations of morphological operator in the pixel arrangement rule and replacement criteria, the reference pixel is introduced. In order to avoid the cross substitution phenomenon at the boundary of different object categories in the image, an endmember is extracted by calculating the generalized opening-closing(GOC) operator which uses the modified energy function as a distance measure. The algorithm is verified by using simulated data and real data. Experimental results show that the proposed algorithm can extract endmember automatically without prior knowledge and achieve relatively high extraction accuracy.展开更多
文摘A small-signal equivalent circuit model and the ted. The equivalent lumped circuit, which takes the main extraction techniques for photodetector chips are presen- factors that limit a photodetector's RF performance into consideration,is first determined based on the device's physical structure. The photodetector's S parameters are then on-wafer measured, and the measured raw data are processed with further calibration. A genetic algorithm is used to fit the measured data, thereby allowing us to calculate each parameter value of the model. Experimental resuits show that the modeled parameters are well matched to the measurements in a frequency range from 130MHz to 20GHz, and the proposed method is proved feasible. This model can give an exact description of the photodetector chip's high frequency performance,which enables an effective circuit-level prediction for photodetector and optoelectronic integrated circuits.
基金supported by the National Natural Science Foundation of China (Grant Nos. 40930531, 41001294, 41301422)the Open Project Foundation of State Key Laboratory of Resources and Environmental Information System in China (Grant No. 2010KF0002SA)
文摘Shoulder lines are the most important landform demarcations for geographical analysis,soil erosion modeling and land use planning in the Loess Plateau area of China.This paper proposes an automatic,effective and accurate method of determining loess shoulder line from DEMs by integrating a hydrological D8 algorithm and a snake model.The watershed boundary line is adopted as the initial contour which evolves to identify the exact position of loess shoulder-line by the guidance of an external force of snake model from DEMs.Experiments show that the method overcomes the difficulties in both threshold selection for edge detection and the disconnecting issues in former extraction approaches.The accuracy evaluation of shoulder-line maps from the two test sites of the loess plateau area show obvious improvements in the extraction.The average contour matching distance of the new method is 12.0 m on 5 m resolution DEM,and shows improvement in the accuracy and continuity.The comparisons of accuracy evaluations of the two test sites show that the snake model method performs better in the loess plain area than in the area with high gully density.
基金Under the auspices of National Youth Science Foundation of China(No.41001294)Key Project of National Natural Science Foundation of China(No.40930531)Research Fund of State Key Laboratory Resources and Environment Information System(No.2010KF0002SA)
文摘In China′s Loess Plateau area, gully head is the most active zone of a drainage system in gully areas. The differentiation of loess gully head follows geospatial patterns and reflects the process of the loess landform development and evolution of its drainage system to some extent. In this study, the geomorphic meaning, basic characteristics, morphological structure and the basic types of loess gully heads were systematically analysed. Then, the loess gully head′s conceptual model was established, and an extraction method based on Digital Elevation Model(DEM) for loess gully head features and elements was proposed. Through analysing the achieved statistics of loess gully head features, loess gully heads have apparently similar and different characteristics depending on the different loess landforms where they are found. The loess head characteristics reflect their growth period and evolution tendency to a certain degree, and they indirectly represent evolutionary mechanisms. In addition, the loess gully developmental stages and the evolutionary processes can be deduced by using loess gully head characteristics. This study is of great significance for development and improvement of the theoretical system for describing loess gully landforms.
基金supported by the National Science Foundation of China (grant Nos. 41271024, 41444430204, and J1210065)the Fundamental Research Funds for the Central Universities (Nos. lzujbky-2016-266 and lzujbky2016-270)
文摘Glacier length is a key morphological element that has many glaciological applications; however, it is often difficult to determine, especially for glaciers that cover larger spatial areas or those that exhibit frequent temporal change. In this paper, we describe a new Arc GIS-based method that can derive glacier flow lines for determining glacier length based on digital elevation model and glacier outlines. This method involves(1) extraction of the highest and lowest points on a glacier,(2) calculation of 10-m contour lines on the glacier from 10 m to 100 m height, and(3) connection of the midpoints of each contour line with the highest and the lowest points in order to create a flow line, which is subsequently smoothed. In order to assess the reliability of this method, we tested the algorithm's results against flow lines calculated using field measurements, analysing data from the Chinese Glacier Inventory, and manual interpretation. These data showed that the new automated method is effective in deriving glacier flow lines when contour lines are relatively large; in particular, when they are between 70 m and 100 m. Nonetheless, a key limitation of the algorithm is the requirement to automatically delete repeated and closed curves in the pre-treatment processes. In addition to calculating glacier flow lines for derivation of glacier length, this method also can be used to effectively determine glacier terminus change.
基金National Natural Science Foundation of China (Grant No.30973597)
文摘Biapenem, a new parenteral carbapenem, has been widely used for treating bacterial infections. A simple, effective and accurate method based on solid-phase extraction (SPE) and HPLC was developed for the quantitative determination of biapenem in human plasma. Stability and feasibility of the method was validated through a series of experiments. Using Vitamin B6 as an internal standard, analyte was separated on a Capcell Pak C18 column after SPE on Oasis hydrophilic-lipophilic balance (HLB) cartridge. The mobile phase was comprised of 0.05 mol/L NaH2PO4 (pH 5.7) and methanol (98:2, v/v) at a flow rate of 1.0 mL/min. Ultraviolet absorbance was measured at 300 nm. The calibration curve was linear in the concentration range of 0.04-50.00 μg/mL, and the lower limit of quantification was as low as 0.04 μg/mL. Recovery rates of biapenem at 0.10, 5.00, and 25.00 μg/mL were about 70%. The validated method has been successfully applied for quantifying biapenem in human samples and a pharmacokinetic study of 12 healthy volunteers who received three different doses (150, 300 and 600 mg) of biapenem by intravenous infusion. Our method has featured good accuracy and precision, and the processed sample was stable. Therefore, it can be propagated for clinical use.
基金Suzhou Youth science and technology plan(Grant No.KJXW2015028)
文摘Cimicifugae Rhizome (RC) is one of many commonly used traditional Chinese medicines. This study used Box-Behnken Design (BBD), a widely used form of response surface methodology (RSM), to optimize the conditions of the ultrasound-assisted extraction (UAE) for the extraction of phenolic compounds from CimicifugaeRhizome. The influence of three independent variables, including ethanol concentration (%), extraction time (min) and solvent-to-material ratio (mL/g), on the extraction yields of phenolic compounds were examined. The results demonstrated that the optimal ultrasound-assisted extraction (UAE) conditions were as follows: ethanol concentration of 68%, an extraction time of 19 min, and solvent-to-material ratio of 30 mL/g for the extraction of caffeic acid, cimicifugoside, ferulic acid, isoferulicacid, cimifugin, 4′-O-β-glucopyranosyl-5-O-methylvisamminol. These results demonstrated the suitability of UAE for the extraction of phenolic compounds from CimicifugaeRhizome.
基金supported by the National Key Technology R&D Program (2006BAI09B07-02)
文摘This paper reports the extraction of aloe-emodin from aloe by microwave-assisted extraction. The effects of various factors, including the solvent, the ratio (mL/g) of the solvent to the sample, microwave irradiation time and microwave power, were discussed in the experiments. The yield of aloe-emodin was determined by HPLC. The optimized conditions for micro- wave-assisted extraction of aloe-emodin were concluded as follows: the solvent is 80% ethanol (V/V) solution, microwave ir- radiation time is 3 rain and microwave power is 340 W. Additionally, HPLC fingerprint was developed for consistency evalua- tion of aloe. The similarities of 3 aloe samples obtained by microwave-assisted extraction, ultrasound-assisted extraction and Soxhlet extraction were more than 0.9, indicating that 3 aloe samples were consistent. Compared with Soxhlet extraction and ultrasound-assisted extraction, microwave extraction is a rapid method with higher yield and less solvent consumption. Aloe samples treated by microwave-assisted extraction, ultrasound-assisted extraction and Soxhlet extraction were observed using transmission electronic microscopy. The micrographs provide evidence of more breakage of chloroplasts treated by micro- wave-assisted extraction as compared to Soxhlet extraction and ultrasound-assisted extraction.
基金supported by the National Natural Science Foundation of China (50632030 & 10804130)
文摘CaBi2Nb2O9 (CBNO) ceramics was prepared at 1050℃ using regular flake-like CBNO powders as the precursor, and synthe-sized by the molten salts synthesis method. The tropism degree and microstructure of the ceramics were analyzed, and the die-lectric, ferroelectric and piezoelectric properties were characterized. Compared with conventional methods, the properties of CBNO ceramics by the new preparation method were found to be better. As the sinter temperature decreases, the grain growth becomes regular with textured features. The polarization process becomes easy to be realized at room temperature. Moreover, the dielectric loss decreases and the piezoelectric constant increases significantly.
基金supported by the National Natural Science Foundation of China(No.61275010)the PhD Programs Foundation of Ministry of Education of China(No.20132304110007)
文摘Generalized morphological operator can generate less statistical bias in the output than classical morphological operator. Comprehensive utilization of spectral and spatial information of pixels, an endmember extraction algorithm based on generalized morphology is proposed. For the limitations of morphological operator in the pixel arrangement rule and replacement criteria, the reference pixel is introduced. In order to avoid the cross substitution phenomenon at the boundary of different object categories in the image, an endmember is extracted by calculating the generalized opening-closing(GOC) operator which uses the modified energy function as a distance measure. The algorithm is verified by using simulated data and real data. Experimental results show that the proposed algorithm can extract endmember automatically without prior knowledge and achieve relatively high extraction accuracy.