In light of the situation that the nationwide interconnection of power networks in China in the coming years will take shape, it is imperative to emphasize the importance of setting up rational power network configura...In light of the situation that the nationwide interconnection of power networks in China in the coming years will take shape, it is imperative to emphasize the importance of setting up rational power network configuration. Combined with the characteristics of regional power networks in China, problems in network planning that need to be solved are put forward in this paper, such as, the access of power plants to grid by layers and zones, the share of external power in the load of local network, the power network configuration study in-depth in planning and design stage, and enforcement of receiving-end power network trunk etc. The background of these problems and their countermeasures are also analyzed in the paper.展开更多
This paper analyzes the power markets both in northwest sending end and, east receiving ends, points out the favorable and unfavorable conditions for power development In, the northwest area, brings forward,the develo...This paper analyzes the power markets both in northwest sending end and, east receiving ends, points out the favorable and unfavorable conditions for power development In, the northwest area, brings forward,the development planning of power sources and power network constructions, and presents the benefit estimation of sending power from northwest to east.展开更多
The detection of protein/small molecule interactions plays important roles in drug discovery and protein/metabolite interactions in biology. In this work, by coupling the terminal protection of small molecule-linked s...The detection of protein/small molecule interactions plays important roles in drug discovery and protein/metabolite interactions in biology. In this work, by coupling the terminal protection of small molecule-linked ss DNA strategy with the unmodified and positively charged gold nanoparticle((+)Au NP) nanoprobes, we have developed a sensitive and simple colorimetric sensor for the detection of folate receptor, a highly expressed protein in many kinds of malignant tumors. The target folate receptor binds the folate moieties of the folate-linked ss DNA through high affinity interactions and protects the protein-bound ss DNA from digestion by exonuclease I. The protected ss DNA thus adsorbs the((+)Au NP) through electrostatic interactions, leading to a red-to-blue color change of the sensing solution for sensitive colorimetric detection of folate receptor at the sub-nanomolar level. Besides, this colorimetric sensor shows high selectivity toward folate receptor against other control proteins. The developed sensor avoids the modification/conjugation of the Au NP nanoprobes and the involvement of any expensive instruments for signal transduction in protein detection. Featured with these obvious advantages, the colorimetric sensor strategy demonstrated herein can be easily expanded for sensitive and convenient detection of various protein/small molecule interactions.展开更多
文摘In light of the situation that the nationwide interconnection of power networks in China in the coming years will take shape, it is imperative to emphasize the importance of setting up rational power network configuration. Combined with the characteristics of regional power networks in China, problems in network planning that need to be solved are put forward in this paper, such as, the access of power plants to grid by layers and zones, the share of external power in the load of local network, the power network configuration study in-depth in planning and design stage, and enforcement of receiving-end power network trunk etc. The background of these problems and their countermeasures are also analyzed in the paper.
文摘This paper analyzes the power markets both in northwest sending end and, east receiving ends, points out the favorable and unfavorable conditions for power development In, the northwest area, brings forward,the development planning of power sources and power network constructions, and presents the benefit estimation of sending power from northwest to east.
基金supported by the National Natural Science Foundation of China (21505010, 21173274)Chongqing Research Program of Basic Research and Frontier Technology (cstc2015jcyj A1357)Scientific Research Innovation Team of Chongqing University of Technology (2015TD22)
文摘The detection of protein/small molecule interactions plays important roles in drug discovery and protein/metabolite interactions in biology. In this work, by coupling the terminal protection of small molecule-linked ss DNA strategy with the unmodified and positively charged gold nanoparticle((+)Au NP) nanoprobes, we have developed a sensitive and simple colorimetric sensor for the detection of folate receptor, a highly expressed protein in many kinds of malignant tumors. The target folate receptor binds the folate moieties of the folate-linked ss DNA through high affinity interactions and protects the protein-bound ss DNA from digestion by exonuclease I. The protected ss DNA thus adsorbs the((+)Au NP) through electrostatic interactions, leading to a red-to-blue color change of the sensing solution for sensitive colorimetric detection of folate receptor at the sub-nanomolar level. Besides, this colorimetric sensor shows high selectivity toward folate receptor against other control proteins. The developed sensor avoids the modification/conjugation of the Au NP nanoprobes and the involvement of any expensive instruments for signal transduction in protein detection. Featured with these obvious advantages, the colorimetric sensor strategy demonstrated herein can be easily expanded for sensitive and convenient detection of various protein/small molecule interactions.
