偏钒酸钠对小鼠心室肌的正性变力效应及量效关系的实验研究

偏钒酸钠对小鼠心室肌的正性变力效应及量效关系的实验研究湖南湘潭师范学院生物系（４１１２１０）陈筱春，文质君钒是人体内必需的微量元素之一，然其在体内过多的积累或缺乏都将对机体造成危害。有关钒对人体危害的临床流行病学研究迄今成果甚少，仅对某些临床表现进行...

肾上腺素受体与心血管病治疗

一、α1B-AR拮抗剂治疗高血压病 我们实验室的基础研究显示α1-AR三种亚型在血压调节、心肌正性变力效应及蛋白合成中的作用如下表:

Influence of pre-deformation on age-hardening response and mechanical properties of extruded Mg-6%Zn-1%Mn alloy

The effect of cold plastic deformation between solution treatment and artificial aging on the age-hardening response and mechanical properties of alloy was investigated by micro-hardness test,tensile test,optical microscopy（OM） and TEM observation.After solution treatment at 420 ℃ for 1 h,three kinds of pre-deformation strains,i.e.0,5% and 10%,were applied to extruded ZM61 bars.Age-hardening curves show that pre-deformation can significantly accelerate the precipitation kinetics and increase peak-hardness value;however,as pre-deformation strain rises from 5% to 10%,there is no gain in peak hardness value.The room temperature（RT） tensile properties demonstrate that increasing the pre-deformation degree can enhance the yield strength（YS） and ultimate tensile strength（UTS） but moderately reduce elongation（EL）;furthermore,the enhancement of YS is larger than that of UTS.No twin can be observed in 5% pre-deformed microstructure;however,a large number of twins are activated after 10% pre-deformation.The peak-aged TEM microstructure shows that pre-deformation can increase the number density of rod-shaped β 1 ＇ precipitates which play a key role in strengthening ZM61 alloy.

心脏α-肾上腺素受体的反应特性和功能意义

从60年代起至今已积累充分的证据说明心脏存在α-肾上腺素受体,其反应特性不同于β受体。α受体兴奋引起缓的正性变力作用,不加快心率,可延长心肌功能不应期,延长蒲肯野纤维动作电位时程;不使细胞内cAMP增加。α受体在协调心肌正常活动、维持正常心律、以及在某些病症的发生上有一定意义。

烧损血浆中分子对大鼠动脉血压的影响

本文观察了烧伤血浆中分子物质(BMMS) 对36只正常SD大鼠的动脉血压心电活动及呼吸运动等的影响,结果表明:与对照组相比,1.心率明显减慢,由427.5±6.9次/分,减至320.1±3.7次/分,收缩压和舒张压分别下降38.2％和42％;动脉压的最大上升及下降速率也相应降低44.8％和55.7％(P【0.001);2.抑制心电活动,在标准11导联,P波,QRS波群。

Binding Energies of Screened Excitons in a Strained(111)-Oriented Zinc-Blende GaN/AlGaN Quantum Well Under Hydrostatic Pressure

We investigate the binding energies of excitons in a strained （111）-oriented zinc-blende GaN/Al0.3 Ga0.7 N quantum well screened by the electron-hole （e-h） gas under hydrostatic pressure by combining a variational method and a selfconsistent procedure. A built-in electric field produced by the strain-induced piezoelectric polarization is considered in our calculations. The result indicates that the binding energies of excitons increase nearly linearly with pressure,even though the modification of strain with hydrostatic pressure is considered, and the influence of pressure is more apparent under higher e-h densities. It is also found that as the density of an e-h gas increases,the binding energies first increase slowly to a maximum and then decrease rapidly when the e-h density is larger than about 1 ×10^11 cm^-2. The excitonic binding energies increase obviously as the barrier thickness decreases due to the decrease of the built-in electric field.

Impact of anisotropic growth on kinetics of solid-state phase transformation

Based on the statistical analysis of blocking effect arising from anisotropic growth,the anisotropic effect on the kinetics of solid-state transformation was investigated.The result shows that the blocking effect leads to the retardation of transformation and then a regular behavior of varying Avrami exponent.Following previous analytical model,the formulations of Avrami exponent and effective activation energy accounting for blocking effect were obtained.The anisotropic effect on the transformation depends on two factors,non-blocking factor γ and blocking scale k,which directly acts on the dimensionality of growth.The effective activation energy is not affected by the anisotropic effect.The evolution of anisotropic effect with the fraction transformed is taken into account,showing that the anisotropic effect is more severe at the middle stage of transformation.

Influence of Device Narrowing on HALO-pMOSFETs' Degradation Under V_g= V_d/2 Stress Mode

The degradation characteristics of both wide and narrow devices under V _g= V _d/2 stress mode is investigated.The width-enhanced device degradation can be seen with devices narrowing.The main degradation mechanism is interface state generation for pMOSFETs with different channel width.The cause of the width-enhanced device degradation is attributed to the combination of width-enhanced threshold voltage and series resistance.

Mechanical behavior of deep sandstone under high stress-seepage coupling

The mechanical behavior evolution characteristics of sandstone are important to the application and practice of rock engineering.Therefore,a new method and concept of deep rock mechanics testing are proposed to reveal the mechanical behavior evolution mechanism of deep roadway surrounding rock after excavation with a depth over 1000 m.High stress-seepage coupling experiments of deep sandstone under various confining pressures are conducted using GCTS.Stress−strain and permeability curves are obtained.The three-stage mechanical behavior of deep sandstone is better characterized.A platform and secondary compaction phenomena are observed.With the confining pressure increasing,the platform length gradually decreases,even disappears.In the stade I,the rigid effect of deep sandstone is remarkable.In the stage II,radial deformation of deep sandstone dominates.The transient strain of confining pressure compliance is defined,which shows three-stage evolution characteristics.In the stage III,the radial deformation is greater than the axial deformation in the pre-peak stage,but the opposite trend is observed in the post-peak stage.It is found that the dynamic permeability can be more accurately characterized by the radial strain.The relations between the permeability and stress−strain curves in various stages are revealed.

An Analytical Model of Electron Mobility for Strained-Si Channel nMOSFETs

An analytical model of electron mobility for strained-silicon channel nMOSFETs is proposed in this paper. The model deals directly with the strain tensor,and thus is independent of the manufacturing process. It is suitable for （100〉/ 〈110） channel nMOSFETs under biaxial or （100〉/〈 110 ） uniaxial stress and can be implemented in conventional device simulation tools .

Simulation study on fluctuant flow stress scale effect

Crystal plasticity theory was used to simulate upsetting tests of different dimensions and grain size micro copper cylinders in this study on the fluctuant flow stress scale effect. Results showed that with the decrease of billet grain quantity, flow stress fluctuation is not always increased, but there is a maximum. Through this study, the fluctuant flow stress scale effect can be understood deeper, and relevant necessary information was obtained for further prediction and control of this scale effect and to design the microforming process and die.

Compression behavior and constitutive model establishment of fly ash cenosphere/polyurethane aluminum alloy syntactic foam

The aluminum matrix syntactic foam was fabricated by pressure infiltration technique,and the filling material is syntactic foam material with fly ash cenosphere as the main component and polyurethane foam as the binder.Split Hopkinson pressure bar(SHPB)dynamic compression and quasi-static tests were carried out to examine the compressive response of syntactic foam in this study.Then the dynamic constitutive model was established.Results show that the compressive stress-strain curve of syntactic aluminum foam is similar to that of other metallic foam materials:both kinds of aluminum matrix syntactic foams have strain rate effect,and the syntactic foam has higher compressive strength and energy absorption than the same density aluminum foams.However,due to the different sizes of cenospheres,the dynamic compression results of two kinds of syntactic foams are different,and the energy absorption effect of syntactic foam with small size under dynamic impact is the best.In the range of strain rate and density studied experimentally,the curves of constitutive model fit well with the curves of experimental data.

Effects of Heat Softening on Initiation of Landslides

Effects of heat softening on the initiation of slide surface(shear banding) in clayey slopes during fast deformation were discussed.Controlling equations considering heat,pore pressure and mechanical movement were presented.By perturbation method,the instability condition of localized zone(i.e.criterion for initiation of shear banding) for thermal related soils,such as clayey slope,was obtained.It is shown that slide surface initiates once the thermal-softening effects overcome the strain-hardening effects whether it is adiabatic or not.Without strain hardening effects,strain rate hardening obviously plays a role in initiation of shear band.During initiating process,heat is trapped inside the shear band,which leads rapidly to a pore pressure increase and fast loss of strength.The localized shear strain is concentrated in a narrow zone with a width of several centimeters at most and increases fast.This zone forms the sliding surface.Temperature can increase more than 2?C,pore pressure can increase 160% in about 0.1s inside this zone.These changes cause the fast decrease in friction-coefficient by about 36% over the initial value.That is how shear band initiated and developed in clayey slopes.

Pressure relief, gas drainage and deformation effects on an overlying coal seam induced by drilling an extra-thin protective coal seam

Numerical simulations and field tests were used to investigate the changes in ground stress and deformation of, and gas flow from, a protected coal seam under which an extra-thin coal seam was drilled. The geological conditions were: 0.5 meter mining height, 18.5 meter coal seam spacing and a hard limestone/fine sandstone inter-stratum. For these conditions we conclude: 1) the overlying coal-rock mass bends and sinks without the appearance of a caving zone, and 2) the protected coal seam is in the bending zone and undergoes expansion deformation in the stress-relaxed area. The deformation was 12 mm and the relative defor- mation was 0.15%. As mining proceeds, deformation in the protected layer begins as compression, then becomes a rapid expansion and, finally, reaches a stable value. A large number of bed separation crannies are created in the stress-relaxed area and the permeability coefficient of the coal seam was increased 403 fold. Grid penetration boreholes were evenly drilled toward the protected coal seam to affect pressure relief and gas drainage. This made the gas pressure decrease from 0.75 to 0.15 MPa, the gas content decrease from 13 to 4.66 m3/t and the gas drainage reach 64%.

Closed-form solution for shear lag effects of steel-concrete composite box beams considering shear deformation and slip

Based on the consideration of longitudinal warp caused by shear lag effects on concrete slabs and bottom plates of steel beams,shear deformation of steel beams and interface slip between steel beams and concrete slabs,the governing differential equations and boundary conditions of the steel-concrete composite box beams under lateral loading were derived using energy-variational method.The closed-form solutions for stress,deflection and slip of box beams under lateral loading were obtained,and the comparison of the analytical results and the experimental results for steel-concrete composite box beams under concentrated loading or uniform loading verifies the closed-form solution.The investigation of the parameters of load effects on composite box beams shows that:1) Slip stiffness has considerable impact on mid-span deflection and end slip when it is comparatively small;the mid-span deflection and end slip decrease significantly with the increase of slip stiffness,but when the slip stiffness reaches a certain value,its impact on mid-span deflection and end slip decreases to be negligible.2) The shear deformation has certain influence on mid-span deflection,and the larger the load is,the greater the influence is.3) The impact of shear deformation on end slip can be neglected.4) The strain of bottom plate of steel beam decreases with the increase of slip stiffness,while the shear lag effect becomes more significant.

Primary and recency effects based on loading path in classical plasticity

We have established an elastoplastic analysis model to explore the effect of loading path in an incompressible thin-walled tube under the combined action of axial force and torque based on Mises yield condition and isotropic linear hardening assumption.Further,four stress areas(σx,τx)are divided according to the characteristics of the final stress,and the plastic stress-strain relationship of twelve stress paths in different stress areas is derived.The"primary effect"of the stress path on plastic strain is demonstrated,namely,the plastic strain caused by the pre-loaded stress in path A(tensile stress is initially applied,followed by shear stress)is always greater than that caused by the post-loaded stress in path C(shear stress is initially applied,followed by tensile stress)irrespective of the value of final stress.The"recency effect"of the strain path on the stress is also established,which indicates that the stress caused by the post-loaded strain in path A is always greater than that caused by the pre-loaded strain in path C irrespective of the value of final strain.From the perspective of deformation,the"primary effect"of the stress path on the plastic strain and the"recency effect"of the strain path on the stress are unified.These effects are succinct and universal,and they provide useful insights on the plastic stress-strain relationship under different loading paths.Furthermore,they can serve as a useful reference for optimizing the processing technologies and construction procedures.

Stress-drop effect on brittleness evaluation of rock materials

Uniaxial or triaxial compression test of cylindrical rock specimens using rock mechanics testing machine is a basic experimental method to study the strength and deformation characteristics of rock and the development process of rock fracture. Extensive literature review has been conducted on this issue;meanwhile, experimental and numerical studies have been conducted on the stress-drop effect on the brittleness of rock materials. A plastic flow factor of λ is proposed to describe the stress-drop effect. Evaluation methods of the factor λ corresponding to the four yield criteria of rock mass are proposed. Those four yield criteria are Tresca criterion, von-Mises criterion, Mohr-Coulomb criterion and Drucker-Prager criterion. For simplicity purposes, an engineering approximation approach has been proposed to evaluate the stress-drop with a non-zero strain increment. Numerical simulation results validated the effectiveness of the plastic flow factors λ as well as the engineering approximation approach. Based on the results in this study, finite element code can be programmed for brittle materials with stress-drop, which has the potential to be readily incorporated in finite element codes.

Properties of failure mode and thermal damage for limestone at high temperature

The mechanical properties of limestone such as the stress-strain curve, the variable characteristics of peak strength and the modulus of elasticity of limestone were studied under the action of temperatures ranging from room temperature to 800 °C.Our results show that:1) the temperature has not clear effect on the mechanical properties of limestone from room temperature to 600 °C.However, the mechanical properties of limestone deteriorate rapidly when the temperature is above 600 °C.In this case, the peak stress and modulus of elasticity decrease rapidly.When the temperature reaches 800 °C, the entire process, showing the stress-strain curve is displayed indicating an obvious state of plastic-deformation;2) the failure mode of limestone shows the breakdown of tensile strength from room temperature to 600 °C, as well as the compress shearing damage over 600 °C;3) combining our test results with the concept of thermal damage, a thermal damage equation was derived.