This paper carries out quantitative analysis on the land use/cover (LU/C) change of 13anjin Binhai New Area in recent 10 years through using land use transition matrix from the three-stage LU/C classification maps o...This paper carries out quantitative analysis on the land use/cover (LU/C) change of 13anjin Binhai New Area in recent 10 years through using land use transition matrix from the three-stage LU/C classification maps of 2000, 2005 and 2010 drafted by means of the National Land Classification System of China based on Landsat TM satellite remote sensing image and the Tianjin Binhai New Area 1:50 000 relief maps. On this basis, the impact of such driving factors as the economy and population on LU/C is further analyzed. The results show that the area of the building land in Binhai New Area has increased significantly over the ten years, and the greenland, wetland, and shoals of high ecological value have been dramatically transformed into the building land and unused land for the development and construction, and the change is more significant in the later five years.展开更多
Using path analysis, correlation analysis, partial correlation analysis and system dynamics method to study the driving force of cultivated land in Qinghai Lake Area, and using gradually regression analysis to establi...Using path analysis, correlation analysis, partial correlation analysis and system dynamics method to study the driving force of cultivated land in Qinghai Lake Area, and using gradually regression analysis to establish the driving force model of utilized change of cultivated land. Driving factors, action mechanism and process of utilized change of cultivated land were analyzed, and the differences during all factors were compared. The study provides some decision basis for sustainable utilization and management of land resources in Qinghai Lake Area.展开更多
The contribution rate of ecosystem service value variation was used to analyze the effects of land use changes on the changes of ecosystem service value in Xingguo County during 1996-2005.Grey integrated correlation w...The contribution rate of ecosystem service value variation was used to analyze the effects of land use changes on the changes of ecosystem service value in Xingguo County during 1996-2005.Grey integrated correlation was employed to explore the contribution level of the indicators such as total population,urbanization level,proportion of primary industry and investment of social fixed assets on ecosystem service value,and the correlation analysis was also carried out.The results showed that the ecosystem service value in Xingguo County during 1996-2005 mainly was woodland,and the decrease of woodland area was the major reason for the sustained reduction of ecosystem service value.With the further increase of market demand and the incentives of local government,the garden area rapidly increased during 2001-2005,and the influence degree of garden towards the changes of ecosystem service value was only second to woodland,ranking No.2.Four socio-economic indicators had different correlation degree with ecosystem service value during the different research periods.Total population,urbanization level and proportion of primary industry had high correlation degree with ecosystem service value,whereas the influence degree of various socio-economic indicators on ecosystem service value was equal with each other day by day.Urbanization level,investment of social fixed assets and total population had significant negative correlation with ecosystem service value,while the proportion of primary industry had positive correlation with ecosystem service value.展开更多
In this paper, numerical method is used als. A typical unit of masonry is selected to serve merical model of RVE is established with detailed to study the strain rate effect on masonry materias a representative volume...In this paper, numerical method is used als. A typical unit of masonry is selected to serve merical model of RVE is established with detailed to study the strain rate effect on masonry materias a representative volume element (RVE). Nudistinctive modeling of brick and mortar with their respective dynamic material properties obtained from laboratory tests. The behavior of brick and mortar are characterized by a dynamic damage model that accounts for rate-sensitive and pressuredependent properties of masonry materials. Dynamic loads of different loading rates are applied to RVE. The equivalent homogenized uniaxial compressive strength, threshold strain and elastic modulus in three directions of the masonry are derived from the simulated responses of the RVE. The strain rate effect on the masonry material with clay brick and mortar, such as the dynamic increase factor (DIF) of the ultimate strength and elastic modulus as a function of strain rate are derived from the numerical results.展开更多
AIM: To investigate the protein expression profi le of mismatch repair (MMR) genes in suspected cases of Lynch syndrome and to characterize the associated germline mutations. METHODS: Immunohistochemical analysis of t...AIM: To investigate the protein expression profi le of mismatch repair (MMR) genes in suspected cases of Lynch syndrome and to characterize the associated germline mutations. METHODS: Immunohistochemical analysis of tumor samples was performed to determine the protein expression profile of MMR protein. Germline mutation screening was carried out on peripheral blood samples. The entire exon regions of MLH1 and MSH2 geneswere amplifi ed by polymerase chain reaction, screened by denaturing high performance liquid chromatography (dHPLC) and analyzed by DNA sequencing to characterize the germline mutations. RESULTS: Three out of 34 tissue samples (8.8%) and four out of 34 tissue samples (11.8%) showed loss of nuclear staining by immunohistochemistry, indicating the absence of MLH1 and MSH2 protein expression in carcinoma cells, respectively. dHPLC analysis followed by DNA sequencing showed these samples to have germline mutations of MSH2 gene. However, no deleterious mutations were identifi ed in any of the 19 exons or coding regions of MLH1 gene, but we were able to identify MLH1 promoter polymorphism, -93G > A (rs1800734), in 21 out of 34 patients (61.8%). We identified one novel mutation, transversion mutation c.2005G > C, which resulted in a missense mutation (Gly669Arg), a transversion mutation in exon 1, c.142G > T, which resulted in a nonsense mutation (Glu48Stop) and splice-site mutation, c.2006-6T > C, which was adjacent to exon 13 of MSH2 gene. CONCLUSION: Germline mutations were identified in four Malaysian Lynch syndrome patients. Immunohistochemical analysis of tumor tissue proved to be a good pre-screening test before proceeding to germline mutation analysis of DNA MMR genes.展开更多
Urban growth is a key indicator of economic development.At the same time,haphazard urban growth creates serious socioeconomic,environmental and urban land management problems.In this context,understanding the process ...Urban growth is a key indicator of economic development.At the same time,haphazard urban growth creates serious socioeconomic,environmental and urban land management problems.In this context,understanding the process of urban landscape change is important for guiding the sustainable growth of urban areas.This study analyzes the urban land changes during 1990–2018 in two metropolitan cities of Gandaki basin:Pokhara and Bharatpur.Landsat satellite images were analyzed using supervised classification methods.The results revealed that the built-up area has increased significantly by 300%in Pokhara and by nearly 500%in the Bharatpur during the past 28 years.Population growth,migration from surrounding areas due to urban facilities and the easy lifestyle in cities were found to be major determinants of urban growth within the study area.In addition,the changing urban definition and expansion of municipal boundaries are key factors for rapid urban growth.Both cities are likely to grow in the future as they are both located in areas that encompass the high levels of commercial activity and modern service facilities.The haphazard urban growth should be minimized through planning and policies for sustainable urban development.展开更多
文摘This paper carries out quantitative analysis on the land use/cover (LU/C) change of 13anjin Binhai New Area in recent 10 years through using land use transition matrix from the three-stage LU/C classification maps of 2000, 2005 and 2010 drafted by means of the National Land Classification System of China based on Landsat TM satellite remote sensing image and the Tianjin Binhai New Area 1:50 000 relief maps. On this basis, the impact of such driving factors as the economy and population on LU/C is further analyzed. The results show that the area of the building land in Binhai New Area has increased significantly over the ten years, and the greenland, wetland, and shoals of high ecological value have been dramatically transformed into the building land and unused land for the development and construction, and the change is more significant in the later five years.
基金Supported by The Regional Sustainable Development of the Qing-TibetPlateau(2004)~~
文摘Using path analysis, correlation analysis, partial correlation analysis and system dynamics method to study the driving force of cultivated land in Qinghai Lake Area, and using gradually regression analysis to establish the driving force model of utilized change of cultivated land. Driving factors, action mechanism and process of utilized change of cultivated land were analyzed, and the differences during all factors were compared. The study provides some decision basis for sustainable utilization and management of land resources in Qinghai Lake Area.
基金Supported by Natural Science Foundation of Jiangxi Province"Research on Optimization Model of Land Use in Southern Hilly Region with Red Soil in Jiangxi Province based on Ecological Security Evaluation"(2008GQH0057)Educational Commission of Jiangxi Province"Research on Scenario Simulation of Land Use Security Pattern in Southern Hilly Region with Red Soil in Jiangxi Province" (GJJ09557)Innovative Experimental Projects of National University Students"Research on Land Use Ecological Security Assessment in Hilly Region with Red Soil based on GIS-Xingguo County in Jiangxi Province as an Example"(101042124)~~
文摘The contribution rate of ecosystem service value variation was used to analyze the effects of land use changes on the changes of ecosystem service value in Xingguo County during 1996-2005.Grey integrated correlation was employed to explore the contribution level of the indicators such as total population,urbanization level,proportion of primary industry and investment of social fixed assets on ecosystem service value,and the correlation analysis was also carried out.The results showed that the ecosystem service value in Xingguo County during 1996-2005 mainly was woodland,and the decrease of woodland area was the major reason for the sustained reduction of ecosystem service value.With the further increase of market demand and the incentives of local government,the garden area rapidly increased during 2001-2005,and the influence degree of garden towards the changes of ecosystem service value was only second to woodland,ranking No.2.Four socio-economic indicators had different correlation degree with ecosystem service value during the different research periods.Total population,urbanization level and proportion of primary industry had high correlation degree with ecosystem service value,whereas the influence degree of various socio-economic indicators on ecosystem service value was equal with each other day by day.Urbanization level,investment of social fixed assets and total population had significant negative correlation with ecosystem service value,while the proportion of primary industry had positive correlation with ecosystem service value.
基金Supported by Australia Research Council(No.DP0451966)
文摘In this paper, numerical method is used als. A typical unit of masonry is selected to serve merical model of RVE is established with detailed to study the strain rate effect on masonry materias a representative volume element (RVE). Nudistinctive modeling of brick and mortar with their respective dynamic material properties obtained from laboratory tests. The behavior of brick and mortar are characterized by a dynamic damage model that accounts for rate-sensitive and pressuredependent properties of masonry materials. Dynamic loads of different loading rates are applied to RVE. The equivalent homogenized uniaxial compressive strength, threshold strain and elastic modulus in three directions of the masonry are derived from the simulated responses of the RVE. The strain rate effect on the masonry material with clay brick and mortar, such as the dynamic increase factor (DIF) of the ultimate strength and elastic modulus as a function of strain rate are derived from the numerical results.
基金Supported by USM Research University Grant, No. 1001/CIPPT/813005
文摘AIM: To investigate the protein expression profi le of mismatch repair (MMR) genes in suspected cases of Lynch syndrome and to characterize the associated germline mutations. METHODS: Immunohistochemical analysis of tumor samples was performed to determine the protein expression profile of MMR protein. Germline mutation screening was carried out on peripheral blood samples. The entire exon regions of MLH1 and MSH2 geneswere amplifi ed by polymerase chain reaction, screened by denaturing high performance liquid chromatography (dHPLC) and analyzed by DNA sequencing to characterize the germline mutations. RESULTS: Three out of 34 tissue samples (8.8%) and four out of 34 tissue samples (11.8%) showed loss of nuclear staining by immunohistochemistry, indicating the absence of MLH1 and MSH2 protein expression in carcinoma cells, respectively. dHPLC analysis followed by DNA sequencing showed these samples to have germline mutations of MSH2 gene. However, no deleterious mutations were identifi ed in any of the 19 exons or coding regions of MLH1 gene, but we were able to identify MLH1 promoter polymorphism, -93G > A (rs1800734), in 21 out of 34 patients (61.8%). We identified one novel mutation, transversion mutation c.2005G > C, which resulted in a missense mutation (Gly669Arg), a transversion mutation in exon 1, c.142G > T, which resulted in a nonsense mutation (Glu48Stop) and splice-site mutation, c.2006-6T > C, which was adjacent to exon 13 of MSH2 gene. CONCLUSION: Germline mutations were identified in four Malaysian Lynch syndrome patients. Immunohistochemical analysis of tumor tissue proved to be a good pre-screening test before proceeding to germline mutation analysis of DNA MMR genes.
基金The National Natural Science Foundation of China(41761144081)The Second Tibetan Plateau Scientific Expedition and Research(2019QZKK2203)+1 种基金The International Partnership Program of Chinese Academy of Sciences(131C11KYSB20160061)The Chinese Academy of Sciences-The World Academy of Sciences(CAS-TWAS)President’s Fellowship Program for Ph D Study
文摘Urban growth is a key indicator of economic development.At the same time,haphazard urban growth creates serious socioeconomic,environmental and urban land management problems.In this context,understanding the process of urban landscape change is important for guiding the sustainable growth of urban areas.This study analyzes the urban land changes during 1990–2018 in two metropolitan cities of Gandaki basin:Pokhara and Bharatpur.Landsat satellite images were analyzed using supervised classification methods.The results revealed that the built-up area has increased significantly by 300%in Pokhara and by nearly 500%in the Bharatpur during the past 28 years.Population growth,migration from surrounding areas due to urban facilities and the easy lifestyle in cities were found to be major determinants of urban growth within the study area.In addition,the changing urban definition and expansion of municipal boundaries are key factors for rapid urban growth.Both cities are likely to grow in the future as they are both located in areas that encompass the high levels of commercial activity and modern service facilities.The haphazard urban growth should be minimized through planning and policies for sustainable urban development.