目的观察小儿肺咳颗粒联合布地奈德治疗儿童咳嗽变异性哮喘的疗效及对机体免疫力的影响。方法选取73例咳嗽变异性哮喘儿童作为研究对象,用随机数字表法分为联合组(n=36)和对照组(n=37)。对照组给予布地奈德治疗,联合组给予小儿肺咳颗粒...目的观察小儿肺咳颗粒联合布地奈德治疗儿童咳嗽变异性哮喘的疗效及对机体免疫力的影响。方法选取73例咳嗽变异性哮喘儿童作为研究对象,用随机数字表法分为联合组(n=36)和对照组(n=37)。对照组给予布地奈德治疗,联合组给予小儿肺咳颗粒联合布地奈德治疗。比较2组的临床疗效、不良反应的发生情况、复发率以及治疗前后咳嗽症状、免疫功能、肺功能和炎症指标的水平。结果联合组的总有效率(94.44%)明显高于对照组(75.68%),P<0.05。治疗后,2组的日间、夜间咳嗽症状评分均明显降低,且联合组低于对照组(P<0.05);2组的CD4^(+)、CD4^(+)/CD8^(+)水平明显降低,CD8^(+)水平明显升高,且联合组的改善程度明显优于对照组(P<0.05);2组的第1秒用力呼气容积(forced expiratory volume in first second,FEV_(1))、用力肺活量(forced vital capacity,FVC)、第1秒用力呼气容积占用力肺活量百分比(forced expiratory volume in first second/forced vital capacity,FEV_(1)/FVC)均明显升高,且联合组高于对照组(P<0.05);2组的血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-4(interleukin-4,IL-4)水平均明显降低,且联合组低于对照组(P<0.05)。联合组的不良反应发生率(13.89%)与对照组(18.92%)比较差异无统计学意义(P>0.05),联合组的随访期复发率为5.56%,明显低于对照组(27.03%),P<0.05。结论小儿肺咳颗粒联合布地奈德治疗儿童咳嗽变异性哮喘的临床疗效显著,不仅能提高患儿的免疫力,同时能有效缓解患儿的咳嗽症状,降低炎症因子水平,改善肺功能,有效降低复发率。展开更多
目的:观察麻荆止咳颗粒对咳嗽变异性哮喘(CVA)模型大鼠肺组织病理形态学变化及咳嗽次数的影响,探讨麻荆止咳颗粒改善CVA气道炎症的作用及疗效。方法:将60只SPF级SD雄性大鼠按照随机数字表法分为空白组、模型组、孟鲁司特钠组和麻荆止咳...目的:观察麻荆止咳颗粒对咳嗽变异性哮喘(CVA)模型大鼠肺组织病理形态学变化及咳嗽次数的影响,探讨麻荆止咳颗粒改善CVA气道炎症的作用及疗效。方法:将60只SPF级SD雄性大鼠按照随机数字表法分为空白组、模型组、孟鲁司特钠组和麻荆止咳颗粒低、中、高剂量组各10只。空白组不予造模,其余各组均采用卵清白蛋白(OVA)和氢氧化铝凝胶致敏并用OVA雾化激发的方法复制CVA模型大鼠。造模成功后,孟鲁司特钠组给予孟鲁司特钠溶液,麻荆止咳颗粒低、中、高剂量组分别给予麻荆止咳颗粒溶液对应药物剂量灌胃给药,空白组、模型组给予等体积蒸馏水,每天1次,连续14天。观察6组大鼠HE染色肺组织病理形态学变化及末次给药后3 min内咳嗽次数。结果:与空白组比较,模型组可见显著的气道炎症表现,末次给药后3 min咳嗽次数明显增多(P P P P > 0.05),麻荆止咳颗粒低、中、高剂量组气道炎症浸润改善情况无显著性差异(P > 0.05)。结论:麻荆止咳颗粒可减轻CVA大鼠肺组织的气道炎性损伤,减少咳嗽次数,从而减轻气道炎症,促进疾病恢复。Objective: To observe the effect of Majing Zhike Granules on the pathological morphological changes of lung tissue and the number of coughs in rats with cough variant asthma (CVA) model, and to explore the effect and efficacy of Majing Zhike Granules in improving CVA airway inflammation. Methods: Sixty SPF SD male rats were randomly divided into a blank group, a model group, a montelukast sodium group, and a low-, medium-, and high-dose Majing Zhike Granules group, 10 in each group. The blank group was not modeled, and the remaining groups were sensitized with ovalbumin (OVA) and aluminum hydroxide gel and stimulated with OVA aerosol to replicate the CVA model rats. After successful modeling, the montelukast sodium group was given montelukast sodium solution, and the low-, medium-, and high-dose Majing Zhike Granules groups were given Majing Zhike Granules solution by gavage at the corresponding drug doses. The blank group and model group were given equal volumes of distilled water once a day for 14 consecutive days. The pathological morphological changes of lung tissues stained with HE and the number of coughs within 3 minutes after the last administration of the drug were observed in the six groups of rats. Results: Compared with the blank group, the model group showed significant airway inflammation, and the number of coughs increased significantly 3 minutes after the last administration (P P P P > 0.05). There was no significant difference in the improvement of airway inflammatory infiltration in the low, medium and high dose groups of Majing Zhike Granules (P > 0.05). Conclusion: Majing Zhike Granules can reduce airway inflammatory damage in the lung tissue of CVA rats, reduce the number of coughs, thereby reducing airway inflammation and promoting disease recovery.展开更多
文摘目的观察小儿肺咳颗粒联合布地奈德治疗儿童咳嗽变异性哮喘的疗效及对机体免疫力的影响。方法选取73例咳嗽变异性哮喘儿童作为研究对象,用随机数字表法分为联合组(n=36)和对照组(n=37)。对照组给予布地奈德治疗,联合组给予小儿肺咳颗粒联合布地奈德治疗。比较2组的临床疗效、不良反应的发生情况、复发率以及治疗前后咳嗽症状、免疫功能、肺功能和炎症指标的水平。结果联合组的总有效率(94.44%)明显高于对照组(75.68%),P<0.05。治疗后,2组的日间、夜间咳嗽症状评分均明显降低,且联合组低于对照组(P<0.05);2组的CD4^(+)、CD4^(+)/CD8^(+)水平明显降低,CD8^(+)水平明显升高,且联合组的改善程度明显优于对照组(P<0.05);2组的第1秒用力呼气容积(forced expiratory volume in first second,FEV_(1))、用力肺活量(forced vital capacity,FVC)、第1秒用力呼气容积占用力肺活量百分比(forced expiratory volume in first second/forced vital capacity,FEV_(1)/FVC)均明显升高,且联合组高于对照组(P<0.05);2组的血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-4(interleukin-4,IL-4)水平均明显降低,且联合组低于对照组(P<0.05)。联合组的不良反应发生率(13.89%)与对照组(18.92%)比较差异无统计学意义(P>0.05),联合组的随访期复发率为5.56%,明显低于对照组(27.03%),P<0.05。结论小儿肺咳颗粒联合布地奈德治疗儿童咳嗽变异性哮喘的临床疗效显著,不仅能提高患儿的免疫力,同时能有效缓解患儿的咳嗽症状,降低炎症因子水平,改善肺功能,有效降低复发率。
文摘目的:观察麻荆止咳颗粒对咳嗽变异性哮喘(CVA)模型大鼠肺组织病理形态学变化及咳嗽次数的影响,探讨麻荆止咳颗粒改善CVA气道炎症的作用及疗效。方法:将60只SPF级SD雄性大鼠按照随机数字表法分为空白组、模型组、孟鲁司特钠组和麻荆止咳颗粒低、中、高剂量组各10只。空白组不予造模,其余各组均采用卵清白蛋白(OVA)和氢氧化铝凝胶致敏并用OVA雾化激发的方法复制CVA模型大鼠。造模成功后,孟鲁司特钠组给予孟鲁司特钠溶液,麻荆止咳颗粒低、中、高剂量组分别给予麻荆止咳颗粒溶液对应药物剂量灌胃给药,空白组、模型组给予等体积蒸馏水,每天1次,连续14天。观察6组大鼠HE染色肺组织病理形态学变化及末次给药后3 min内咳嗽次数。结果:与空白组比较,模型组可见显著的气道炎症表现,末次给药后3 min咳嗽次数明显增多(P P P P > 0.05),麻荆止咳颗粒低、中、高剂量组气道炎症浸润改善情况无显著性差异(P > 0.05)。结论:麻荆止咳颗粒可减轻CVA大鼠肺组织的气道炎性损伤,减少咳嗽次数,从而减轻气道炎症,促进疾病恢复。Objective: To observe the effect of Majing Zhike Granules on the pathological morphological changes of lung tissue and the number of coughs in rats with cough variant asthma (CVA) model, and to explore the effect and efficacy of Majing Zhike Granules in improving CVA airway inflammation. Methods: Sixty SPF SD male rats were randomly divided into a blank group, a model group, a montelukast sodium group, and a low-, medium-, and high-dose Majing Zhike Granules group, 10 in each group. The blank group was not modeled, and the remaining groups were sensitized with ovalbumin (OVA) and aluminum hydroxide gel and stimulated with OVA aerosol to replicate the CVA model rats. After successful modeling, the montelukast sodium group was given montelukast sodium solution, and the low-, medium-, and high-dose Majing Zhike Granules groups were given Majing Zhike Granules solution by gavage at the corresponding drug doses. The blank group and model group were given equal volumes of distilled water once a day for 14 consecutive days. The pathological morphological changes of lung tissues stained with HE and the number of coughs within 3 minutes after the last administration of the drug were observed in the six groups of rats. Results: Compared with the blank group, the model group showed significant airway inflammation, and the number of coughs increased significantly 3 minutes after the last administration (P P P P > 0.05). There was no significant difference in the improvement of airway inflammatory infiltration in the low, medium and high dose groups of Majing Zhike Granules (P > 0.05). Conclusion: Majing Zhike Granules can reduce airway inflammatory damage in the lung tissue of CVA rats, reduce the number of coughs, thereby reducing airway inflammation and promoting disease recovery.
