目的:探讨鱼肝油软膏在变态反应性接触性皮炎(ACD)治疗中的应用及其对免疫因子水平的影响。方法:选取ACD患儿76例,随机分为ACD1组和ACD2组,每组各38例。另选取健康儿童38例设为对照组。ACD1组患儿给予弱效糖皮质激素等治疗,ACD2组在弱...目的:探讨鱼肝油软膏在变态反应性接触性皮炎(ACD)治疗中的应用及其对免疫因子水平的影响。方法:选取ACD患儿76例,随机分为ACD1组和ACD2组,每组各38例。另选取健康儿童38例设为对照组。ACD1组患儿给予弱效糖皮质激素等治疗,ACD2组在弱效糖皮质激素治疗的基础上,增加鱼肝油软膏涂抹患处。两组患儿均治疗4周。比较对照组及ACD1组、ACD2组治疗前后的血清免疫因子水平,包括IL-1β、IL-2、IL-4、IL-10、IL-17、IFN-γ、TNF-α;比较ACD1组、ACD2组治疗前后的局部皮损症状评分;比较两组治疗4周内的不良反应发生率及治疗8周内的复发率。结果:治疗前,ACD1组与ACD2组血清IL-1β、IL-2、IL-17、IFN-γ、TNF-α水平均高于对照组,IL-4、IL-10水平均低于对照组(P<0.05或P<0.01)。治疗后,ACD1组与ACD2组血清中IL-1β、IL-2、IL-17、IFN-γ、TNF-α均有不同程度的降低,IL-4、IL-10均有不同程度的升高(P<0.05或P<0.01);且ACD2组血清IL-1β、IL-2、IL-17、IFN-γ、TNF-α水平均低于ACD1组,IL-4、IL-10水平均高于ACD1组(P<0.05)。治疗后,ACD1组与ACD2组局部瘙痒、烧灼感、红斑、丘疹、水疱、皮损面积等症状的体征评分均不同程度地降低(P<0.05或P<0.01);且ACD2组上述评分均低于ACD1组(P<0.05)。治疗后,ACD2组总有效率高于ACD1组(94.74%vs 86.84%,P<0.05),复发率低于ACD1组(0 vs 10.53%,P<0.05)。两组均未出现明显的药物不良反应。结论:鱼肝油软膏应用于ACD的临床治疗具有较好的效果,其可有效改善机体的炎症反应程度,缓解局部病灶症状,降低复发率和不良反应发生率,效果优于常规治疗方法,对于ACD的临床治疗具有一定的参考价值和借鉴意义。展开更多
The non-steroidal anti-inflammatory drug ketoprofen is widely used for topical treatment. In Sweden, ketoprofen has been available for topical application since 1995. Photoallergic contact dermatitis from ketoprofen-c...The non-steroidal anti-inflammatory drug ketoprofen is widely used for topical treatment. In Sweden, ketoprofen has been available for topical application since 1995. Photoallergic contact dermatitis from ketoprofen-containing topical preparations usually includes severe eczematous reactions. Ketoprofen is derived from propionic acid, and it is also a substituted benzophenone and therefore structurally similar to fenofibrate and sunscreen agents based on benzophenones. During the last 2 years, 35 patients have been refereed to our department with suspected photoallergic or allergic reactions after having used ketoprofen-containing gels. Photopatch testing with the photopatch standard series, the ketoprofen-containing gels and their ingredients, fenofibrate, benzophenone-3, benzophenone-10 and benzophenone-4, was performed. Photoallergic reactions to ketoprofen were noted in 35 patients and a simultaneous contact allergy to ketoprofen in 2 patients. Simultaneous photoallergy to fentichlor, tetrachlorosalicylanilide and fenofibrate was registered in 74%, 40%and 73%of the patients, respectively.展开更多
Chromium allergy has become synonymous with Cr(VI) allergy.However, real exposure to chromium from leather products may include both Cr(III) and Cr(VI). In this study,we investigate the reactivity to both Cr(VI) and C...Chromium allergy has become synonymous with Cr(VI) allergy.However, real exposure to chromium from leather products may include both Cr(III) and Cr(VI). In this study,we investigate the reactivity to both Cr(VI) and Cr(III) in consecutive patients to analyse the relation between foot eczema/leather exposure and reactivity to Cr(III). From March 2002 to December 2004, 2211 consecutive patients with suspected allergic contact dermatitis were patch tested with 0.5%potassium dichromate (Cr(VI)) and 13%chromium trichloride(Cr(III)). A total of 71 (3.2%) patients had a positive reaction to Cr(VI), of which 31 also had a positive Cr(III) reaction. No Cr(VI) negative patients had a positive reaction to Cr(III). An increased risk of foot dermatitis was found in Cr(VI) positive patients with a concomitant positive or doubtful reaction to Cr(III) compared with Cr(VI) positive patients with no reactions to Cr(III). The increased risk was not due to a higher degree of sensitivity to Cr(VI). Leather was reported most frequently as the suspected cause of chromium dermatitis (54%).However, Cr(VI) allergics having foot eczema and positive or doubtful Cr(III) reactions often had positive reactions to other shoe allergens. Thus, Cr(III) allergy is part of a multiple shoe allergy pattern.展开更多
Introduction of new potential contact-sensitizing chemicals have in the past led to epidemics of contact dermatitis. A new preservative containing only methylisothiazolinone (MI)- and not methyl chloro isothiazolinone...Introduction of new potential contact-sensitizing chemicals have in the past led to epidemics of contact dermatitis. A new preservative containing only methylisothiazolinone (MI)- and not methyl chloro isothiazolinone (MCI) has recently been introduced in the European Union for use in products, such as paint, glue and cosmetics. The objective of this article is to describe a factory outbreak of contact allergy to MI and MCI preservatives. This factory outbreak describes allergic contact dermatitis towards MI in 4 patients of 14 persons working at a paint manufacturer. Patch test results from all patients showed positive reactions for MI and MCI/MI. The reactions were stronger for MI than MCI/MI indicating a primary sensitization to MI. The combination of MCI/MI remains widely used, and therefore various patterns of exposure and sensitization could be seen in the future. Our data show that MI holds a potential for eliciting and propably inducing contact allergy in humans. Whether this preservative is safe to use in cosmetics where billions of consumers are exposed needs a care full monitoring.展开更多
文摘目的:探讨鱼肝油软膏在变态反应性接触性皮炎(ACD)治疗中的应用及其对免疫因子水平的影响。方法:选取ACD患儿76例,随机分为ACD1组和ACD2组,每组各38例。另选取健康儿童38例设为对照组。ACD1组患儿给予弱效糖皮质激素等治疗,ACD2组在弱效糖皮质激素治疗的基础上,增加鱼肝油软膏涂抹患处。两组患儿均治疗4周。比较对照组及ACD1组、ACD2组治疗前后的血清免疫因子水平,包括IL-1β、IL-2、IL-4、IL-10、IL-17、IFN-γ、TNF-α;比较ACD1组、ACD2组治疗前后的局部皮损症状评分;比较两组治疗4周内的不良反应发生率及治疗8周内的复发率。结果:治疗前,ACD1组与ACD2组血清IL-1β、IL-2、IL-17、IFN-γ、TNF-α水平均高于对照组,IL-4、IL-10水平均低于对照组(P<0.05或P<0.01)。治疗后,ACD1组与ACD2组血清中IL-1β、IL-2、IL-17、IFN-γ、TNF-α均有不同程度的降低,IL-4、IL-10均有不同程度的升高(P<0.05或P<0.01);且ACD2组血清IL-1β、IL-2、IL-17、IFN-γ、TNF-α水平均低于ACD1组,IL-4、IL-10水平均高于ACD1组(P<0.05)。治疗后,ACD1组与ACD2组局部瘙痒、烧灼感、红斑、丘疹、水疱、皮损面积等症状的体征评分均不同程度地降低(P<0.05或P<0.01);且ACD2组上述评分均低于ACD1组(P<0.05)。治疗后,ACD2组总有效率高于ACD1组(94.74%vs 86.84%,P<0.05),复发率低于ACD1组(0 vs 10.53%,P<0.05)。两组均未出现明显的药物不良反应。结论:鱼肝油软膏应用于ACD的临床治疗具有较好的效果,其可有效改善机体的炎症反应程度,缓解局部病灶症状,降低复发率和不良反应发生率,效果优于常规治疗方法,对于ACD的临床治疗具有一定的参考价值和借鉴意义。
文摘The non-steroidal anti-inflammatory drug ketoprofen is widely used for topical treatment. In Sweden, ketoprofen has been available for topical application since 1995. Photoallergic contact dermatitis from ketoprofen-containing topical preparations usually includes severe eczematous reactions. Ketoprofen is derived from propionic acid, and it is also a substituted benzophenone and therefore structurally similar to fenofibrate and sunscreen agents based on benzophenones. During the last 2 years, 35 patients have been refereed to our department with suspected photoallergic or allergic reactions after having used ketoprofen-containing gels. Photopatch testing with the photopatch standard series, the ketoprofen-containing gels and their ingredients, fenofibrate, benzophenone-3, benzophenone-10 and benzophenone-4, was performed. Photoallergic reactions to ketoprofen were noted in 35 patients and a simultaneous contact allergy to ketoprofen in 2 patients. Simultaneous photoallergy to fentichlor, tetrachlorosalicylanilide and fenofibrate was registered in 74%, 40%and 73%of the patients, respectively.
文摘Chromium allergy has become synonymous with Cr(VI) allergy.However, real exposure to chromium from leather products may include both Cr(III) and Cr(VI). In this study,we investigate the reactivity to both Cr(VI) and Cr(III) in consecutive patients to analyse the relation between foot eczema/leather exposure and reactivity to Cr(III). From March 2002 to December 2004, 2211 consecutive patients with suspected allergic contact dermatitis were patch tested with 0.5%potassium dichromate (Cr(VI)) and 13%chromium trichloride(Cr(III)). A total of 71 (3.2%) patients had a positive reaction to Cr(VI), of which 31 also had a positive Cr(III) reaction. No Cr(VI) negative patients had a positive reaction to Cr(III). An increased risk of foot dermatitis was found in Cr(VI) positive patients with a concomitant positive or doubtful reaction to Cr(III) compared with Cr(VI) positive patients with no reactions to Cr(III). The increased risk was not due to a higher degree of sensitivity to Cr(VI). Leather was reported most frequently as the suspected cause of chromium dermatitis (54%).However, Cr(VI) allergics having foot eczema and positive or doubtful Cr(III) reactions often had positive reactions to other shoe allergens. Thus, Cr(III) allergy is part of a multiple shoe allergy pattern.
文摘Introduction of new potential contact-sensitizing chemicals have in the past led to epidemics of contact dermatitis. A new preservative containing only methylisothiazolinone (MI)- and not methyl chloro isothiazolinone (MCI) has recently been introduced in the European Union for use in products, such as paint, glue and cosmetics. The objective of this article is to describe a factory outbreak of contact allergy to MI and MCI preservatives. This factory outbreak describes allergic contact dermatitis towards MI in 4 patients of 14 persons working at a paint manufacturer. Patch test results from all patients showed positive reactions for MI and MCI/MI. The reactions were stronger for MI than MCI/MI indicating a primary sensitization to MI. The combination of MCI/MI remains widely used, and therefore various patterns of exposure and sensitization could be seen in the future. Our data show that MI holds a potential for eliciting and propably inducing contact allergy in humans. Whether this preservative is safe to use in cosmetics where billions of consumers are exposed needs a care full monitoring.
