A core trisaccharide of laminin, β-D-Gal-（1→4）-β-D-GlcpNAc-（1→6）-α-D-Manp-OMe, with potential anti-rumor metastatic activity was designed and prepared. 2-Iodoglactosyl azide was used as the donor to construct...A core trisaccharide of laminin, β-D-Gal-（1→4）-β-D-GlcpNAc-（1→6）-α-D-Manp-OMe, with potential anti-rumor metastatic activity was designed and prepared. 2-Iodoglactosyl azide was used as the donor to construct 2-N-acetamido-2-deoxylactosyl moiety through an azidoiodo-glycosylation reaction. Simultaneously, 1, 2-trans-β-glycosic bond was formed stereoselectively in one step with a moderate yield. This novel procedure avoided the use of 2-amino-2-deoxyglucose as both donor and acceptor.展开更多
A simple and efficient process involving the Rh(II)-catalyzed[1+1+3]annulation of diazooxindoles and vinyl azides has been developed for the synthesis of spiropyrrolidine oxindoles with potential biological activity a...A simple and efficient process involving the Rh(II)-catalyzed[1+1+3]annulation of diazooxindoles and vinyl azides has been developed for the synthesis of spiropyrrolidine oxindoles with potential biological activity and significant synthetic applications.This process involves a novel rhodium-catalyzed olefination of diazo compounds,followed by annulation with vinyl azides.This method is compatible with a broad range of substrates and affords moderate to good yields under mild reaction conditions.展开更多
This paper studies blast-induced wing crack behavior in a dynamic–static superimposed stress field using high-speed photography in combination with the optical method of caustics. With a static–dynamic loading setup...This paper studies blast-induced wing crack behavior in a dynamic–static superimposed stress field using high-speed photography in combination with the optical method of caustics. With a static–dynamic loading setup, four PMMA plate specimens with pre-existing cracks under different static loading and the same dynamic loading were tested to observe the mechanical characteristics and the kinematic characteristics of blast-induced wing cracks during the propagation process, including crack length, crack velocity and dynamic stress intensity factor(SIF) at the crack tip. The results show that the behavior of the blast-induced wing crack is affected by the explosion stress wave and initial static stress, and the initial static stress with the direction being perpendicular to the wing crack propagation direction hinders crack propagation. Furthermore, the boundary constraint condition of the specimen plays an important role on the behavior of the crack propagation in the experiment.展开更多
基金National Science Foundation of China (Grant No.20732001 and 90713004).
文摘A core trisaccharide of laminin, β-D-Gal-（1→4）-β-D-GlcpNAc-（1→6）-α-D-Manp-OMe, with potential anti-rumor metastatic activity was designed and prepared. 2-Iodoglactosyl azide was used as the donor to construct 2-N-acetamido-2-deoxylactosyl moiety through an azidoiodo-glycosylation reaction. Simultaneously, 1, 2-trans-β-glycosic bond was formed stereoselectively in one step with a moderate yield. This novel procedure avoided the use of 2-amino-2-deoxyglucose as both donor and acceptor.
基金supported by the National Natural Science Foundation of China(21572225)~~
文摘A simple and efficient process involving the Rh(II)-catalyzed[1+1+3]annulation of diazooxindoles and vinyl azides has been developed for the synthesis of spiropyrrolidine oxindoles with potential biological activity and significant synthetic applications.This process involves a novel rhodium-catalyzed olefination of diazo compounds,followed by annulation with vinyl azides.This method is compatible with a broad range of substrates and affords moderate to good yields under mild reaction conditions.
基金the financial support received from the PhD Programs Foundation of Ministry of Education of China (No. 20120023120020)the National Natural Science Foundation of China (No. 51134025)
文摘This paper studies blast-induced wing crack behavior in a dynamic–static superimposed stress field using high-speed photography in combination with the optical method of caustics. With a static–dynamic loading setup, four PMMA plate specimens with pre-existing cracks under different static loading and the same dynamic loading were tested to observe the mechanical characteristics and the kinematic characteristics of blast-induced wing cracks during the propagation process, including crack length, crack velocity and dynamic stress intensity factor(SIF) at the crack tip. The results show that the behavior of the blast-induced wing crack is affected by the explosion stress wave and initial static stress, and the initial static stress with the direction being perpendicular to the wing crack propagation direction hinders crack propagation. Furthermore, the boundary constraint condition of the specimen plays an important role on the behavior of the crack propagation in the experiment.
