口服液体缓控释制剂技术的研究进展

目的针对各类口服液体缓控释技术的释药机理、应用特点及局限性进行综述,为此类制剂的开发提供参考。方法查阅国内外相关文献,对口服液体缓控释技术进行整理归纳。结果目前已有基于离子交换树脂和微囊技术的口服液体缓控释制剂上市,此外,微球、固体脂质纳米粒、原位凝胶等技术也应用于口服液体缓控释制剂领域。结论口服液体缓控释给药系统相比于传统固体缓控释制剂,因其口服可接受性良好,剂量调整灵活,给药依从性优势明显,具有良好的开发应用前景。

离子交换树脂在药物制剂中的应用

本文对目前文献所报道的离子交换树脂及其在药物制剂中的应用进行了综述,并对药用级离子交换树脂在控释给药系统中的应用作了重点介绍。

离子交换树脂在药物制剂中的应用

目的对离子交换树脂及其于药物制剂中的应用进行综述。方法查阅近10年来国内外有关离子交换树脂于药物制剂中应用的文献,并对其中的21篇进行规纳整理。结果离子交换树脂在药物制剂中应用广泛,最重要是应用于口服液体缓控释给药系统。结论离子交换树脂在药物制剂领域倍受关注,为新型给药系统的研制提供了新的思路与方法。

新型药用辅料在液体缓控释制剂中的应用

液体控释给药系统属多相复合体系,是一种新型药物传递系统。因其在贮存中存在不稳定性,所以阻碍了许多产品的上市。本文立足于新型辅料的应用来解决上述问题,并着重介绍了药用级离子交换树脂在控释给药系统中的应用。

阳离子交换树脂对钙拮抗剂的吸附及控释特性

The purpose of this work was to investigate the effect of the chemical structure of various drugs on the exchange reaction kinetics and the release kinetics of calcium channel blockers such as verapamil hydrochloride (VH),diltiazem hydrochloride (DH).It was found that the exchange rates and equilibrium constants of exchange reaction increased with increasing of temperatures.The exchange reaction rate and apparent equilibrium constant of DH with low molecular weight and simple chemical structure were greater than that of VH with high molecular weight and complex chemical structure.The drug release studies in vitro showed that there was no found of VH and DH releasing from resinate when the deionic water was the release medium.The release rate increased with increasing of ionic strength of solutions,which indicates that the release of VH and DH from resinate strongly depends on the ionic strength of the release media.The diffusion of VH and DH within resin particles was controlled by particle diffusion process based on the equations of Body and Viswanathan.The diffusion coefficients increase with increasing of ionic strength of the releasing media.The release kinetics of VH and DH could be described satisfactorily by the equations of Boyd and Viswanathan.The results obtained in this study demonstrates that the exchange reaction process and the release process depend on the chemical structure and the molecular weight of the drugs as well as the category of the counter-ions.

口服液体剂型研究进展

本文综述了临床常用的各种口服液体剂型的特点及优势,指出了口服缓控释液体制剂血药浓度平稳、可以减少服药次数、患者顺从性高等优点,因而成为国内外研究的热点。

离子交换树脂在制药工业中的应用

本文主要对离子交换树脂概念、原理、优势与劣势、其在制药工业和药物制剂中的应用及其使用与保存进行综述,离子交换色谱在制药领域被广泛应用,应用最为普遍的是缓控释给药系统和靶向释放系统。