OBJECTIVE A system was established to evaluate the metastasis and prognosis of oral squamous cell carcinoma by analyzing the tumor differentiation, the TNM stage, the mode of invasion, and the expression of E-cadherin...OBJECTIVE A system was established to evaluate the metastasis and prognosis of oral squamous cell carcinoma by analyzing the tumor differentiation, the TNM stage, the mode of invasion, and the expression of E-cadherin and S100A4. METHODS Squamous cell carcinoma of the oral cavity of 86 cases was the focus of our study. In this system, the histopathological grade and the histochemical patterns were estimated on a 0-3 point scale, the total points graded from 0 to 13. RESULTS The incidence of metastasis and prognosis in the cases with total points more than 8 was significantly higher than that with total points less than 7 （P 〈 0.05,χ^2= 22.0658 and P 〈 0.05, χ^2= 10.7047）. The system had a significant higher specificity than that of ＇DIAGS index＇ system （Differentiation, Invasion mode, Adhesion molecules, Glycosaminoglycan, and the Sugar chain） in the evaluation of metastasis （P 〈 0.05, u = 2.2339）. Moreover, the specificity for evaluation of metastasis in the system was significantly higher than that of E-cadherin （P 〈 0.05, u = 2.4996） or S100A4 （P 〈 0.05, u = 2.4289） only. Furthermore the specificity for evaluation of unfavorable prognosis in the system was also significantly higher than that of E-cadherin （P 〈 0.05, u = 2.1313） or S100A4 only （P 〈 0.05, u = 2.0301）. CONCLUSION This is a valuable evaluation system with high specificity to predict metastatic potential and prognosis of oral squamous cell carcinoma.展开更多
基金supported by a grant from the Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry,China(No.2005383).
文摘OBJECTIVE A system was established to evaluate the metastasis and prognosis of oral squamous cell carcinoma by analyzing the tumor differentiation, the TNM stage, the mode of invasion, and the expression of E-cadherin and S100A4. METHODS Squamous cell carcinoma of the oral cavity of 86 cases was the focus of our study. In this system, the histopathological grade and the histochemical patterns were estimated on a 0-3 point scale, the total points graded from 0 to 13. RESULTS The incidence of metastasis and prognosis in the cases with total points more than 8 was significantly higher than that with total points less than 7 （P 〈 0.05,χ^2= 22.0658 and P 〈 0.05, χ^2= 10.7047）. The system had a significant higher specificity than that of ＇DIAGS index＇ system （Differentiation, Invasion mode, Adhesion molecules, Glycosaminoglycan, and the Sugar chain） in the evaluation of metastasis （P 〈 0.05, u = 2.2339）. Moreover, the specificity for evaluation of metastasis in the system was significantly higher than that of E-cadherin （P 〈 0.05, u = 2.4996） or S100A4 （P 〈 0.05, u = 2.4289） only. Furthermore the specificity for evaluation of unfavorable prognosis in the system was also significantly higher than that of E-cadherin （P 〈 0.05, u = 2.1313） or S100A4 only （P 〈 0.05, u = 2.0301）. CONCLUSION This is a valuable evaluation system with high specificity to predict metastatic potential and prognosis of oral squamous cell carcinoma.
