Herein, we review the development, applications and potential prospects of CBT-Cys click reaction. This click condensation reaction is based on the condensation reaction between 2-cyanobenzothiazole(CBT) and D-cystein...Herein, we review the development, applications and potential prospects of CBT-Cys click reaction. This click condensation reaction is based on the condensation reaction between 2-cyanobenzothiazole(CBT) and D-cysteine(D-Cys) in fireflies and has high biocompatibility and controllability in physiological solutions. Under the control of p H, reduction, or enzyme, this CBTbased click reaction has been widely applied to a wide range of biomedical fields such as protein labeling, molecular imaging(e.g., optical imaging, nuclear imaging, magnetic resonance imaging and photoacoustic imaging), nanomaterial fabrication, cancer therapy, and other potentialities.展开更多
基金supported by the Ministry of Science and Technology of China (2016YFA0400904)the National Natural Science Foundation of China (21725505, 21675145)the Major program of Development Foundation of Hefei Center for Physical Science and Technology (2016FXZY006)
文摘Herein, we review the development, applications and potential prospects of CBT-Cys click reaction. This click condensation reaction is based on the condensation reaction between 2-cyanobenzothiazole(CBT) and D-cysteine(D-Cys) in fireflies and has high biocompatibility and controllability in physiological solutions. Under the control of p H, reduction, or enzyme, this CBTbased click reaction has been widely applied to a wide range of biomedical fields such as protein labeling, molecular imaging(e.g., optical imaging, nuclear imaging, magnetic resonance imaging and photoacoustic imaging), nanomaterial fabrication, cancer therapy, and other potentialities.
