In this paper, we produce porous silicon （PSi） by electrochemical etching, and it is the first time to evaluate the performance of label-free porous silicon biosensor for detection of variable domain of heavy chain ...In this paper, we produce porous silicon （PSi） by electrochemical etching, and it is the first time to evaluate the performance of label-free porous silicon biosensor for detection of variable domain of heavy chain of heavy-chain antibody （VHH）. The binding of hen egg white lysozyme （HEWL） and VHH causes a red shift in the reflection spectrum of the biosensor. The red shift is proportional to the VHH concenlration in the range from 14 gg.ml-I to 30 pg.ml~ with a detection limit of 0.648 ng.ml~. The research is useful for the development of label-free biosensor applied in the rapid and sensitive determination of small molecules.展开更多
Wearable and stretchable physical sensors that can conformally contact on the surface of organs or skin provide a new opportunity for human-activity monitoring and personal healthcare. Particularly, various attempts h...Wearable and stretchable physical sensors that can conformally contact on the surface of organs or skin provide a new opportunity for human-activity monitoring and personal healthcare. Particularly, various attempts have been made in exploiting wearable and conformal sensors for ther- mal characterization of human skin. In this respect, skin- mounted thermochromic films show great capabilities in body temperature sensing. Thermochromic temperature sensors are attractive because of their easy signal analysis and optical recording, such as color transition and fluorescence emission change upon thermal stimuli. Here, desirable mechanical properties that match epidermis are obtained by physical crosslinking of polydiacetylene （PDA） and transparent elas- tomeric polydimethylsiloxane （PDMS） networks. The result- ing PDA fdm displayed thermochromic and thermo- fluorescent transition temperature in the range of 25-85℃, with stretchability up to 300% and a skin-like Young＇s mod- ulus of -230 kPa. This easy signal-handling provides excellent references for further design of convenient noninvasive sen- sing systems.展开更多
基金supported by the Influence de la Vitesse sur le Comportement de la Structure de Assise(INVICSA)Research Project Funded by SNCF-RESEAUthe Association Nationale de Recherche et Technologie(ANRT)with a Convention Industrielle pour la Formation dans la Recherché(CIFRE)(No.2012/1150)
基金supported by the National Natural Science Foundation of China (No.60968002)
文摘In this paper, we produce porous silicon （PSi） by electrochemical etching, and it is the first time to evaluate the performance of label-free porous silicon biosensor for detection of variable domain of heavy chain of heavy-chain antibody （VHH）. The binding of hen egg white lysozyme （HEWL） and VHH causes a red shift in the reflection spectrum of the biosensor. The red shift is proportional to the VHH concenlration in the range from 14 gg.ml-I to 30 pg.ml~ with a detection limit of 0.648 ng.ml~. The research is useful for the development of label-free biosensor applied in the rapid and sensitive determination of small molecules.
基金supported by the National Key Research and Development Program of China (2016YFB0700300)the National Natural Science Foundation of China (51503014 and51501008)the State Key Laboratory for Advanced Metals and Materials (2016Z-03)
文摘Wearable and stretchable physical sensors that can conformally contact on the surface of organs or skin provide a new opportunity for human-activity monitoring and personal healthcare. Particularly, various attempts have been made in exploiting wearable and conformal sensors for ther- mal characterization of human skin. In this respect, skin- mounted thermochromic films show great capabilities in body temperature sensing. Thermochromic temperature sensors are attractive because of their easy signal analysis and optical recording, such as color transition and fluorescence emission change upon thermal stimuli. Here, desirable mechanical properties that match epidermis are obtained by physical crosslinking of polydiacetylene （PDA） and transparent elas- tomeric polydimethylsiloxane （PDMS） networks. The result- ing PDA fdm displayed thermochromic and thermo- fluorescent transition temperature in the range of 25-85℃, with stretchability up to 300% and a skin-like Young＇s mod- ulus of -230 kPa. This easy signal-handling provides excellent references for further design of convenient noninvasive sen- sing systems.
